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Retinal Degenerative Diseases - Mechanisms and Experimental Therapy (Hardcover, 1st ed. 2016)
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Retinal Degenerative Diseases - Mechanisms and Experimental Therapy (Hardcover, 1st ed. 2016)
Series: Advances in Experimental Medicine and Biology, 854
Expected to ship within 12 - 19 working days
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Contains the proceedings of the XVI International Symposium on
Retinal Degeneration (RD2014), to be held July 13-18, 2014 at the
Asilomar Conference Center in Pacific Grove, California. A majority
of those who will speak and present posters at the meeting will
contribute to this volume. The Symposium addresses the blinding
diseases of inherited retinal degenerations, which have no
effective treatments and age-related macular degeneration, which
has no cures, despite the fact that it is an epidemic among the
elderly, with 1 in 3-4 affected by the age of 75. The RD2014
Symposium will focus on the exciting new developments aimed at
understanding these diseases and providing therapies for them. The
volume will present representative state-of-the-art research in
almost all areas of retinal degenerations, ranging from
cytopathologic, physiologic, diagnostic and clinical aspects;
animal models; mechanisms of cell death; molecular genetics; and
developing potential therapeutic measures such as gene therapy and
neuroprotective agents for potential pharmaceutical therapy; and
several sight restoration approaches, including optogenetics. While
advances in these areas of retinal degenerations will be included,
several new topics either were in their infancy or did not exist at
the time of the last RD Symposium, RD2012. These include many new
developments in sight restoration using optogenetics, retinal or
RPE cell transplantation, stem cell approaches and visual
prosthetic devices. In addition, major advances will be presented
in other basic mechanisms in age-related macular degeneration,
several new aspects of gene and antioxidant therapy and
revolutionary new imaging and functional testing that will have a
huge impact on the diagnosis and following the course of retinal
degenerations, as well as to provide new quantitative endpoints for
clinical trials. The retina is an approachable part of the central
nervous system (CNS), and there is a major interest in
neuroprotective and gene therapy for CNS diseases and
neurodegenerations, in general. It should be noted that with
successful and exciting initial clinical trials in neuroprotective
and gene therapy, including the restoration of sight in blind
children, the retinal degeneration therapies are leading the way
towards new therapeutic measures for neurodegenerations of the CNS.
Many of the successes recently reported in these areas of retinal
degeneration sprang from collaborations established at previous RD
Symposia, and many of those will be reported at the RD2014 meeting
and included.
General
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