Leveraging Biomedical and Healthcare Data: Semantics, Analytics and Knowledge provides an overview of the approaches used in semantic systems biology, introduces novel areas of its application, and describes step-wise protocols for transforming heterogeneous data into useful knowledge that can influence healthcare and biomedical research. Given the astronomical increase in the number of published reports, papers, and datasets over the last few decades, the ability to curate this data has become a new field of biomedical and healthcare research. This book discusses big data text-based mining to better understand the molecular architecture of diseases and to guide health care decision. It will be a valuable resource for bioinformaticians and members of several areas of the biomedical field who are interested in understanding more about how to process and apply great amounts of data to improve their research.

In order to remain up-to-date on the best healthcare initiatives, medical professionals must continuously seek new research on best practices and procedures to provide efficient medical care to their patients. As heart and lung disease accounts for many illnesses and deaths, and are both a major concern to many members of society, it is especially important for cardiovascular intensivists to hone their skills and use the best surgical and treatment options available. Coronary and Cardiothoracic Critical Care: Breakthroughs in Research and Practice is an essential reference source for the latest scholarly material on emerging strategies and methods for delivering optimal healthcare for those with coronary and cardiothoracic diseases. It also examines the latest techniques and methods used in cardiovascular care. Highlighting a range of pertinent topics such as coronary artery disease, patient monitoring, and endocrine and metabolic management, this publication is an ideal reference source for medical students, residents, fellows, anesthesiologists, cardiac surgeons, nurses, physician assistants, and pharmacists who assist patients who require coronary and cardiothoracic care.

Sudden Cardiac Death (SCD) is a sudden, unexpected death caused by loss of heart function (sudden cardiac arrest) and Sudden Cardiac Arrest (SCA) occurs when the electrical system to the heart malfunctions and suddenly becomes very irregular. Death can often be a result if not handled quick enough or effectively. New technologies seek to help with this issue. Data processing is a crucial step to developing prognostic models. Some of the challenges in data processing are non-linear prediction models, a large number of patients and numerous predictors with complicated correlations. In traditional hypothesis-driven statistical analysis it is difficult to overcome these challenges. Current approaches to predict cardiovascular risk fail to identify many people who would benefit from preventive treatment, while others receive unnecessary intervention. So, there is an emergent need of an adaptation of AI technologies such as Machine Learning and Deep Learning Techniques to overcome the challenges. The Machine Learning (ML) approaches have great potential in increasing the accuracy of cardiovascular risk prediction and to avoid unnecessary treatment. The application of ML techniques may have the potential to improve Heart Failure outcomes and management, including cost savings by improving existing diagnostic and treatment support systems. Moreover, ML algorithms can also be applied to predict SCD. Also, Machine Learning offers an opportunity to improve accuracy by exploiting complex interactions between risk factors. The book addresses the impact and power of technology driven approaches for prevention and detection of SCA and SCD. It will provide insights on causes and symptoms of SCA and SCD and evaluate whether AI Technologies can improve the accuracy of cardiovascular risk prediction. It will explore the current issues and future technology driven solutions for SCA and SCD prevention and detection.

In this issue of Emergency Medicine Clinics, guest editors Drs. Jeremy G. Berberian and Leen Albkaihed bring their considerable expertise to the topic of Cardiovascular Emergencies. Top experts in the field cover key topics such as approach to the pediatric ECG; ACS in women; the aging heart; cardiogenic syncope; the ischemic ECG; and more. Contains 14 relevant, practice-oriented topics including evaluation and management of pacemaker malfunction; medicolegal topics in emergency cardiology; tachydysrhythmias; ED evaluation and management of patients with LVAD; acute heart failure; cardiovascular pharmacology; and more. Provides in-depth clinical reviews on cardiovascular emergencies, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Cardiology Clinics, guest editors Drs. Scott Hummel and Matthew Konerman bring their considerable expertise to the topic of Heart Failure with Preserved Ejection Fraction. Top experts in the field cover key topics such as risk factors for heart failure with preserved ejection fraction (HFpEF); cardiopulmonary stress testing in HFpEF; hemodynamic assessment in HFpEF; the role of multi-modality imaging in the evaluation of HFpEF; and more. Contains 13 relevant, practice-oriented topics including pharmacologic, non-pharmacologic, and device therapy for HFpEF; geriatric domains in patients with HFpEF; pulmonary hypertension in HFpEF; infiltrative, genetic, and other non-standard causes of HFpEF; echocardiography in HFpEF; and more. Provides in-depth clinical reviews on heart failure with preserved ejection fraction, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Scientific developments in recent years have led to significant strides and advancements within the medical field. By integrating these findings into medical practice, optimal healthcare can be delivered to the public. Emerging Applications, Perspectives, and Discoveries in Cardiovascular Research is a comprehensive reference source for the latest academic material on the exploration of cardiovascular diseases and provides an interdisciplinary examination of novel developments and applications for cardiovascular sciences. Highlighting a range of diverse topics, such as pharmacology, pathophysiology, and alternative medicine, this book is ideally designed for researchers, professionals, practitioners, graduate students, and academics interested in the latest medical advancements.

The prevalence of autoimmune diseases and rheumatic conditions is constantly increasing. Autoimmune diseases affect approximately 7-10% of the population of the United States, while more than 50,000,000 American adults suffer from some type of arthritis. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases examines the complex mechanisms relating to cardiac diseases from a pathophysiological and clinical point of view. Autoimmune rheumatic diseases can affect the coronary vessels, myocardium, pericardium, heart valves and the conduction system. The diagnosis of these unique cardiac complications necessitates medical awareness and a high index of suspicion. Increased risk of advanced atherosclerosis plays a pivotal role in the development of cardiac diseases in systemic, rheumatic and autoimmune illnesses. Yet, other complex immune medicated mechanisms may contribute to the pathogenesis. Patients' optimal care requires coordination between the primary caregiver, the rheumatologist, immunologist and cardiologist. Screening for cardiovascular risk factors, recognition of high-risk patients and identification of subclinical cardiac conditions are of great importance. Moreover, regulation of inflammation, as well as abnormal immune responses and the initiation of early treatments should be the focus of patient management. A continuous attempt to identify novel therapeutic targets and change the natural history of the underlying disease and its cardiac manifestations is in progress. The book aims at providing the readers with a state of the art collection of up to date information regarding clinically important topics based on experts' perspectives. This book was a result of an extended coordinated collaboration of one-hundred and fifty-four distinguished scientists from thirty-one countries around the globe.

Approx.542 pages

The HDL Handbook: Biological Functions and Clinical Implications, Third Edition, brings laboratory research in HDL from bench to bedside in a reference format for both researchers and clinicians studying cholesterol, lipids, epidemiology, biochemistry, molecular medicine, and pathophysiology of cardiovascular diseases. Information presented is valuable for the development of clinical trials with the aim of improvement of HDL-C levels and the prevention of cardiovascular events. Highlights of this new edition include the science underpinning HDL metabolism including information on HDL-C metabolism, gene expression, gene-bioactive compounds interaction, and post-translational modifications of gene expression of apo-lipoproteins.

Cardio-Oncology: Principles, Prevention and Management is a clinical volume that focuses on the basic science of cardio-oncology, addresses cardiotoxicity as a consequence of cancer therapy, and discusses prevention, diagnosis and management of cardiovascular disease in patients with cancer. This comprehensive volume presents unique perspectives ranging from basic science to clinical medicine in the field of cardio-oncology. It would be a valuable resource for cardiologists, oncologists, internists, and pediatricians caring for patients with cancer who have cardiovascular risk factors, as well as for cardio-oncology researchers.

Computing and Visualization for Intravascular Imaging and Computer-Assisted Stenting presents imaging, treatment, and computed assisted technological techniques for diagnostic and intraoperative vascular imaging and stenting. These techniques offer increasingly useful information on vascular anatomy and function, and are poised to have a dramatic impact on the diagnosis, analysis, modeling, and treatment of vascular diseases. After setting out the technical and clinical challenges of vascular imaging and stenting, the book gives a concise overview of the basics before presenting state-of-the-art methods for solving these challenges. Readers will learn about the main challenges in endovascular procedures, along with new applications of intravascular imaging and the latest advances in computer assisted stenting.

Technological tools and computational techniques have enhanced the healthcare industry. These advancements have led to significant progress in the diagnosis of heart disorders. Electrocardiogram Signal Classification and Machine Learning: Emerging Research and Opportunities is a critical scholarly resource that examines the importance of automatic normalization and classification of electrocardiogram (ECG) signals of heart disorders. Featuring a wide range of topics such as common heart disorders, particle swarm optimization, and benchmarks functions, this publication is geared toward medical professionals, researchers, professionals, and students seeking current and relevant research on the categorization of ECG signals.

Endocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart covers the traditional concepts of cardio-endocrinology, the role of the various hormone systems, both in health and disease, therapeutic implications, and other recent advances in the various fields represented. The book explores how cardiac hormones are changed in various cardiac pathologies and the recent success that has been uncovered in their therapeutic use. Additional focus is placed on how the heart responds both physiologically and pathophysiologically to a plethora of circulating hormones, reinforcing the importance of the heart as a target of numerous endocrine systems, such as the brain, renal, and adipose. Significant advances have come from basic, clinical, and translational research from a multiplicity of investigators with diverse backgrounds. The book features over 200 photomicrographs, diagrams of molecular relationships, and tables that complement and support the text. It is aimed at a wide audience, including graduate students and post-doctoral fellows in a wide array of biomedical departments and PhD programs (e.g. Pathology, Physiology, Genetics, Pharmacology, Molecular Biology, and Cell Biology) related to the endocrine and cardiovascular sciences curricula, as well as medical residents in pathology, laboratory medicine, internal medicine, and cardiology.