This issue of Interventional Cardiology Clinics will explore Updates in Percutaneous Coronary Intervention. Curated by the series Editor-in-Chief, Dr. Matthew J. Price, this issue will cover topics and advances in the field that are relevant for practicing clinicians. This issue is one of four selected each year by Dr. Price. The volume will include articles on: Current Concepts in Intraprocedural Pharmacology During PCI; Periprocedural Myocardial Infarction in Contemporary Practice; Newer Generation Metallic Stents: Design, Performance Characteristics, and Outcomes; Distal Transradial Access for Coronary Angiography and Intervention; Clinical Outcomes Data for iFR-guided PCI; Culprit-only or Complete Revascularization During STEMI in Patients with and Without Shock; Technical Approaches to Left Main Coronary Intervention: Contemporary Best Practices; Robotic Assisted Percutaneous Coronary Intervention; Orbital Atherectomy: A Comprehensive Review; and Percutaneous revascularization of spontaneous coronary artery dissection, among others.

This issue of Cardiac Electrophysiology Clinics, edited by Drs. Noel G. Boyle and Bruce Wilkoff, will focus on Lead Management for Electrophysiologists. Topics include, but are not limited to, Overview of Lead Management; Vein Management; Electrode Management; Infection Management; Definitions and Metrics; Tensile Properties; TOOLS for Lead Extraction; Complications : Vascular, Cardiac, Thrombotic & Hemorrhage; Rescue; Outcomes & Registries; Reimplantation after Lead Removal; Venoplasty and Stenting; Palliation & Non Extraction Approaches; Surgical and Hybrid Extraction; Anesthesia Considerations for Lead Extraction; and Role of Imaging in Lead Extraction.

This issue of Heart Failure Clinics, guest edited by Gina Price Lundberg and Laxmi S. Mehta, with consulting editor Eduardo Bossone, will focus on Heart Failure in Women. Topics include, but are not limited to, Gender Based Differences in Risk Factors for Development of Heart Failure, Imaging of Heart Failure , Heart Failure with Preserved Ejection Fraction in Women, Heart failure with Reduced Ejection Fraction in Women, Peripartum Cardiomyopathy, Stress Induced Cardiomyopathy, Atrial fibrillation and Heart Failure in Women, Breast Cancer and Heart Failure, Valvular Heart Disease and Heart Failure in Women, Congenital Heart Disease and Heart Failure, Advanced Therapies for Advanced Heart Failure in Women, CRT and ICDs in Women, Heart Transplants and Women, Sleep apnea and Heart Failure in Women, and Pulmonary Hypertension in Women.

Guest edited by Dr. Daniel Levi, this issue of Interventional Cardiology Clinics will cover several key areas of interest related to Congenital Heart Disease Intervention. This issue is one of four selected each year by our series Editor-in-Chief, Dr. Matthew Price of Scripps Translational Science Center. Articles in this issue include, but are not limited to: Current Transcatheter Approaches for the Treatment of Aortic Coarctation in Children and Adults, Biodegradable Stents for Congenital Heart Disease, State of the Art ASD Closure Devices for Congenital Heart, New PDA Closure Devices and Techniques, Lymphatic Interventions, VSD Closure Devices, Techniques and Outcomes, Pulmonary Artery and Bronchial Stenting: Available Devices, Techniques and Outcomes, and Transcatheter Valve, and Interventions for Adults with Congenital Heart Disease.

Since its initial publication nearly a decade ago, The Vein Book continues to serves as the ultimate comprehensive resource on venous disease. Upholding its reputation as the go-to reference for complete, authoritative, and up-to-date information about venous function and dysfunction, this second edition effectively bridges the gap between clinical medicine and basic science, suitable both for the seasoned surgeon as well as the medical student. The book is divided into five essential sections: basic considerations, primary superficial venous insufficiency, venous thromboembolism, chronic venous insufficiency, and congenital venous malformations. The book covers the entire spectrum of venous conditions from clarification of the pathophysiology of venous insufficiency, molecular mechanisms in the cause of varicose veins, new treatment options for varicose veins and spider veins, startling new treatment for venous thromboembolic disease, and effective treatment for leg ulcers. More user-friendly and encyclopedic than ever, The Vein Book is still a must-have for vascular surgeons, phlebologists, interventional radiologists, research scientists, epidemiologists, and surgeons at all levels.

This new account of the pathogenesis of essential hypertension (EH) represents a detailed analysis of the main components of the circulatory control system. The latter's properties resemble those of man-made adaptive control systems in which regulatory parameters are altered when operating conditions exceed certain limits, often through neural mechanisms.
Inheritance of EH depends on both genes and environment. The high blood pressure (BP) genes have not yet been definitively identified, whilst the main environmental causes are mental stress, high dietary salt intake and obesity. EH occurs as two major syndromes, each initiated by chronic stress: 1) Stress-and-salt related EH, and 2) Hypertensive obesity. Stress is perceived by the cortex, from which increased dopaminergic (DA) neuron activity stimulates the hypothalamic defense area, raising sympathetic neural activity (SNA) and BP. Normally these subside quickly when the stress is over, but in those susceptible to EH the DA synapses become sensitized so that the defense response is evoked by ever lower levels of stress. Sensitization is common in memory circuits, but not in autonomic neurons, so that this property in EH may be genetically determined.
Stress-related hypertension increases hypothalamic responsiveness to high salt, resulting in further rises in SNA and BP. Later, non-neural functional changes (e.g. reduction in nitric oxide) and the structural remodeling of resistance vessels further enhance the vasoconstriction. In contrast, in those developing hypertensive obesity food consumption is excessive, which transiently alleviates stress-related anxiety. The brain ignores the leptin-mediated signals that normally curbappetite, contrasting with normal energy regulation in SSR-EH. In hypertensive obesity, the SNA pattern is similar to that in SSR-EH, but vasoconstriction is masked by vasodilatation and fluid retention due to hyperinsulinemia. This syndrome is a volume overload hypertension, where high cardiac output, renal impairment and other non-neural factors contribute to the elevation of BP.
Other topics include the role of various transmitters in autonomic regulation; the place of baroreflexes in the intact organism; why exercise training lowers resting BP; obstructive sleep apnea; non-pharmacological and drug treatment of EH; the role of the kidney in EH and in different types of renal hypertension and the pathogenesis of the Japanese spontaneously hypertensive rat, which provides a valuable animal model for EH.
The work suggests that physiological systems analysis in a complex disorder like EH is a valuable tool for using the great advances in molecular biology to best advantage.

This issue of Interventional Cardiology Clinics, guest edited by Dr. Susheel Kodali, will cover several key topics of importance surrounding Transcatheter Aortic Valve Replacement. The series is overseen by the Editor-in-Chief, Dr. Matthew Price of Scripps Translational Science Center. Subjects discussed in the issue include: Embolic protection during TAVR; Impact of Atrial Fibrillation on Outcomes Following TAVR; When to Intervene; Innovations in Transcatheter Valve Technology; Paravalvular Regurgitation; Challenges and Pitfalls of Bicuspid Valves; Tips and Tricks for Valve in Valve, and When to Choose Surgery in the Era of TAVR, among others.

This issue of Cardiac Electrophysiology Clinics, edited by Drs. Pramod Deshmukh and Kenneth A. Ellenbogen, will focus on His Bundle Pacing. Topics include, but are not limited to, Bundle of His - A contemporary reappraisal, Electrophysiology of bundle branch block, Pacing-induced cardiomyopathy, Tricuspid valve dysfunction caused by RV leads, His Bundle Pacing - concept to reality, How to perform HBP - Tools and techniques, Electro-anatomical atlas of HBP (LAO/RAO views & recorded Egms), Hemodynamics of His bundle pacing in comparison Apical & Septal pacing, HBP for cardiac resynchronization, Long-term results of HBP, Getting on the curve - learning HBP, HBP in conjunction with AV node ablation in AF, and Ongoing clinical trials and future developments.

This issue of Interventional Cardiology Clinics, edited by Dr. Apostolos Tzikas, will cover several important elements of Left Atrial Appendage Closure. Articles in this issue include, but are not limited to: Ischemic stroke in atrial fibrillation; History of LAAO; Anatomy of the left atrial appendage, including implications for endocardial and epicardial device closure; Indications, patient selection and referral pathways for LAAO; CT for LAAO; The Watchman device; The Amplatzer Amulet device; and The current device landscape and future perspectives.

Get a quick, expert overview of stroke risks among patients with treated and untreated atrial fibrillation, in addition to best practices for management and treatment of patients with atrial fibrillation to minimize stroke risks. This concise, clinically-focused resource by Dr. Greg Flaker consolidates today's available information on this timely topic into one convenient resource, making it an ideal, easy-to-digest reference for practicing and trainee cardiologists as well as general practitioners treating and monitoring these patients. Covers a broad spectrum of management and treatment options for atrial fibrillation including anticoagulants, surgical and implanted devices. Presents information on recent drug trials to keep you up to date with the latest developments. Includes guidance on anticoagulation in special situations, such as cardioversion and ablation, in addition to atrial fibrillation treatment in patients with other medical conditions including cancer, major bleeding disorders, and renal or liver disease. Chapter on Risk Stratification assists in identifying patients with a high risk of stroke and predicting treatment outcomes. Chapter on The New Anticoagulation Clinic overviews best practices for patient education, compliance, follow-up monitoring, and quality assurance to aid in better patient outcomes.

This issue of Cardiology Clinics, edited by Dr. Stephen Nicholls, focuses on Lipidology. Topics include, but are not limited to: Impact of lipoproteins on atherobiology; Lessons from genomic studies; Lipids and lipoproteins in risk prediction; Optimizing statins and ezetimibe in guideline focused management; Statin intolerance; Lipid lowering agents and diabetes risk; PCSK9 inhibitors; Bempedoic Acid; Triglyceride rich lipoproteins; Omega 3 Fatty Acids; Lipoprotein; CETP inhibitors; HDL infusions; and Targeting HDL functionality.

This issue of Heart Failure Clinics--edited by Drs. Giuseppe Limongelli, Sharlene Day, and Perry Elliott--will cover Clinical and Molecular Aspects of Cardiomyopathies: On the Road from Gene to Therapy. Topics include, but are not limited to, Epidemiology and Clinical aspects of Genetic Cardiomyopathies, Existing and New therapies, Gene editing and gene-based therapeutics, Controversies surrounding exercise in genetic cardiomyopathies, Genetic infiltrative cardiomyopathies, LV Noncompaction, Clinical presentation and natural history of hypertrophic cardiomyopathy in Rasopathies, and Moelcular basis and new treatments of cardiac diseases in Rasopathies.

Coronary Microvascular Obstruction in Acute Myocardial Infarction: From Mechanisms to Treatment provides a comprehensive understanding of the phenomenon of coronary microvascular obstruction (CMVO) that is the main limitation of reperfusion therapies in ST-elevation myocardial infarction. It provides in-depth coverage of the phenomenon of CMVO which heavily affects prognosis by increasing the risk of death and heart failure at follow-up. A first of its kind reference dedicated solely to this topic, it is appropriate for a wide audience, from researchers, to those who aid in the management, prevention and treatment of CMVO.

This issue of Cardiac Electrophysiology Clinics, edited by Drs. Mohammad Shenasa, N. A. Mark Estes III, and Gordon F. Tomaselli, will cover Contemporary Challenges in Sudden Cardiac Death. Topics covered in this issue include Pathophysiology; Basic electrophysiological mechanism; Channelopathy and Myopathy as causes of sudden cardiac death; Public access to defibrillation; Sudden cardiac death in children adolescence; Sudden cardiac death in specific cardiomyopathies; Ventricular arrhythmias and sudden cardiac death; lessons learned from cardiac implantable rhythm devices; future directions, and more.

This volume of Interventional Cardiology Clinics will have two parts. Part I will cover Transcatheter Tricuspid Valve Intervention and be edited by Dr. Azeem Latib. Part II will focus on Interventional Therapy for Pulmonary Embolism, with editorial direction from Dr. Jay Giri. Topics covered in Part I include: Interventional Imaging of the Tricuspid Valve; Percutaneous Tricuspid Annuloplasty; Tricuspid Spacers; Caval valve implantation; and Transcatheter Tricuspid Valve Replacement. Articles in Part II include, but are not limited to: Systemic Thrombolysis for Pulmonary Embolism; Catheter-Based Embolectomy for Acute Pulmonary Embolism; Mechanical Hemodynamic Support for Acute Pulmonary Embolism; Caval Filters: Current and Future Concepts; and Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension.

Get a quick, expert overview of the many key facets of heart failure research with this concise, practical resource by Dr. Longjian Liu. This easy-to-read reference focuses on the incidence, distribution, and possible control of this significant clinical and public health problem which is often associated with higher mortality and morbidity, as well as increased healthcare expenditures. This practical resource brings you up to date with what's new in the field and how it can benefit your patients. Features a wealth of information on epidemiology and research methods related to heart failure. Discusses pathophysiology and risk profile of heart failure, research and design, biostatistical basis of inference in heart failure study, advanced biostatistics and epidemiology applied in heart failure study, and precision medicine and areas of future research. Consolidates today's available information and guidance in this timely area into one convenient resource.

This issue of Cardiac Electrophysiology Clinics--edited by Drs. Amin Al-Ahmad, Raymond Yee, and Mark Link--will focus on Contemporary Issues in Patients with Implantable Devices. Topics include, but are not limited to: Management of Device infections; Device longevity; Inappropriate ICD therapies; ILR for cryptogenic stroke; ICD implantation without DFT testing; S-ICD; Lead extraction; Use of the WCD as a bridge to ICD; Important parameters for ICD selection; Leadless pacemakers; Management of perioperative anticoagulation for device implantation; HIS bundle pacing; Single coil ICD leads; Venous system interventions for device implantation; and Remote monitoring.

Heart Failure in the Child and Young Adult: From Bench to Bedside combines multiple etiologies for pediatric heart failure, including congenital heart disease, cardiomyopathies, infectious diseases and metabolic abnormalities. This comprehensive resource combines research from multiple contributors with current guidelines to bridge the knowledge gap for the recognition and management of heart failure in children. Coverage begins with the basic science of heart failure, then progresses through diagnosis, management, treatment and surgery, finally concluding with advanced special topics, including genetics, self-management and nanomedicine.

This issue of Cardiology Clinics, edited by Dr. Amal Mattu and Dr. John Field, focuses Emergency Cardiology. Topics include, but are not limited to: Evaluation of Chest Pain and Acute Coronary Syndromes; Evolving Electrocardiographic Indications for Emergent Reperfusion; Cardiac biomarkers in emergency care; Non-ST-Segment Elevation Myocardial Infarction; Cardiogenic Shock, Acute Dyspnea and Decompensated Heart Failure; Evolving Strategies for Management of Cardiac Arrest; Multidisciplinary management post-cardiac arrest; Acute Myopericardial Syndromes; Acute Valvular Heart Disease; Ventricular Arrhythmias; Atrial Fibrillation, A New Face of Cardiac Emergencies: HIV-Related Cardiac Disease; Cardiovascular Emergencies in Pregnancy, and Blunt Cardiac Trauma.