Cardiovascular Diseases: Genetic Susceptibility, Environmental Factors and Their Interaction covers the special heritability characteristics and identifying genetic and environmental contributions to cardiovascular health. This important reference provides an overview of the genetic basis of cardiovascular disease and its risk factors. Included are important topics, ranging from lifestyle choices, risk factors, and exposure, to pollutants and chemicals. Also covered are the influences of Mendelian traits and familial aggregation and the interactions and interrelationships between genetics and environmental factors which, when compared, provide a sound understanding of the interplay between inherited and acquired risk factors. The book provides a much needed reference for this rapidly growing field of study. By combining the latest research within the structured chapters of this reference, a better understanding of genetic and environmental contribution to cardiovascular disease is found, helping to substantiate further investigations in the field and design prevention and treatment strategies.

Endocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart covers the traditional concepts of cardio-endocrinology, the role of the various hormone systems, both in health and disease, therapeutic implications, and other recent advances in the various fields represented. The book explores how cardiac hormones are changed in various cardiac pathologies and the recent success that has been uncovered in their therapeutic use. Additional focus is placed on how the heart responds both physiologically and pathophysiologically to a plethora of circulating hormones, reinforcing the importance of the heart as a target of numerous endocrine systems, such as the brain, renal, and adipose. Significant advances have come from basic, clinical, and translational research from a multiplicity of investigators with diverse backgrounds. The book features over 200 photomicrographs, diagrams of molecular relationships, and tables that complement and support the text. It is aimed at a wide audience, including graduate students and post-doctoral fellows in a wide array of biomedical departments and PhD programs (e.g. Pathology, Physiology, Genetics, Pharmacology, Molecular Biology, and Cell Biology) related to the endocrine and cardiovascular sciences curricula, as well as medical residents in pathology, laboratory medicine, internal medicine, and cardiology.

In this issue of Cardiac Electrophysiology Clinics, guest editors Drs. Kenneth A. Ellenbogen, Pugazhendhi Vijayaraman, and Santosh Padala bring their considerable expertise to the topic of Advances in Physiologic Pacing (such as dual-chamber (DDD and DDDR) and atrium-based pacing (AAI and AAIR) in contrast to ventricle-based pacing (VVI and VVIR). Top experts in the field cover key topics such as what we have learned from computer modeling of hemodynamics and LV pacing; troubleshooting the pacemaker EKG in patients with conduction system pacing; what intracardiac tracings have taught us about LBBB; multisite pacing in CRT; and more. Contains 20 relevant, practice-oriented topics including basic principles of hemodynamics during pacing; pacing optimized by dP/dt; optimization of CRT: Q-LV; programming algorithms for CRT; and more. Provides in-depth clinical reviews on physiologic pacing, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Cardiology Clinics, guest editors Drs. Scott Hummel and Matthew Konerman bring their considerable expertise to the topic of Heart Failure with Preserved Ejection Fraction. Top experts in the field cover key topics such as risk factors for heart failure with preserved ejection fraction (HFpEF); cardiopulmonary stress testing in HFpEF; hemodynamic assessment in HFpEF; the role of multi-modality imaging in the evaluation of HFpEF; and more. Contains 13 relevant, practice-oriented topics including pharmacologic, non-pharmacologic, and device therapy for HFpEF; geriatric domains in patients with HFpEF; pulmonary hypertension in HFpEF; infiltrative, genetic, and other non-standard causes of HFpEF; echocardiography in HFpEF; and more. Provides in-depth clinical reviews on heart failure with preserved ejection fraction, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Regenerative Medicine for Peripheral Artery Disease is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of peripheral arterial disease. This reference includes a general overview of regenerative medicine and covers important vascular topics, including intermittent claudication and critical limb ischemia, with important mechanisms clearly presented in full color images throughout the book. This important reference includes clear and concise information on both human clinical trials, as well as important and pertinent animal studies, and is a must-have reference for researchers and practitioners of peripheral artery disease.

Technological tools and computational techniques have enhanced the healthcare industry. These advancements have led to significant progress in the diagnosis of heart disorders. Electrocardiogram Signal Classification and Machine Learning: Emerging Research and Opportunities is a critical scholarly resource that examines the importance of automatic normalization and classification of electrocardiogram (ECG) signals of heart disorders. Featuring a wide range of topics such as common heart disorders, particle swarm optimization, and benchmarks functions, this publication is geared toward medical professionals, researchers, professionals, and students seeking current and relevant research on the categorization of ECG signals.

The fully revised second edition of the Encyclopedia of Heart Diseases is an ideal resource for practicing clinicians and researchers. Available in print, online, and with dual access, it is a clear and comprehensive aggregation of the most crucial information and essential data on cardiovascular diseases and therapeutics. Comprised of over 95 entries with regular online updates, the Encyclopedia of Heart Diseases is fully referenced, and major points of interests are hyperlinked to complementary sections. Each entry is logically and superbly written, providing accurate core knowledge of pathogenesis, pathophysiology, clinical features, diagnostic techniques, and management strategies. Specific detail is paid to technological advances in imaging and diagnostics. Therapy focused entries give powerful insights into not only prescribing drug regimens, but also into the controversies surrounding their use. This major reference work is invaluable for all those involved in the care of cardiovascular patients. From the front-line practitioner to the basic science researcher to the student in training, the Encyclopedia of Heart Diseases offers an astute authoritative guide to navigating an immense body of fascinating information. From the trainee to the internist and cardiologist, all will find it useful. It is an essential resource for medical libraries and academic institutions worldwide. From the Foreword: So, what would we want from an encyclopedia on heart disease? Ideally, a book would be comprehensive, yet concise, and be practically oriented, and explain pathophysiology and treatment. In addition, it should be accessible online so that it can be accessed at the bedside or anywhere. Dr. Khan has written exactly such a book. Encyclopedia of Heart Diseases is comprehensive, yet concise, and very practically oriented. Importantly, it takes a step-by-step approach, walking the reader through a thorough pathophysiology of conditions, their evaluation and treatment. For therapies, he provides the mechanism of the drug, its doses, side effects and clinical efficacy. ...A terrific online resource with all the information you need! - Christopher P. Cannon, MD, TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

Vascular Responses to Pathogens focuses on the growing research from leaders in the field for both the short and long-term impact of pathogens on the vasculature. It discusses various organisms, including bacteria, parasites, and viruses, and their role in key events leading to vascular disease. Formatted to discuss the topic of the interaction of pathogens with the vascular rather than individual diseases described separately, this reference demonstrates that common mechanisms are at play in many different diseases because they have a similar context, their vasculature. This all-inclusive reference book is a must-have tool for researchers and practicing clinicians in the areas of vascular biology, microvasculature, cardiology, and infectious disease.

Back to Basics in Physiology: O2 and CO2 in the Respiratory and Cardiovascular Systems exploits the gap that exists in current physiology books, tackling specific problems and evaluating their repercussions on systemic physiology. It is part of a group of books that seek to provide a bridge for the basic understanding of science and its direct translation to the clinical setting, with a final aim of helping readers further comprehend the basic science behind clinical observations. The book is interspersed with clinical correlates and key facts, as the authors believe that highlighting direct patient care issues leads to improved understanding and retention. Physiology students, including graduate and undergraduate students, nursing students, physician associate students, and medical students will find this to be a great reference tool as part of an introductory course, or as review material.

Sudden Cardiac Death (SCD) is a sudden, unexpected death caused by loss of heart function (sudden cardiac arrest) and Sudden Cardiac Arrest (SCA) occurs when the electrical system to the heart malfunctions and suddenly becomes very irregular. Death can often be a result if not handled quick enough or effectively. New technologies seek to help with this issue. Data processing is a crucial step to developing prognostic models. Some of the challenges in data processing are non-linear prediction models, a large number of patients and numerous predictors with complicated correlations. In traditional hypothesis-driven statistical analysis it is difficult to overcome these challenges. Current approaches to predict cardiovascular risk fail to identify many people who would benefit from preventive treatment, while others receive unnecessary intervention. So, there is an emergent need of an adaptation of AI technologies such as Machine Learning and Deep Learning Techniques to overcome the challenges. The Machine Learning (ML) approaches have great potential in increasing the accuracy of cardiovascular risk prediction and to avoid unnecessary treatment. The application of ML techniques may have the potential to improve Heart Failure outcomes and management, including cost savings by improving existing diagnostic and treatment support systems. Moreover, ML algorithms can also be applied to predict SCD. Also, Machine Learning offers an opportunity to improve accuracy by exploiting complex interactions between risk factors. The book addresses the impact and power of technology driven approaches for prevention and detection of SCA and SCD. It will provide insights on causes and symptoms of SCA and SCD and evaluate whether AI Technologies can improve the accuracy of cardiovascular risk prediction. It will explore the current issues and future technology driven solutions for SCA and SCD prevention and detection.

In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

In this issue of Heart Failure Clinics, guest editors Drs. Ragavendra R Baliga and George A. Mensah bring their considerable expertise to the topic of Translational Research in Cardio-Oncology. Top experts in the field cover key topics such as radiation-induced cardiac dysfunction; training and career development; cardiovascular imaging; CAR-T cell therapy and cardiovascular disease; and more. Contains 12 relevant, practice-oriented topics including cardio-protection of high-risk individuals; myocardial metabolism; amyloidosis; arrhythmic complications associated with cancer therapies; and more. Provides in-depth clinical reviews on translational research in cardio-oncology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

CVD, or cardiovascular disease, is a general term that describes a disease of the heart or blood vessels. It is one of the most common causes of death. Statins are a group of medicines that can help lower the level of low-density lipoprotein (LDL) cholesterol in the blood. LDL cholesterol of often referred to as 'bad cholesterol', and statins reduce its production in the liver. Having a high level of LDL is potentially dangerous as it can lead to hardening and narrowing of the arteries (NHS). Comprising nearly 1000 pages, this book is a comprehensive guide to the latest advances in statin therapy and its clinical application for cardiovascular disease. Divided into 29 sections, the text begins with clinical aspects of CVD, dyslipidemia (the imbalance of lipids such as cholesterol), and the use of statins for treatment. The next sections provide detailed discussion on the use of statins for different types of CVD, including coronary artery disease, hypertension, heart failure, arrhythmia, stroke, and more. The following chapters cover statin use for other systemic diseases such as obesity, kidney disease, diabetes, ocular disorders, skin conditions and many more. The book concludes with an insight into future therapies, with emphasis on PCSK9 inhibitors, a new treatment for lowering cholesterol in the blood.

In this issue of Medical Clinics of North America, guest editor Dr. Douglas S. Jacoby brings his considerable expertise to the topic of Update in Preventive Cardiology. Top experts in the field cover key topics such as how to manage patients with elevated triglycerides, and when to refer; biomarkers and advanced lipid testing; cardiovascular genetics; noninvasive imaging for the asymptomatic patient; selecting the best oral contraceptives and hormone replacement therapy for women; racial disparities in preventive cardiology; and more. Contains 15 relevant, practice-oriented topics including the heart healthy diet; the most evidence-based exercise strategies for men and women; pre-diabetes, obesity, and pharmacologic interventions to lower cardiovascular risk; who should be evaluated for secondary hypertension; what is the optimal LDL; and more. Provides in-depth clinical reviews on preventive cardiology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.