Long QT syndrome is a heart rhythm disorder that can cause fast, chaotic heartbeats. In some cases, long QT syndrome can cause sudden death. Long QT syndrome may result from a genetic mutation or be caused by certain medications and medical conditions. The condition is treatable with medication, surgery, or an implantable device. Because it may have serious consequences, it's important for electrophysiologists to know about long QT syndrome.

Topics in this issue include: Automated external defibrillation; Airway management during CPR; Could we remove ventilation from ABC's of CPR?; Advances in mechanical interventions during CPR; The role of vasopressor agents during CPR; Optimizing the timing of defibrillation: the role of VF waveform analysis during CPR; Therapeutic hypothermia during and after CPR; and Advances in brain resuscitation: beyond hypothermia.

In the joint American College of Cardiology /American Heart Association classification system, Stage B heart failure refers to patients with structural heart disease but no symptoms of heart failure.? Preventing progression of heart failure in Stage B patients is a central concern to heart failure specialists, so two issues have been devoted to this topic.? Part II focuses on screening to identify patients with Stage B HF and monitoring and therapeutic approaches to patients with a diagnosis of Stage B HF.

Chronic Kidney Disease (CKD) is a recognized risk factor for cardiovascular events and death. The coexistence of CKD and heart failure is increasing in prevalence worldwide and requires a unique and subtle approach to patient management. The Kidney in Heart Failure focuses on the changes that occur in kidney physiology as a function of a failing heart. This comprehensive resource covers epidemiology, pathophysiology, management of kidney disorders and advances in nephropathy management. In addition, the latest therapies, common heart failure dilemmas and kidney disease markers are included. Each chapter is co-authored by a Nephrologist and Cardiologist, offering a unified perspective to these chronic conditions. This indispensible volume provides the reader with the depth-of-knowledge needed for assessing and treating the cardio renal patient.

Topics in this issue include: Cardiac Arrest as a Public Health Concern; Prehospital Cardiac Arrest; Cardiopulmonary Resuscitation; Cardioactive Medications in Cardiac Arrest; Airway Management in Cardiac Arrest; Rapid Response Teams; and? Pediatric Cardiac Arrest.

This issue consists of 17 case studies, each involving a difficult decision that has to be made in the catheterization laboratory. Reading about the cases and seeing the ECGs will help cardiac electrophysiologists sharpen their clinical skills. The cases are also useful reading for those studying for board certification.

This volume of "Advances in Cell Aging and Gerontology" provides a timely review on the molecular and cellular basis of cardiovascular diseases (CVD). Age itself is the leading risk factor for cardiovascular diseases, which include loss of vasomotor function, athero- and arterio-sclerosis, hypertension, congestive heart failure and stroke. Together these pathologies comprise the leading causes of permanent disability, hospitalization and death for individuals over the age of 65. Thus, there is a critical need to assess both the age-associated causes leading to CVD as well as the current state of knowledge on preventive regimens designed to slow or modulate disease progression.

This book concisely summarizes the current knowledge related to the major aspects contributing to cardiovascular disfunction in the elderly as well as potential ways of maintaining or improving human cardiovascular healthspan.

"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "Guidance molecules in Cancer and cancer angiogenesis" and contains outstanding and original reviews.
Provides invaluable information on the exciting and fast-moving field of cancer research. This volumelooks at "Guidance molecules in Cancer and cancer angiogenesis."Outstanding and original reviews"

This issue of Medical Clinics of North America provides the latest essential updates on coronary risk factors. The following key questions are answered. Are new biomarkers informative? LDL: the lower the better? How important is HDL? How much credit does triglyceride deserve? How important is family history of coronary disease? How important is age in determining coronary risk factors? Endothelial progenitor cells, menopause, and coronary risk factors? What is the role of imaging in prevention of coronary artery disease? Is genomics ready for primetime? Pediatric statinization? Individualized statinization? Polypill for some, polypill for all?

The developing heart is the first functional organ, and its proper formation and function is essential for life. This volume compiles the exciting new advances that have been made in understanding the regulation of heart development, the genes and pathways involved, and the impact these have in heart disease. A stellar collection of scientists tackles an important facet of heart development, providing a comprehensive set of reviews.
Cutting-edge science Authority of contributors Exciting field of research

Historical Perspective of Venous Thromboembolism;Coagulation for the Intensivist;VTE Prophylaxis in the Critically Ill;Risk Stratification of Pulmonary Embolism; Treatment of Pulmonary Embolism: Anti
Coagulation; Thrombolytic Therapy and Complications; Major Pulmonary Embolism;Catheter and Surgical Thromboembolectomy;Vena Caval Interruption;New Anti-Coagulants;Heparin Induced Thrombocytopenia

Heart disease is the leading cause of death among US women over the age of 65, resulting in more deaths than all forms of cancer combined. Women are less likely to survive heart attacks than are men, possibly because symptoms in women may differ and may be less recognizable.? In addition, women consistently tend to have worse clinical outcomes in percutaneous coronary interventions than do men. For these reasons, an issue on percutaneous interventions in women is timely.

Nuclear medicine has played a significant role in imaging cardiovascular diseases.? With developments in PET imaging, that role has expanded.? This issue reviews the latest uses for PET in the imaging of cardiac sarcoidosis, cardiac and arterial calcifications, coronary vascular disease, vulnerable atherosclerotic plaque, and myocardial viability.

Implantable cardioverter-defibrillators (ICDs) are electronic devices installed in the chest to prevent sudden death caused by abnormally fast heart rhythms. Cardiac electrophysiologists are the physicians usually responsible for implanting and maintaining these devices.? The technology for ICDs is rapidly evolving, and the articles in this issue will help electrophysiologists to keep up to date with the current generation of ICDs, including selection of patients who are appropriate for the device, monitoring patients after the device is implanted, and troubleshooting problems with the device.

Echocardiography in Heart Failure - a volume in the exciting new Practical Echocardiography Series edited by Dr. Catherine M. Otto - provides practical, how-to guidance on effectively applying echocardiography to evaluate heart failure, make therapeutic decisions, and monitor therapy. Definitive, expert instruction from Drs. Martin St. John Sutton and Denise Wiegers is presented in a highly visual, case-based approach that facilitates understanding and equips you to accurately apply this technique while avoiding any potential pitfalls. Access the full text online at www.expertconsult.com along with cases, procedural videos, and abundant, detailed figures and tables that show you how to proceed, step by step, and get the best results. Master challenging and advanced echocardiography techniques such as cardiac resynchronization therapy through a practical, step-by-step format that provides a practical approach to image acquisition and analysis, technical details, pitfalls, and case examples. Expand your knowledge and apply the latest findings on cardiomyopathy and dyssynchrony. Reference the information you need quickly thanks to easy-to-follow, templated chapters, with an abundance of figures and tables that facilitate visual learning. Access the complete text and illustrations online at www.expertconsult.com plus video clips, additional cases, and much more! Overcome challenges and master techniques with expert guidance on echocardiography in heart failure

This issue of Heart Failure Clinics is dedicated to an in-depth analysis of the conduct of clinical investigation in patients with acute decompensated heart failure (ADHF). It tackles the difficult questions involved in patient population, trial conduct, surrogate endpoints, clinical endpoints, and statistical considerations.? The purpose of the issue is to provide information that will be?meaningful and useful to help physicians in thinking about the design of clinical trials in this field.

A left ventricular assist device (LVAD) is a surgically implanted pump that helps the left ventricle pump blood to the rest of the body.? The purpose of this issue is to let cardiologists know about the latest devices, their complications, and the clinical situations in which they are most beneficial.

Cardiac electrophysiologists face many challenging situations in which there is no clear-cut answer about the best way to handle a particular clinical problem. This issue brings together articles on many such situations, presents arguments on both sides, and lets the reader conclude which is the best way to manage a particular patient.? Among the controversial and debatable topics included are how to handle device recalls, optimal timing for assessment of ICD efficacy, extraction o f broken leads, and anticoagulation therapy in device patients.

Advanced Approaches in Echocardiography - a volume in the exciting new Practical Echocardiography Series edited by Dr. Catherine M. Otto - provides practical, how-to guidance on advanced and challenging echocardiographic techniques such as 3D echo, contrast echo, strain echo, and intracardiac echo. Definitive, expert instruction from Drs. Linda D. Gillam and Catherine M. Otto is presented in a highly visual, case-based approach that facilitates understanding and equips you to master these difficult and cutting-edge modalities. Access the full text online at www.expertconsult.com along with cases, procedural videos and abundant, detailed figures and tables that show you how to proceed, step by step, and get the best results. Master new and advanced echocardiography techniques such as 3D echocardiography, contrast echocardiography, strain echocardiography, and intracardiac echocardiography through a practical, step-by-step format that provides a practical approach to image acquisition and analysis, technical details, pitfalls, and case examples. Tap into the knowledge and experience of two noted authorities in the field: Dr. Linda D. Gillam, former president of the American Society of Echocardiography, and world-renowned echocardiography expert and author Dr. Catherine M. Otto. Reference the information you need quickly thanks to easy-to-follow, templated chapters, with an abundance of figures and tables that facilitate visual learning. Access the complete text and illustrations online at www.expertconsult.com plus video clips, additional cases, and much more! Master advanced and novel techniques in echocardiography

A new volume in the Weil Integrative Medicine Library, a groundbreaking series under the general editorship of Dr. Andrew Weil, Integrative Cardiology offers a new and much-needed perspective in cardiac care and prevention, blending conventional medicine with alternative approaches not typically part of the Western medical curriculum. This unique perspective highlights specific gaps in conventional heart care, and examines how alternative approaches may be ideally suited to address these missed opportunities. The book introduces topics not typically addressed in conventional cardiology texts including: nutritional therapies, exercise, botanicals, mind/body approaches, spirituality, aspirin, metabolic cardiology, acupuncture, and energy medicine. The focus of this work is on prevention and it recommends an approach that emphasizes the collaboration of the patient and health care provider--both seeking to obtain the best possible outcome taking into account the intangible, but vital, nuances of the patient's culture, beliefs, and preferences.The contributors, all of whom have a background in academic medicine, share the approaches that they have found most effective in their own practices, basing their work on the best scientific evidence available.

Cardiovascular disease is the leading cause of morbidity and premature death of modern era medicine. It is estimated that approximately 81 million people in the United States (US) currently have one or more of the many forms of cardiovascular disease, resulting in 1 in every 2.8 deaths, or 900,000 deaths per year. 40% of all deaths in Europe are a result of cardiovascular disease in people under the age of 75. Aneurysms form a significant portion of these cardiovascular related deaths and are defined as a permanent and irreversible localised dilation of a blood vessel greater than 50% of its normal diameter. Although aneurysms can form in any blood vessel, the more lethal aneurysms develop in the cranial arteries, and in the thoracic aorta and abdominal aorta. Frequently aneurysms are undetected and if left untreated may eventually expand until rupture with very high levels of morbidity and mortality. The biomechanics and mechanobiology of aneursymal diseases are not fully understood and this monograph aims to provide new insights into aneurysm aetiology and behavior based on the most recent biomechanics research related to this important topic. The contributors to this volume bring together a unique blend of expertise in experimental, computational and tissue biomechanics relating to aneurysm behavior and enable the reader to gain a fresh understanding of key factors influencing aneurysm behavior and treatment. Biological risk factors such as tobacco smoking, sex, age, hypertension, family history and mechanobiological risk factors such as aneurysm geometry and shape as well as mechanical properties of the diseased tissues are considered in detail as are many of the diagnostic and treatment options.

The use of proteomics to study complex diseases such as cardiovascular disease, the leading cause of death in developed countries, has grown exponentially in recent years. Proteomics is a rapidly expanding investigation platform in cardiovascular medicine and is becoming integrated and incorporated into cardiovascular research. The proteomics field continues to develop with major improvements in mass spectrometry instrumentation, methodology and data analysis. Heart Proteomics: Methods and Protocols complies a selection of techniques and methods that target the numerous processes implicated in the pathophysiology of heart. Chapters cover protocols and updated methods in the heart proteomic area with a particular focus on MS-based methods of protein and peptide quantification and the analysis of posttranslational modifications as well as descriptions of system biology approaches, which provide a better understanding of normal and pathological processes. Written in the successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Heart Proteomics: Methods and Protocols is a representative selection of methods that will prove to be a useful resource for experienced proteomics practitioners and newcomers alike.

Intraoperative Echocardiography - a volume in the exciting new Practical Echocardiography Series edited by Dr. Catherine M. Otto - provides practical, how-to guidance on intraoperative echocardiography in adult and pediatric patients. Definitive, expert instruction from Dr. Donald C. Oxorn is presented in a highly visual, case-based approach that facilitates understanding and equips you to master this difficult technique while overcoming the unique challenges and risks it presents. Access the full text online at www.expertconsult.com along with cases, procedural videos and abundant, detailed figures and tables that show you how to proceed, step by step, and get the best results. Master challenging and advanced intraoperative echocardiography techniques such as epiaortic echocardiography and 3-D echocardiography through a practical, step-by-step format that provides a practical approach to image acquisition and analysis, technical details, pitfalls, and case examples. Reference the information you need quickly thanks to easy-to-follow, templated chapters, with an abundance of figures and tables that facilitate visual learning. Become an expert in echocardiographic evaluation of complex valvular heart disease, congenital heart disease, and intravascular devices in patients undergoing cardiac surgery and interventional cardiology procedures. Access the complete text and illustrations online at www.expertconsult.com plus video clips, additional cases, and much more! Master the challenges of Intraoperative Echocardiography with guidance from the experts