This is the first book covering all aspects of high pressure
biochemistry and biophysics of proteins.
Hydrostatic pressure is a powerful tool for study of biological
systems. As a thermodynamic parameter, hydrostatic pressure has
been known for a century to act on biological materials in a
similar, but not identical, way to temperature. However, pressure
was disregarded for a long time by biochemists mainly because the
basic concepts (and the thermodynamics) focused on the chemical
reactions involved and because general ideas on what pressure can
add to the understanding of the behaviour of proteins were lacking.
In recent decades, technological progress in the field of physics
has shown, along with parameters such as temperature and solvent
conditions, that pressure can be used for more refined
thermodynamic and kinetic descriptions of biological processes and
regulation of biological systems. The effects of pressure on
proteins, nucleoproteins and membranes have recently been reviewed
and several proceedings books have been published.
General
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