Historical Perspective of Venous Thromboembolism;Coagulation for the Intensivist;VTE Prophylaxis in the Critically Ill;Risk Stratification of Pulmonary Embolism; Treatment of Pulmonary Embolism: Anti
Coagulation; Thrombolytic Therapy and Complications; Major Pulmonary Embolism;Catheter and Surgical Thromboembolectomy;Vena Caval Interruption;New Anti-Coagulants;Heparin Induced Thrombocytopenia

Heart disease is the leading cause of death among US women over the age of 65, resulting in more deaths than all forms of cancer combined. Women are less likely to survive heart attacks than are men, possibly because symptoms in women may differ and may be less recognizable.? In addition, women consistently tend to have worse clinical outcomes in percutaneous coronary interventions than do men. For these reasons, an issue on percutaneous interventions in women is timely.

Nuclear medicine has played a significant role in imaging cardiovascular diseases.? With developments in PET imaging, that role has expanded.? This issue reviews the latest uses for PET in the imaging of cardiac sarcoidosis, cardiac and arterial calcifications, coronary vascular disease, vulnerable atherosclerotic plaque, and myocardial viability.

Implantable cardioverter-defibrillators (ICDs) are electronic devices installed in the chest to prevent sudden death caused by abnormally fast heart rhythms. Cardiac electrophysiologists are the physicians usually responsible for implanting and maintaining these devices.? The technology for ICDs is rapidly evolving, and the articles in this issue will help electrophysiologists to keep up to date with the current generation of ICDs, including selection of patients who are appropriate for the device, monitoring patients after the device is implanted, and troubleshooting problems with the device.

This issue of Heart Failure Clinics is dedicated to an in-depth analysis of the conduct of clinical investigation in patients with acute decompensated heart failure (ADHF). It tackles the difficult questions involved in patient population, trial conduct, surrogate endpoints, clinical endpoints, and statistical considerations.? The purpose of the issue is to provide information that will be?meaningful and useful to help physicians in thinking about the design of clinical trials in this field.

A left ventricular assist device (LVAD) is a surgically implanted pump that helps the left ventricle pump blood to the rest of the body.? The purpose of this issue is to let cardiologists know about the latest devices, their complications, and the clinical situations in which they are most beneficial.

Cardiac electrophysiologists face many challenging situations in which there is no clear-cut answer about the best way to handle a particular clinical problem. This issue brings together articles on many such situations, presents arguments on both sides, and lets the reader conclude which is the best way to manage a particular patient.? Among the controversial and debatable topics included are how to handle device recalls, optimal timing for assessment of ICD efficacy, extraction o f broken leads, and anticoagulation therapy in device patients.

A new volume in the Weil Integrative Medicine Library, a groundbreaking series under the general editorship of Dr. Andrew Weil, Integrative Cardiology offers a new and much-needed perspective in cardiac care and prevention, blending conventional medicine with alternative approaches not typically part of the Western medical curriculum. This unique perspective highlights specific gaps in conventional heart care, and examines how alternative approaches may be ideally suited to address these missed opportunities. The book introduces topics not typically addressed in conventional cardiology texts including: nutritional therapies, exercise, botanicals, mind/body approaches, spirituality, aspirin, metabolic cardiology, acupuncture, and energy medicine. The focus of this work is on prevention and it recommends an approach that emphasizes the collaboration of the patient and health care provider--both seeking to obtain the best possible outcome taking into account the intangible, but vital, nuances of the patient's culture, beliefs, and preferences.The contributors, all of whom have a background in academic medicine, share the approaches that they have found most effective in their own practices, basing their work on the best scientific evidence available.

Cardiovascular disease is the leading cause of morbidity and premature death of modern era medicine. It is estimated that approximately 81 million people in the United States (US) currently have one or more of the many forms of cardiovascular disease, resulting in 1 in every 2.8 deaths, or 900,000 deaths per year. 40% of all deaths in Europe are a result of cardiovascular disease in people under the age of 75. Aneurysms form a significant portion of these cardiovascular related deaths and are defined as a permanent and irreversible localised dilation of a blood vessel greater than 50% of its normal diameter. Although aneurysms can form in any blood vessel, the more lethal aneurysms develop in the cranial arteries, and in the thoracic aorta and abdominal aorta. Frequently aneurysms are undetected and if left untreated may eventually expand until rupture with very high levels of morbidity and mortality. The biomechanics and mechanobiology of aneursymal diseases are not fully understood and this monograph aims to provide new insights into aneurysm aetiology and behavior based on the most recent biomechanics research related to this important topic. The contributors to this volume bring together a unique blend of expertise in experimental, computational and tissue biomechanics relating to aneurysm behavior and enable the reader to gain a fresh understanding of key factors influencing aneurysm behavior and treatment. Biological risk factors such as tobacco smoking, sex, age, hypertension, family history and mechanobiological risk factors such as aneurysm geometry and shape as well as mechanical properties of the diseased tissues are considered in detail as are many of the diagnostic and treatment options.

The use of proteomics to study complex diseases such as cardiovascular disease, the leading cause of death in developed countries, has grown exponentially in recent years. Proteomics is a rapidly expanding investigation platform in cardiovascular medicine and is becoming integrated and incorporated into cardiovascular research. The proteomics field continues to develop with major improvements in mass spectrometry instrumentation, methodology and data analysis. Heart Proteomics: Methods and Protocols complies a selection of techniques and methods that target the numerous processes implicated in the pathophysiology of heart. Chapters cover protocols and updated methods in the heart proteomic area with a particular focus on MS-based methods of protein and peptide quantification and the analysis of posttranslational modifications as well as descriptions of system biology approaches, which provide a better understanding of normal and pathological processes. Written in the successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Heart Proteomics: Methods and Protocols is a representative selection of methods that will prove to be a useful resource for experienced proteomics practitioners and newcomers alike.

Intraoperative Echocardiography - a volume in the exciting new Practical Echocardiography Series edited by Dr. Catherine M. Otto - provides practical, how-to guidance on intraoperative echocardiography in adult and pediatric patients. Definitive, expert instruction from Dr. Donald C. Oxorn is presented in a highly visual, case-based approach that facilitates understanding and equips you to master this difficult technique while overcoming the unique challenges and risks it presents. Access the full text online at www.expertconsult.com along with cases, procedural videos and abundant, detailed figures and tables that show you how to proceed, step by step, and get the best results. Master challenging and advanced intraoperative echocardiography techniques such as epiaortic echocardiography and 3-D echocardiography through a practical, step-by-step format that provides a practical approach to image acquisition and analysis, technical details, pitfalls, and case examples. Reference the information you need quickly thanks to easy-to-follow, templated chapters, with an abundance of figures and tables that facilitate visual learning. Become an expert in echocardiographic evaluation of complex valvular heart disease, congenital heart disease, and intravascular devices in patients undergoing cardiac surgery and interventional cardiology procedures. Access the complete text and illustrations online at www.expertconsult.com plus video clips, additional cases, and much more! Master the challenges of Intraoperative Echocardiography with guidance from the experts

Advanced Approaches in Echocardiography - a volume in the exciting new Practical Echocardiography Series edited by Dr. Catherine M. Otto - provides practical, how-to guidance on advanced and challenging echocardiographic techniques such as 3D echo, contrast echo, strain echo, and intracardiac echo. Definitive, expert instruction from Drs. Linda D. Gillam and Catherine M. Otto is presented in a highly visual, case-based approach that facilitates understanding and equips you to master these difficult and cutting-edge modalities. Access the full text online at www.expertconsult.com along with cases, procedural videos and abundant, detailed figures and tables that show you how to proceed, step by step, and get the best results. Master new and advanced echocardiography techniques such as 3D echocardiography, contrast echocardiography, strain echocardiography, and intracardiac echocardiography through a practical, step-by-step format that provides a practical approach to image acquisition and analysis, technical details, pitfalls, and case examples. Tap into the knowledge and experience of two noted authorities in the field: Dr. Linda D. Gillam, former president of the American Society of Echocardiography, and world-renowned echocardiography expert and author Dr. Catherine M. Otto. Reference the information you need quickly thanks to easy-to-follow, templated chapters, with an abundance of figures and tables that facilitate visual learning. Access the complete text and illustrations online at www.expertconsult.com plus video clips, additional cases, and much more! Master advanced and novel techniques in echocardiography

Echocardiography in Heart Failure - a volume in the exciting new Practical Echocardiography Series edited by Dr. Catherine M. Otto - provides practical, how-to guidance on effectively applying echocardiography to evaluate heart failure, make therapeutic decisions, and monitor therapy. Definitive, expert instruction from Drs. Martin St. John Sutton and Denise Wiegers is presented in a highly visual, case-based approach that facilitates understanding and equips you to accurately apply this technique while avoiding any potential pitfalls. Access the full text online at www.expertconsult.com along with cases, procedural videos, and abundant, detailed figures and tables that show you how to proceed, step by step, and get the best results. Master challenging and advanced echocardiography techniques such as cardiac resynchronization therapy through a practical, step-by-step format that provides a practical approach to image acquisition and analysis, technical details, pitfalls, and case examples. Expand your knowledge and apply the latest findings on cardiomyopathy and dyssynchrony. Reference the information you need quickly thanks to easy-to-follow, templated chapters, with an abundance of figures and tables that facilitate visual learning. Access the complete text and illustrations online at www.expertconsult.com plus video clips, additional cases, and much more! Overcome challenges and master techniques with expert guidance on echocardiography in heart failure

The textbook will describe the relationship between human cardiopulmonary system and exercise in a format that is related to the mode of exercise, health status and aging. It will include data regarding exercise training principles and the adaptations of the cardiopulmonary following: anaerobic, resistance and aerobic training. A more in-depth presentation of the cardiopulmonary system adaptations in pressing environments such as: warm, cold and altitude. Therefore, students will experience a depth and extent of content balanced with unique and effective learning features: It will help students find the way by both the text and subject matter. Knowing cardiopulmonary exercise function in health and disease will allow understand new research and findings relevant to cardiovascular status as assessed by cardiopulmonary exercise indices. It will bring together investigational exercise physiologists, cardiologists and scientists who share a wealth of experience needed to judge the cardiovascular status and function, and the impairments of patients with a variety of cardiac dysfunction. This book will provide a comprehensive, updated presentation of the information of the cardiovascular system as a whole, and its individual components.

As the number of effective anti-neoplastic agents has grown, there has been a concomitant increase in side effects.? Cardiotoxicity, and specifically LV dysfunction, remains the limiting factor for many such agents, and is the focus of growing research and clinical emphasis.? This issue summarizes for the heart failure specialist the possible ways that chemotherapeutic agents might cause cardiotoxicity as well as the methods for detecting, treating and preventing cardiotoxicity.

Sudden cardiac death (SCD) is the number one killer in the United States, claiming the lives of more than 300,000 Americans every year. Thus, it is important for heart failure specialists to be knowledgeable about strategies to prevent, manage risk for, and treat conditions leading to sudden cawrdiac death. These topics and more are covered in this issue.

Cardiac catheterization is a significant part of the practice of cardiology. Physicians who don't perform catheterization do refer patients for these procedures, and need to know what catheterization can accomplish in terms of diagnosis and treatment. This issue provides an excellent picture of what can be learned in the catheterization laboratory about blood flow in the heart and coronary vessels.

Preventive Cardiology-a new Companion to Braunwald's Heart Disease-addresses the prevention and risk stratification of cardiovascular disease so that you can delay the onset of disease and moderate the effects and complications. Drs. Roger Blumenthal, JoAnne Foody, and Nathan Wong discuss the full range of relevant considerations, including the epidemiology of heart disease, risk assessment, risk factors, multiple risk factor-based prevention strategies, and developments in genetics and personalized medicine. With access to the fully searchable text online at www.expertconsult.com, this authoritative reference gives you the clinically relevant information you need for the effective prevention of cardiovascular disease. Access the fully searchable text online at www.expertconsult.com. Recognize the factors for prevention and risk stratification around cardiovascular disease and effectively delay the onset of disease and moderate the effects and complications, even for individual who are genetically predisposed. Effectively navigate full range of considerations in prevention from epidemiology of heart disease, biology of atherosclerosis and myocardial infraction, risk assessment-established risk factors and emerging risk factors, multiple risk factor-based prevention strategies, and future directions-through genetics, personalized medicine, and much more. Tap into the expertise of prominent leaders in cardiovascular disease prevention with guidance from Drs. Roger Blumenthal-longtime director of the Framingham Heart Study-JoAnne Foody, and Nathan Wong. Gain a deeper understanding of the pathogenesis of disease and the rationale for management through discussions of basic science. Apply current clinical practice guidelines to ensure optimal outcomes in both primary and secondary prevention. The most authoritative and relevant reference on Prevention of Cardiovascular Diseases is now available!

The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning.
Volume 3 is devoted to the set of mediators of the cell surface, especially ion and molecular carriers and catalytic receptors that, once liganded and activated, initiate signal transduction pathways. Intracellular cascades of chemical reactions trigger the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Primary mediators are included in models of regulated cellular processes, but multiple secondary signaling components are discarded to allow simple, representative modeling and to manage their inverse problems.

Cardiovascular disease remains a major cause of death and disability in developed countries and, increasingly so, in the developing world.Presented in this volume of Advances in Pharmacology are some of the most promising possibilities for treating large numbers of individuals afflicted with these conditions

This volume contains up-to-date reviews of the most important emerging cardiovascular therapies written by world leaders in the field."

This issue explores the genetic basis of specific cardiomyopathies and? phenotypic components of heart failure with an eye to the clinical implications of this genetic knowledge.? An understanding of the genetic causes of disease can aid in development of effective prevention and management strategies.

This collection of reviews will be of considerable interests to biologists and MDs working on any aspect of cardiovascular function. With state-of-the-art reviews written by competent experts in the field, the content is also of interest for MSc and PhD students in most fields of cardiovascular physiology.