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Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics
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Human Epigenomics (Hardcover, 1st ed. 2018)
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Human Epigenomics (Hardcover, 1st ed. 2018)
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The term epigenetics describes regulatory and information storing
mechanisms of specific genes that do not involve any change of
their DNA sequence. Epigenetics is closely related to the
extensively folded state, in which the genome is packaged, known as
chromatin. New genomic tools nowadays allow the genome-wide
assessment of, for example, chromatin states and DNA modifications,
and led to the discovery of unexpected new epigenetic principles,
such as epigenomic memory. This was the start of the field of
epigenomics, the relation of which to human health and disease is
discussed in this textbook. This book aims to summarize, in a
condensed form, the role of epigenomics in defining chromatin
states that are representative of active genes (euchromatin) and
repressed genes (heterochromatin). Moreover, this book discusses
the principles of gene regulation, chromatin stability, genomic
imprinting and the reversibility of DNA methylation and histone
modifications. This information should enable a better
understanding of cell type identities and will provide new
directions for studies of, for example, cellular reprograming, the
response of chromatin to environmental signals and epigenetic
therapies that can improve or restore human health. In order to
facilitate the latter, we favor a high figure-to-text ratio
following the rule "a picture tells more than thousand words". The
content of the book is based on the lecture course "Molecular
Medicine and Genetics" that is given by one of us (C. Carlberg) in
different forms since 2002 at the University of Eastern Finland in
Kuopio. Thematically, this book is located between our textbooks
"Mechanisms of Gene Regulation" (ISBN 978-94-017-7741-4) and
"Nutrigenomics" (ISBN 978-3-319-30415-1), studying of which may
also be interesting to our readers. The book is sub-divided into
three sections and 13 chapters. Following the Introduction (section
A), section B will explain the molecular basis of epigenomics,
while section C will provide examples for the impact of epigenomics
in human health and disease. The lecture course is primarily
designed for Master level students of biomedicine, but is also
frequented by PhD students as well as by students of other
bioscience disciplines. Besides its value as a textbook, Human
Epigenomics will be a useful reference for individuals working in
biomedicine.
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