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New discoveries in the field of stem cells increasingly dominate
the news and scientific literature revealing an avalanche of new
knowledge and research tools that are producing therapies for
cancer, heart disease, diabetes, and a wide variety of other
diseases that afflict humanity. The Handbook of Stem Cells
integrates this exciting area of life science, combining in two
volumes the requisites for a general understanding of adult and
embryonic stem cells. Organized in two volumes entitled Pluripotent
Stem Cells & Cell Biology and Adult & Fetal Stem Cells,
this work contains contributions from the world s experts in stem
cell research to provide a description of the tools, methods, and
experimental protocols needed to study and characterize stem cells
and progenitor populations as well as a the latest information of
what is known about each specific organ system.
The second edition of this classic reference deals exclusively with
the biology and diseases of bone as they affect children. Rapid
advances have been made in our understanding of the mechanisms and
factors controlling the growth and development of bone, and these
are discussed in detail in this book. Further, the various diseases
of bone that are peculiar to children are highlighted and discussed
in the light of our current knowledge with regard to causation,
clinical signs and treatment. The book is aimed to provide those
clinicians interested in children's diseases and basic scientists
with a comprehensive resource covering the various aspects of bone
health and disease in children.
An expanded, up-to-date resource for students and researchers, "The
Dictionary of Cell & Molecular Biology, Fifth Edition,"
provides clear and concise definitions needed for laboratory study.
With over 12,000 entries and a breadth of terms across bioscience,
including plant molecular biology, microbiology and biotechnology,
this revision reflects the changes in the research over the past
few years. The latest edition of "The Dictionary of Cell and
Molecular Biology" maintains its outstanding reputation as an
authoritative, clear, and accessible reference with short,
cross-referenced definitions of important technical terminology.
Protein NMR Spectroscopy combines a comprehensive theoretical
treatment of NMR spectroscopy with an extensive exposition of the
experimental techniques applicable to proteins and other biological
macromolecules in solution. Beginning with simple theoretical
models and experimental techniques, Protein NMR Spectroscopy
develops the complete repertoire of theoretical principles and
experimental techniques necessary for understanding and
implementing the most sophisticated NMR experiments.
"Designing Science Presentations "guides researchers and graduate students of virtually any discipline in the creation of compelling science communication. Most scientists never receive formal training in the creation, delivery, and evaluation of such material, yet it is essential for publishing in high-quality journals, soliciting funding, attracting lab personnel, and advancing a career.
This clear, readable volume fills that gap and provides visually
intensive guidance at every step-from the construction of original
figures to the presentation and delivery of those figures in
papers, slideshows, posters, and websites. It provides pragmatic
advice on the preparation and delivery of exceptional scientific
presentations; demonstrates hundreds of visually striking
presentation techniques, giving readers inspiration for creating
their own; and is structured so that readers can easily find
answers to particular questions.
Drawing together literature from a variety of fields, Food Texture
and Viscosity, 2E, includes a brief history of this area and its
basic principles. It reviews how texture and viscosity are
measured, including the physical interactions between the human
body and food, objective methods of texture measurements, the
latest advances in texture-measuring instruments, various types of
liquid flow, and more.
Nitric oxide (NO) is a gas naturally found in the body that
conveys information between cells. In the last decade researchers
have found that NO is a signaling molecule of key importance for
the cardiovascular system, regulating blood pressure and blood flow
to different organs. In addition, discoveries surrounding nitric
oxide s role as a principal neurotransmitter moderating erectile
function, a pathophysiological negotiator and messenger in
inflammation, and a weapon against infections have increased
research attention across the fields of biochemistry, chemistry,
molecular biology, gene therapy, cell biology, immunology,
pharmacology, neuroscience, and physiology.
Up-to-date therapeutic implications of nitric oxide research Authored by world experts on nitric oxide Detailed research of the biochemistry and synthesis of nitric oxide
Clinical or translational science is the field of study devoted to
investigating human health and disease, interventions and outcomes
for the purposes of developing new treatment approaches, devices,
and modalities to improve health. New molecular tools and
diagnostic technologies based on clinical and translational
research have lead to a better understanding of human disease and
the application of new therapeutics for enhanced health.
This book is the first systematic, detailed treatment of the approaches to ethical issues taken by biotech and pharmaceutical companies. The application of genetic/genomic technologies raises a whole spectrum of ethical questions affecting global health that must be addressed. Topics covered in this comprehensive survey include considerations for bioprospecting in transgenics, genomics, drug discovery, and nutrigenomics, as well as how to improve stakeholder relations, design ethical clinical trials, avoid conflicts of interest, and establish ethics advisory boards. The expert authors represent multiple disciplines including law, medicine, bioinformatics, pharmaceutics, business, and ethics.
This manual is an indispensable tool for introducing advanced
undergraduates and beginning graduate students to the techniques of
recombinant DNA technology, or gene cloning and expression. The
techniques used in basic research and biotechnology laboratories
are covered in detail. Students gain hands-on experience from start
to finish in subcloning a gene into an expression vector, through
purification of the recombinant protein.
A primary component of cell signaling research, this title covers the principal membrane-bound receptor families, including their structural organization. Written and edited by experts in the field, this book provides up-to-date research on transmembrane signaling entities and their initiating responses following extracellular stimulation.
Articles written and edited by experts in the field
The growing area of peptide and protein therapeutics research is
of paramount importance to medical application and advancement. A
needed reference for entry level researchers and researchers
working in interdisciplinary / collaborative projects, Peptide and
Protein Delivery addresses the current and emerging routes for
delivery of therapeutics. Covering cerebral delivery, pulmonary
delivery, transdermal delivery, intestinal delivery, ocular
delivery, parenteral delivery, and nasal delivery, this resource
offers an overview of the main routes in therapeutics. Researchers
across biochemistry, pharmaceutical, molecular biology, cell
biology, immunology, chemistry and biotechnology fields will find
this publication invaluable for peptide and protein laboratory
This must-have cell signaling title will appeal to researchers across molecular biology, biochemistry, cell biology and genetics. The articles are written and edited by experts in the field and emphasize signaling to and from intracellular compartments including transcriptional responses to cytoplasmic and nuclear signaling events, chromatin remodeling and stress responses, the regulation of endoplasmic reticulum function, control of cell cycle progression and apoptosis and the modulation of the activities of mitochondria and other organelles.
Articles written and edited by experts in the field
The third edition of this innovative work again provides a unique
perspective on the clinical discovery process by providing input
from experts within the NIH on the principles and practice of
clinical research. Molecular medicine, genomics, and proteomics
have opened vast opportunities for translation of basic science
observations to the bedside through clinical research. As an
introductory reference it gives clinical investigators in all
fields an awareness of the tools required to ensure research
protocols are well designed and comply with the rigorous regulatory
requirements necessary to maximize the safety of research subjects.
Complete with sections on the history of clinical research and
ethics, copious figures and charts, and sample documents it serves
as an excellent companion text for any course on clinical research
and as a must-have reference for seasoned researchers.
Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management.
This book reviews the latest developments providing insights
into the signalling processes involved in morphogenesis and
pathogenesis with emphasis on using the elements of the signalling
cascades as targets for therapeutic deployment.
Provides afundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes
Aids the development of therapeutic treatments for cancer
Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research "
The concept of network as a mathematical description of a set of
states, or events, linked according to a certain topology has been
developed recently and has led to a novel approach of real world.
This approach is no doubt important in the field of biology. In
fact biological systems can be considered networks. Thus, for
instance, an enzyme-catalysed reaction is a network that links,
according to a certain topology, the various states of the protein
and of its complexes with the substrates and products of the
chemical reaction. Connections between neurons, social relations in
animal and human populations are also examples of networks. Hence
there is little doubt that the concept of network transgresses the
boundaries between traditional scientific disciplines.
This Handbook provides a complete compendium of methods for
evaluation of IT-based systems and solutions within healthcare.
Emphasis is entirely on assessment of the IT-system within its
organizational environment. The author provides a coherent and
complete assessment of methods addressing interactions with and
effects of technology at the organizational, psychological, and
This highly engaging guide for clinical researchers provides a
foundation for improving skills in the understanding of ethical
requirements in the design and conduct of clinical research. It
includes practical information on ethical principles in clinical
research, designing appropriate research studies, writing consent
and assent documents, getting protocols approved, special
populations, confidentiality issues, and the reporting of adverse
events. A valuable appendix includes a listing of web resources
about research ethics as well as a glossary. This will be an
invaluable resource for basic scientists collaborating in clinical
trials, physician investigators, clinical research fellows,
research nurse coordinators, residents, and anyone who wants a
better understanding of the clinical trials process.
Edited by Daniel Rothbart of George Mason University in Virginia,
this book is a collection of Rom Harre's work on modeling in
science (particularly physics and psychology). In over 28 authored
books and 240 articles and book chapters, Rom Harre of Georgetown
University in Washington, DC is a towering figure in philosophy,
linguistics, and social psychology. He has inspired a generation of
scholars, both for the ways in which his research is carried out
and his profound insights. For Harre, the stunning discoveries of
research demand a kind of thinking that is found in the
construction and control of models. Iconic modeling is pivotal for
representing real-world structures, explaining phenomena,
manipulating instruments, constructing theories, and acquiring
Ageing is of perennial interest as a universal feature in all human societies. The genetic background and biochemical bases of ageing processes are currently being revealed in unprecedented detail. It is emerging that one of the main hurdles to be overcome in achieving a long and healthy lifespan is the maintenance of a properly functioning immune system. The main cause of death in people who have achieved "successful ageing" (which mostly means not having succumbed to cancer or cardiovascular disease) is infectious disease, caused by immunosenescence. This book contains chapters by many of the leaders in the field of immune-related issues in ageing and remediation.
This volume of "Advances in Cell Aging and Gerontology" critically reviews the rapidly advancing area of telomerase research with a focus at the molecular and cellular levels. The clearly established function of telomerase is to maintain chromosome ends during successive rounds of cell division by adding a six base DNA repeat on to the telomeric ends of chromosomes. As presented in the chapters of this volume, the mechanisms that regulate telomerase expression and activity are complex. Moreover, emerging data suggest additional roles for telomerase in the regulation of cell differentiation and survival.
The present volume focuses on microbial invasion strategies of
pathogen uptake. An accompanying volume (Vol. 5) in the series
presents the phagocytic process from the viewpiont of the host
This volume presents work from six different groups working on
various aspects of cycloaddition chemistry. Jose Mascarenas gives
us a very interesting account of the chemistry of
&Bgr;-alkoxy-&ggr;-pyrones and related species. Al Padwa
and Chris Staub discuss further advances in rhodium carbenoid
chemistry and the unusual cycloaddition processes possible with
these intermediates. Higher order cycloadditions mediated by
transition metals highlight Jim Rigby's update on his group's
efforts in this area. Lily Lee and John Snyder present us with a
detailed account of the indole ring as a dienophile, challenging us
to consider the untapped potential in this area. Brian Keay and Ian
Hunt discuss the intramolecular Diels-Alder reactions of furan; a
report that is both top-notch science, and what could be a great
learning tool for students who need to see how fundamental chemical
principles can and should be applied to synthetic problems.
Finally, Kay Brummond introduces us to a new version of the
Pauson-Khand reactions, one that will no doubt be further exploited
in productive ways by her group well into the future.
Living organisms exhibit specific responses when confronted with
sudden changes in their environmental conditions. The ability of
the cells to acclimate to their new environment is the integral
driving force for adaptive modification of the cells. Such
adaptation involves a number of cellular and biochemical alteration
including metabolic homeostasis and reprogramming of gene
expression. Changes in metabolic pathways are generally short-lived
and reversible, while the consequences of gene expression are a
long-term process and may lead to permanent alternation in the
pattern of adaptive responses.
This groundbreaking work, now available in paperback, has helped to shape the emerging discipline of molecular epidemiology. Molecular Epidemiology has proven useful to epidemiologists unfamiliar with the terminology and techniques of molecular biology as well as to the molecular biologist working to understand the determinants of human disease and to use that information to control disease. This book demonstrates how molecular epidemiology utilizes the same paradigm as traditional epidemiology in addition to using biological markers to identify exposure, disease, or susceptibility.
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