This volume is a state-of-the art resource on the recent advances and clinical management of NSAIDs and aspirin. The text provides a thorough overview of NSAIDS and aspirin, reviewing such topics as pharmacology and mechanisms, clinical effects, and the safety and efficacy of these drugs. It also focuses on the effect of the drugs on the cardiovascular system and in the prevention of GI cancer. Practical recommendations for a safe prescription of NSAIDs are also included. Written by experts in the field, NSAIDs and Aspirin: Recent Advances and Implications for Clinical Management is a comprehensive text of great value to gastroenterologists, rheumatologists, cardiologists, oncologists, orthopedists, trauma and internal medicine specialists.

With over 6 million patients affected only in the United States, atrial fibrillation (AF) is a major health problem with profound effects on both the individual patient and society at large. In this issue of Heart Failure Clinics, we have focused on AF and tried to cover the most important and relevant aspects in a comprehensive and contemporary review. A distinguished group of experts and leaders in basic and experimental electrophysiology, epidemiology, clinical pharmacology, interventional clinical electrophysiology, and cardiac surgery contributed state-of-the-art reviews and also shared their insight to the future of AF. Topics include but are not limited to: Risk Factors and Genetics of Atrial Fibrillation; Mechanisms of Atrial Fibrillation: Rotors, Ionic Determinants, and Excitation Frequency; Diagnostic Evaluation and Follow-Up of Patients with Atrial Fibrillation; Catheter Ablation of Atrial Fibrillation; Antithrombotic and Anticoagulant Therapy for Atrial Fibrillation; Postoperative Atrial Fibrillation: Incidence, Mechanisms, and Clinical Correlates; and Novel Upstream Approaches to Prevent Atrial Fibrillation Perpetuation.

This special case-based issue of Cardiac Electrophysiology Clinics features a selection of cases on the following topics: Use of the Surface ECG to Define the Nature of Challenging Arrhythmias; Diagnostic and Prognostic Implications of Surface Recordings from Patients with A-V Block; Supraventricular Tachycardia; Ventricular Tachycardia; Atrial Fibrillation and Flutter; Troubleshooting Device Function; Adult Congenital Cardiac Disease; and Arrhythmias in Patients with Genetic Arrhythmia Syndromes.

This book shares the latest research and practice-oriented findings in medical sciences with a wide audience. It addresses a range of contemporary issues, often unresolved or contentious, across various medical fields, including advances in the management of hemorrhagic brain stroke. It also discusses metastatic renal cell carcinoma - a global scourge with an extremely poor long-term survival prognosis, the course and sequelae of renal cell carcinoma, as well as advances in targeted molecular therapy with sunitinib, a receptor tyrosine kinase inhibitor. Further, it examines the molecular targeting of proliferative signaling of the epidermal growth factor receptor in the first-line treatment of patients with metastatic non-small-cell lung cancer. Other articles cover clearance of toxins in hemodialyzed patients; the search for diagnostic and therapeutic markers in the connective tissue disease scleroderma; obesity linked to inappropriate dietary habit; clinical problems related to the diagnosis of sensitization to fungi and its role in asthma; and reasons for the perilous trend of avoiding basic vaccinations in children. Lastly, the book explores the rapid developments in e-health technologies that increase access to health services, particularly for the elderly. The book is intended for clinical specialists, researchers, and all allied health professionals from various fields.

This issue of Cardiac Electrophysiology Clinics examines Arrhythmias in Cardiomyopathies. Articles include Atrial and Ventricular Arrhythmias in Hypertrophic Cardiomyopathy and Its Variants; Role of Cardiac MRI in Risk Stratification of Hypertrophic Cardiomyopathy; Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy; Exercise-Induced Right Ventricular Cardiomyopathy; Dilated Cardiomyopathy; Sarcoidosis; Amyloidosis; Chagas Disease; Fabry Disease; Left Ventricular Hypertrophy: Ventricular Arrhythmias and SCD; Left Ventricular Non-compaction; Mitochondrial Cardiomyopathy and Related Arrhythmias; Arrhythmias in Viral Myocarditis and Pericarditis Cardiomyopathy; Takotsubo Cardiomyopathy; Post-partum Cardiomyopathy; Arrhythmias in Alcohol- and Drug-Associated Cardiomyopathies; Arrhythmias in Neuromuscular Dystrophies; Cardiomyopathies Related to Anti-cancer Therapy- and Radiation- Induced Heart Disease; Arrhythmias After Myocardial Stem Cell Therapy; and more.

This special issue of Heart Failure Clinics examines heart failure with a truly global perspective, exposing health inequities in the treatment of heart failure.

The latest developments in the field of Cardiac Resynchronization Therapy are featured in this issue of Cardiac Electrophysiology Clinics. The issue includes more than 20 articles in the following areas: heart failure; cost of heart failure; ventricular dissynchrony and resynchronization; assessment of dissynchrony; indication for CRT implantation; implantation technique; measures to improve CRT benefit on AF patients; and many more.

This issue of Cardiology Clinics, edited by Sharmila Dorbala and Piotr Slomka, examines Nuclear Cardiology. Topics include Advances in SPECT Hardware and Software; Advances in PET Hardware and Software; Technical Advances and Clinical Applications of Cardiac PET/MR; Translational Coronary Atherosclerosis Imaging (NaF PET, FDG); Quantitative Nuclear Cardiology Using New Generation Equipment; Myocardial Perfusion Flow Tracers; Translational Molecular Nuclear Cardiology; Radionuclide Imaging in Congestive Heart Failure (Sarcoid, Amyloid, Viability); Clinical Applications of Imaging Myocardial Innervation; Gated Radionuclide Imaging Including Dyssynchrony Assessment; Clinical PET Myocardial Perfusion Imaging Including Flow Quantitation; and Novel Applications of Radionuclide Imaging in Peripheral Vascular Disease.

This issue of Interventional Cardiology Clinics, edited by Allen Jeremias, is devoted to Intravascular Physiology. Dr. Jeremias assembled a group of expert contributors to review the following topics: Evolution of Coronary Physiology - Basic Concepts of FFR and CFR; Concept of "Functional PCI" - The Rational for Physiologic Lesion Assessment for PCI Guidance; Limitations and Pitfalls of FFR and Adenosine-Induced Hyperemia; Evidence for the Use of FFR to Guide Clinical Decision-Making - The Landmark FFR Clinical Trials; Evaluation of Microvascular Disease and Clinical Outcomes; Hyperemic vs. Resting Indices for the Assessment of CAD; FFR for the Evaluation of Tandem and Bifurcations Lesions, Left Main, and Acute Coronary Syndromes; and CT-FFR: Basic Concept and Clinical Implementation.

This book presents techniques necessary to predict cardiac arrhythmias, long before they occur, based on minimal ECG data. The authors describe the key information needed for automated ECG signal processing, including ECG signal pre-processing, feature extraction and classification. The adaptive and novel ECG processing techniques introduced in this book are highly effective and suitable for real-time implementation on ASICs.

Translational Research in Coronary Artery Disease: Pathophysiology to Treatment covers the entire spectrum of basic science, genetics, drug treatment, and interventions for coronary artery disease. With an emphasis on vascular biology, this reference fully explains the fundamental aspects of coronary artery disease pathophysiology. Included are important topics, including endothelial function, endothelial injury, and endothelial repair in various disease states, vascular smooth muscle function and its interaction with the endothelium, and the interrelationship between inflammatory biology and vascular function. By providing this synthesis of current research literature, this reference allows the cardiovascular scientist and practitioner to access everything they need from one source.

The Scientists Guide to Cardiac Metabolism combines the basic concepts of substrate metabolism, regulation, and interaction within the cell and the organism to provide a comprehensive introduction into the basics of cardiac metabolism. This important reference is the perfect tool for newcomers in cardiac metabolism, providing a basic understanding of the metabolic processes and enabling the newcomer to immediately communicate with the expert as substrate/energy metabolism becomes part of projects. The book is written by established experts in the field, bringing together all the concepts of cardiac metabolism, its regulation, and the impact of disease.

This issue of Medical Clinics of North America, Guest Edited by Deborah Wolbrette, MD is devoted to Cardiovascular Disease. Dr. Wolbrette has assembled a group of expert authors to review the following topics: Syncope due to Autonomic Dysfunction: Diagnosis and Management; 2013 Lipid Guidelines; 2014 Guideline for the Management of High Blood Pressure (JNC8); How to Follow Patients with Aortic and Mitral Valve Disease; The New Anticoagulants; Management of Atrial Fibrillation; Indications for Pacemakers, Implantable Defibrillators and Resynchronization Therapy; Current Status of Transcatheter Aortic Valve Replacement (TAVR); Chest Pain Evaluation: When to Order Troponin and Stress Tests/Cost Analysis; Indications for Cardiac MRI; Current Management of Heart Failure: When to Refer to Heart Failure Specialist and When is Hospice the Best Option; and Emerging Role of Digital Technology/Remote Monitoring in the Care of Cardiac Patients.

Controversies in Cardiac Electrophysiology are examined in this issue of Cardiac Electrophysiology Clinics. Difficult cases are presented and esteemed leaders in the field debate the pros and cons of various forms of management and treatment.

Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas - cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool.

Drs. Tewelde and Reynolds have put together an excellent issue on Cardiovascuar Emergencies. Articles include:Pregnancy Related Coronary Artery Disease, Decompensated Cyanotic Heart Disease, Blunt Cardiac Injury, Blunt Cardiac Injury, STEMI Chameleons, Hypertensive Emergency, Troubleshooting the Pacer/ICD, Cardiogenic Shock, Cardiac Arrest, and more!

This issue of Interventional Cardiology Clinics, edited by Sunil V. Rao, is devoted to Transradial Angiography and Intervention. Dr. Rao assembled a group of expert contributors to review the following topics: Diagnostic and Guide Catheter Selection and Manipulation for Radial Approach; Slender Approach and Sheathless Techniques; Transradial Primary PCI; Complications of Transradial Cardiac Catheterization and Management; The Transradial Learning Curve and Volume-Outcome Relationship; Strategies to Traverse the Arm and Chest Vasculature; The Transradial Approach and Antithrombotic Therapy: Rationale and Outcomes; Transradial Peripheral Arterial Procedures; and Radial Artery Access, Hemostasis and Radial Artery Occlusion.

This issue of Cardiac Electrophysiology Clinics examines Frontiers in Non-invasive Cardiac Mapping. Topics include imaging of heart rhythm disorders, experimental validation and modeling of validation, challenges and future directions of inverse problems, phase mapping of cardiac fibrillation, frequency domain analysis, analysis of diagnostic 12-lead electrocardiography and 3D non-invasive mapping, and many more.

This issue of Interventional Cardiology Clinics, edited by Matthew J. Price, is devoted to Intravascular Imaging. Dr. Price assembled a group of expert contributors to review the following topics: IVUS for the assessment of coronary lesion severity and optimization of PCI; IVUS for the diagnosis and treatment of left main coronary artery disease; Fundamentals of OCT: image acquisition and interpretation; Technique and Best Practices for Intracoronary OCT; Assessment and quantitation of stent results by intracoronary OCT; PCI planning and optimization with intracoronary OCT; Advances in Automated Assessment of Intracoronary OCT and Their Clinical Application; Diagnosis and evaluation of stent thrombosis using OCT; Acute and long-term evaluation of bioresorbable scaffolds by OCT; Role of OCT in the diagnosis, evaluation, and management of spontaneous coronary artery dissection; and Neointimal Coverage after Drug-Eluting Stent Implantation: Insights from Optical Coherence Tomography.

Translational Cardiometabolic Genomic Medicine, edited by Dr. Annabelle Rodriguez-Oquendo, is an important resource to postgraduate (medical, dental and graduate) students, postdoctoral fellows, basic scientists, and physician scientists seeking to understand and expand their knowledge base in the field of genomic medicine as it is applied to cardiometabolic diseases. This handbook integrates cutting-edge experimental approaches such as chromatin immunoprecipitation paired end tagging (CHIA-PET), to population studies such as the Multi-Ethnic Study of Atherosclerosis. It encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome to the use of molecular diagnostic testing in predicting increased risk of cardiovascular diseases. Where applicable, this reference also includes chapters related to therapeutic options specifically aligned to molecular targets.

This issue of Cardiology Clinics devoted to syncope, a disorder that is associated with increased mortality. Internationally recognized experts discuss the many causes of syncope, helping the clinician to distinguish life-threatening etiologies from benign ones.

In cardiovascular prevention, there is classically a small number of cardiovascular risk factors to treat, such as hypertension, diabetes, hyperlipidemia and smoking excess, which are widely detected and treated. Recently, it has been widely recognized that new mechanical factors should be detected and treated and involves specifically pulsatile arterial hemodynamic (PAH) parameters such as: arterial stiffness, pulse pressure, and, to a lesser extent, augmentation index and pulse pressure amplification. The pedagogic aspect of this new CV specialty involves 3 principal parts: a. -Basic concepts and pathophysiological mechanisms of PAHb. -Clinical aspects and end-organ damage in PAHc. - Clinical pharmacology and therapeutics of PAH This book represents the first that spans basic science and clinical management of this new CV subspecialty. Much has been learned regarding the management of these patients in recent years and this book presents extensive data on the techniques needed to maximize outcomes.

The term "Translational Research" reflects today's integration of basic research ("bench") findings with the clinical practice of medicine, and in a wider scope the application of results from the individual patient ("bedside") to entire populations for the improvement of public health. This book offers future researchers a stimulus in many aspects of cardiovascular research, so as to promote their interest in future fields of cardiovascular disease, diagnosis and treatment. Introduction to Translational Cardiovascular Research discusses the fundamental and important aspects of the topic. It describes the renin-angiotensin-aldosterone system, the beta adrenergic receptors and the hypothalamic-pituitary-adrenal axis, while covering genetic polymorphisms both generally and specifically as regards the vascular endothelium and the use of microRNAs. As such, this book will be relevant to young physicians, nurses and other scientists engaged in the clinical cardiovascular field who want to added research-oriented dimension to their efforts towards better understanding and practicing of medicine. It also aims to attract young basic researchers who want to develop a better comprehension of the organism as a whole, man or animal, that they are investigating.

The approach to anesthesia in children poses specific challenges such as acute emotional fear and distress, fluid imbalances, greater risks for dangerous upper respiratory infections, and most importantly, dosing requirements. The guest editors on this issue are the leaders in this field and will collect the best contributors to address new research advances in perioperative and postoperative scenarios, as well as offering best practices for common pediatric procedures.