Elsevier now offers a series of derivative works based on the acclaimed Meylers Side Effect of Drugs, 15th Edition. These individual volumes are grouped by specialty to benefit the practicing physician or health care clinician.

Each year, heart disease kills more people than cancer. Patients are treated by a variety of specialists and primary care practitioners, depending on the organ system involved. This volume enables practitioners to assess the adverse effects of the complete range of drugs used in cardiovascular medicine, including antihypertensive drugs, and drugs used in the treatment of heart failure, angina, angina pectoris, and cardiac arrhythmia and enable practitioners to prescribe preventative treatments with medications such as blood pressure reducers, aspirin, and cholesterol-lowering drugs, as well as drugs used for more aggressive therapy.

The material is drawn from the 15th edition of the internationally renowned encyclopedia, Meyler s Side Effects of Drugs, and the latest volumes in the companion series, Side Effects of Drugs Annuals. Drug names have usually been designated by their recommended or proposed International Non-proprietary Names (rINN or pINN); when those are not available, clinical names have been used. In some cases, brand names have been used.

This volume is critical for any health professional involved in the administration of cardiovascular mediations.
Surpasses the Physician s Desk Reference (c) by including clinical case studies and independent expert analysisComplete index of drug namesMost complete cross referencing of drug-drug interactions availableExtensive references to primary and secondary literatureAlso includes information on adverse effects in pregnancy

The book is divided into six sections:

Drugs used to treat hypertension, heart failure and angina pectorisDiuretics - a general introduction to their adverse effects, followed by monographs on individual drugsAntidysrhythmic drugs - a general introduction to their adverse effects, followed by monographs on individual drugsDrugs that act on the cerebral and peripheral circulationsAnticoagulants, thrombolytic agents, and anti-platelet drugsCardiovascular adverse effects of non-cardiovascular drugs "

Discoveries in Pharmacology: Volume 1: Nervous system and hormones (2nd Ed.) presents selected articles from the historic Discoveries in Pharmacology series enhanced with commentary from contemporary scholars about the reception and importance of the chapter along with an updated bibliography on the subject with contributions from a Nobel Prize winner and other pioneers in Pharmacology. The Discoveries in Pharmacology series brought acknowledged experts in their fields together to provide first-hand accounts of important pharmacological discoveries discussing the scientific background and stories behind these pivotal moments. They allow a true understanding of the means by which pharmacological discoveries are made. This volume brings forth discussions on key discoveries in psycho- and neuro-pharmacology, haemodynamics, and hormones including chapters on antipsychotic agents by Nobel winner Anders Carlsson, Willy Haefely on benzodiazepine, and butyrophenone-type neuroleptics by P. A. J. Janssen and J. P. Tollenaere. Academic and industry researchers in pharmacology and medicine, as well as advanced students in the area will find this series a useful teaching tool and launch to new discoveries. Chapters can also be used to supplement course material in pharmacology and medical courses. It will also be of interest to those who are interested in the history of medicine.

This book provides an introduction to the biological background of heart functioning and analyzes the various materials and technologies used for the development of microfluidic systems dedicated to cell culture, with an emphasis on cardiac cells. The authors describe the characterization of microfluidic systems for cardiac cell culture and center their discussion of the use of stem cell stimulation based on four different types: electrical, biochemical, physical, and mechanical. This book is appropriate for researchers focused on on-chip technologies and heart studies, students in bioengineering and microengineering courses, and a variety of professionals, such as biotechnologists, biomedical engineers, and clinicians working in the cardiac diseases field.

J. Willis Hurst, MD, a pioneer in the development of cardiology, and his colleague, Douglas C. Morris, M.D., both of Emory University, have edited this book and chose its unusual title for very specific reasons. Patients sometimes have an odd view as to anatomic landmarks that identify the location of the chest, and may assign terms other than pain to their discomfort. Hence the quotation marks around "chest pain." The arrow (-->) after "chest pain" indicates that the physician initially may not know the cause of the symptom, so a differential diagnosis must be established.

This book was written to reintroduce in the modern clinical setting the knowledge and skills needed to analyze symptoms, physical findings, and ECG and x-ray abnormalities in order to accurately diagnose more than 50 different conditions that may bring about a complaint of "chest pain." Experts in the fields of cardiology, pulmonology, dermatology, orthopedics, thoracic surgery, and psychiatry contribute a unique perspective on this common but compelling medical problem. Each chapter concentrates on one causative syndrome or malady, from its initial presentation to its etiology, to differential diagnosis and treatment, while an abundance of well-designed figures serve to illustrate the location of the "chest pain."

Any cardiologist, primary care, or emergency care physician who may encounter a patient complaining of "chest pain" will benefit from this book''s clear, concise and thorough approach to the problem.

Atherogenesis: Lipid Accumulation and Plaque Disruption: Processes Triggering Clinical Instability in Coronary Disease-An Overview; B.G. Brown. Expression of 92 kDa Gelatinase in Human Atherosclerotic Lesions Following Recent Plaque Rupture; D.L. Brown. Atherogenic Lipoproteins: Current Concepts of the Plasma Lipoproteins and Their Role in Atherosclerosis-An Overview; H.B. Brewer, Jr. Homeostasis of Lipid Oxidation in the Artery Wall; A.M. Fogelman, et al. Antiatherogenesis/Cholesterol Removal Mechanisms: The Role of HDL Receptors in Removal of Cellular Cholesterol; J.F. Oram, et al. Signal Transduction in Vascular Proliferation: Identification of FGF1-Inducible Genes by Differential Display; J.A. Winkles, et al. Adhesion Pathobiology: Molecular Basis and Pathological Consequences of Neutrophil Adherence to Endothelium; J.M. Harlan, et al. Thrombosis/Fibrinolysis: Regulation of Vascular Fibrinolysis by Type 1 Plasminogen Activator Inhibitor (PAI1): D. Seiffert, et al. Modified Gene Expression/Clues to Cause, Prevention, and Treatment of Atherosclerosis: Genetic Factors Contributing to Atherosclerosis: From Humans to Mice and Back Again; C.H. Warden, A.J. Lusis. Atherosclerosis Prevention and Public Policy: Cholesterol and Mortality: What Can Metaanalysis Tell Us? D.J. Gordon. 35 additional articles. Index.

Regenerative Medicine for Peripheral Artery Disease is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of peripheral arterial disease. This reference includes a general overview of regenerative medicine and covers important vascular topics, including intermittent claudication and critical limb ischemia, with important mechanisms clearly presented in full color images throughout the book. This important reference includes clear and concise information on both human clinical trials, as well as important and pertinent animal studies, and is a must-have reference for researchers and practitioners of peripheral artery disease.

Angiotensin II Receptor (T. Inagami et al.). Molecular Biology of Angiotensin II Receptors (B. Lassegue et al.). Defining Angiotensin Receptor Subtypes (A.T. Chiu et al.). Medicinal Chemistry of Angiotensin II Antagonists (W.J. Greenlee, R.W. Wexler). The Angiotensin II AT2 Receptor Subtype (M. de Gasparo et al.). Medicinal Chemistry of AT2 Receptors (J.J. Edmonds, J.C. Hodges). Pharmacology of AT2 Receptors (J.A. Keiser, R.L. Panek). Brain Angiotensin II Receptor Subtypes (J.M. Saavedra). Second Messengers for Brain Angiotensin Receptor Subtypes (F.M.J. Heemskerk, J.M. Saavedra). Angiotensin Receptor Subtypes and Cerebral Blood Flow (C. Stroemberg et al.). Angiotensin II Receptor Subtypes and Growth (M. Viswanathan, J.M. Saavedra). Inhibiting Effects of Angiotensin II on Cardiovascular Hypertrophy in Experimental Hypertension (J.J. Morton). Inhibiting the Effects of Angiotensin on Cardiovascular Hypertrophy (K.P. Metsarinne et al.). 8 additional articles. Index.

This volume is a state-of-the art resource on the recent advances and clinical management of NSAIDs and aspirin. The text provides a thorough overview of NSAIDS and aspirin, reviewing such topics as pharmacology and mechanisms, clinical effects, and the safety and efficacy of these drugs. It also focuses on the effect of the drugs on the cardiovascular system and in the prevention of GI cancer. Practical recommendations for a safe prescription of NSAIDs are also included. Written by experts in the field, NSAIDs and Aspirin: Recent Advances and Implications for Clinical Management is a comprehensive text of great value to gastroenterologists, rheumatologists, cardiologists, oncologists, orthopedists, trauma and internal medicine specialists.

The 1990s have been characterized by a reappraisal of allocating expenditure for health care interventions. Coronary artery bypass in the elderly has emerged as an example of burgeoning expensive surgery whose appropriateness is under challenge. This book comprises the proceedings of an international symposium where leading experts in aspects such as health economics, ethics, clinical cardiology, cardiac surgery, epidemiology and health-care policy discussed the need and outcome of the operation in old and very old patients. Clinical issues and operative results complement national costs and quantitated benefits in terms of quality of life as a justification of surgery. The book is addressed to cardiologists, geriatricians, cardiac surgeons, psychiatrists, rehabilitation physicians and public health-care administrators.

The unique and award-winning Unofficial Guides series is a collaboration between senior students, junior doctors and specialty experts. This combination of contributors understands what is essential to excel on your course, in exams and in practice - as well as the importance of presenting information in a clear, fun and engaging way. Packed with hints and tips from those in the know, when you are in a hurry and need a study companion you can trust, reach for an Unofficial Guide. The Unofficial Guide to ECGs is a straightforward yet complete guide to interpreting ECGs and easily translating this knowledge to clinical contexts. Edited by experts in cardiology, the book systematically goes through how an ECG is performed and what every part of the ECG tracing represents. It covers common conditions associated with ECG changes and explains the underlying pathophysiology of why these changes occur. An extensive collection of 40 clinical cases with fully annotated ECGs and 120 MCQs are included to allow readers to practise ECG interpretation. Primarily aimed at medical students, this new book will also be useful for all those who may need to brush up on ECGs, including junior doctors, nurses, paramedics, physicians' associates and advanced nurse practitioners. Clearly defined and systematic structure that is accessible to new learners Explanations for every component of an ECG tracing and their changes to aid understanding and memorisation 40 cases with real-life ECGs, ranging in difficulty from beginner to advanced, and clinically-focused questions for the reader to test themselves Real-life fully annotated ECG images to clearly highlight features of ECG changes 120 MCQs with detailed explanations of correct and incorrect answers alongside annotated and unannotated ECGs A handy quick reference guide at the end of book covers ECG basics and important changes for rapid revision on the wards

This book shares the latest research and practice-oriented findings in medical sciences with a wide audience. It addresses a range of contemporary issues, often unresolved or contentious, across various medical fields, including advances in the management of hemorrhagic brain stroke. It also discusses metastatic renal cell carcinoma - a global scourge with an extremely poor long-term survival prognosis, the course and sequelae of renal cell carcinoma, as well as advances in targeted molecular therapy with sunitinib, a receptor tyrosine kinase inhibitor. Further, it examines the molecular targeting of proliferative signaling of the epidermal growth factor receptor in the first-line treatment of patients with metastatic non-small-cell lung cancer. Other articles cover clearance of toxins in hemodialyzed patients; the search for diagnostic and therapeutic markers in the connective tissue disease scleroderma; obesity linked to inappropriate dietary habit; clinical problems related to the diagnosis of sensitization to fungi and its role in asthma; and reasons for the perilous trend of avoiding basic vaccinations in children. Lastly, the book explores the rapid developments in e-health technologies that increase access to health services, particularly for the elderly. The book is intended for clinical specialists, researchers, and all allied health professionals from various fields.

CVD, or cardiovascular disease, is a general term that describes a disease of the heart or blood vessels. It is one of the most common causes of death. Statins are a group of medicines that can help lower the level of low-density lipoprotein (LDL) cholesterol in the blood. LDL cholesterol of often referred to as 'bad cholesterol', and statins reduce its production in the liver. Having a high level of LDL is potentially dangerous as it can lead to hardening and narrowing of the arteries (NHS). Comprising nearly 1000 pages, this book is a comprehensive guide to the latest advances in statin therapy and its clinical application for cardiovascular disease. Divided into 29 sections, the text begins with clinical aspects of CVD, dyslipidemia (the imbalance of lipids such as cholesterol), and the use of statins for treatment. The next sections provide detailed discussion on the use of statins for different types of CVD, including coronary artery disease, hypertension, heart failure, arrhythmia, stroke, and more. The following chapters cover statin use for other systemic diseases such as obesity, kidney disease, diabetes, ocular disorders, skin conditions and many more. The book concludes with an insight into future therapies, with emphasis on PCSK9 inhibitors, a new treatment for lowering cholesterol in the blood.

This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart. There has been significant progress in our understanding of the function-related structure, developmental processes and their determinants, mechanisms of cell cycle regulation, post-natal growth, energy metabolism, and reversible and irreversible response of cardiomyocytes to diverse forms of physiological stress and injury. There is also more clarity on the alterations in the biological mechanisms in cardiomyocytes that lead to pathological states and the changes in the cells that occur secondary to disease conditions. Thanks to these advances in knowledge, there have been great gains in attempts to identify disease biomarkers and therapeutic targets for better management of patients with heart diseases. Possibilities to induce regeneration or proliferation of cardiomyocytes and thus repair and or regenerate the damaged heart are also on the horizon.

This book describes those psychological features specifically characteristic of patients with congenital heart disease, from birth to adulthood. The combination of case studies, descriptions of life experiences and psychological recommendations and collaboration with non-profit organizations in the field ensure that it will serve as an excellent day-to-day learning tool. Technological advances in cardiology and cardiac surgery have resulted in an increase in the number of adults with congenital heart disease, creating a new emergency. From when they are born, these patients and their relatives require extensive support for many reasons, including the uncertainty and restrictions in their lives, frequent hospitalizations and difficulties in the work and social spheres. Clinical Psychology and Congenital Heart Disease explains how psychology can contribute to healthcare treatment of patients with congenital heart disease and their families. Emphasis is placed on the need for a multidisciplinary approach to ensure the well-being of the patient and the clinician is provided with insights and instruments that will assist greatly in the provision of appropriate support.

This book provides a road map for the efficient and successful management of atrial fibrillation (AF) in the short stay unit. It describes the problem, defines the measures of successful treatment, elucidates interventions, and supplies the tools for achieving quality care. Organized in four parts, it covers the impact of AF on patient populations; the presentation and management of AF; the transition to the outpatient environment; and systems management. Topics include the economic consequences of AF; cardioversion and cardiac implantable electronic devices in AF management; education of the AF patient and discharge planning; and quality metrics in AF. The book also provides order sheets and process criteria with which institutions can successfully manage the AF patient in the short stay unit, thus optimizing patient outcomes, patient satisfaction, and operational efficiencies. Short Stay Management of Atrial Fibrillation is a valuable resource for cardiologists, emergency medicine physicians, electrophysiologists, and other healthcare professionals involved in AF management.

This book presents techniques necessary to predict cardiac arrhythmias, long before they occur, based on minimal ECG data. The authors describe the key information needed for automated ECG signal processing, including ECG signal pre-processing, feature extraction and classification. The adaptive and novel ECG processing techniques introduced in this book are highly effective and suitable for real-time implementation on ASICs.

The term "Translational Research" reflects today's integration of basic research ("bench") findings with the clinical practice of medicine, and in a wider scope the application of results from the individual patient ("bedside") to entire populations for the improvement of public health. This book offers future researchers a stimulus in many aspects of cardiovascular research, so as to promote their interest in future fields of cardiovascular disease, diagnosis and treatment. Introduction to Translational Cardiovascular Research discusses the fundamental and important aspects of the topic. It describes the renin-angiotensin-aldosterone system, the beta adrenergic receptors and the hypothalamic-pituitary-adrenal axis, while covering genetic polymorphisms both generally and specifically as regards the vascular endothelium and the use of microRNAs. As such, this book will be relevant to young physicians, nurses and other scientists engaged in the clinical cardiovascular field who want to added research-oriented dimension to their efforts towards better understanding and practicing of medicine. It also aims to attract young basic researchers who want to develop a better comprehension of the organism as a whole, man or animal, that they are investigating.