Myocardial Preservation and Cellular Adaptation, Volume 6 (Hardcover)

Living organisms exhibit specific responses when confronted with sudden changes in their environmental conditions. The ability of the cells to acclimate to their new environment is the integral driving force for adaptive modification of the cells. Such adaptation involves a number of cellular and biochemical alteration including metabolic homeostasis and reprogramming of gene expression. Changes in metabolic pathways are generally short-lived and reversible, while the consequences of gene expression are a long-term process and may lead to permanent alternation in the pattern of adaptive responses.
The heart possesses remarkable ability to adapt itself against any stressful situation by increasing resistance to the adverse consequences. Stress composes the foundation of many degenerative heart diseases including atherosclerosis, spasm, thrombosis, cardiomyopathy, and congestive heart failure. Based on the concept that excessive stress may play a crucial role in the pathogenesis of ischemic heart disease, attempts were made to design methods for preventing of myocardial injury. Creation of stress reactions by repeated ischemia and reperfusion or subjecting the hearts to heat or oxidative stress enables them to meet the future stress challenge. Repeated stress exposures adapt the heart to withstand more severe stress reactions probably by upregulating the cellular defense and direct accumulation of intracellular mediators, which presumably constitute the material basis of increased adaptation to stress. Thus, the powerful cardioprotective effect of adaptation is likely to originate at the cellular and molecular levels that compose fundamental processes in the prophylaxis of such diseases.
Volume six of the Advances in Organ Biology series contains state-of-the-art reviews on myocardial preservation and cellular adaptation from the leading authorities in this subject.

General

Imprint:	JAI Press Inc.
Country of origin:	United Kingdom
Series:	Advances in Organ Biology
Release date:	December 1998
First published:	1999
Editors:	D.K. Das
Dimensions:	234 x 156 x 17mm (L x W x T)
Format:	Hardcover
Pages:	274
ISBN-13:	978-0-7623-0391-5
Categories:	Books > Medicine > Clinical & internal medicine > Cardiovascular medicine Books > Science & Mathematics > Biology, life sciences > Molecular biology Books > Science & Mathematics > Biology, life sciences > Zoology & animal sciences > Animal physiology Books > Science & Mathematics > Biology, life sciences > Human biology & related topics > General Books > Academic & Education > Professional & Technical > Biochemistry Promotions
LSN:	0-7623-0391-3
Barcode:	9780762303915

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