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The cellular mechanisms of valvular heart disease have not been elucidated until the last decade. To date, there is no medical therapy that is FDA or CE mark approved for the treatment and/or slowing the progression of this disease. This textbook will provide the cellular basis for medical therapy. Over the past decade, research laboratories are more and more evolving into valvular biology programs from the traditional vascular biology. The science between the two disciplines, although has several similarities has unique cellular targets secondary to the embryologic derivation of the heart valve and the hemodynamics involved in the understanding of this disorders. This textbook will be a natural progression from the recently published text Cardiac Valvular Medicine, Springer 2012. This new textbook will provide the cellular details and the more basic molecular biology approaches towards understanding the disease, providing novel cellular targets and finally developing future clinical trials in the medical treatment of valvular heart disease in the future.
A comprehensive guide to the assessment, diagnosis, investigation and management of complex clinical scenarios in cardiovascular medicine. This book contains a series of challenging concepts in cardiovascular medicine covering all subspecialty areas including general cardiology, intervention, cardiac imaging, electrophysiology, heart failure and cardiomyopathies, cardiac devices, transplant medicine, epidemiology, heart disease in pregnancy and congenital heart disease. Each case provides an in-depth review of current practice, the application of national and international guidelines and a summary of evidence from the medical literature. Data sets, investigation results and cardiac imaging give the reader a 'real-life' sense of being in the outpatient clinic, emergency room, coronary care unit or cardiac catheterisation laboratory. Each case is punctuated by 'Clinical Tips', 'Learning Points' and 'Landmark Trial Summaries' to enhance the learning process alongside an 'Expert Commentary' written by internationally-renowned leaders in the field of cardiology.
The fourth edition of this well-received book offers a comprehensive update on recent developments and trends in the clinical and scientific applications of multislice computed tomography. Following an initial section on the most significant current technical aspects and issues, detailed information is provided on a comprehensive range of diagnostic applications. Imaging of the head and neck, the cardiovascular system, the abdomen, and the lungs is covered in depth, describing the application of multislice CT in a variety of tumors and other pathologies. Emerging fields such as pediatric imaging and CT-guided interventions are fully addressed, and emergency CT is also covered. Radiation exposure, dual-energy imaging, contrast enhancement, image postprocessing, CT perfusion imaging, and CT angiography all receive close attention. The new edition has been comprehensively revised and complemented by contributions from highly experienced and well-known authors who offer diverse perspectives, highlighting the possibilities offered by the most modern multidetector CT systems. This book will be particularly useful for general users of CT systems who wish to upgrade and enhance not only their machines but also their knowledge.
A comprehensive, accessible summary of the latest research in heart disease risk factors Cardiovascular Disease (CVD) is a major cause of early death and disability across the world. The major markers of risk--including high blood cholesterol, smoking, and obesity--are well known, but studies show that such markers do not account for all cardiovascular risk. Written by a team of renowned experts in the field, this comprehensive and accessible book examines the evidence for emerging and novel risk factors, and their relationship with diet and nutrition. Fully updated throughout, Cardiovascular Disease: Diet, Nutrition and Emerging Risk Factors, 2nd Edition covers everything from the epidemiology of cardiovascular disease, to genetic factors, to inflammation and much more - offering invaluable advice on reducing risk factors and preventing CVD. This new edition: Authoritatively reports on the link between emerging aspects of diet, lifestyle and cardiovascular disease risk Focuses on novel risk factors of CVD, including the human gut microbiome and fetal and childhood origins, and how it can be prevented Features recommendations for interventions and future research Includes references, commonly asked questions that summarise the take-home messages, and an online glossary Cardiovascular Disease: Diet, Nutrition and Emerging Risk Factors, 2nd Edition is an important book for researchers and postgraduate students in nutrition, dietetics, food science, and medicine, as well as for cardiologists and cardiovascular specialists.
Pediatric intensivists, cardiologists, cardiac surgeons, and anesthesiologists from the leading centers around the world present the collaborative perspectives, concepts, and state-of-the-art knowledge required to care for children with congenital and acquired heart disease in the ICU. Their multidisciplinary approach encompasses every aspect of the relevant basic scientific principles, medical and pharmacologic treatments, and surgical techniques and equipment. From the extracardiac Fontan procedure, and the Ross procedure through new pharmacologic agents and the treatment of pulmonary hypertension to mechanical assist devices, heart and lung transplantation, and interventional cardiac catheterization-all of the developments that are affecting this rapidly advancing field are covered in depth. Features comprehensive updates throughout the text, including indications, techniques, potential complications in perioperative management of patients, and surgical techniques for congenital heart disease. Covers recent advances in the treatment of pulmonary hypertension, developments in mechanical assist devices, heart and lung transplantation, and interventional cardiac catheterization. Features an all-new, full-color format that speeds navigation and helps clarify complex concepts. Contains 27 new chapters with an emphasis on the team approach to patient care in the ICU including creating multidisciplinary teams, quality and performance improvement, training , and challenges and solutions to developing a cohesive team environment. Includes a detailed chapter on bedside ultrasound, walking you through the techniques you're most likely to encounter in the ICU. Employs well-documented tables, text boxes, and algorithms to make clinical information easy to access, and more than two dozen video clips provide a more complete understanding of echocardiography, imaging modalities, pulmonary hypertension, and more. Describes the basic pharmacology and clinical applications of new pharmacologic agents. Examines issues affecting adults with congenital heart disease. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. Offers four completely new chapters: Cardiac Trauma, Congenital Heart Disease in the Adult, Congenitally Corrected Transposition of the Great Arteries, and Outcome Evaluation. Describes the basic pharmacology and clinical applications of all of the new pharmacologic agents. Details important refinements and developments in surgical techniques, including the Ross pulmonary autograft replacement of the aortic valve, video-assisted fluoroscopy, and the extracardiac Fontan connection, and discusses their indications and potential complications. Explores the latest advances in the treatment of pulmonary hypertension, new developments in mechanical assist devices, heart and lung transplantation, and interventional cardiac catheterization. Examines issues affecting adults with congenital heart disease.
The book presents the overview of the current knowledge in some fields of vascular biology, addressing cellular and molecular aspects of blood-vessel formation and their role in health and disease. The major factors involved in the formation of blood vessels are presented by scientists actively involved in this area of research. Special emphasis is put on the presentation of various molecular mechanisms not addressed in similar works to date. The book is divided into three parts. The first part describes the cells and mediators in angiogenesis. The significance of various populations of potential endothelial progenitors is particularly highlighted. The chapters of the second part focus on molecular mechanisms, with special emphasis on the role of hypoxia, gasotransmitters and reactive oxygen species as well as microRNAs in regulation of angiogenic processes. In the third part, the pathological aspects of disturbed aggravated or impaired vascularization are discussed and new modalities for potential therapies are presented. The book is intended for scientists and PhD students in the fields of vascular biology and cancer research. It may be of interest for medical professionals in the fields of cardiovascular disease, diabetes, oncology and rheumatoid arthritis.
Highly Commended, BMA Medical Book Awards 2015 Since the first edition of this book was published in 2004, the management of congenital heart disease has continued to evolve at a rapid pace. Not only have new operations been developed and expanded, such as the intra/extracardiac conduit Fontan and the double root translocation for corrected transposition, but in addition, diagnostic methods-particularly cardiac CT and MRI-have been dramatically transformed. Understanding of the genetic basis of congenital heart disease and the embryology of cardiac development has progressed even more rapidly. What has not changed is that optimal outcomes for children and adults with congenital heart disease can only be achieved by a collaborative team effort. The team includes not only congenital cardiac surgeons but also pediatric cardiac nurses, pediatric cardiologists, perfusion and respiratory technicians, pediatric cardiac intensivists, pediatric cardiac anesthesiologists, ultrasonographers, and MRI and catheter laboratory technicians. This second edition of Comprehensive Surgical Management of Congenital Heart Disease describes in detail the contemporary practice of Richard A. Jonas and the cardiac team at Children's National Medical Center in Washington, D.C. The book once again includes numerous beautiful illustrations providing comprehensive and detailed information about intra-operative management of the entire spectrum of congenital heart surgery. In addition, the companion VitalSource ebook contains more than 50 operative videos that have been edited and narrated to highlight the key steps in complex surgical procedures. The book incorporates an evidence-based approach, supported throughout by numerous scientific citations, to explain when and why an operation should be done as well as the risks, benefits, and potential complications.
With the rapid development of the field of cardiac biomarkers comes
a need for updated guidance on how to use them clinically. Drs.
Adams, Jaffe, and Apple meet that need with this timely
Taking a case-oriented approach for the greatest clinical
relevance, the book bridges the gap between science and practice.
If you use - or want to use - cardiac markers such as BNP and
troponin to help your patients, you will find this clear and
comprehensive reference provides a dependable source of valuable
The 19 chapters are divided into three parts:
- Cardiac Troponins
The authors cover the technical, clinical, and outcome assessments for each marker used in clinical practice. After each case scenario, an extensive discussion explains the clinical decisions and provides valuable context.
Huzar's ECG and 12-Lead Interpretation, 5th Edition, by Keith Wesley, M.D., helps you correlate ECG interpretation with clinical findings to identify and address selected heart rhythms. The text is structured to match the order in which you learn specific skills: ECG components are presented first, followed by rhythm interpretation and clinical implications. Take-Home Points, key definitions, chapter review questions, and practice strips help you understand and retain complex information NEW! Discusses the difference between sinus arrest and SA block to help clarify concepts that learners often find confusing. UPDATED! STEMI and NSTEMI treatment guidelines updated to the latest standards. Coverage of both basic and advanced concepts incorporates the latest research developments and provides material pertinent to both beginning and experienced prehospital care providers. UPDATED and EXPANDED! Key characteristics of each heart rhythm are summarized to allow you to learn or review each rhythm at a glance. Patient care algorithms?outline step-by-step management and treatment, correlating ECG interpretation with history and exam findings. Advanced treatment content, such as complete coverage of thrombus formation, treatment, and management, offers critical information for both hospital and prehospital settings. UPDATED AND EXPANDED! Key definitions define important terms right on the page, near relevant content, making it unnecessary to flip to the back-of-book glossary while reading or studying. Key definitions, chapter review questions, and glossary updated to reflect new content. Chapter review questions (with answers in an appendix) test your understanding of key topics. Appendix with 200+ practice strips, questions, and answer keys reinforces major concepts and ties information together. UPDATED! Glossary defines key terms, supplementing the on-page Key Definitions. Expert authorship?from Dr. Keith Wesley, who has been involved in EMS since 1989 and is a board-certified emergency medicine physician. Self-assessment answer key?allows you to check their own work for self-evaluation. Chapter outlines?offer a quick overview of each chapter's content. NEW! Updated content throughout?ensures?all chapters comply with the latest 2015 ECC guidelines. NEW! ECG Keys boxes highlight basic clinical information, such as indications and end points for administration of certain drugs, helping you integrate clinical knowledge with heart rhythm interpretation. NEW! Author's Notes highlight special considerations, alternative diagnoses, possible complications or warning signs, normal variations, and more, allowing learners to benefit from the author's expertise. NEW! A bulleted Take-Home Points summary of each chapter highlights need-to-know information about the most important topics covered. NEW! Updated process for distinguishing ventricular tachycardia from supraventricular tachycardia keeps you at the forefront of practice. NEW! Now examines treatment of bradycardias and blocks with and without wide QRS.
This book equips readers with the knowledge required in order to successfully treat coronary chronic total occlusion by means of percutaneous coronary interventions. All the essential background knowledge is provided, including with regard to procedurally relevant histopathology, assessment of chronic total occlusion by means of angiography and computed tomography, patient preparation, and selection and use of guidewires. Both basic and advanced techniques employing antegrade and retrograde approaches are then described in detail with the aid of numerous high-quality illustrations that ensure ease of understanding. Helpful tips and tricks are highlighted, and guidance provided on the troubleshooting of problems and the prevention and management of complications. The book will serve as a superb guide for all who are involved in percutaneous coronary interventions for chronic total occlusion, including interventional cardiologists, fellows in training, nurses, and technicians in catheterization laboratories.
Gain a foundational understanding of cardiovascular physiology and how the cardiovascular system functions in health and disease. Cardiovascular Physiology, a volume in the Mosby Physiology Series, explains the fundamentals of this complex subject in a clear and concise manner, while helping you bridge the gap between normal function and disease with pathophysiology content throughout the book. Helps you easily master the material in a systems-based curriculum with learning objectives, Clinical Concept boxes, highlighted key words and concepts, chapter summaries, self-study questions, and a comprehensive exam to help prepare for USMLEs. Keeps you current with the latest concepts in vascular, molecular, and cellular biology as they apply to cardiovascular function, thanks to molecular commentaries in each chapter. Includes clear, 2-color diagrams that simplify complex concepts. Features clinical commentaries that show you how to apply what you've learned to real-life clinical situations. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. Complete the Mosby Physiology Series! Systems-based and portable, these titles are ideal for integrated programs. Blaustein, Kao, & Matteson: Cellular Physiology and Neurophysiology Cloutier: Respiratory Physiology Koeppen & Stanton: Renal Physiology Johnson: Gastrointestinal Physiology White, Harrison, & Mehlmann: Endocrine and Reproductive Physiology Hudnall: Hematology: A Pathophysiologic Approach
The endothelium is a thin mono-cellular layer which covers the inner surface of the blood vessels, separating the circulating blood from the tissues and also has the responsibility for uninterrupted maintenance of circulation to all the vital tissues. Endothelium is a very active organ, it works as a receptor-effector organ and responds to each physical or chemical stimulus with the release of the appropriate substance with which it may maintain vasomotor balance and vascular-tissue homeostasis. It has the property of producing, independently, both agonistic and antagonistic substances that help to keep homeostasis and its function is not only autocrine, but also paracrine and endocrine. In this way it modulates the vascular smooth muscle cells producing relaxation or contraction, and therefore vasodilatation or vasoconstriction. The vascular endothelium is vulnerable to maximum wear and tear due to its positioning and requires prompt regeneration of the cells. Whenever the imbalance between substances with vasodilating, antimitogenic, and antithrombogenic properties and substances with vasoconstricting, prothrombotic and proliferative characteristics takes place, it causes a pathological condition known as endothelial dysfunction. These substances intervenes in cell proliferation and migration, in leukocyte adhesion and activation and in immunological and inflammatory processes, further which is responsible for apoptosis of vascular endothelial cells resulting in overall endothelial dysfunction and vasculopathy. This book discusses, in further detail, the risk factors, and the role of endothelial dysfunction in cardiovascular diseases and therapeutic approaches to dealing with endothelial dysfunction.
A guide to the management of common cardiological scenarios, this book offers the response of leading experts in each field to the more common, and often poorly dealt with problems of cardiology. It is a very useful 'how-to' guide, based on sound evidence.
Keeping up with the use of new technologies in cardiology is becoming increasingly challenging. Case Studies in Clinical Cardiac Electrophysiology helps to bridge the gap between knowledge and application with 28 cases spanning both common and uncommon arrhythmias and ablation scenarios, each of which includes the clinical presentation, baseline ECG, ECG during arrhythmia, stepwise electrophysiologic diagnostic maneuvers and some of their pitfalls, and optimal therapy. Online access to the complete contents ensures the information you need is right at your fingertips. Includes 28 cases spanning the spectrum of what an electrophysiologist is likely to see in practice. Shows the correct way of conducting procedures, as well as "detours" that an unwary practitioner may take: misdiagnoses and why they are wrong; incorrect therapeutic choices and why these may be not only unsuccessful but even harmful. Encourages you to read and interpret the ECGs, mapping diagrams, and other diagnostic information before revealing the expert opinion or actual results of each case. Summarizes the key learning points in each case. Discusses potential procedural complications, including anticipation, avoidance, recognition, and response and resolution. Covers complex ablations (atrial fibrillation, ventricular tachycardia) as well as prior failed ablations. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices.
This book sheds new light on the management of patients with borderline cardiovascular risk factors in order to prevent their progression to end organ damage. The book stimulates discussion of this poorly understood condition and lays the groundwork for developing recommendations and guidelines. While the diagnostic and therapeutic approach to full-blown diabetes, hypertension, dyslipidemia and obesity is well defined, there is still a lack of clear understanding and guidelines as far as patients with borderline conditions - especially when multiple - are concerned. Moreover, end-organ damage depends on several factors, including genetic factors, making it difficult to predict its extent. As such, the gradual transition from a healthy subject to one with functional hemodynamic changes, and then one with structurally asymptomatic changes and lastly to overt disease needs further investigation. In order to address these knowledge gaps, the book covers a broad variety of topics, making it a valuable tool for identifying which asymptomatic subjects could profit from being appropriately screened and at what stage. Furthermore it offers insights into better treating these patients to prevent their progression to overt disease. The book appeals to cardiologists, primary care physicians and all those healthcare professional looking to optimize the management of these complex and often undiagnosed cases.
Provide the best possible emergency cardiovascular care - using the newest ECC guidelines! ACLS Study Guide, 5th Edition offers a complete, full-color overview of advanced cardiovascular life support. An easy-to-read approach covers everything from airway management to cardiac arrest rhythms and their management, electrical therapy, acute coronary syndromes, and acute stroke. In addition to the latest ACLS treatment algorithms, this edition includes case studies and hundreds of full-color photos and illustrations. Case studies present common, realistic clinical situations, helping you learn and apply skills in cardiac rhythm interpretation, medication administration, and other essential interventions. ACLS Pearls boxes offer brief explanations of complex topics and useful tips for clinical practice. End-of-chapter quizzes include answers and rationales, helping you learn and remember the most important information. Easy-to-understand approach simplifies your study of advanced cardiac life support, thanks to Barbara Aehlert's unique, conversational writing style. NEW! UPDATED content centers on evidence-based practice recommendations, including the 2015 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care and the 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. NEW! Improved format integrates all case studies into the appropriate chapters, so that you can apply concepts immediately to real-world situations.
"Cardiology: Clinical Cases Uncovered" is the ideal integrated text to help you recognize, understand and know how to investigate and manage many heart-related disorders and conditions. Written by three practising cardiologists, it leads students through a clinical approach to managing problems with 26 real-world cardiovascular cases. There is strong emphasis on high-quality figures, particularly 12-lead ECGs, as these play such a major role in the evaluation of the cardiac patient.
Following a question-answer approach throughout the narrative, with self-assessment MCQs, EMQs and SAQs, "Cardiology: Clinical Cases Uncovered" includes sections on cardiac anatomy, physiology and pathology which provide the essentials required to understand clinical cardiology, and is ideal for medical students and junior doctors on the Foundation Programme, specialist nurses and nurse practitioners, and for those with plans for a career in cardiology.
This book presents a valuable new perspective on Post-Cardiac Arrest Syndrome (PCAS), which was defined as system failure following whole-body ischemia-reperfusion injuries by the 2008 International Liaison Committee on Resuscitation. Recently, improving the survival rate of PCAS has become a major priority all over the world. A Perspective on Post-Cardiac Arrest Syndrome addresses various aspects, including: neurological outcomes in non-convulsive status epilepticus, target temperature management, interventions for PCAS after acute coronary syndrome, the significance of measuring lactate clearance, a specific scoring system in prognostication for PCAS, therapeutic indications for suicide hanging cases. This book will help a broad readership, including emergency physicians, intensivists, cardiologists and neurologists treating PCAS patients, to understand the history, current issues and future challenges in PCAS, presented by respected experts in this field.
This book presents advanced molecular imaging techniques used to assess metabolic function. Covering state-of-the art modalities, it discusses the evaluation of a wide range of diseases that have a metabolic component, including cancer, inflammatory conditions, diabetes, neurodegeneration, and cardiovascular disorders. Imaging provides a quantitative perspective to the assessment of metabolic function and complements genetic analysis of disorders related to disrupted metabolism. Organized into four parts, the book highlights basic principles in molecular imaging techniques; metabolic imaging approaches, including magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and hybrid modalities; metabolic diseases; and future perspectives. Featuring contributions from leading authorities in radiology, oncology, cardiology, and neurology, Imaging and Metabolism is a pioneering exploration of the role of imaging modalities in assessing the physiological status of abnormal cells and diagnosing disease.
All cardiologists will be called on to assess and manage pregnant
women, however the majority have had little or no training in the
subject. In the same way, obstetricians assess women with cardiac
conditions, and therefore require the knowledge to both refer
patients with heart disease as well as to manage them through the
pregnancy. However a recent enquiry into maternal deaths has
highlighted that morbidity and mortality of women with heart
disease in pregnancy has continued to increase over the last 15
years and substandard care has been identified in 40% of cases.
Recommendations have been made that women with, or at risk of,
heart disease are screened and counselled on the appropriate risks
of undergoing a pregnancy, and as a result all physicians involved
need a good understanding of the subject and access to the relevant
Percutaneous cardiac and endovascular procedures performed by a variety of interventional physicians continue to evolve and expand. One of the most important steps in performing these procedures is vascular access and their Achilles heel is vascular access site complications. This volume is here to help the clinician, providing a practical overview of the techniques and technologies used in top catheterization laboratories to access the arterial and venous beds. Dr. Mazen Abu-Fadel and his contributors, part of the renowned cardiovascular team at the University of Oklahoma College of Medicine, carefully walk the reader through the various techniques used to obtain vascular access into most arterial and venous sites. They thoroughly describe current data, techniques, advantages, risks, and benefits of each vascular access site. Covering everything from anatomic landmarks to closures devices, Arterial and Venous Access in the Cardiac Catheterization Lab offers a complete overview of each procedure. In addition, it provides an up-to-date guide to the best medical technologies and equipment used when performing these procedures. Arterial and Venous Access in the Cardiac Catheterization Lab is an invaluable resource for a wide range of clinical personnel, from attending physicians and trainees to nursing staff and vascular technicians. Written by experienced leaders in the field, it demonstrates how to perform complex, risky procedures while providing patients with expert care.
Hypertension: from basic research to clinical practice" contains a unique collection of selected chapters written by experts and enthusiasts engaged in research and treatment of hypertension, a condition that affects around a billion people in the world. The chapters describe fundamental researches at cellular and molecular levels to the science, and art of treatment of the condition in clinical practice. The topics included ranges from pathophysiology of hypertension, through monitoring of hypertension, to the treatment of hypertension in different patient categories. It contains essential background information as well as cutting edge research, and state of the art treatment alternatives in this broad field. From the beginners, and research students to the expert clinicians, and established scientists, everybody has something to learn from this book.
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