This volume of "Advances in Cell Aging and Gerontology" critically
reviews the rapidly advancing area of telomerase research with a
focus at the molecular and cellular levels. The clearly established
function of telomerase is to maintain chromosome ends during
successive rounds of cell division by adding a six base DNA repeat
on to the telomeric ends of chromosomes. As presented in the
chapters of this volume, the mechanisms that regulate telomerase
expression and activity are complex. Moreover, emerging data
suggest additional roles for telomerase in the regulation of cell
differentiation and survival.
It is expected that this quite comprehensive volume will provide a
valuable resource for graduate students and postdocs in the
telomerase field and for established investigators in other fields
who are beginning to study telomerase in their particular research
program. With an increasing number of proteins being brought into
the fold of telomerase research (e.g., DNA damage and repair
response proteins, heat-shock proteins, and proteins in various
signal transduction cascades) many new scientists are beginning to
study this enzyme from novel vantage points.
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