Landmark Papers in Cardiovascular Medicine provides a thorough and wide-ranging analysis of core examples of novel research, clinical trials and seminal papers published in the medical literature that have paved the way for breakthroughs in the management of the entire spectrum of cardiovascular disease. These papers may have produced positive, negative or equivocal findings but are regarded by the experts as having either stimulated a paradigm shift in therapeutic strategy or been the catalyst for new and improved methods of research, diagnosis or drug development. Our aim is to provide both a benchmark and inspiration for future work in the field of cardiovascular medicine and also to give the reader an insight into the mechanics and infrastructure of how high-quality evidence-based medicine has been produced. Each trial summary is punctuated by sections on 'strengths and limitations', 'impact on the field', 'learning points' and 'further reading' suggestions that allow for a completely holistic analysis of the data. The experts also give their views on what research is currently underway, their hopes for the future and what advances they predict will occur in each subspecialty field of cardiovascular medicine, making this book essential reading for all those individuals with an interest in the field.

This book provides an up-to-date review of the fundamentals of lipid metabolism and its role in cardiovascular diseases. Focusing on lipid transfer proteins in the circulation and cells, the role of important lipid transporters, the effect of recently discovered lipid binding proteins, and the link between lipid metabolism disorders and cardiovascular diseases, it covers phospholipid transfer protein, cholesteryl ester transfer protein, lipopolysaccharide binding protein, microsomal triglyceride transfer protein, ABC binding cassette members, and more. The book offers graduate students and researchers a coherent overview of lipid transfer and transport, as well as the limitations of current research in the field, and promotes further studies on cardiovascular diseases, as well as pharmaceutical research on drug discovery based on lipid transfer, transport, and binding.

The heart is invested with a complex, intertwining network of blood and lymphatic vessels which, respectively, provide the cardiac tissue with oxygen and nutrients and eliminate excess fluid from the interstitium. The coronary blood vessels have been the focus of much investigation in the past few decades. On the other hand, the literature regarding the cardiac lymphatic vessels remains sparse, despite their important role in maintaining normal heart function. With this in mind, a better understanding of the cardiac lymphatic network and its ability to regulate fluid homeostasis within the heart could give us insight into developing therapies for the alleviation of several cardiac pathological conditions.

Inquiry, Treatment Principles and Plans in Integrative Cardiovascular Chinese Medicine, volume five in the Integrative Cardiovascular Chinese Medicine series, provides the benefits of using the intake form, patient narratives and proper inquiry based on Chinese and Western medicine methods within the clinical setting to establish reliable treatment plans for cardiovascular patients. This reference is organized systematically into three sections covering questionnaires and testimony from patients, inquiry and physical examination techniques that are useful for examining cardiac patients, and specific cardiovascular symptoms in the new and returning patient, including definition of the symptom and clinical significance from Chinese and Western perspectives and treatment principles. This important reference will aid cardiovascular researchers in the study of integrative Chinese and Western medicine with its clear, structured base to guide clinical practice and encourage collaboration between Chinese and Western medicine practitioners.

This issue of Interventional Cardiology Clinics, guest edited by Dr. Binita Shah, will cover the latest updated in Transradial Angiography and Intervention. This issue is one of four selected each year by the series Editor-in-Chief, Dr. Matthew Price. Topics discussed in this issue will include: Accessing the Wrist, Coronary Cannulation, Optimizing Transradial Access, The Value of Transradial: Healthcare Economics and Patient Satisfaction, Vascular Complications of the Wrist: Prevention and Management, #RadialFirst in CHiP and Cardiogenic Shock, Radial versus Femoral Access in Acute Coronary Syndrome, Accessing the Arm for Peripheral Interventions, Using the Arm for Structural Interventions, and the Neuro Radialist.

Perspectives of Ayurveda in Integrative Cardiovascular Chinese Medicine for Patient Compliance, volume four in the Integrative Cardiovascular Chinese Medicine series, provides a systematic perspective of therapeutic priority by examining the homeostasis of the body, mind and spirit through Ayurveda philosophies and universal attributes, including five key elements. Holism, patient compliance and ethics in medicine are discussed, as are responsibility, awareness and guidance for compliance in cardiac patients. Finally, strategies of compliant patients outline and compare Ayurvedic and Chinese medicine for dietary laws and recovery techniques, utilizing both systems for personal benefit and what compliance means and looks like in clinical settings. This important reference will aid cardiovascular researchers in the study of integrative Chinese and Western medicine, while also providing a clear, structured base to guide clinical practice and encourage collaboration between practitioners.

Medical Empathy, Pharmacological Systems, and Treatment Strategies in Integrative Cardiovascular Chinese Medicine, volume two in the Integrative Cardiovascular Chinese Medicine series, presents sections on holism and humanity in medicine, considering the patient, medical empathy in prescribing, modifying and weaning, an overview of pharmacologic systems, an overview of pharmacology sciences and the cardiovascular drug classes and types as revealed from perspectives of Chinese and Western medicine, including descriptions of pharmaceutical drugs from China and the United States, with current pictures and inpatient directions. Finally, principles and treatments according to disease stages for each cardiovascular disease within the scope of integrative medicine is outlined. This important reference will aid cardiovascular researchers in the study of integrative Chinese and Western medicine and provide a clear, structured base to guide clinical practice and encourage collaboration between Chinese and Western medicine practitioners

This collection of papers represents an edited version of the Proceedings of the 9th European Symposium on Metabolism which was held at the University of Padua (Italy) from October 12-14, 2006. As did the Symposium itself, this work unites under a single cover topics dealing with four important metabolic alterations: diabetes, obesity, hyperlipidemia and hypertension. Of vital interest to the scientific community because of their cost in human life and medical expenditure, the latest edition of this Symposium received much attention from investigators in these fields. The 2006 edition focusses on the most recent epidemiologic findings on the role of oxidative stress and of endothelial dysfunction on the development of atherosclerosis. Other topics of particular interest are: abdominal obesity, pro-inflammatory adipokines and atherogenesis; the metabolic syndrome and cardiovascular global risk; coronary and cerebrovascuclar disease in diabetes and in the metabolic syndrome. Finally, the management, prevention and treatment of the metabolic syndrome and its cardiovascular complications are examined in the light of several recent clinical trials in these fields. This volume will certainly be of interest to all those practitioners and specialists who are looking for a broad, though specific overview on several aspects of insulin resistance as a possible pathogenetic mechanism and a guide to preventing and treating the metabolic syndrome and its cardiovascular complications in their patients.

MORBID OBESITY: WILL YOU ALLOW IT TO KILL YOU?
Following the style of his previous books, Sex and the Cardiac Patient and AnsweringYour Questions About Heart Disease and Sex, informative, educational, entertaining, andbold, Dr. Eduardo Chapunoff takes us this time into the complex world of the morbidlyobese.
This work describes how and why the cardiovascular and other systems become affectedby excessive weights. His own simple, schematic illustrations will help you to understandhow morbid obesity leads to heart attacks, heart failure, strokes, sleep apnea, and manyother conditions, including sudden death.
Major treatment decisions are facilitated by Dr. Chapunoff's down-to-earth explanations.Also addressed here is the unfairness and ineffectiveness of some insurance corporations incovering the costs of weight-loss surgery. For many of those who read this book -patients aswell as health care practitioners and undergraduates- the concepts and the understandingof what morbid obesity is all about will never be the same.

This issue of Heart Failure Clinics, Guest Edited by Drs. George L. Bakris and Ragavendra R. Baliga, will focus on Hypertensive Heart Disease. Areas covered include Epidemiology and Natural History, Pathophysiology and Natural History, Special Populations, and Prognostic Markers and Management. Topics include, but are not limited to, Progression of Hypertensive Heart Disease, Diagnosis and Prevention of Hypertensive of Heart Failure, Evolution from Hypertension to Heart Failure, Changes in Kidney Function in Heart Failure, Implication of Acute Kidney Injury in heart failure, Myocardial fibrosis in hypertensive patients with heart failure, Hypertensive Heart Failure in the Very Old, Hypertension in the Cardio-Oncology Clinic, Hypertension after Cardiac Transplantation, Hypertensive Heart Failure in Women, Hypertensive Heart Failure in Obesity and Obstructive Sleep Apnea, Hypertensive Heart Failure in African Americans, Reverse J-curve relationship between on-treatment blood pressure and mortality in patients with heart failure, Hypertension and Heart Failure with Ejection Fraction, Hypertension and Arrhythmias, Hypertension Treatment in Diabetes: Focus on Heart Failure Prevention, and Management of Acute Hypertensive Heart Failure.

Coronary Calcium: A Comprehensive Understanding of Its Biology, Use in Screening, and Interventional Management provides a comprehensive update on the current understanding of the significance of coronary artery calcification, showing the connection to the development of advanced atherosclerosis that will lead to better risk evaluations. Coverage includes information on the basic science behind the development of coronary calcium in atherosclerotic lesions, the pathology of calcified coronary lesions in humans, its differential development by race, and its relationship to plaque progression. Computed tomography is also covered to show the significance of coronary calcium for risk prediction and the potential role of various pharmacologic interventions. Each chapter contains summaries with salient and important points, making this book perfect for researchers and physicians interested in the field of vascular calcification.

This issue of Heart Failure Clinics, Guest Edited by Dr. Pasquale Perrone Filardi, will focus on Hormonal and Metabolic Abnormalities in Heart Failure Patients. This issue is one of four selected for the year by the series Consulting Editor, Eduardo Bossone. Topics include, but are not limited to, Glucose metabolism abnormalities in heart failure patients, Diabetic cardiomyopathy, New oral antidiabetics in chronic heart failure, Metabolic syndrome and heart failure, Eritropoietin anemia and iron vs. exercise capacity in chronic heart failure, Prognostic value of hormonal abnormalities in heart failure patients, Hormonal Replacement Therapy in Heart Failure, The management of thyroid abnormalities in chronic heart failure, Acromegaly and heart failure, Beta-receptor signaling and heart failure, and Evaluation of cardiac metabolism by magnetic resonance spectroscopy in heart failure.

This issue of Neurologic Clinics, guest edited by Dr. David S. Younger, covers Vasculitis and the Nervous System. Topics include, but are not limited to, History and Background of Vasculitis, Overview of Primary and Secondary Vasculitis, Epidemiology of Primary Systemic Vasculitis, Comorbidity and Health Outcomes of Vasculitis, Experimental Autoimmune Vasculitis, Genetic Basis of Vasculitides, General Approach to the Patient with Vasculitis, ANCA-Associated Vasculitis, Polyarteritis Nodosa, Giant Cell Arteritis, Dermatologic Aspects of Vasculitides, Neuro-Ophthalmologic Aspects of Vasculitides, The Blood-Brain Barrier: Implications for Vasculitis, Adult Primary Angiitis of the Central Nervous System, Childhood Inflammatory Brain Diseases, Adult Vasculitic Stroke, Central Nervous System Vasculitis Due to Substance Abuse, Peripheral Nerve Vasculitis: Classification and Disease Associations, Hashimoto Encephalopathy: Autoimmune Encephalitis or Vasculitis, and Treatment of Primary Systemic and Nervous System Vasculitis.

This issue of Interventional Cardiology Clinics will explore Transcatheter mitral valve repair and replacement. Curated by the series Editor-in-Chief, Dr. Matthew J. Price, this issue will cover topics and advances in the field that are relevant for practicing clinicians. This issue is one of four selected each year by Dr. Price. The volume will include articles on: Transcatheter Mitral Valve Direct Annuloplasty With the Millipede Device, Transcatheter Mitral Valve Replacement with Intrepid, Transcatheter Mitral Valve Replacement with Tendyne, Treatment of functional mitral regurgitation with transcatheter edge-to-edge repair, Transcatheter Edge-to-Edge repair for Degenerative Mitral Regurgitation, Predicting Left Ventricular Outflow Tract Obstruction Following Transcatheter Mitral Valve Replacement, Prevention and Treatment of Left Ventricular Outflow Tract Obstruction after Transcatheter Mitral Valve Replacement, and Transatrial implantation of transcatheter heart valve for mitral disease, among others.

This issue of Medical Clinics of North America, guest edited by Dr. Otto Costantini, is devoted to Cardiac Arrhythmias. Articles in this important issue include: Basic principles of cardiac electrophysiology; The electrocardiogram: Still a useful tool in the primary care office; Palpitation: Extended electrocardiogram monitoring: Which tests to use and when; Inherited cardiac arrhythmias/channelopathies; Antiarrhythmic drugs: Benefits and risks; Stroke prevention in atrial fibrillation: Anticoagulants and/or devices; Pharmacologic and non-pharmacologic management of atrial fibrillation; Supraventricular tachycardia; Ventricular tachycardia with and without structural heart disease; Cardiac Devices: Pacemakers, Defibrillators and Biventricular Devices; Brady-arrhythmias; When is syncope arrhythmic?; Sudden Cardiac Death: Who is at risk?; and Arrhythmias and Congenital Heart Disease. A CME program is also available for this title.

The Internet and other technological developments are now playing increasing roles in consumer health and the delivery of health services. Ubiquitous Cardiology: Emerging Wireless Telemedical Applications provides developmental solutions and explanations for cardiovascular diagnostics. Useful to field researchers, academicians, and healthcare practitioners, this Premier Reference Source presents a collection of studies on medical data redundancy, priority, and validity.

This book covers the latest research development in heart valve biomechanics and bioengineering, with an emphasis on novel experimentation, computational simulation, and applications in heart valve bioengineering. The most current research accomplishments are covered in detail, including novel concepts in valvular viscoelasticity, fibril/molecular mechanisms of tissue behavior, fibril kinematics-based constitutive models, mechano-interaction of valvular interstitial and endothelial cells, biomechanical behavior of acellular valves and tissue engineered valves, novel bioreactor designs, biomechanics of transcatheter valves, and 3D heart valve printing. This is an ideal book for biomedical engineers, biomechanics, surgeons, clinicians, business managers in the biomedical industry, graduate and undergraduate students studying biomedical engineering, and medical students.