Over 25 million people in the U.S. alone have benefited from statins--such drugs as Lipitor, Zocor, Crestor, Pravachol, and other cholesterol-lowering medicines--in preventing stroke, heart attack, and other forms of coronary heart disease. But how did these remarkable, life-saving drugs come into being? In Triumph of the Heart, Dr. Jie Jack Li, a medicinal chemist and expert on drug discovery, tells for the first time the fascinating story of statins. Drawn from discussions with many scientists involved in the discovery and development of these drugs, the book illuminates the human side of science by revealing the role played by persistence, luck, and sudden insight that characterize major discoveries. For scientists in the drug industry, health care professionals, students of medicine, and all those intrigued by the basic human drive to explore and discover, Triumph of the Heart offers a compelling view of one of the most important drug discoveries of our time.

The Heart and Toxins brings together global experts to provide the latest information and clinical trials that make the connection between genetic susceptibility, gene expression, and environmental factors in cardiovascular diseases. This unique reference, edited by renowned cardiologist Meenakshi Sundaram Ramachandran, solves the problem of managing multiple clinical cases of cardiovascular toxicity. It allows connections to be made between research, diagnosis, and treatment to avoid higher morbidity and mortality rates as a result of cardiovascular toxicity.

This important reference, edited by Ronald Ross Watson and Betsy Dokken, collects the research needed to make the distinct connection between pre-diabetes, diabetes, and cardiovascular disease. Glucose Intake and Utilization in Pre-Diabetes and Diabetes: Implications for Cardiovascular Disease explains the mechanisms of progression from pre-diabetes to diabetes to cardiovascular disease. Since pre-diabetes and diabetes are important cardiovascular disease risk factors, and impaired glucose metabolism among cardiac patients is extremely prevalent, the importance of reviewing pre-diabetes and its involvement in CVD complications is vital as one applies food and glycemic control to slow progress to diabetes and heart disease. The book further focuses on glucose intake and utilization in diabetes, including coverage of diabetes in the development and pathology of cardiovascular disease, risks and epidemiology of cardiovascular problems promoted by diabetes, macrovascular effects and their safety in therapy of diabetics, beta cell biology and therapy of diabetes, and nutrition to modulate diabetes.

This issue of Critical Care Clinics, guest edited by Shashank S. Desai and Nitin Puri, covers Cardiac Emergencies in the Intensive Care Unit. Articles include: Acute Myocardial Infarction, Managing Arrhythmias in the Intensive Care Unit, Cardiogenic Shock, Hemodynamic Assessment in the Contemporary Intensive Care Unit: A Review of Circulatory Monitoring Devices, Submassive Pulmonary Embolism, Management of Right Heart Failure in the Critically Ill, Cardiothoracic Surgical Emergencies in the Intensive Care Unit, Perioperative Complications of Cardiac Surgery and Postoperative Care, Mechanical Circulatory Devices in Acute Heart Failure, and more!

This issue of Heart Failure Clinics examines Heart Failure with Preserved Ejection Fraction (HFPEF). The followings aspects of HFPEF are addressed: epidemiology, etiologic factors and pathophysiology, diagnosis, clinical spectrum, imaging, invasive hemodynamic characterization, exercise physiology, natriuretic peptides, novel biomarkers, differential diagnoses and comorbidities, outcomes, clinical trials, current therapeutic approach, and novel therapeutic targets.

This issue of Interventional Cardiology Clinics, edited by Susheel K. Kodali, is devoted to Transcatheter Aortic Valve Replacement. Dr. Kodali assembled a group of expert contributors to review the following topics: Risk Assessment in Patient Selection for Transcatheter Aortic Valve Replacement; Management of Coronary Disease in the Era of Transcatheter Aortic Valve Replacement: Comprehensive Review of the Literature; Imaging the Aortic Annulus with Multi-Detector Computed Tomography and 3-Dimensional Transesophageal Echocardiography; The Role of Preoperative and Intraoperative Imaging in Guiding Transcatheter Aortic Valve Replacement; Assessment of Paravalvular Regurgitation Following Transcatheter Aortic Valve Replacement; Impact and Management of Paravalvular Regurgitation After Transcatheter Aortic Valve Replacement; Neurologic Events After Transcatheter Aortic Valve Replacement; Nontransfemoral Approaches to Transcatheter Aortic Valve Replacement; and Valve-in-Valve Therapy for Failed Surgical Bioprosthetic Valves: Clinical Results and Procedural Guidance.

The arteries to the upper extremities can be involved at multiple levels by a variety of diseases. Because of the critical sensitivity of motor function and sensation in the arms and hands, minor degrees of ischemia can have major clinical significance. It is essential to understand the exact pathologic process and the sites of involvement to provide proper therapy. This issue will include articles such as: The diagnosis of vaso-occlusive disease within the hand, Botox in the management of vascospastic disorders, Vascular injuries in sports activities, Present options for the management of hypothenar hammer syndrome and many more!

This issue of Cardiac Electrophysiology Clinics examines electrocardiography of complex arrhythmias. Topics include concealed conduction, right and left atrial macroreentrant tachycardias, focal atrial fachycardias, AV nodal and AV reentrant tachycardia, wide complex tachycardias, ventricular tachycardia in CAD, ECG characteristics of outflow tract VT, fascicular tachycardias, VT in non-ischemic dilated cardiomyopathy, VT originating from unusual sites, incessant VT and VT storms, ECG characteristics of TdP, VT in ARVC, and ventricular arrhythmia in inherited channelopathies, arrrhythmias in complex congenital heart disease, AV conduction disease and block, electrocardiographic analysis of paced rhythms.

This issue of Interventional Cardiology Clinics examines approaches to left atrial appendage exclusion. Topics include stroke and bleeding risks in patients with atrial fibrillation, embryology and anatomy, rationale, catheter-based endocardial closure, pericardial access, catheter-based epicardial closure, surgical closure, device and left atrial appendage specific characteristic for successful closure, clinical results, the role of CTA and MRA imaging, imaging with TEE, post-procedural management, and prevention and management of complications. ".An excellent book, written by experts in the field...I would highly recommend it to medical and surgical staff interested in this subject." Reviewed by Perfusion, Apr 2015

Interventional cardiologists are able to perform minimally invasive procedures, such as angioplasty and stenting, due to imaging technologies that allow them to see inside the heart and blood vessels without open surgery. Such imaging often requires injection of contrast media, which are generally safe, but for some patients with drug sensitivities or compromised kidney function, contrast-induced nephropathy (CIN) can result. CIN is a major complication that can increase in-hospital mortality. This issue of Interventional Cardiology Clinica addresses the management, treatment, and prevention of renal complications in the catheterization laboratory.

This issue of Heart Failure Clinics examines co-morbidities in patients with heart failure. Topics include hypertension, diabetes, pulmonary disorders, cardiorenal syndrome, anemia, depression, atrial fibrillation, obesity and cardiac cachexia, peripheral vascular disease, rheumatologic disorders, co-morbidities and polypharmacy, coronary artery disease, and clinical trials.

Combining the research and study of integrative Chinese and Western Medicine, Integrative "Cardiovascular Chinese Medicine: A Prevention and Personalized Medicine Perspective" presents a clear, structured base to guide clinical practice and encourage collaboration between Chinese medicine and Western medicine practitioners.

This complete reference work thoroughly covers the pathophysiology of cardiology-related diseases, and compares, juxtaposes, and integrates Western and traditional Chinese medicine (TCM). Anika Niambi Al-Shura provides a realistic scope of cardiology treatment and the integration of Western and Chinese medicine, establishing a basis for standardization and a rationale for the inclusion of TCM in cardiology, and identifying and inspiring ideas for future research.
Integrates Western and Chinese medicine for a realistic scope of cardiology treatmentEstablishes basis for standardization and rationale for the inclusion of traditional Chinese medicine in cardiology"Clinical pearls" provide a guiding base of traditional Chinese medicine in clinical useOffers a reference section that lists the latest in published studiesPresents easy access to the medicines and herbs used in both Chinese and Western medicine, including photos and information about the current patents

Coronary artery disease is the number one killer in the United States, affecting more than 13 million Americans each year. This issue of Cardiology Clinics comprehensively examines the epidemiology, traditional and novel risk factors, and management of coronary artery syndromes; invasive and noninvasive testing; CT angiography; medically refractory angina; diabetes and coronary artery disease, revascularization options, and Syndrome X.

Because atrial fibrillation promotes the formation of blood clots that can travel to the brain and block an artery, atrial fibrillation independently increases the risk of ischemic stroke four-to-five-fold. In this issue expert authors review drug therapies for stroke prevention, use of the new anticoagulants, ablation strategies for stroke prevention, LAA closure for stroke prevention, stroke in heart rhythm device patients, transesophageal echo in atrial fibrillation, and other topics important to the management of this serious complication. "A comprehensive and well-referenced source of evolving information, clinical trials and their implications." Reviewed by Perfusion, Apr 2015

This issue of Cardiology Clinics examines pacemakers and implantable cardioverter defibrillators (ICD). Topics include device selection, indications and guidelines for device therapy, shock avoidance, lead advisories and recalls, lead extraction, subcutaneous ICDs, device tools to manage the heart failure patient, and many more.

This volume of the esteemed "Progress in Molecular Biology and Translational Science" series focuses on cutting-edge research related to the genetics of cardiovascular disease. Written by top experts in the field, this volume covers a range of topics, including:

Genetic models of atherosclerosis

MicroRNAs in cardiovascular disease

The role of the transcription factor KLF2 in vascular development and disease

Zebrafish as models of cardiovascular disease and hematopoietic development

"Progress in Molecular Biology and Translational Science" provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references.

Key features: The authors are all experts in the fieldThe reviews are in themselves comprehensiveEach topic has the potential to lead to advances in therapy of cardiovascular disease

Most physicians entering the field of pediatric cardiology are drawn to it by an interest in the wide variety of congenital heart defects which present at various ages. Most congenital heart disease will be evident in early life, presenting with cyanosis, heart murmur, congestive heart failure or shock. Textbooks in pediatric cardiology are filled overwhelmingly with chapters on the various congenital heart lesions which are encountered, both rare and common. However, practicing pediatric cardiologists will be quick to point out that a significant number of referrals to any practice do not involve congenital heart problems. Reviewing our own statistics at the Children's Hospital of Michigan Cardiology Center for the past two years (2010-2012) reveals that outpatient visits for new patient consultations examined by age groups are: less than 1 year of age - 11%; 1-5 years - 23%; 6-10 years - 21%; 11-18 years - 45%. Retrospective data collected from billing codes, as in this brief survey, may imprecise. However, it does provide a snapshot of the usual referral problems encountered by pediatric cardiologists. In our practice, the most common overall reason for referral in all ages was "heart murmur", constituting 26% of total referrals. Second were rhythm and rhythm related problems (inclusive of palpitations, abnormal ECG and diagnosed premature beats) constituted 19% of the total. In the age group of interest for this book of 11-18 years, the most common presenting issues were rhythm related (23%) and chest pain (23%), followed by syncope or dizziness (19%) and heart murmur (12%). Congenital heart disease diagnoses encountered in the 11 to 18 year age group comprised only 6.5% of referrals within that age group. It is likely that many of these were not new diagnoses (with a few exceptions), but rather represented transfers to our practice. Our own outpatient clinical experience reveals that the majority of outpatients referred by pediatricians for pediatric cardiology evaluation are between the ages of 11 and 18. The majority of these new referrals are not for congenital heart disease. Our intent for this edition of Pediatric Clinics of North America is to describe the types of problems which seem to be of concern to the pediatric community within this age group and to describe strategies for evaluation. "This issue of PCNA surely will prove to be a valuable collection for any motivated primary care professional dealing with adolescents health." Reviewed by: Neel Kamal, Feb14

"Erectile Dysfunction as a Cardiovascular Impairment" organizes and summarizes the many aspects of biology and metabolism in cardiovascular and sexual function. Coverage includes how blood vessels are discovered to work, their role in hypertension, atherosclerosis, type-2 diabetes, oxidative stress, metabolic syndrome, and erectile dysfunction.
Unifies medical disorders linked to cardiovascular and heart disease as endothelium impairment, to which
vasculogenic erectile dysfunction is now added and given equal rank for the first timePresents hypertension, atherosclerosis, metabolic syndrome, and erectile dysfunction as symptoms of diseaseOffers clinical research on vasculogenic erectile dysfunction predicting onset and severity of heart disease.

Topics in this clinically focused publication devoted to Cardiac Markers include: Overview of cardiac markers in heart disease; Methodologies for measurement of cardiac markers; Natriuretic peptides in HF and ACS; Tropoinins and high sensitivity troponins; Point-of-care testing for cardiac markers; ST-2 and galectin 3 in patients with heart failure; Cardiac markers following heart surgery and percutaneous coronary intervention; Cholesterol, lipoproteins, high sensitivity CRP and other risk factors for atherosclerosis; Myocarditis and cardiac transplant and rejection; New molecular genetic tests in the diagnosis of heart disease; Biomarkers for cholesterol balance.

2014 BMA Medical Book Awards Highly Commended in Cardiology category! Apply the latest percutaneous techniques with the practical, highly illustrated Interventional Procedures for Structural Heart Disease. This brand-new medical reference book presents full-color images, numerous tables, and invaluable clinical pearls to help you utilize today's hottest techniques and technologies for each disease, so you can offer your patients the most desirable outcomes possible. Master today's hottest percutaneous procedures for structural heart disease as perfected by experts from around the world, including transcatheter aortic valve replacement (TAVR), percutaneous paravalvular leak closure, transcatheter mitral valve interventions, a wide variety of adult congenital cardiovascular defect interventions, and more. Grasp the specific knowledge you will need for success in a variety of clinical scenarios, as well as the patient selection criteria for each invasive procedure. Make informed, evidence-based decisions with the latest clinical trial results and evidence integrated into each chapter. Visualize the newest techniques and technologies more clearly through a full-color design featuring illustrations, tables, clinical pearls, complications, and current evidence boxes. Seamlessly search the full text online at Expert Consult.

This issue of Interventional Cardiology Clinics reviews pharmacologic agents currently used to treat patients in the cath lab. All the pharmaceutical knowledge an interventionalist needs is summarized in this handy reference.

"Electrocardiography of Laboratory Animals" is the only book covering electrocardiography of laboratory animals, including dogs, mini-pigs, and cynomologus monkeys. As more countries institute requirements for the care of laboratory animals in research, this publication offers an effective standard on performing and analyzing ECGs. Topics covered include safety electrocardiography, toxicology, safety pharmacology, and telemetry. "Electrocardiography of Laboratory Animals" will assist biological and medical researchers, veterinarians, zoologists, and students in understanding electrocardiography of various species of animals used in research.
Covers safety electrocardiography of large laboratory animalsOffers comprehensive analysis of ECGs for practical laboratory useIncludes a self-evaluation section for testing of ECG reading and analysis

This issue of Cardiac Electrophysiology Clinics covers remote monitoring in heart failure, atrial fibrillation, and stroke/TIA among other conditions. The issue also includes cardiac and vascular pressure sensors and leadless cardiac pacing, helping the clinician to keep current with the latest advances in technology.