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This book is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of cardiovascular disease. It provides a much-needed review of the rapid development and evolution of bio-fabrication techniques to engineer cardiovascular tissues as well as their use in clinical settings. The book incorporates recent advances in the biology, biomaterial design, and manufacturing of bioengineered cardiovascular tissue with their clinical applications to bridge the basic sciences to current and future cardiovascular treatment. The book begins with an examination of state-of-the-art cellular, biomaterial, and macromolecular technologies for the repair and regeneration of diseased heart tissue. It discusses advances in nanotechnology and bioengineering of cardiac microtissues using acoustic assembly. Subsequent chapters explore the clinical applications and translational potential of current technologies such as cardiac patch-based treatments, cell-based regenerative therapies, and injectable hydrogels. The book examines how these methodologies are used to treat a variety of cardiovascular diseases including myocardial infarction, congenital heart disease, and ischemic heart injuries. Finally, the volume concludes with a summary of the most prominent challenges and perspectives on the field of cardiovascular tissue engineering and clinical cardiovascular regenerative medicine. Cardiovascular Regenerative Medicine is an essential resource for physicians, residents, fellows, and medical students in cardiology and cardiovascular regeneration as well as clinical and basic researchers in bioengineering, nanomaterial and technology, and cardiovascular biology.
"An engaging, compelling and disturbing confrontation with evil .a book that will be transformative in its call for individual and collective moral responsibility." - Michael A. Grodin, M.D., Professor and Director, Project on Medicine and the Holocaust, Elie Wiesel Center for Judaic Studies, Boston University Human Subjects Research after the Holocaust challenges you to confront the misguided medical ethics of the Third Reich personally, and to apply the lessons learned to contemporary human subjects research. While it is comforting to believe that Nazi physicians, nurses, and bioscientists were either incompetent, mad, or few in number, they were, in fact, the best in the world at the time, and the vast majority participated in the government program of "applied biology." They were not coerced to behave as they did- they generated the eugenic theories that rationally led them to design horrendous medical experiments, gas chambers, euthanasia programs and, ultimately, mass murder in the concentration camps. Americans provided financial support for their research, modeled their medical education and research after the Germans, and continued to perform unethical human subjects research even after the Nuremberg Doctors' Trial. The German Medical Association apologized in 2012 for the behavior of its physicians during the Third Reich. By examining the medical crimes of human subjects researchers during the Third Reich, you will naturally examine your own behavior and that of your colleagues, and perhaps ask yourself "If the best physicians and bioscientists of the early 20th century could treat human beings as they did, can I be certain that I will never do the same?" Presents relatively unknown aspects of human subjects research during the Third Reich Reveals surprising relationships between German and American human subjects research Dispels myths about Nazi human subjects research Compels introspection and self-examination by today'
This book is designed to provide the practicing interventionist with a comprehensive list of procedural reports that covers the vast majority of the currently performed interventional procedures outside the cardiac system. It offers up-to-date explanatory notes, synopsis of the indications, contraindications and potential complications in an organized and practical format that follows the various body systems and progresses from the simple image guided FNA to the most complex procedures and incorporates the current societal guidelines. The book is divided for ease of reference into three main parts: Non vascular, Vascular and Neurovascular interventions. This information is not currently available in any single publication. The text provides residents, fellows as well as staff members with a quick, detailed and user-friendly resource for documentation of image-guided interventional procedures that will facilitate their tasks, improve the standard of documentation and reduce errors. The text can serve as a valuable tool for a quick review prior to a procedure or in preparation for an oral board certifying examination. The entries are vetted by recognized experts in the field of image-guided intervention. Procedural Dictations in Image-Guided Intervention: Non-Vascular, Vascular & Neuro Interventions covers the vast majority of the currently practiced image-guided interventions in the various body systems. This information is supported by up-to-date references and international guidelines. This book is a must-have for residents and fellows undergoing training and all specialists in image-guided intervention.
Mathematical and numerical modelling of the human cardiovascular system has attracted remarkable research interest due to its intrinsic mathematical difficulty and the increasing impact of cardiovascular diseases worldwide. This book addresses the two principal components of the cardiovascular system: arterial circulation and heart function. It systematically describes all aspects of the problem, stating the basic physical principles, analysing the associated mathematical models that comprise PDE and ODE systems, reviewing sound and efficient numerical methods for their approximation, and simulating both benchmark problems and clinically inspired problems. Mathematical modelling itself imposes tremendous challenges, due to the amazing complexity of the cardiovascular system and the need for computational methods that are stable, reliable and efficient. The final part is devoted to control and inverse problems, including parameter estimation, uncertainty quantification and the development of reduced-order models that are important when solving problems with high complexity, which would otherwise be out of reach.
On an annual basis, over 17 million people die due to cardiovascular disease. This represents a third of all global deaths. The World Health Organisation have identified cardiovascular disease as the leading cause of death worldwide. Although many cardiovascular conditions are preventable, there is a need for accurate characterisation and diagnosis of cardiovascular conditions before, during and after treatments. Much of this characterisation entails the use of biological indicators, i.e biomarkers. Biomarkers in Cardiovascular Disease combines detailed information on different cardiovascular conditions and the concomitant application of conventional, new and emerging biomarkers. It covers the latest knowledge, trends and applications. New platforms are described which combine advances in biomedical sciences, physics, computing and chemistry.
This is the second edition of a well-received book that has been recommended for inclusion in any vascular library or vascular radiology suite. The first edition has been fully revised so as to provide a comprehensive, up-to-date account of vascular ultrasound that reflects recent advances. The emphasis remains on the clinical aspects most relevant to angiologists and vascular surgeons. Ultrasound anatomy is discussed, examination procedures explained, normal and pathological findings described, and the clinical impact of ultrasound assessed. Atlas sections present pertinent case material to illustrate typical ultrasound findings for both the more common vascular diseases and rarer conditions. This book will serve not only as an invaluable guide for beginners, but also as an indispensable reference for experienced sonographers, who will benefit from the detailed evaluation of the role of ultrasound as compared with other modalities and the discussion of ultrasound findings in their clinical context. Content Level Professional/practitioner Keywords Angiography - Sonoanatomy - Vascular disease - Vascular ultrasound Related subjects Cardiology & Angiology - Radiology - Surgery
This card discusses the management of acute stroke, the localization of stroke based on clinical symptoms, various prognostic scores, and other management topics. Most of the management information on this card pertains to ischemic stroke. Specifics topics covered are as follows: * Guidelines for management of patients who are receiving tPA * Guidelines for intra-arterial thrombolysis and mechanical clot removal * Information on stroke localization and relevant syndromes * Illustrations with the vasculature and vascular territories of the brain * Definition and classification of TIAs * Information on the prognosis of stroke based on the NIH, (NIHSS) * Information on imaging modalities used in stroke diagnosis, their advantages and disadvantages * Stroke workup informations * General guidelines for hospital management and supportive care * Guidelines for the prevention of secondary stroke * Guidelines for the prevention of cardioembolic stroke * Guidelines for carotid endarterectomy
This book describes a wide range of interventional procedures currently employed in the treatment of cardiac diseases in women with the aim of enabling not only interventional cardiologists but also cardiologists and cardiac surgeons to refine their approach to female patients and thus improve outcomes. The book reflects the increasing awareness of gender differences with regard to coronary artery disease and structural valve heart disease. Examples include myocardial infarction, which carries a worse prognosis in women in part because they suffer from this disease mostly in the 7th decade of life, present more frequently with hemodynamic instability and later from symptom onset, and have fragile, small and tortuous coronary arteries that are more technically demanding in the context of primary percutaneous coronary intervention. Another example is symptomatic aortic stenosis, which carries a better prognosis in women who undergo trans-catheter aortic valve implantation partially due to a better annulus-prosthesis match, which leads to less residual paravalvular regurgitation, better left ventricular function and lower aggregation of comorbidities. Further, in women left ventricular response to aortic stenosis is typified by muscle hypertrophy with a small ventricular cavity. These differences are reflected in the clinical manifestations and their impact on diagnosis, treatment, and choice of tools and devices for use in interventional procedures. By explaining the at times subtle variances in disease and treatment techniques for female and male patients, this book will help practitioners select the most appropriate procedures and materials in a range of settings.
For more than 30 years, The Secrets Series (R) has provided students and practitioners in all areas of health care with concise, focused, and engaging resources for quick reference and exam review. Cardiology Secrets, 5th Edition, features the Secrets' popular question-and-answer format that also includes lists, tables, and an easy-to-read style - making reference and review quick, easy, and enjoyable. The Secrets Series (R) format gives you the most return for your time - concise, easy to read, engaging, and highly effective - now with an improved organization that makes information even easier than ever to find. Written by global experts and thought leaders in cardiovascular disease. Top 100 Secrets and Key Points boxes provide a fast overview of the secrets you must know for success in practice. Portable size makes it easy to carry with you for quick reference or review anywhere, anytime. New dedicated sections on peripheral vascular and cerebrovascular disease, venous thromboembolic disease, and specific populations and conditions, plus a dedicated chapter on new direct oral anticoagulant agents. New chapters added on hypercoagulability states, specific valvular lesions, sleep apnea and the heart, heart disease in women, cardio-oncology, cardiac arrest, transcatheter aortic valve replacement (TAVR), carotid artery disease, and hemorrhagic stroke. Several hundred illustrations, figures, and flow diagrams - 100+ are new! Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.
Interpreting an ECG correctly and working out what to do next can seem like a daunting task to the non-specialist, yet it is a skill that will be invaluable to any doctor, nurse or paramedic when evaluating the condition of a patient. Making Sense of the ECG has been written specifically with this in mind, and will help the student and more experienced healthcare practitioner to identify and answer crucial questions. This popular, easy-to-read and easy-to-remember guide to the ECG as a tool for diagnosis and management has been fully updated in its fifth edition to reflect the latest guidelines.
In cardiovascular prevention, there is classically a small number of cardiovascular risk factors to treat, such as hypertension, diabetes, hyperlipidemia and smoking excess, which are widely detected and treated. Recently, it has been widely recognized that new mechanical factors should be detected and treated and involves specifically pulsatile arterial hemodynamic (PAH) parameters such as: arterial stiffness, pulse pressure, and, to a lesser extent, augmentation index and pulse pressure amplification. The pedagogic aspect of this new CV specialty involves 3 principal parts: a. -Basic concepts and pathophysiological mechanisms of PAHb. -Clinical aspects and end-organ damage in PAHc. - Clinical pharmacology and therapeutics of PAH This book represents the first that spans basic science and clinical management of this new CV subspecialty. Much has been learned regarding the management of these patients in recent years and this book presents extensive data on the techniques needed to maximize outcomes.
Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood but reactivated during wound healing and under a number of pathological conditions including cancer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progenitor cells ) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable blood proof neovessels.
This book reviews recent advances in our understanding of the molecular and cellular mechanisms of angiogenesis, with a focus on how to integrate these observations into the context of developmental, post-natal and pathological neovascularization.
The book was published under the auspices of the French Angiogenesis Society. Most contributors are prominent members of this Society or international researchers who have actively contributed to the Annual Meetings of the Society."
Cardiovascular disease remains the chief cause of mortality and morbidity in adults in many parts of the world, and diagnosis and treatment is increasingly based on cellular, intracellular, and molecular parameters as well as systems analysis. Consequently, it is vital that medical students learn the fundamental physiology of the cardiovascular system. This book, along with its interactive electronic learning modules, breathes life into the subject, with animations, videos, and game-like decision-making.
Crash Course - your effective every-day study companion PLUS the perfect antidote for exam stress! Save time and be assured you have the essential information you need in one place to excel on your course and achieve exam success. A winning formula now for over 20 years, each series volume has been fine-tuned and fully updated - with an improved full-colour layout tailored to make your life easier. Especially written by senior students or junior doctors - those who understand what is essential for exam success - with all information thoroughly checked and quality assured by expert Faculty Advisers, the result are books which exactly meet your needs and you know you can trust. Each chapter guides you succinctly through the full range of curriculum topics, integrating clinical considerations with the relevant basic science and avoiding unnecessary or confusing detail. A range of text boxes help you get to the hints, tips and key points you need fast! A fully revised self-assessment section matching the latest exam formats is included to check your understanding and aid exam preparation. The accompanying enhanced, downloadable eBook completes this invaluable learning package. Series volumes have been honed to meet the requirements of today's medical students, although the range of other health students and professionals who need rapid access to the essentials of cardiology will also love the unique approach of Crash Course. Whether you need to get out of a fix or aim for a distinction Crash Course is for you!? Provides the exam syllabus in one place - saves valuable revision time Written by senior students and recent graduates - those closest to what is essential for exam success Quality assured by leading Faculty Advisors - ensures complete accuracy of information Features the ever popular 'Hints and Tips' boxes and other useful aide-memoires - distilled wisdom from those in the know Updated self-assessment section matching the latest exam formats - confirm your understanding and improve exam technique fast
Cardiovascular disease is the leading cause of death in the United States and is the focus of ongoing research. Consequently, treatment of cardiovascular disorders is among the most highly evidence-based area of medicine and pharmacy practice.
Endocrinology, and diabetes care in particular, is a dynamic field where clinicians must translate new evidence into clinical practice at a rapid pace. Designed in an engaging, case-based format, Endocrinology and Diabetes: A Problem Oriented Approach offers a wide range of thought-provoking case studies that reflect contemporary, challenging, hands-on clinical care. Further, by providing a list of specific clinical problems, this format offers the reader a more convenient and pointed way to solve precise clinical problems in a timely manner. Developed by a renowned, international group of experts, this comprehensive title covers the most common clinical problems in endocrinology and diabetes and should be of great interest to endocrinologists, diabetologists, internal medicine physicians, family physicians, fellows, and residents.
Akin to nitric oxide, carbon monoxide (CO) was initially viewed as a pure toxic gas, yet it has been recently demonstrated to be an important endogenous molecule of gas that has profound physiological and pathophysiological effects on the cardiovascular system. In spite of the growing understanding achieved in this field, until now a comprehensive book summarizing the extraordinary advances in the research of the cardiovascular effects of CO has not been available. Carbon Monoxide and Cardiovascular Functions responds to the vexing challenges and exciting opportunities that confront researchers and clinicians studying the biological roles of CO in the cardiovascular system. This book presents many never-before-published results including the first case of human CO deficiency. It also discusses disorders where the cardiovascular effects of CO might have been altered, including hypertension, diabetes, stroke, and ischemic heart damage. A product of the collected knowledge of internationally respected scientists, this book serves as a standard reference summarizing recent developments, scientific controversies, and future directions in the study of the biological actions of CO on the cardiovascular system. By covering both ancient and state-of-the-art methodologies in great detail, Carbon Monoxide and Cardiovascular Functions, affords a rapid mastery of the powerful new advances in CO study.
Since the introduction of laser devices to the medical sciences this technology has created great interest. Specifically, the laser's unique physical properties and precise bio-tissue interactions render this versatile source of biologic energy an attractive tool for multiple therapeutic purposes in cardiovascular medicine. Over the course of the last 2 decades the utilization of laser technology has become an important component for the management of patients with complex cardiovascular diseases. During this time period, cutting edge laser technology including a variety of wave length generators, newly designed catheters, and a selection of advanced optic fibers have been introduced and applied in the cardiovascular circulation. Improved lasing techniques in the cardiac catheterization suites and operation rooms have been implemented for treatment of ischemic coronary syndromes, peripheral arterial occlusive disease and other atherosclerotic thrombotic conditions. Moreover, during this 20 year time frame, several multicenter and single center clinical studies have been published focusing on the role and utilization of lasers in coronary and peripheral revascularization. And within the rapidly expanding field of interventional cardiac electrophysiology, laser technology has recently revolutionized the management of fractured, abandoned and malfunctioning leads of cardiac pacemakers and automatic defibrillators. Consequently, replacing a notoriously cumbersome and high risk open heart surgery with safe and markedly efficient percutaneous laser based extraction. This textbook will provide the most authoritative, comprehensive and contemporary information covering technological progress, clinical experience and pertinent aspects of laser applications in cardiovascular medicine. It will be of interest to cardiologists, vascular surgeons and interventional radiologist as well as medical students, scientists, biomedical engineering students and graduates.
Not too long ago, it was thought that inflammation of blood vessels was the sole manifestation of systemic autoimmune diseases. Today, however, we know that disorders of coagulation, injuries to both neutrophils and endothelial cells, and certain lipids and amino acids are all intricately involved in the development of vascular disease. How are all these processes linked? What strategies can we employ or develop to halt the progression of vascular damage? What are the best ways to control acute vasculitis and vasospasm therapeutically? What are the risks and benefits of various strategies for the prevention of clotting? How soon should we initiate preventive strategies that protect blood vessels from arteriosclerosis in people with acute rheumatic diseases? What should be the nature of those strategies?
This book provides the most up-to-date coverage of the combined use of imaging modalities in order to acquire important functional and morphological information on cardiovascular disease and enhance disease detection. The recent developments in PET/MRI, cardiac CT, PET/CT and SPECT/CT and their impact on clinical practice are explained and special attention is also devoted to imaging parameters and protocols for use in practice and research. The utility of multimodality imaging techniques for diagnosis and evaluation is discussed in the context of various clinical scenarios, including ischemic cardiomyopathy, myocarditis, myocardial fibrosis, cardiac sarcoidosis and atherosclerotic plaque disease. Written by renowned researchers and clinicians, the book is an ideal concise reference on today's most advanced imaging techniques. It will appeal to all clinicians, trainees and technicians who are involved in the diagnosis and risk assessment of cardiovascular disease.
The new 2014 (6th Edition) of the ECG Pocket Brain has just come out We have greatly enhanced and more than doubled the content of ECG-2011 PB. This new ECG-2014-PB (Expanded) retains its pocket size - adds spiral binding - and now contains 260 pages (plus 200 illustrations). Written in the same user-friendly style that is Dr. Grauer's trademark - this new 6th Edition takes ECG education to a new level. Aimed for beginning, novice AND experienced interpreters (acclaimed by students, nurses, physician extenders, EMS personnel, residents, and clinicians in practice of all specialties). Ideal for use on the ward, in the office or ED - and/or as a study aid for ECG workshops, classes, or more intense courses. Greatly enhanced sections include Bundle Branch Block/Hemiblocks, Chamber Enlargement, Acute MI/Ischemia. NEW topics include ECG signs of Pulmonary Embolus; Clinical Use of Lead aVR; ECG identification of the Culprit Vessel with Acute STEMI; RV MI; Posterior MI; Wellens Syndrome; DeWinter T waves; Giant T Waves; Takotsubo Cardiomyopathy; and more ...
This comprehensive reference textbook examines in detail physiological and pathophysiological aspects of the cardiovascular system and cardiovascular disease in the sporting population. In the first part of the book, the non-invasive and invasive diagnostic techniques employed in cardiology are systematically reviewed, with explanation of their indications and clinical utility. The second, more extensive part is devoted to clinical cardiology and covers the great majority of cardiological problems encountered among athletes and other sportsmen and -women. Syncope, cardiac arrhythmias, and sudden cardiac death are extensively addressed, and guidance is provided on sports practice for individuals with different forms of heart disease. Cardiologic rehabilitation is discussed, and attention is also paid to the legal implications of diagnosed or unsuspected cardiovascular diseases for sportspeople. Sports Cardiology will be an invaluable resource for trainee and experienced health care professionals, including in particular cardiologists and sports medicine physicians. It will provide the knowledge required in order to make critical decisions regarding eligibility, thereby preventing tragic events and especially sudden death -- the most devastating occurrence in sport.
Atherosclerosis is the most significant cause of cardiovascular disease worldwide. Vascular biology is the key to understanding how atherosclerosis arises and operates. The ESC Textbook of Vascular Biology is a rich and clearly laid-out guide by leading European scientists providing comprehensive information on vascular physiology, disease, and reasearch. The textbook covers molecular findings and novel targets within the speciality while also providing the basics of vascular biology and disease pathophysiology. It also covers the major changes in the diagnosis, prevention and treatment of atherosclerosis that have occurred in recent years, developments and recent breakthroughs in the field are specifically highlighted. The official publication of the ESC Working Group on Arthrosclerosis and Vascular Biology, this print edition comes with access to the online version on Oxford Medicine Online, for as long as the edition is published by Oxford University Press. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables. The textbook particularly appeals to vascular biologists, cardiologists, and other practising clinicians.
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