An expanded, up-to-date resource for students and researchers, "The Dictionary of Cell & Molecular Biology, Fifth Edition," provides clear and concise definitions needed for laboratory study. With over 12,000 entries and a breadth of terms across bioscience, including plant molecular biology, microbiology and biotechnology, this revision reflects the changes in the research over the past few years. The latest edition of "The Dictionary of Cell and Molecular Biology" maintains its outstanding reputation as an authoritative, clear, and accessible reference with short, cross-referenced definitions of important technical terminology.
Thoroughly revised and expanded by over 20% with over 12,000 entries in cellular and molecular biologyIncludes expanded coverage of terms, including plant molecular biology, microbiology and biotechnology areasConsistently provides the most complete short definitions of technical terminology for anyone working in life sciences todayFeatures extensive cross-references Provides multiple definitions, notes on word origins, and other useful features

The detection and measurement of the dynamic interactions of proteins within the living cell are critical to our understanding of cell physiology and pathophysiology. With FRET microscopy and spectroscopy techniques, basic and clinical scientists can make such measurements at very high spatial and temporal resolution. But sources of background information about these tools are very limited, so this book fills an important gap. It covers both the basic concepts and theory behind the various FRET microscopy and spectroscopy techniques, and the practical aspects of using the techniques and analyzing the results. The critical tricks for obtaining a good FRET image and precisely quantitating the signals from living specimens at the nanomolecular level are explained. Valuable information about the preparation of biological samples used for FRET image analysis is also provided.
The methods covered include different types of microscopy systems and detectors (wide-field, confocal, multi-photon) as well as specialized techniques such as photobleaching FRET, FLIM-FRET microscopy, spectral imaging FRET, single molecule FRET, and time and image correlation spectroscopy. Starting from the basics, the chapters guide readers through the choice of probes to be used for FRET experiments and the selection of the most suitable experimental approaches to address specific biological questions. Up-to-date, consistently organized, and well-illustrated, this unique book will be welcomed by all researchers who wish to use FRET microscopy and spectroscopy techniques.

Retaining the introductory flavor of the now classic First Edition, this revision includes all the latest techniques in the field. New information on methods of radio tag harnessing, new sections on satellite tracking techniques and new types of data analysis are all included. Still the only comprehensive, up-to-date, introduction to this fundamental technique for wildlife and behavioral biologists.
* A unique guide to the subject
* Full coverage of the very latest techniques in both terrestrial and satellite tracking
* Detailed, practical guidance in how to fit tags, track animals, source and evaluate equipments and techniques and analyse resulting data

The third edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to maximize the safety of research subjects. Complete with sections on the history of clinical research and ethics, copious figures and charts, and sample documents it serves as an excellent companion text for any course on clinical research and as a must-have reference for seasoned researchers.
Incorporates new chapters on Managing Conflicts of Interest in Human Subjects Research, Clinical Research from the Patient's Perspective, The Clinical Researcher and the Media, Data Management in Clinical Research, Evaluation of a Protocol Budget, Clinical Research from the Industry Perspective, and Genetics in Clinical ResearchAddresses the vast opportunities for translation of basic science observations to the bedside through clinical researchDelves into data management and addresses how to collect data and use it for discoveryContains valuable, up-to-date information on how to obtain funding from the federal government

The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research.
Discusses the most recent data, ideas and conceptsPresents case studies and an industrial perspectiveDetails information from the molecular level to bioprocessingThought provoking, for the novice to the specialistTimely, for today's biopharmaceuticals market

Cytosol, the liquid found inside cells, is the site for multiple cell processes, including signaling from the cell membrane to sites within the cell. Cytosolic signaling mechanisms are researched and studied in graduate programs in cell biology, molecular biology, biochemistry, pharmacology, molecular and cellular physiology, pharmacy, and biomedical sciences.

Articles written and edited by experts in the field
Thematic volume covering material needed for young professionals joining the field of research and graduate students taking survey courses
Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease

This handbook provides the first comprehensive overview of the emerging field of glycomics, defined as the study of all complex carbohydrates in an organism or cell ("the glycome"). Beginning with analytic approaches and bioinformatics, this work provides a detailed discussion of relevant databases, data integration, and analysis. It then moves on to a discussion of specific model organism and pathogen glycomes followed by therapeutic approaches to human disorders of glycosylization. Structure and function of glycomes are included along with state-of-the-art technologies and systems approaches to the analysis of glycans.
* Synthesizes contributions from experts in biology, chemistry, bioinformatics, biotechnology, and medicine
* Highlights chapters devoted to chemical synthesis, cancer glycomics and immune cell glycomics
* Includes discussions of proteomics, mass spectrometry, NMR, array technology, and transcriptomics analytic approaches

Much like the "Chicago Manual of Style," "The Manual of Scientific Style" addresses all stylistic matters in the relevant disciplines of physical and biological science, medicine, health, and technology. It presents consistent guidelines for text, data, and graphics, providing a comprehensive and authoritative style manual that can be used by the professional scientist, science editor, general editor, science writer, and researcher.
Scientific disciplines treated independently, with notes where variances occur in the same linguistic areas

Organization and directives designed to assist readers in finding the precise usage rule or convention

A focus on American usage in rules and formulations with noted differences between American and British usage

Differences in the various levels of scientific discourse addressed in a variety of settings in which science writing appears

Instruction and guidance on the means of improving clarity, precision, and effectiveness of science writing, from its most technical to its most popular

Description
Using chips composed of thousands of spots, each with the capability of holding DNA molecules corresponding to a given gene, DNA microarray technology has enabled researchers to measure simultaneously gene expression across the genome. As with other large scale genomics approaches, microarray technologies are broadly applicable across disciplines of life and biomedical sciences, but remain daunting to many researchers. This guide is designed to demystify the technology and inform more biologists about this critically important experimental technique.
.Provides a basic overview of microarray technology and available platforms for those unfamiliar with the technology
.Includes detailed discussion of experimental design and analysis of microarray experiments, giving first-time users valuable information that can be tailored to their own research needs
.Provides discussion of such hot areas as ChIP (chromatin immunoprecipitation) with hybridization to DNA arrays, microarray-based comparative genomic hybridization (CGH), and cell and tissue arrays
Expert author team highlights the utility of the technology using examples from human health and disease--e.g., malaria and cancer diagnostics.

This volume reviews the techniques Forster Resonance Energy Transfer (FRET) and Fluorescence Lifetime Imaging Microscopy (FLIM) providing researchers with step by step protocols and handy hints and tips. Both have become staple techniques in many biological and biophysical fields.

Jeff's Views provide witty, insightful, and thought-provoking looks into the life of a modern scientist. From starting off to letting go, Gottfried ("Jeff") Schatz leads us through the trials and triumphs of scientific life. With his tongue firmly in his cheek, and his humour always intact, the Austrian essayist leads us through the confusing and seemingly insurmountable hill that is the career path of European scientists. In addition to giving useful insights into how to get funding, give seminars, and still find time to make that leading edge scientific discovery, Jeff explores the philosophical dimensions of recent biological breakthroughs such as the sequencing of the human genome, the evolution of sensory receptors, and cellular suicide.
Gottfried Schatz is one of the world's leading scientists in the field of bioenergetics and mitochondria biology. Born in a small Austrian village, he started his scientific career at the University of Graz, and ended it as President of the Swiss Science and Technology Council. With stints as a violinist in Austrian opera houses, professorships in the USA and Switzerland, and numerous prestigious awards along the way, Jeff is a true European, whose unique, and often controversial, viewpoints are appreciated by scientists and politicians alike.
These essays look at science from a very personal angle - often critical, sometimes sad, but always with excitement, wonder, and admiration. It is hoped that they will make you look at science with a slightly different view.
*Witty, insightful, and thought-provoking looks into life of a modern scientist
*Provides useful insights on how to get funding, give seminars, and still find time to makethat scientific discovery
*Explores recent breakthroughs in science: genome sequencing, sensory receptor evolution, and cellular suicide

"Recent Events in the Psychology of Aging" documents the successful integration of aging into the mainstream of psychology. Leading psychologists present overviews of the key issues and research findings on mainstream topics. These include cognitive neuroscience, visual attention, learning, memory and cognition, as well as personality and happiness. The intersection of aging content with mainstream psychology is also prominent in the areas of emotions, personality, and social psychology as seen in the chapters on subjective well-being, emotional development, self-esteem and personality trajectories.
The seven chapters of this book offer information on such topics as: the seven sins of memory, categorizing the common breakdowns of memory in everyday life and the special breakdown of sins that increase with aging; problems with attention and learning; and offers answers to questions such as do emotions get blunted with age; do older people focus more on positive feelings; and the age old question of whether older people are happier than younger people is given in the chapter on the evolving concept of subjective well-being and the multifaceted nature of happiness. Questions about what occurs to one's self-esteem and personality are also masterfully discussed and the answers may be surprising. The concluding seventh chapter provides a cultural lens on the biopsychosocial study of aging.

Collectively, the chapters in this work will provide the reader with novel insight into the inter-relationships of the function of different organelles in the sequences of events that lead to cellular dysfunction and degeneration in the aging human population. The chapters are rich in information for cell and molecular biologists pursuing studies of the different diseases covered. In addition, the clinician will find value in understanding mechanisms underlying age-related disease as such an understanding will lead to novel therapeutic approaches for an array of age-related diseases.

An accompanying volume (Volume 6) in this series presents strategies of cellular invasion from the viewpoint of the microbe.
This filed of study is growing rapidly after a somewhat slow start over recent decades. This collection of invited chapters attempts to reflect current research, and brings together cell biologists, microbiologists and immunologists with disparate interests. However, there is a certain unity, even repetition of key themes, hopefully like a symphony rather than a boring catalogue. It will be evident that editorial bias favors intracellular paratism and medically important organisms. The neutrophil is far more than a supporting player to the macrophage, and some attempt is made to remind the reader of some of its unique skills. To retain a manageable size, the emphasis is on relatively early events such as mutual recognition, cell entry, and response, rather than on longterm changes in gene expression by either host cell or pathogen. Viruses are excluded not because of lack of importance but because of somewhat different research approaches, although it is cytogenes, share common strategies in invasion and intercellular spread.

This volume of "Advances in Cell Aging and Gerontology" critically reviews the rapidly advancing area of telomerase research with a focus at the molecular and cellular levels. The clearly established function of telomerase is to maintain chromosome ends during successive rounds of cell division by adding a six base DNA repeat on to the telomeric ends of chromosomes. As presented in the chapters of this volume, the mechanisms that regulate telomerase expression and activity are complex. Moreover, emerging data suggest additional roles for telomerase in the regulation of cell differentiation and survival.

It is expected that this quite comprehensive volume will provide a valuable resource for graduate students and postdocs in the telomerase field and for established investigators in other fields who are beginning to study telomerase in their particular research program. With an increasing number of proteins being brought into the fold of telomerase research (e.g., DNA damage and repair response proteins, heat-shock proteins, and proteins in various signal transduction cascades) many new scientists are beginning to study this enzyme from novel vantage points.

This book focuses on emerging themes in the molecular mechanisms of calcium signal transduction through calmodulin-regulated pathways. It provides the reader with selected examples and experimental precedents that underlie current models of cell regulation through calmodulin-regulated pathways and their linkage with other regulatory pathways.
Highlights:
* Molecular mechanisms of calcium signal transduction through calmodulin-regulated enzymes
* Selected case studies and precedents related to molecular mechanisms
* Protein-protein recognition between calmodulin and the enzymes it regulates
* Cross-talk and interdigitation with other signal transduction pathways

This is the fourth volume in the series, aimed at those wishing to stay abreast of developments in the mechanisms and synthetic applications of 1,3-dipolar cycloaddition reactions.

This newly revised and updated edition of Radiation Biophysics provides an in-depth description of the physics and chemistry of radiation and its effects on biological systems. Coverage begins with fundamental concepts of the physics of radiation and radioactivity, then progresses through the chemistry and biology of the interaction of radiation with living systems. The Second Edition of this highly praised text includes major revisions which reflect the rapid advances in the field. New material covers recent developments in the fields of carcinogenesis, DNA repair, molecular genetics, and the molecular biology of oncogenes and tumor suppressor genes. The book also includes extensive discussion of the practical impact of radiation on everyday life.
Key Features
* Covers the fundamentals of radiation physics in a manner that is understandable to students and professionals with a limited physics background
* Includes problem sets and exercises to aid both teachers and students
* Discusses radioactivity, internally deposited radionuclides, and dosimetry
* Analyzes the risks for occupational and non-occupational workers exposed to radiation sources

Living organisms exhibit specific responses when confronted with sudden changes in their environmental conditions. The ability of the cells to acclimate to their new environment is the integral driving force for adaptive modification of the cells. Such adaptation involves a number of cellular and biochemical alteration including metabolic homeostasis and reprogramming of gene expression. Changes in metabolic pathways are generally short-lived and reversible, while the consequences of gene expression are a long-term process and may lead to permanent alternation in the pattern of adaptive responses.
The heart possesses remarkable ability to adapt itself against any stressful situation by increasing resistance to the adverse consequences. Stress composes the foundation of many degenerative heart diseases including atherosclerosis, spasm, thrombosis, cardiomyopathy, and congestive heart failure. Based on the concept that excessive stress may play a crucial role in the pathogenesis of ischemic heart disease, attempts were made to design methods for preventing of myocardial injury. Creation of stress reactions by repeated ischemia and reperfusion or subjecting the hearts to heat or oxidative stress enables them to meet the future stress challenge. Repeated stress exposures adapt the heart to withstand more severe stress reactions probably by upregulating the cellular defense and direct accumulation of intracellular mediators, which presumably constitute the material basis of increased adaptation to stress. Thus, the powerful cardioprotective effect of adaptation is likely to originate at the cellular and molecular levels that compose fundamental processes in the prophylaxis of such diseases.
Volume six of the Advances in Organ Biology series contains state-of-the-art reviews on myocardial preservation and cellular adaptation from the leading authorities in this subject.

Radiological Imaging: The Theory of Image Formation, Detection, and Processing is intended to prepare the student to do research in radiological imaging, to teach general image science within a radiographic context, and to help the student gain fluency with the essential analytical tools of linear systems theory and the theory of stochastic processes that are applicable to any imaging system. The book contains chapters devoted to the discussion of linear systems, Poisson processes, analysis of radiographic systems, radiographic image detectors, and the various aspects of three-dimensional or tomographic imaging. Computed tomography, psychophysics, and scattered radiation and its effect on image are also elucidated. Radiology technicians will find the book very invaluable.

Written with corporate regulatory compliance officers, health and safety managers, loss control managers, and human resource specialists in mind, this book offers workplace-tested strategies for meeting the health and safety needs of a modern corporation. Emphasizing the practical means of achieving compliance with OSHA regulations, this book also provides a unique assessment of the more extensive factors that influence the management of workplace health and safety. The integration of practical regulation strategies with corporate objectives is particularly relevant to graduate curricula in business management, public policy, and occupational medicine.
Key Features
* Provides practical guidelines for industrial compliance with major OSHA regulations
* Presents concise explanations of technical and scientific concepts underlying regulatory requirements
* Integrates specific examples of the global economy's influence on the design and implementation of workplace health and safety
* Elucidates the effects of health and safety programs on financial and legal risk management practices in industry
* Includes explanations of practical alternative compliance strategies for company health and safety officers

DNA Structure and Function, a timely and comprehensive resource, is intended for any student or scientist interested in DNA structure and its biological implications. The book provides a simple yet comprehensive introduction to nearly all aspects of DNA structure. It also explains current ideas on the biological significance of classic and alternative DNA conformations. Suitable for graduate courses on DNA structure and nucleic acids, the text is also excellent supplemental reading for courses in general biochemistry, molecular biology, and genetics.
Special Features
* Explains basic DNA Structure and function clearly and simply
* Contains up-to-date coverage of cruciforms, Z-DNA, triplex DNA, and other DNA conformations
* Discusses DNA-protein interactions, chromosomal organization, and biological implications of structure
* Highlights key experiments and ideas within boxed sections
* Illustrated with 150 diagrams and figures that convey structural and experimental concepts

This series provides a variety of different discussions on topics within the field of growth factors and cytokines in health and disease.

This volume deals with aspects of the cytoskeleton in different cell types and also describe examples of changes in the cytoskeleton which occur during various pathological states. These studies bring the exciting area of cytoskeleton research into the domain of medical science.

This is the third volume in a series on membrane protein transfer. Membrane protein transport underlies the topological disposition of many proteins within cells and it is this disposition that allows for the co-ordination of the central cellular processes, such as metabolism.