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Induction and Segregation of the Vertebrate Cranial Placodes (Paperback)
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Induction and Segregation of the Vertebrate Cranial Placodes (Paperback)
Series: Colloquium Series on Developmental Biology
Expected to ship within 10 - 15 working days
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During evolution the vertebrate head has acquired a number of
unique features including specialized paired sense organs and
cranial sensory ganglia. These evolutionary novelties arise from
discrete thickenings of the head ectoderm known as cranial
placodes. They include the adenohypophyseal, olfactory, lens,
trigeminal, profundal, otic, epibranchial and lateral line
placodes. While distinct in the derivatives and cell types they
will form, all cranial placodes originate from a common preplacodal
domain surrounding the anterior neural plate. Recent evidence
suggests that the induction of this pre-placodal domain and its
subsequent subdivision into individual placodes with specific
identities is a multi-step process. Here we describe the
development of these placodes and their derivatives and summarize
recent advances in the characterization of the repertoire of
transcription factors underlying their development. We also review
recent studies that have started to address the role of several
classes of signaling molecules in placode induction and
segregation, including Bone Morphogenetic Proteins, Fibroblast
Growth Factors and Wnt molecules.Table of Contents: Introduction /
Cranial Placodes and Their Derivatives / Molecular Identity of
Cranial Placodes / Induction and Segregation of the Cranial
Placodes / Conclusion / Acknowledgments / References / Author
Biographies
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