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Books > Academic & Education > Professional & Technical > Biochemistry
Protein NMR Spectroscopy combines a comprehensive theoretical
treatment of NMR spectroscopy with an extensive exposition of the
experimental techniques applicable to proteins and other biological
macromolecules in solution. Beginning with simple theoretical
models and experimental techniques, Protein NMR Spectroscopy
develops the complete repertoire of theoretical principles and
experimental techniques necessary for understanding and
implementing the most sophisticated NMR experiments.
Volume 1 of the series "Fundamentals of Medical Cell Biology" is
devoted to evolutionary biology. This is presented in two parts: in
the first, the structure and dynamics of RNA, DNA, and protein are
dealt with. The second part is concerned with the origins and
cellular basis of life.
The purpose of this volume is to provide a synopsis of present
knowledge of the structure, organisation, and function of cellular
organelles with an emphasis on the examination of important but
unsolved problems, and the directions in which molecular and cell
biology are moving. Though designed primarily to meet the needs of
the first-year medical student, particularly in schools where the
traditional curriculum has been partly or wholly replaced by a
multi-disciplinary core curriculum, the mass of information made
available here should prove useful to students of biochemistry,
physiology, biology, bioengineering, dentistry, and nursing.
Volume 1 of the series "Fundamentals of Medical Cell Biology" is
devoted to evolutionary biology. This is presented in two parts: in
the first, the structure and dynamics of RNA, DNA, and protein are
dealt with. The second part is concerned with the origins and
cellular basis of life.
Since the publication of the first edition of Regenerative Biology and Medicine in 2006, steady advances have been made in understanding the origin and characteristics of stem cells in epithelia, skeletal muscle, and bone, and in the niche signals that regulate the activities of these cells. Simultaneously, breakthroughs including the creation of iPSCs and transdifferentiation have created a momentum for regenerative biology with implications in regenerative biology that are far-reaching. This book highlights these advances in the field to embrace a
vast audience of investigators in chemistry, computer science,
informatics, physics and mathematics as well as graduate students,
clinical physicians, and biologists who are realizing the
importance of the fields of regenerative biology and medicine in
practice. Organized in three parts - biology of regeneration,
regenerative medicine, and perspectives - this second edition
creates a framework for integrating old and new data in this
progressive field.
This manual is an indispensable tool for introducing advanced
undergraduates and beginning graduate students to the techniques of
recombinant DNA technology, or gene cloning and expression. The
techniques used in basic research and biotechnology laboratories
are covered in detail. Students gain hands-on experience from start
to finish in subcloning a gene into an expression vector, through
purification of the recombinant protein.
Calcium is a versatile carrier of signals regulating many aspects of cellular activity such as fertilization to create a new life and programmed cell death to end it. Calcium homeostasis is strictly controlled by channels, pumps and exchangers functioning as gates for calcium entry and release. Given that calcium is such a versatile messenger the field of calcium signaling is continuously and rapidly expanding. This book reviews the most recent developments in calcium signaling by leading experts in the field. It is a state-of-the-art summary of our present knowledge in this quickly growing field and provides insight into the impressive progress made in many areas of calcium signaling, while reminding us of how much remains to be learned.
Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.
Molecular Diagnostics covers current molecular biological
techniques used to identify the underlying molecular defects in
inherited disease. Although an increasing number of laboratories,
both academic and private are moving in that direction, there are
only a few books in the existing literature, and they deal only
partly with diagnosis at the molecular level. Each chapter includes
the principle and a brief description of the technique, followed by
exmples from the authors' own epertise. Contributors are well-known
experts in their field, and derive from a variety of disciplines,
to ensure breadth and depth of coverage.
This book is the latest volume in a highly successful series within Comprehensive Biochemistry and provides a historical and autobiographical perspective of the development of the field through the contributions of leading individuals who reflect on their careers and their impact on biochemistry. The book is essential reading for everybody, from graduate student to professor, placing in context major advances not only in biochemical terms but in relation to historical and social developments. Readers will be delighted by the lively style and the insight into the lives and careers of leading scientists of their time.
This is the first book covering all aspects of high pressure biochemistry and biophysics of proteins. Hydrostatic pressure is a powerful tool for study of biological
systems. As a thermodynamic parameter, hydrostatic pressure has
been known for a century to act on biological materials in a
similar, but not identical, way to temperature. However, pressure
was disregarded for a long time by biochemists mainly because the
basic concepts (and the thermodynamics) focused on the chemical
reactions involved and because general ideas on what pressure can
add to the understanding of the behaviour of proteins were lacking.
In recent decades, technological progress in the field of physics
has shown, along with parameters such as temperature and solvent
conditions, that pressure can be used for more refined
thermodynamic and kinetic descriptions of biological processes and
regulation of biological systems. The effects of pressure on
proteins, nucleoproteins and membranes have recently been reviewed
and several proceedings books have been published.
Drawing together literature from a variety of fields, Food Texture
and Viscosity, 2E, includes a brief history of this area and its
basic principles. It reviews how texture and viscosity are
measured, including the physical interactions between the human
body and food, objective methods of texture measurements, the
latest advances in texture-measuring instruments, various types of
liquid flow, and more.
This is the third edition of an established and successful
university textbook. The original structure and philosophy of the
book continue in this new edition, providing a genuine synthesis of
modern ecological and physiological thinking, while entirely
updating the detailed content. New features include a fresh,
unified treatment of toxicity, emphasizing common features of plant
response to ionic, gaseous, and other toxins, explicit treatment of
issues relating to global change, and a section on the role of fire
in plant physiology and communities. The illustrations in the text
are improved over previous editions, including color plates for the
first time, and the authors' continuing commitment to providing
wide citation of the relevant literature has further improved the
reference list. This revision of Environmental Physiology of Plants
will ensure the reputation of this title as a useful and relevant
text well into the 21st century.
This newest edition to the Laboratory Techniques Series gives
current state of the art use of synthetic peptides in molecular
biology and practical protocols on how to conjugate peptides,
immunize animals with peptides and monitor immune responses to
peptides in vitro.
The central role of RNA in many cellular processes, in
biotechnology, and as pharmaceutical agents, has created an
interest in experimental methods applied to RNA molecules. This
book provides scientists with a comprehensive collection of
thoroughly tested up-to-date manuals for investigating RNA-protein
complexes "in vitro." The protocols can be performed by researchers
trained in standard molecular biological techniques and require a
minimum of specialized equipment. The procedures include
recommendation of suppliers of reagents.
The elucidation during the latter half of the 20th century of the mechanisms by which information flows from nucleic acids to proteins has completely changed the face of biological research. Many diseases are caused by abnormalities in control mechanisms which are not immediately essential for life itself but which maintain the normal social behavior of differentiated cells in multicellular organisms. The complex sugar chains of glycoproteins and glycolipids are believed to play important roles in the control of cellular functions and in recognition between the cell and its cellular and fluid environment. Investigations into the abnormalities of complex sugar chain assembly are expected to yield an important new underatanding of the etiology and pathogenesis of human diseases. This volume discusses several representative diseases which emphasize the current status of glycopathology, and will stimulate further research in this exciting field.
This publication contains full papers of both oral and poster presentations of the symposium "Immobilized Cells: Basics and Applications" that was held in Noordwijkerhout, The Netherlands, 26-29 November 1995. This volume covers recent developments in the field of immobilization e.g.: new support materials, characterization of support materials, kinetic characterizations, dynamic modelling, bioreactor types, scale up and applications are also given. Applications in the field of medicine, fermentation technology, food technology and environmental technology are described. Guidelines for research with immobilized cells. Based on the scientific sessions a strategy of research and methods for characterization of immobilized cells, especially in view of applications are given. The goal was to relate basic research to applications and to extract guidelines for characterization of immobilized cells in view of process design and application from the contributions. The manuscripts presented in these proceedings give an extensive and recent overview of the research and applications of immobilized-cell technology.
Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights
into the signalling processes involved in morphogenesis and
pathogenesis with emphasis on using the elements of the signalling
cascades as targets for therapeutic deployment. Provides afundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes Aids the development of therapeutic treatments for cancer Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research "
"Designing Science Presentations "guides researchers and graduate students of virtually any discipline in the creation of compelling science communication. Most scientists never receive formal training in the creation, delivery, and evaluation of such material, yet it is essential for publishing in high-quality journals, soliciting funding, attracting lab personnel, and advancing a career. This clear, readable volume fills that gap and provides visually
intensive guidance at every step-from the construction of original
figures to the presentation and delivery of those figures in
papers, slideshows, posters, and websites. It provides pragmatic
advice on the preparation and delivery of exceptional scientific
presentations; demonstrates hundreds of visually striking
presentation techniques, giving readers inspiration for creating
their own; and is structured so that readers can easily find
answers to particular questions.
The accelerated globalization of the food supply, coupled with
toughening government standards, is putting global food production,
distribution, and retail industries under a high-intensity
spotlight. High-publicity cases about foodborne illnesses over
recent years have heightened public awareness of food safety
issues, and momentum has been building to find new ways to detect
and identify foodborne pathogens and eliminate food-related
infections and intoxications. This extensively revised 4e covers
how the incidence and impact of foodborne diseases is determined,
foodborne intoxications with an introduction noting common features
among these diseases and control measures that are applicable
before and after the basic foodstuff is harvested.
The functional properties of any molecule are directly related to,
and affected by, its structure. This is especially true for DNA,
the molecular that carries the code for all life on earth.
An important and comprehensive review of an expanding research
area. The book will combine all classical knowledge in the field
with recent advances to provide a full and comprehensive coverage
of the field.
Presents the principles of human gene evolution in a concise and
easy to understand fashion. Uses examples of how evolutionary
processes have molded present day genes, drawn from the evolution
of humans and other primates, as well as from more primitive
organisms. With increasing attention in this expanding area, this
review forms a timely publication of our current knowledge of this
important field.
Nitric oxide (NO) is a gas naturally found in the body that
conveys information between cells. In the last decade researchers
have found that NO is a signaling molecule of key importance for
the cardiovascular system, regulating blood pressure and blood flow
to different organs. In addition, discoveries surrounding nitric
oxide s role as a principal neurotransmitter moderating erectile
function, a pathophysiological negotiator and messenger in
inflammation, and a weapon against infections have increased
research attention across the fields of biochemistry, chemistry,
molecular biology, gene therapy, cell biology, immunology,
pharmacology, neuroscience, and physiology. Up-to-date therapeutic implications of nitric oxide research Authored by world experts on nitric oxide Detailed research of the biochemistry and synthesis of nitric oxide
The clinical picture of diseases, caused by trinucleotide repeats,
such as fragile X syndrome, myotonic dystrophy, Huntington's
disease and forms of spinocerebella ataxia, provide the starting
point for this authoritative review volume. |
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