This issue of Heart Failure Clinics, edited by Drs. Wilbert Aronow and Ali Ahmed, will cover a wide array of topics related to Heart Failure in Older Adults. Subjects covered include, but are not limited to: Epidemiology, Pathophysiology, and Prognosis of Heart Failure in the Older Adult; DEFEAT Heart Failure: Clinical Manifestations, Diagnostic Assessment, and Etiology of Geriatric Heart Failure; Heart Failure with Preserved Ejection Fraction in the Older Adult; Heart Failure-Complicating Acute Myocardial Infarction; Interventional Therapies for Heart Failure in the Older Adult; Cardiac Resynchronization Therapy for Treatment of Heart Failure in the Older Adult; and Left Ventricular Assist Devices in Treatment of Heart Failure in the Older Adult, among others.

This issue of Interventional Cardiology Clinics, guest edited by Dr. Srihari S. Naidu, will discuss Interventional techniques for Heart Failure. Subjects covered in the articles include, but are not limited to: Invasive Hemodynamics of Myocardial Disease: Systolic and Diastolic Dysfunction; Invasive Hemodynamics of Pericardial Disease: Constriction and Tamponade; Invasive Hemodynamics of Pulmonary Disease and the Right Ventricle; TAVR and MitraClip to Reverse Heart Failure; Mechanical Circulatory Support in Acute Decompensated Heart Failure and Shock; Adult Congenital Interventions in Heart Failure; Future Directions in Device Treatment of Heart Failure; and Prioritizing and Combining Interventional Therapies for Heart Failure, among others.

This issue of Cardiology Clinics, edited by Drs. Gerald Bloomfield and Melissa Burroughs-Pena, will cover a broad range of issues in the field of Global Cardiovascular Health. Topics covered in this issue include, but are not limited to Diagnosis and management of endomyocardial fibrosis; Chagas disease; Tuberculosis and the heart; Cardiovascular manifestations of human immunodeficiency virus infection; Improving global access to essential cardiovascular medicines; Innovative approaches to hypertension control in the community; Causes and treatment of infective endocarditis in developing countries; and Strategies for Patient Centered Blood Pressure Control in Low- and Middle income Countries, among others.

The Complete Reference for Scimitar Syndrome: Anatomy, Epidemiology, Diagnosis and Treatment gives the complete picture of this rare syndrome that is usually treated with tactics such as imaging. The book goes beyond imaging, providing a pathological and clinical description of this rare syndrome. All aspects beginning with development, clinical presentation, current surgical options (including recent techniques) and indications to treat patients based on current results coming from multicenter study experiences are included. This book is a must-have reference for all cardiologists, cardiac surgeons, thoracic surgeons, pathologists, physicians, residents and students involved in Scimitar Syndrome cases.

This issue of the Cardiac Electrophysiology Clinics, edited by Drs. Amin Al- Ahmad and Francis Marchlinski, will cover Ventricular Tachycardia in Structural Heart Disease. Topics discussed in the issue include, but are not limited to, ECG localization of VT in patients with structural heart disease; Anatomy for VT ablation in structural heart disease; Ablation of VT in ischemic and non-ischemic heart disease; Pace mapping; Ablation of VT in ARVD; Epicardial VT ablation; and VT clinical trials, among others.

Atherogenesis: Lipid Accumulation and Plaque Disruption: Processes Triggering Clinical Instability in Coronary Disease-An Overview; B.G. Brown. Expression of 92 kDa Gelatinase in Human Atherosclerotic Lesions Following Recent Plaque Rupture; D.L. Brown. Atherogenic Lipoproteins: Current Concepts of the Plasma Lipoproteins and Their Role in Atherosclerosis-An Overview; H.B. Brewer, Jr. Homeostasis of Lipid Oxidation in the Artery Wall; A.M. Fogelman, et al. Antiatherogenesis/Cholesterol Removal Mechanisms: The Role of HDL Receptors in Removal of Cellular Cholesterol; J.F. Oram, et al. Signal Transduction in Vascular Proliferation: Identification of FGF1-Inducible Genes by Differential Display; J.A. Winkles, et al. Adhesion Pathobiology: Molecular Basis and Pathological Consequences of Neutrophil Adherence to Endothelium; J.M. Harlan, et al. Thrombosis/Fibrinolysis: Regulation of Vascular Fibrinolysis by Type 1 Plasminogen Activator Inhibitor (PAI1): D. Seiffert, et al. Modified Gene Expression/Clues to Cause, Prevention, and Treatment of Atherosclerosis: Genetic Factors Contributing to Atherosclerosis: From Humans to Mice and Back Again; C.H. Warden, A.J. Lusis. Atherosclerosis Prevention and Public Policy: Cholesterol and Mortality: What Can Metaanalysis Tell Us? D.J. Gordon. 35 additional articles. Index.

This book provides an introduction to the biological background of heart functioning and analyzes the various materials and technologies used for the development of microfluidic systems dedicated to cell culture, with an emphasis on cardiac cells. The authors describe the characterization of microfluidic systems for cardiac cell culture and center their discussion of the use of stem cell stimulation based on four different types: electrical, biochemical, physical, and mechanical. This book is appropriate for researchers focused on on-chip technologies and heart studies, students in bioengineering and microengineering courses, and a variety of professionals, such as biotechnologists, biomedical engineers, and clinicians working in the cardiac diseases field.

Aneurysms-Osteoarthritis Syndrome: SMAD3 Gene Mutations is a first-of-its-kind compilation of the genetic discovery, research, and care associated with AOS. With the field of genetically triggered aortopathies growing, this important reference will compile the newest discoveries in this field, allowing cardiologists, cardio-thoracic surgeons, clinical geneticists, vascular surgeons, orthopedic surgeons, and researchers to gain the knowledge they need without having to gather the data from various sources. Coverage includes genotype and phenotype correlations, the functional role of SMAD3, and insights into the role of TGFbeta signaling in aortic disease. The book will increase knowledge about AOS, providing awareness and better patient care for this aggressive disease.

Peripheral vascular disease is the obstruction of large arteries that are not in the heart or brain.? With the advent of percutaneous treatment techniques, such obstructions are now often being treated by cardiologists.? This issue provides current information on? diagnosis, medical management, and percutaneous procedures for peripheral vascular disease.

This issue of the Cardiac Electrophysiology Clinics entitled "Ventricular Arrhythmias in Apparently Normal Hearts" is being edited by Drs. Frank M. Bogun, Thomas Crawford, and Rakesh Latchamsetty. The issue will cover topics including, the mechanisms of ventricular arrhythmias, the role of genetic testing, papillary muscle arrhythmias, fascicular arrhythmias, exercised induced VT, VF, and SCD in the normal heart, and various management techniques.

A cardiac dysrhythmia is a disturbance in the cardiac rhythm which can be normal (e.g., sinus arrhythmia) or instantly lethal (e.g., sustained ventricular tachycardia). This issue of Critical Care Nursing Clinics of North America will provide state of the art diagnostic and treatment information for cardiac dysrhythmias as well as addressing how to achieve the most accurate diagnostic approach to interpreting an electrocardiogram, which is omnipresent in critical care and of critical importance in diagnosing arrhythmias. Articles in this issue are devoted to: The Normal Cardiac Conduction System; The Normal Electrocardiogram: Resting 12-lead and Continuous Cardiac Rhythm Strips; Premature Beats; Paroxysmal Supraventricular Tachycardia, Including the Special Type Called Wolff-Parkinson-White; Atrial Fibrillation, The Most Common Type of Supraventricular Arrhythmia; Ventricular Tachycardia and Its Disorganized Counterpart, Ventricular Fibrillation; Brady-Dysrhythmias, When Heart Rate Slows Myocardial Ischemia & Infarction and their Relationship to Dysrhythmias; Pharmacologically Induced Dysrhythmias; and Implantable Cardiac Devices and their Role in Dysrhythmias Management.

This issue of the Cardiology Clinics entitled "Pulmonary Hypertension" is an in-depth review on the subject edited by Dr. Ronald J. Oudiz. The topics covered will include: classification of pulmonary hypertension, epidemiology and pathophysiology, diagnosis, and management in Groups I-V. There are also sections devoted to issues faced in pediatrics and pregnancy, as well as a section on patient support, among other topics.

This issue of the Heart Failure Clinics, edited by Drs. James Fang and Michael Givertz, is entitled "Advanced Heart Failure" and covers a wide array of topics relating to the subject. The issue will delve into the prevalence, history and prognosis of advanced heart failure; cardiorenal interactions; cardiohepatic interactions; the role of temporary mechanical circulatory support; guided therapy; the role of heart transplantation; palliative care; frailty; and novel biological techniques, among other topics.

Angiotensin II Receptor (T. Inagami et al.). Molecular Biology of Angiotensin II Receptors (B. Lassegue et al.). Defining Angiotensin Receptor Subtypes (A.T. Chiu et al.). Medicinal Chemistry of Angiotensin II Antagonists (W.J. Greenlee, R.W. Wexler). The Angiotensin II AT2 Receptor Subtype (M. de Gasparo et al.). Medicinal Chemistry of AT2 Receptors (J.J. Edmonds, J.C. Hodges). Pharmacology of AT2 Receptors (J.A. Keiser, R.L. Panek). Brain Angiotensin II Receptor Subtypes (J.M. Saavedra). Second Messengers for Brain Angiotensin Receptor Subtypes (F.M.J. Heemskerk, J.M. Saavedra). Angiotensin Receptor Subtypes and Cerebral Blood Flow (C. Stroemberg et al.). Angiotensin II Receptor Subtypes and Growth (M. Viswanathan, J.M. Saavedra). Inhibiting Effects of Angiotensin II on Cardiovascular Hypertrophy in Experimental Hypertension (J.J. Morton). Inhibiting the Effects of Angiotensin on Cardiovascular Hypertrophy (K.P. Metsarinne et al.). 8 additional articles. Index.

This issue of Clinics in Geriatric Medicine, guest edited by Drs. Cynthia Boyd, James T. Pacala, and Michael W. Rich, is devoted to Chronic Conditions in Older Adults with Cardiovascular Disease. Articles in this issue include: Epidemiology of multimorbidity in older adults with cardiovascular disease; Impact of multimorbidity on clinical outcomes in older adults with cardiovascular disease; Assessment of goals of care in patients with multiple chronic conditions; Challenges in decision-making: balancing trade-offs; Multimorbidity in older adults with heart failure; Multimorbidity in older adults with acute coronary syndromes; Multimorbidity in older adults with aortic stenosis; Multimorbidity in older adults with atrial fibrillation;Anticoagulation in older adults with multimorbidity; Approach to evaluating the multimorbid patient with cardiovascular disease undergoing non-cardiac surgery; Integrating care across disciplines; Assessing risks and benefits of invasive cardiac procedures in patients with advanced multimorbidity; Multimorbidity and end of life care in patients with cardiovascular disease; and Future research directions for cardiovascular disease.

The 1990s have been characterized by a reappraisal of allocating expenditure for health care interventions. Coronary artery bypass in the elderly has emerged as an example of burgeoning expensive surgery whose appropriateness is under challenge. This book comprises the proceedings of an international symposium where leading experts in aspects such as health economics, ethics, clinical cardiology, cardiac surgery, epidemiology and health-care policy discussed the need and outcome of the operation in old and very old patients. Clinical issues and operative results complement national costs and quantitated benefits in terms of quality of life as a justification of surgery. The book is addressed to cardiologists, geriatricians, cardiac surgeons, psychiatrists, rehabilitation physicians and public health-care administrators.

The full scope of adult congenital heart disease is examined in this issue of the Cardiology Clinics. Topics include Shunt Lesions, Coarctation of the Aorta, Tetralogy of Fallot, Transposition of Great Arteries, Fontan Repair of Single Ventricle Physiology, Arrhythmias in Adult Congenital Heart Disease, Pulmonary Hypertension. It will also feature special articles on Pregnancy, Non-pharmacologic Treatment, Transition and Psychosocial Issues, and Quality Metrics.

With over 6 million patients affected only in the United States, atrial fibrillation (AF) is a major health problem with profound effects on both the individual patient and society at large. In this issue of Heart Failure Clinics, we have focused on AF and tried to cover the most important and relevant aspects in a comprehensive and contemporary review. A distinguished group of experts and leaders in basic and experimental electrophysiology, epidemiology, clinical pharmacology, interventional clinical electrophysiology, and cardiac surgery contributed state-of-the-art reviews and also shared their insight to the future of AF. Topics include but are not limited to: Risk Factors and Genetics of Atrial Fibrillation; Mechanisms of Atrial Fibrillation: Rotors, Ionic Determinants, and Excitation Frequency; Diagnostic Evaluation and Follow-Up of Patients with Atrial Fibrillation; Catheter Ablation of Atrial Fibrillation; Antithrombotic and Anticoagulant Therapy for Atrial Fibrillation; Postoperative Atrial Fibrillation: Incidence, Mechanisms, and Clinical Correlates; and Novel Upstream Approaches to Prevent Atrial Fibrillation Perpetuation.