The fifth edition of ECG in Medical Practice has been fully revised to provide trainees with the latest advances in ECG, helping them recognise, interpret and diagnose cardiac abnormalities. Divided into three sections, the first part of the book presents the basic principles of ECG and normal and abnormal ECG patterns. The following chapters describe ECG changes in different heart diseases, emphasising efficiency and fluency in interpreting the patterns. The final section provides 151 ECG tracings for trainees to practise and interpret on their own. Presented in an easy to read format, with bulleted key points enhanced by pictures to help understanding, this new edition includes even more ECG tracings than the previous edition. Key points Fully revised, new edition helping trainees recognise, interpret and diagnose cardiac abnormalities through ECG Covers normal ECG patterns and ECG abnormalities relating to numerous different cardiac conditions Includes 151 ECG tracings for trainees to practise Previous edition (9789351520061) published in 2014

Session I: Left Ventricular Hypertrophy: Structural Aspects and Mechanisms.- 1. Relations of Left Ventricular Geometry and Function to Prognosis in Hypertension.- 2. Left Ventricular Hypertrophy, Arterial Compliance, and Aging.- 3. Left Ventricular Hypertrophy and Arterial Blood Pressure in Experimental Models of Hypertension.- 4. Regulation and Role of Myocardial Collagen Matrix Remodeling in Hypertensive Heart Disease.- 5. Ultrasonic Reflectivity of the Heart: A Measure of Fibrosis?.- 6. Local Angiotensin II and Myocardial Fibrosis.- 7. Left Ventricular Anatomy and Function in Primary Aldosteronism and Renovascular Hypertension.- Session II: Pathophysiological and Molecular Aspects.- 8. Hypertension Differentially Affects the Expression of the Gap Junction Protein Connexin43 in Cardiac Myocytes and Aortic Smooth Muscle Cells.- 9. Modulation of Cardiac Hypertrophy by Estrogens.- 10. Salt Sensitivity and Left Ventricular Hypertrophy.- 11. Volume Overload, Atrial Natriuretic Peptide, and Left Ventricular Hypertrophy.- 12. The Renin-Angiotensin System Gene Polymorphism and Left Ventricular Hypertrophy.- 13. Renin-Angiotensin System Gene Polymorphisms and Left Ventricular Hypertrophy: The Case against an Association.- Session III: Pathophysiological and Therapeutic Aspects.- 14. Left Ventricular Hypertrophy and Arterial Hypertrophy.- 15. Relationship between Cardiac Hypertrophy and Microalbuminuria.- 16. Physiological versus Pathological Hypertrophy: The Athlete and the Hypertensive.- 17. Bradykinin and Cardiac Protection.- 18. Left Ventricular Hypertrophy and Sympathetic Activity.- 19. Hypertension, Left Ventricular Hypertrophy, and Heart Rate Variability.- 20. Comparison of Meta-Analyses of Therapeutic Studies on Regression of Left Ventricular Hypertrophy.- 21. Comparison of Therapeutic Studies on Regression of Left Ventricular Hypertrophy.- 22. Prognostic Significance of Left Ventricular Hypertrophy Regression.- Session IV: Myocardial Ischemia.- 23. Hypertension and Coronary Microvascular Disease.- 24. Myocardial Perfusion in Hypertensive Patients with Normal Coronary Arteries.- 25. Endothelial Dysfunction in Hypertension.- 26. Endothelial Dysfunction in Hypertensives: An Uncertain Association.- 27. Hypertension, Left Ventricular Hypertrophy, and Coronary Flow Reserve.- 28. Hypertensive Heart Disease, Ventricular Dysrhythmias, and Sudden Death.- 29. Hypertension and Heart Failure.- Speakers.

This new edition is a comprehensive and practical guide to the use of echocardiography in everyday clinical practice. Divided into thirteen sections, the book begins with the basic principles of echocardiography and echocardiographic examination. Subsequent chapters cover the valves of the heart and vascular system, prosthetic valves, ischemic heart disease, cardiomyopathies, pericardial disorders, cardiac tumours and congenital heart disease. The chapters follow a question and answer format and many are supplemented by case studies, as well as full colour images and illustrations. Much of the content of this manual has been abstracted from Comprehensive Textbook of Echocardiography (9789352701643) published in 2019, also by Navin C Nanda.  The second edition has been fully revised and updated to include recent advances in the field. The author and editor team of internationally recognised cardiovascular experts, led by renowned Navin C Nanda, ensures authoritative content throughout the book. Key Points Practical guide to use of echocardiography in everyday clinical practice Fully revised, second edition including recent advances in the field Presented in question and answer format, supplemented by case studies Previous edition (9789351525189) published in 2016

The technical evolution of cardiac surgery in the last decades has been rewarded with long-term survival with few complications. A matching improvement in the quality of this survival as subjectively felt by the patient has now become most important to assess the justification of surgery. This book is the summary of the proceedings of an international symposium which addressed the growing demand in this facet of cardiac surgery. For the first time quality of life after valve replacement, coronary bypass, surgery for congenital heart disease, and heart transplantation has been extensively analyzed in terms of the physiological state, intellectual functioning, emotional state, performance of social roles and general satisfaction. The patient's well-being has become the focus of a joint effort of cardiologists, surgeons, general practitioners, psychologists, sociologists and occupational physicians, for all of whom this book offers a guide to the improvement of our patients' Quality of life after open heart surgery'.

A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

An overview of all the available literature on the various aspects of the regulation of the cardiovascular system`s function and physiology by the adrenergic neurohormonal system, i.e. the catecholamines norepinephrine and epinephrine. Although there are several books describing the adrenergic system`s biology, physiology and pharmacology, and also several excellent books on cardiovascular physiology and pathology, this book focuses exclusively on the interface of these two areas: cardiovascular regulation by the adrenergic system and how it affects cardiovascular diseases and their treatments. Each chapter describe the roles of the adrenergic system first in each cardiovascular cell type (cell type-by-cell type) and then in specific areas of cardiovascular physiology, such as in exercise and in cardiovascular metabolism. Finally, the book concludes with a chapter on the adrenergic system`s role in the currently very "hot" (in terms of scientific investigations) area of cardiovascular stem cell biology. The book covers the adrenergic system-specifically and exclusively in the heart and vessels. It is formatted by cardiovascular cell type-by-cell type manner, rather than in an organ-by-organ or in a disease-by-disease manner, as usually discussed in standard, conventional biomedical textbooks. The book also discusses the adrenergic system in novel, cutting-edge cardiovascular research areas, in which it has not been covered well so far (e.g. stem cells, exercise). These three areas constitute the most important assets of the book, which sets it apart from others in the field.

Podrid's Real-World ECGs: A Master's Approach to the Art and Practice of Clinical ECG Interpretation Podrid's Real-World ECGs combines traditional case-based workbooks with a versatile Web-based program to offer students, health care professionals, and physicians an indispensable resource for developing and honing the technical skills and systematic approach needed to interpret ECGs with confidence. ECGs from real patient cases offer a complete and in-depth learning experience by focusing on fundamental electrophysiologic properties and clinical concepts as well as detailed discussion of important diagnostic findings and relevant management decisions. Six comprehensive volumes encompass more than 600 individual case studies--plus an online repository of hundreds more interactive case studies (www.realworldECGs.com)--that include feedback and discussion about the important waveforms and clinical decision-making involved. From an introductory volume that outlines the approaches and tools utilized in the analysis of all ECGs to subsequent volumes covering particular disease entities for which the ECG is useful, readers will take away the in-depth knowledge needed to successfully interpret the spectrum of routine to challenging ECGs they will encounter in their own clinical practice. Volume 2, Myocardial Abnormalities, breaks down the essential skills necessary for diagnosing acute myocardial ischemia as well as acute and chronic myocardial infarction--arguably the most important component of the ECG armamentarium across the spectrum of health care professions. It also demonstrates the skills needed for the diagnosis of myocardial hypertrophy, atrial abnormality, and pericarditis.

Transradial Access: Discover the Benefits, Understand the Procedure Transradial Access: Techniques for Diagnostic Angiography and Percutaneous Intervention offers a single source for both novice and experienced interventional cardiologists for safely and effectively performing transradial catheterization procedures. First described in 1989, the transradial approach for coronary angiography and percutaneous interventions has seen a constant and progressive increase around the world as a result of significantly reduced procedural complications, shorter hospital stays, increased patient satisfaction, and lower associated costs compared with the transfemoral approach. Yet despite its apparent benefits, adoption of this technique in the United States has been slow, largely due to the increased technical aspects of entering a smaller artery, accessing the central circulation and engaging the coronary arteries from this approach. In addition, until recently the technique was not routinely taught in the majority of training programs. This book flattens that learning curve by highlighting the technical aspects of transradial diagnostic and interventional procedures, and includes detailed discussion of normal vascular anatomy of the hand and arm, indications and contraindications for transradial access procedures, patient and catheter selection, tips and tricks for both beginner and advanced operators, procedural pitfalls and potential complications. Techniques are demonstrated in detail using both still images and video. Whether you are an experienced transfemoral operator who wants to refine and expand your technique or a new transradial operator looking to master the technique, this comprehensive text holds the key to mastering this revolutionary procedure.

The treatment of hypertension has become the most important intervention in the management of all forms of chronic kidney disease. Chronic Kidney Disease and Hypertension is a current, concise, and practical guide to the identification, treatment and management of hypertension in patients with chronic kidney disease. In depth chapters discuss many relevant clinical questions and the future of treatment through medications and or novel new devices. Written by expert authors, Chronic Kidney Disease and Hypertension provides an up-to-date perspective on management and treatment and how it may re-shape practice approaches tomorrow.

When my own father came down with cardiovascular problems, Dr. Fratellone was the physician I called. --Ann Louise Gittleman, PhD., author of New York Times bestsellers Fat Flush Plan and Before the Change. trend of treating health problems with ever-new-and-evolving drugs--often without regard to potentially dangerous side effects. Studies suggest that the best way to prevent cardiovascular disease is by modifying behavior. Yet society is fixated on obtaining easy solutions, which require little or no participation by the patient. lead to complications. In many cases, these medications are unnecessary and produce no great benefit. Instead, Dr. Fratellone focuses on using vitamins, herbs and supplements to treat and prevent disease. by listeners of the New York City radio show House Calls with Dr. Fratellone. This valuable guide provides answers to the most frequently asked questions about vitamins and supplements for treating the heart non-invasively.

As the first primer on the effects of exercise on human hypertension, Effects of Exercise on Hypertension: From Cells to Physiological Systems provides the state-of-the-art effects of exercise on the many possible mechanisms underlying essential hypertension in humans. The book contains chapters by distinguished experts on the effects of exercise on physiological systems known to be involved in hypertension development and maintenance as well as less well known aspects of hypertension such as 24-hour ambulatory blood pressure profile and oxidative stress. An emerging area, the effects of resistance exercise training on blood pressure is also covered. A unique aspect of the book is that it covers the effects of exercise mimetics on vascular cell adaptations in order to begin to elucidate some of the cellular mechanisms that may underlie blood pressure reductions with exercise training. Lastly, the book will end with a chapter on the interactive effects of genes and exercise on blood pressure. Chapters are grouped by physiological system or mechanism. The text begins with two overview chapters; one on the general effects of aerobic exercise training and the second on the general effects of resistance exercise training on blood pressure. Each chapter begins with a bulleted list of key points. Effects of Exercise on Hypertension: From Cells to Physiological Systems will be of great value to professional individuals in cardiovascular medicine, the cardiovascular sciences, allied health care professionals, and medical and graduate students in the cardiovascular sciences and medicine.

The Must-Have Guide for Navigating the ICU. The House Officer's Guide to ICU Care is an eminently practical handbook for junior house officers, medical students, PAs, and nurses that offers nuts-and-bolts guidelines for optimal management of medical and surgical patients in the ICU setting. Using clear, straightforward language, the authors methodically guide clinicians through the decision-making process, first by outlining the pathophysiology of abnormalities seen in the ICU and then by explaining the principles underlying today's therapeutic measures and describing how these agents and devices are used to ensure safe patient recovery. While the text focuses on the postoperative cardiothoracic surgery patient, the principles and therapies covered are broadly relevant to all medical and general surgery ICU patients. This third edition has been thoroughly updated to include the newest diagnostic and treatment technologies, procedures, and practices, and covers everything the house officer needs to know to deliver safe, effective, front-line care - especially during those times when senior staff are not there to rely on. Updated references, self-assessment tools, and an Emergency Response Sheet of essential paradigms, drugs, and doses will ensure confident decision-making when it counts the most. For the house officer, this book gives you everything you need to know, and not a word more. Especially useful for: house officers and medical students embarking on ICU responsibilities,intensive care nurses and nurses in training physicians' assistants,and respiratory therapists.

Technological progress has allowed us to develop devices which make it possible to record blood pressure and heart rate outside the real living conditions. Furthermore, technological progress has provided computer tools to analyse data on a beat-to-beat basis, offering a large body of information on the complex patterns of blood pressure and heart rate variability in health and in disease which has clarified a number of mechanisms responsible for cardiovascular regulation during the day and night. This book aims at providing an updated state of the art on the analysis of blood pressure and heart rate variability from the different perspectives of physiologists, clinicians and engineers by gathering the contributions of experts taken from both the biomedical and the engineering environment. In particular, attention was focused on 1) the methodology of ambulatory blood pressure and heart rate analyses, 2) the mathematical models that can be derived from the data and the implications they have for the understating of normal and deranged cardiovascular control and 3) the present and future use of computer analysis of dynamically collected observations for the diagnosis of cardiovascular diseases.

This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.

Chronic Kidney Disease (CKD) is a recognized risk factor for cardiovascular events and death. The coexistence of CKD and heart failure is increasing in prevalence worldwide and requires a unique and subtle approach to patient management. The Kidney in Heart Failure focuses on the changes that occur in kidney physiology as a function of a failing heart. This comprehensive resource covers epidemiology, pathophysiology, management of kidney disorders and advances in nephropathy management. In addition, the latest therapies, common heart failure dilemmas and kidney disease markers are included. Each chapter is co-authored by a Nephrologist and Cardiologist, offering a unified perspective to these chronic conditions. This indispensible volume provides the reader with the depth-of-knowledge needed for assessing and treating the cardio renal patient.

This text evolved as a response to numerous requests to present a simplified approach to the diagnosis and management of most of the common aspects of both cosmetic and medical venous disorders. The authors, representing experienced plebologists from several different primary disciplines, have attempted to present simplistic paradigm-oriented approaches on how to thoughtfully evaluate and manage common vein issues with contemporary solutions. Several areas of phlebology were not addressed in this text. The management of vascular malformations are beyond the scope of this text and were not covered in detail. Although indications for the appropriate use of IVC filters are discussed, the details about the specific devices, their placement and removal are also beyond the scope of this text. Deep venous obstruction from prior thrombosis, venous compression by arteries such as the compression of the left common iliac vein by the right common iliac artery and pelvic venous insufficiency can now be managed with minimally invasive image guided treatments; the technical aspects of such treatments are complex and not discussed in detail in this handbook. This book will increase the therapeutic skill of the practicing phlebologist and thus increase the quality of care for patients faced with problems related to venous disorders.