Biophysical Basis of Physiology and Calcium Signaling Mechanism in Cardiac and Smooth Muscle acts as a bridge between physiology and physics by discussing the physiology and calcium signaling mechanism in cardiac and smooth muscle. By exploring the mechanism of the cyclic release of stored Ca^(2+) in the SR or ER, this book covers the cell communication system, including excitable cells, recognizing the most relevant mechanisms of cell communication. Serving as a bridge between physiology and physics, coverage spans the physiology and calcium signaling mechanism in cardiac and smooth muscle, offering insight to physiological scientists, pharmaceutical scientists, medical doctors, biologists and physicists.

This unique book shows ECGs as they really appear in everyday practice and not in the usual format as presented in textbooks. Each of the 100 traces is accompanied by a list of the main diagnostic features along with a full report of the ECG, noting any other clinical details that may be important. Boxes list the common causes of the abnormalities shown. Key features of the ECG are reproduced again using annotations to guide the reader. Thus the book provides in itself a collection of full 12-lead ECGs of a wide range of common clinical problems encountered in casualty. This collection of traces, updated for this Third Edition with new cases, will be invaluable to all involved in the diagnosis of the most commonly encountered ECG abnormalities. Provides full size and realistic reproduction of 12-lead ECGs Includes a wide range of cardiac abnormalities Highlights the diagnostic criteria for each abnormality listed Reflects how this subject is encountered in practice Assists the reader by illustrating alongside the key features of the recording; thus these can be viewed in relation to the whole trace The Third Edition is spiral bound to make it easier for a reader to lay the ECG traces flat for study. Several new cases are included plus a new section on the approach to the ECG has been added.

This issue of Cardiology Clinics, edited by Jae K. Oh, William Miranda, and Terrence D. Welch, will cover a broad range of topics related to Pericardial Disease. Subjects discussed include, but are not limited to: Anatomy and Physiology of the Pericardium; Imaging of the Pericardium, Acute and Recurrent Pericarditis; Tuberculous and Infectious Pericarditis; Pericardial Involvement in Systemic Diseases / Special Forms; Cardiac Tamponade; Constrictive Pericarditis; Effusive-constrictive Pericarditis; Surgical Management; Percutaneous Therapy in Pericardial Diseases; Congenital Abnormalities of the Pericardium, and Neoplastic Pericardial Disease.

This issue of Cardiology Clinics, edited by Dr. Fernando Fleischman, will cover a broad range of topics related to Aortic Diseases. Subjects discussed include, but are not limited to: Diseases of the Aortic Root; Genetic Disorders and Indications for Intervention, Type A Dissections; Endovascular Treatment Options for the Aortic Arch; Treatment of Complex Thoracoabdominal Aortic Disease; Treatment of Abdominal Aortic Pathology; and Neuroprotection Strategies in Aortic Surgery, among others.

This issue of Interventional Cardiology Clinics, edited by the series Editor-in-Chief, Dr. Matthew Price, will cover Transcatheter Closure of Patent Foramen Ovale. Some of the topics discussed in this issue include, but are not limited to, PFO and the Interatrial Septum: Clinical-Anatomic Correlations; Current Dataset for PFO Closure in Cryptogenic; Stroke: Randomized Clinical Trials and Observational Studies; PFO closure: Devices and Technique; Identification and quantification of PFO-mediated shunts: echocardiography and transcranial Doppler; PFO closure for Hypoxemia; and Imaging Assessment of the interatrial Septum for ASD and PFO closure, among others.

To say this book is just about coronary heart disease would demean its real value. The author has brought together from innumerable sources, information that places coronary artery disease in a historical, evolutionary, and scientific context. The book is eminently readable by both the lay public and members of the medical profession. Physicians and health workers often fail to appreciate the historical and scientific context of disease. That is because they are critically involved in the day-to-day management of patients. This book makes the topic exciting and provides extraordinary insight into the importance of history and how science, society and social circumstances interact. This book is less about coronary artery disease than it is about certain contexts that author believes are important for a better understanding of this disease and several others. The contexts are biological, clinical, managerial, social and historical, and each chapter is an inquiry into one or more of them. A theme common especially to the last chapters is that the balance between principle and diversity, or between Platonic idealism and Aristotelian empiricism, has been shifted too far in favour of the former, and that this imbalance is inimical to science, agriculture and clinical medicine. A major theme of this book is that we cannot rely on molecular biology and biotechnology to provide solutions to coronary artery disease. Instead, government must integrate health policy with policies for science, industry, urban planning and agriculture. The book is intended for health care professionals, including researchers and administrators, and it is intended for informed laypersons, including politicians, with a general interest in our health care systems.

The Prevention of Cardiovascular Disease through the Mediterranean Diet presents dietary habits that will have maximum impact on cardiovascular health and other major chronic diseases. Data collected through the results of large clinical trials, such as PREDIMED, one of the longest trials ever conducted, has allowed researchers to conclude that the Mediterranean Diet provides the best evidence for health benefits. Studies have shown that the Mediterranean Diet is able to reduce the risk of cardiovascular hard clinical events by 30%. This book explores the components of this diet, including the consumption of extra virgin olive oil, nuts, fresh fruits and vegetables, fatty fish, poultry and red wine for optimal health benefits.

Living organisms exhibit specific responses when confronted with sudden changes in their environmental conditions. The ability of the cells to acclimate to their new environment is the integral driving force for adaptive modification of the cells. Such adaptation involves a number of cellular and biochemical alteration including metabolic homeostasis and reprogramming of gene expression. Changes in metabolic pathways are generally short-lived and reversible, while the consequences of gene expression are a long-term process and may lead to permanent alternation in the pattern of adaptive responses.
The heart possesses remarkable ability to adapt itself against any stressful situation by increasing resistance to the adverse consequences. Stress composes the foundation of many degenerative heart diseases including atherosclerosis, spasm, thrombosis, cardiomyopathy, and congestive heart failure. Based on the concept that excessive stress may play a crucial role in the pathogenesis of ischemic heart disease, attempts were made to design methods for preventing of myocardial injury. Creation of stress reactions by repeated ischemia and reperfusion or subjecting the hearts to heat or oxidative stress enables them to meet the future stress challenge. Repeated stress exposures adapt the heart to withstand more severe stress reactions probably by upregulating the cellular defense and direct accumulation of intracellular mediators, which presumably constitute the material basis of increased adaptation to stress. Thus, the powerful cardioprotective effect of adaptation is likely to originate at the cellular and molecular levels that compose fundamental processes in the prophylaxis of such diseases.
Volume six of the Advances in Organ Biology series contains state-of-the-art reviews on myocardial preservation and cellular adaptation from the leading authorities in this subject.

From basic clinical facts to new advanced guidelines, Practical Cardiology, by Drs. Majid Maleki, Azin Alizadehasl, and Majid Haghjoo, is your new go-to resource for new developments in cardiology knowledge, imaging modalities, management techniques, and more. This step-by-step, practical reference is packed with tips and guidance ideal for residents, fellows, and clinicians in cardiology, as well as internal medicine, cardiac surgery, interventional cardiology, and pediatric cardiology. Features a wealth of information online and in print, including practical points from recently published guidelines, ECGs, hemodynamic traces of advanced imaging modalities in real patients, and much more. Offers a comprehensive review of cardiovascular medicine, from basic to advanced.

This issue of Physician Assistant Clinics, guest edited by Daniel Thibodeau MHP, PA-C, DFAAPA, is devoted to Cardiology. Articles in this issue include: Hypertension: Evaluation, Management and Keeping Patients in the Safe Zone; Cardiovascular Risk and Assessment: Impact of Comorbidities to the Cardiovascular System; Arrhythmia Detection and Management; Anticoagulation: The Successes and Pitfalls of Long-term Management; Dyslipidemia: Long-term Management and Other Uses of Statins for Cardiac Disease; Acute Coronary Syndrome: Care After a Patient Event and Strategies to Improve Adherence; Evaluation of Chest Pain in the Primary Care Setting; Ischemic Heart Disease; Heart Failure and Cardiomyopathy; Pulmonary Hypertension and Thromboembolism: Long-term Management and Chronic Oral Anticoagulation; Approaches to Valvular Disease in the Primary Care Setting; and Syncope: Initial Evaluation and Workup in the Primary Care Office.

This issue of Interventional Cardiology Clinics, guest edited by Dr. Srihari S. Naidu, will discuss Interventional techniques for Heart Failure. Subjects covered in the articles include, but are not limited to: Invasive Hemodynamics of Myocardial Disease: Systolic and Diastolic Dysfunction; Invasive Hemodynamics of Pericardial Disease: Constriction and Tamponade; Invasive Hemodynamics of Pulmonary Disease and the Right Ventricle; TAVR and MitraClip to Reverse Heart Failure; Mechanical Circulatory Support in Acute Decompensated Heart Failure and Shock; Adult Congenital Interventions in Heart Failure; Future Directions in Device Treatment of Heart Failure; and Prioritizing and Combining Interventional Therapies for Heart Failure, among others.

This issue of Heart Failure Clinics, edited by Dr. Roberto Manfredini, will cover an array of topics related to Chronobiology and Cardiovascular Diseases. Topics include, but are not limited to Clock genes, metabolism and cardiovascular risk; Cardiac clocks and preclinical translation; Chronobiology of arterial blood pressure; Circadian periodicity of ischemic heart disease; Seasonal periodicity of ischemic heart disease and heart failure; Chronobiologic aspects of venous thromboembolism; Chronobiologic aspects of acute aortic diseases; Circaseptan periodicity of CV diseases; Gender and periodicity of CV disease; Chronopharmacology of CV drugs; Chronotherapy of Hypertension; and Chronoprevention of CV diseases.

This issue of Cardiology Clinics, edited by Drs. Gerald Bloomfield and Melissa Burroughs-Pena, will cover a broad range of issues in the field of Global Cardiovascular Health. Topics covered in this issue include, but are not limited to Diagnosis and management of endomyocardial fibrosis; Chagas disease; Tuberculosis and the heart; Cardiovascular manifestations of human immunodeficiency virus infection; Improving global access to essential cardiovascular medicines; Innovative approaches to hypertension control in the community; Causes and treatment of infective endocarditis in developing countries; and Strategies for Patient Centered Blood Pressure Control in Low- and Middle income Countries, among others.

This issue of Heart Failure Clinics, edited by Drs. Wilbert Aronow and Ali Ahmed, will cover a wide array of topics related to Heart Failure in Older Adults. Subjects covered include, but are not limited to: Epidemiology, Pathophysiology, and Prognosis of Heart Failure in the Older Adult; DEFEAT Heart Failure: Clinical Manifestations, Diagnostic Assessment, and Etiology of Geriatric Heart Failure; Heart Failure with Preserved Ejection Fraction in the Older Adult; Heart Failure-Complicating Acute Myocardial Infarction; Interventional Therapies for Heart Failure in the Older Adult; Cardiac Resynchronization Therapy for Treatment of Heart Failure in the Older Adult; and Left Ventricular Assist Devices in Treatment of Heart Failure in the Older Adult, among others.

The Complete Reference for Scimitar Syndrome: Anatomy, Epidemiology, Diagnosis and Treatment gives the complete picture of this rare syndrome that is usually treated with tactics such as imaging. The book goes beyond imaging, providing a pathological and clinical description of this rare syndrome. All aspects beginning with development, clinical presentation, current surgical options (including recent techniques) and indications to treat patients based on current results coming from multicenter study experiences are included. This book is a must-have reference for all cardiologists, cardiac surgeons, thoracic surgeons, pathologists, physicians, residents and students involved in Scimitar Syndrome cases.

Peripheral vascular disease is the obstruction of large arteries that are not in the heart or brain.? With the advent of percutaneous treatment techniques, such obstructions are now often being treated by cardiologists.? This issue provides current information on? diagnosis, medical management, and percutaneous procedures for peripheral vascular disease.

This issue of the Cardiac Electrophysiology Clinics, edited by Drs. Amin Al- Ahmad and Francis Marchlinski, will cover Ventricular Tachycardia in Structural Heart Disease. Topics discussed in the issue include, but are not limited to, ECG localization of VT in patients with structural heart disease; Anatomy for VT ablation in structural heart disease; Ablation of VT in ischemic and non-ischemic heart disease; Pace mapping; Ablation of VT in ARVD; Epicardial VT ablation; and VT clinical trials, among others.

Get the tools and knowledge you need for effective diagnosis, evaluation, and management of patients with acute myocardial infarction. Myocardial Infarction: A Companion to Braunwald's Heart Disease, by David A. Morrow, MD, is a comprehensive, hands-on resource that provides practical guidance from a name you trust. Concise and easy to use, this text explores the most recent tools for diagnosis and therapeutic decision-making, as well as the full range of available management strategies, providing outcomes data for each strategy. Myocardial Infarction also includes regular updates with late-breaking clinical trials, reviews of important new articles, and the latest guidance on clinical practice, all selected and masterfully edited by Dr. Eugene Braunwald. Provides thorough discussions of ECG, established and emerging biochemical markers, angiography, nuclear cardiology, echocardiography, and cardiac MRI and CT. Features an extensive treatment section that covers the latest drugs and most recent clinical trials of antiplatelet therapy, coronary revascularization, gene therapy, and approaches to reperfusion injury and ventricular remodeling. Discusses special considerations for the evaluation of acute coronary syndromes in the emergency department, and use of advanced technologies in cardiac critical care. Covers key topics such as in-hospital complications, cardiogenic shock, transitions to post-discharge care, and cardiac rehabilitation. Includes Clinical Practice/Controversy chapters that highlight management-focused, practical topics covering expert approaches for areas of uncertainty. Offers guidance on the management of special populations. Online content includes animations illustrating key pathobiology, including dynamic thrombosis, platelet adherence-activation-aggregation and adverse ventricular remodeling, as well as management strategies and procedural techniques. Regularly updated Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

This book provides an introduction to the biological background of heart functioning and analyzes the various materials and technologies used for the development of microfluidic systems dedicated to cell culture, with an emphasis on cardiac cells. The authors describe the characterization of microfluidic systems for cardiac cell culture and center their discussion of the use of stem cell stimulation based on four different types: electrical, biochemical, physical, and mechanical. This book is appropriate for researchers focused on on-chip technologies and heart studies, students in bioengineering and microengineering courses, and a variety of professionals, such as biotechnologists, biomedical engineers, and clinicians working in the cardiac diseases field.