Welcome to Loot.co.za!
Sign in / Register |Wishlists & Gift Vouchers |Help | Advanced search
|
Your cart is empty |
|||
Books > Academic & Education > Professional & Technical > Biochemistry
New discoveries in the field of stem cells increasingly dominate
the news and scientific literature revealing an avalanche of new
knowledge and research tools that are producing therapies for
cancer, heart disease, diabetes, and a wide variety of other
diseases that afflict humanity. The Handbook of Stem Cells
integrates this exciting area of life science, combining in two
volumes the requisites for a general understanding of adult and
embryonic stem cells. Organized in two volumes entitled Pluripotent
Stem Cells & Cell Biology and Adult & Fetal Stem Cells,
this work contains contributions from the world s experts in stem
cell research to provide a description of the tools, methods, and
experimental protocols needed to study and characterize stem cells
and progenitor populations as well as a the latest information of
what is known about each specific organ system.
The detection and measurement of the dynamic interactions of
proteins within the living cell are critical to our understanding
of cell physiology and pathophysiology. With FRET microscopy and
spectroscopy techniques, basic and clinical scientists can make
such measurements at very high spatial and temporal resolution. But
sources of background information about these tools are very
limited, so this book fills an important gap. It covers both the
basic concepts and theory behind the various FRET microscopy and
spectroscopy techniques, and the practical aspects of using the
techniques and analyzing the results. The critical tricks for
obtaining a good FRET image and precisely quantitating the signals
from living specimens at the nanomolecular level are explained.
Valuable information about the preparation of biological samples
used for FRET image analysis is also provided.
Retaining the introductory flavor of the now classic First Edition,
this revision includes all the latest techniques in the field. New
information on methods of radio tag harnessing, new sections on
satellite tracking techniques and new types of data analysis are
all included. Still the only comprehensive, up-to-date,
introduction to this fundamental technique for wildlife and
behavioral biologists.
The third edition of this innovative work again provides a unique
perspective on the clinical discovery process by providing input
from experts within the NIH on the principles and practice of
clinical research. Molecular medicine, genomics, and proteomics
have opened vast opportunities for translation of basic science
observations to the bedside through clinical research. As an
introductory reference it gives clinical investigators in all
fields an awareness of the tools required to ensure research
protocols are well designed and comply with the rigorous regulatory
requirements necessary to maximize the safety of research subjects.
Complete with sections on the history of clinical research and
ethics, copious figures and charts, and sample documents it serves
as an excellent companion text for any course on clinical research
and as a must-have reference for seasoned researchers.
Jeff's Views provide witty, insightful, and thought-provoking looks
into the life of a modern scientist. From starting off to letting
go, Gottfried ("Jeff") Schatz leads us through the trials and
triumphs of scientific life. With his tongue firmly in his cheek,
and his humour always intact, the Austrian essayist leads us
through the confusing and seemingly insurmountable hill that is the
career path of European scientists. In addition to giving useful
insights into how to get funding, give seminars, and still find
time to make that leading edge scientific discovery, Jeff explores
the philosophical dimensions of recent biological breakthroughs
such as the sequencing of the human genome, the evolution of
sensory receptors, and cellular suicide.
This book focuses on emerging themes in the molecular mechanisms of
calcium signal transduction through calmodulin-regulated pathways.
It provides the reader with selected examples and experimental
precedents that underlie current models of cell regulation through
calmodulin-regulated pathways and their linkage with other
regulatory pathways.
Why a Second Edition?
An expanded, up-to-date resource for students and researchers, "The
Dictionary of Cell & Molecular Biology, Fifth Edition,"
provides clear and concise definitions needed for laboratory study.
With over 12,000 entries and a breadth of terms across bioscience,
including plant molecular biology, microbiology and biotechnology,
this revision reflects the changes in the research over the past
few years. The latest edition of "The Dictionary of Cell and
Molecular Biology" maintains its outstanding reputation as an
authoritative, clear, and accessible reference with short,
cross-referenced definitions of important technical terminology.
The growing area of peptide and protein therapeutics research is
of paramount importance to medical application and advancement. A
needed reference for entry level researchers and researchers
working in interdisciplinary / collaborative projects, Peptide and
Protein Delivery addresses the current and emerging routes for
delivery of therapeutics. Covering cerebral delivery, pulmonary
delivery, transdermal delivery, intestinal delivery, ocular
delivery, parenteral delivery, and nasal delivery, this resource
offers an overview of the main routes in therapeutics. Researchers
across biochemistry, pharmaceutical, molecular biology, cell
biology, immunology, chemistry and biotechnology fields will find
this publication invaluable for peptide and protein laboratory
research.
A primary component of cell signaling research, this title covers the principal membrane-bound receptor families, including their structural organization. Written and edited by experts in the field, this book provides up-to-date research on transmembrane signaling entities and their initiating responses following extracellular stimulation. Articles written and edited by experts in the field
This must-have cell signaling title will appeal to researchers across molecular biology, biochemistry, cell biology and genetics. The articles are written and edited by experts in the field and emphasize signaling to and from intracellular compartments including transcriptional responses to cytoplasmic and nuclear signaling events, chromatin remodeling and stress responses, the regulation of endoplasmic reticulum function, control of cell cycle progression and apoptosis and the modulation of the activities of mitochondria and other organelles. Articles written and edited by experts in the field
Required reading for anyone involved in cell signaling research
with articles written and edited by experts in the field. This
title covers disease states such as lymphoid leukemia, breast
cancer, pulmonary fibrosis, systemic sclerosis, andinflammatory
bowel disease, along with up-to-date research on signaling systems
and mutations in
Cytosol, the liquid found inside cells, is the site for multiple cell processes, including signaling from the cell membrane to sites within the cell. Cytosolic signaling mechanisms are researched and studied in graduate programs in cell biology, molecular biology, biochemistry, pharmacology, molecular and cellular physiology, pharmacy, and biomedical sciences. Articles written and edited by experts in the field
Far more than a comprehensive treatise on initial-rate and
fast-reaction kinetics, this one-of-a-kind desk reference places
enzyme science in the fuller context of the organic, inorganic, and
physical chemical processes occurring within enzyme active sites.
Drawing on 2600 references, Enzyme Kinetics: Catalysis &
Control develops all the kinetic tools needed to define enzyme
catalysis, spanning the entire spectrum (from the basics of
chemical kinetics and practical advice on rate measurement, to the
very latest work on single-molecule kinetics and mechanoenzyme
force generation), while also focusing on the persuasive power of
kinetic isotope effects, the design of high-potency drugs, and the
behavior of regulatory enzymes. - Historical analysis of kinetic principles including advanced enzyme science - Provides both theoretical and practical measurements tools - Coverage of single molecular kinetics - Examination of force generation mechanisms - Discussion of organic and inorganic enzyme reactions
Since the publication of the first edition, the U.S. Surgeon General released the first-ever report on bone health and osteoporosis in October 2004. This report focuses even more attention on the devastating impact osteoporosis has on millions of lives. According to the National Osteoporosis Foundation, 2 million American men have osteoporosis, and another 12 million are at risk for this disease. Yet despite the large number of men affected, the lack of awareness by doctors and their patients puts men at a higher risk that the condition may go undiagnosed and untreated. It is estimated that one-fifth to one-third of all hip fractures occur in men. This second edition brings on board John Bilezikian and Dirk
Vanderschueren as editors with Eric Orwoll. The table of contents
is more than doubling with 58 planned chapters. The format is
larger - 8.5 x 11. This editionof Osteoporosis in Menbrings
together even more eminent investigators and clinicians to
interpret developments in this growing field, and describe
state-of-the-art research as well as practical approaches to
diagnosis, prevention and therapy. Describes state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy. There is no book on the market that covers osteoporosis in men as comprehensively as this book. "
This handbook provides the first comprehensive overview of the
emerging field of glycomics, defined as the study of all complex
carbohydrates in an organism or cell ("the glycome"). Beginning
with analytic approaches and bioinformatics, this work provides a
detailed discussion of relevant databases, data integration, and
analysis. It then moves on to a discussion of specific model
organism and pathogen glycomes followed by therapeutic approaches
to human disorders of glycosylization. Structure and function of
glycomes are included along with state-of-the-art technologies and
systems approaches to the analysis of glycans.
The third edition of this long-serving successful reference work is
a 'must-have' reference for anyone needing or desiring an
understanding of the structure, chemistry, properties, production
and uses of starches and their derivatives. * Includes specific information on corn, wheat, potato, rice, and new chapters on rye, oat and barley (including waxy barley) starches * Covers the isolation processes, properties, functionalities, and uses of the most commonly used starches. * Explores the genetics, biochemistry, and physical structure of starches * Presents current and emerging application trends for starch
This book focuses on the life and work of Nathan Zuntz (1847-1920),
a German physiologist, who made significant contributions to high
altitude physiology and aviation medicine.
Single molecule techniques, including single molecule fluorescence, optical tweezers, and scanning probe microscopy, allow for the manipulation and measurement of single biological molecules within a live cell or in culture. These approaches, amongst the most exciting tools available in biology today, offer powerful new ways to elucidate biological function, both in terms of revealing mechanisms of action on a molecular level as well as tracking the behaviour of molecules in living cells. This book provides the first complete and authoritative treatment of this rapidly emerging field, explicitly from a biological perspective. The contents are organized by biological system or molecule.
Each chapter discusses insights that have been revealed about their
mechanism, structure or function by single molecule techniques.
Among the topics covered are enzymes, motor proteins, membrane
channels, DNA, ribozymes, cytoskeletal proteins, and other key
molecules of current interest. An introduction by the editor
provides a concise review of key principles and an historical
overview. The last section discusses applications in molecular
diagnostics and drug discovery. * Organized by biological system or molecule. * Each chapter discusses insights into mechanism of action, structure, and function * Covers enzymes, motor proteins, membrane channels, DNA, ribozymes, etc. * Includes an introduction to key principles and an historical overview. * Discusses applications in molecular diagnostics and drug discovery. * Provides an expert's perspective on future developments.
This volume reviews the techniques Forster Resonance Energy Transfer (FRET) and Fluorescence Lifetime Imaging Microscopy (FLIM) providing researchers with step by step protocols and handy hints and tips. Both have become staple techniques in many biological and biophysical fields.
Growth in knowledge about the microcirculation has been explosive
with the field becoming fragmented into numerous sub-disciplines
and subspecialties. This volume pulls all of the critical
information into one volume eliminating the need to search through
numerous books and journals which can be exhaustive and demanding.
It provides cardiovascular physiologists with an integrated,
in-depth evaluation of the latest research developments and will
aide in developing new pathways of research and scholarship.
The central goal of this book is to broadly review the modem
techniques and significant applications of chemical sensors and
biosensors. Chapters are written by experts in the field -
including Professor Joseph Wang, the most cited scientist in the
world and renowned expert on sensor science who is also co-editor.
Each chapter provides technical details beyond the level found in
typical journal articles, and explores the application of chemical
sensors and biosensors to a significant problem in biomedical
science, also providing a prospectus for the future.
Today, in the era of the statins (cholesterol lowering drugs),
there is no longer any doubt about the value of lowering blood
cholesterol levels. This book chronicles the controversy that
swirled around the 'lipid hypothesis' of atherosclerosis for so
many years. In fact, 'the lower the better' is the position of many
clinicians. However, getting to this point has been a long uphill
battle marked by heated debate and sometimes violent disagreement.
The history of this controversy is told here for its own sake and
because remembering it may help us avoid similar mistakes in the
future.
Gene regulatory networks are the most complex, extensive control
systems found in nature. The interaction between biology and
evolution has been the subject of great interest in recent years.
The author, Eric Davidson, has been instrumental in elucidating
this relationship. He is a world renowned scientist and a major
contributor to the field of developmental biology.
This book offers pertinent basic science information on strategies
used for the rational design and discovery of novel anticancer
agents, and, in addition, translational studies involving clinical
trial design and execution with these novel, mostly cytostatic
agents. This book covers basic science strategies that are being
used in drug discovery and preclinical evaluation focused on novel
molecular targets, as well as clinical trial methodology including
clinical pharmacokinetics and imaging to address issues of efficacy
evaluation of the new, relatively non-cytotoxic anticancer agents.
|
You may like...
Signal Transduction
Bastien D. Gomperts, Ijsbrand M. Kramer, …
Paperback
R1,592
Discovery Miles 15 920
Biomedical Electron Microscopy…
Arvid B. Maunsbach, Bjoern A. Afzelius
Hardcover
R2,894
Discovery Miles 28 940
Automated DNA Sequencing and Analysis
Mark D. Adams, Chris Fields, …
Hardcover
R1,435
Discovery Miles 14 350
The Manual of Scientific Style - A Guide…
Harold Rabinowitz, Suzanne Vogel
Hardcover
R1,394
Discovery Miles 13 940
Microarray Technology in Practice
Steve Russell, Lisa A Meadows, …
Paperback
Principles and Practice of Clinical…
Richard Chin, Bruce Y. Lee
Hardcover
R2,052
Discovery Miles 20 520
|