Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this book the cutting edge research being carried out in this field is compiled and summarized. The book focuses on key areas, including the anatomy and physiology of the eye, biology of ocular transporters and receptors, techniques in characterization of transporters and receptors, transporters and receptors in the anterior and posterior segment in the eye, the role of ocular transporters and receptors in drug delivery, and transporter-metabolism interplay in the eye.
Highly focused on ocular transportersMost up-to-date research compilationDetailed description of role of transporters and receptors in ocular drug discovery and delivery

The book is divided into three sections: The first section covers basic materials (from choice of suture materials to why powdered gloves can cause latex allergy), instruments (such as why scissors are right or left handed) and basic techniques (for example, how to deliberately tie a slip knot and how to avoid doing so accidentally!). The second section covers local anaesthetic agents and techniques. The third section describes the most commonly performed operations and the complications that may be encountered including how to avoid and how to deal with them. There are also chapters that deal with the highly important but often neglected topics of biometry and orbital and lens implant biomaterials and design. Throughout, the scientific basis has been emphasized where possible. Professionals who work with ophthalmic patients such as nursing staff and optometrists will also find a clear description of the commonly performed procedures to be of interest. * an easy-to-use book, rectifying any immediate gaps in surgical knowledge * a highly practical text which covers everything that the ophthalmic trainee needs to know * beautifully illustrated text, covering all the basic procedures from anesthesia to instruments, wounds and their aftercare to the most commonly performed ophthalmic operations

This up-to-date text offers a practical approach to the theory and practice of how spectacle lenses are made and how they work in correcting vision. It also covers the more fundamental aspects of spectacle lens dispensing with relevance to areas such as visual optics and geometric optics.Pitched at the correct level for study - easy to follow for undergraduates Theory is related to practical reality - so students can take the textbook through to the early years of practice Extensive examples enable the reader to follow through calculations - great for revision and quick reference!

This book provides a concise guide to learning the art of refraction and its principles applicable to retinoscopy. It also provides a well-signposted pathway to success in the Royal College of Ophthalmologists' Refraction Certificate Examination.

Ophthalmology residents are faced with learning a highly complex subspecialty; proper training and education are critical to their success. Practical Ophthalmology, A Manual for Beginning Residents helps residents gain confidence and specific knowledge in the early transition to becoming skilled practitioners. This updated edition includes: Thorough coverage of the ophthalmic examination. A comprehensive discussion of ocular emergencies. Common ocular medications. 240 photographs, diagrams and tables. Stepwise instructions for 54 specific examination and testing techniques. 20+ new videos and interactive activities. Practical Ophthalmology, A Manual for Beginning Residents is part of a suite of Academy textbooks for ophthalmology residents and trainees that helps them build a solid foundation of clinical and surgical knowledge. These resources are written and edited by leading residency program directors and are powerful tools for mastering needed skills.

This biography of the eye surgeon Arthur Ferguson MacCallan is an insightful perspective on the life and work of the exceptional medical and ophthalmic pioneer. In 1903, Arthur MacCallan accepted a position in Egypt to establish the country's first travelling ophthalmic hospital, funded by the British philanthropist Sir Ernest Cassel. Over the next two decades, Arthur established an extensive network of over twenty ophthalmic hospitals which attended to over 1.5 million patients and performed over 76,000 operations. He also founded the Memorial Ophthalmic Laboratory at Giza which continues to play a pivotal role in ophthalmic care today. Arthur was a world authority on trachoma, and the MacCallan Classification, developed in 1905, was adopted by the World Health Organisation as its standard in 1952. This is still recognised today as a major contribution in the fight against trachoma. Set against the backdrop of political unrest, world war, and the rapidly changing relationship between Britain and Egypt during the momentous years of the early 1900s, Arthur's grandson Michael tells his fascinating story, brought to life through original letters, documents, colourful anecdotes and 160 photographs. Lord Cromer, British Consul General, Egypt (1883-1907) said "I regard the campaign against ophthalmia as one of the most important and useful works undertaken in Egypt."

Retinal Computation summarizes current progress in defining the computations performed by the retina, also including the synaptic and circuit mechanisms by which they are implemented. Each chapter focuses on a single retinal computation that includes the definition of the computation and its neuroethological purpose, along with the available information on its known and unknown neuronal mechanisms. All chapters contain end-of-chapter questions associated with a landmark paper, as well as programming exercises. This book is written for advanced graduate students, researchers and ophthalmologists interested in vision science or computational neuroscience of sensory systems. While the typical textbook's description of the retina is akin to a biological video camera, the real retina is actually the world's most complex image processing machine. As part of the central nervous system, the retina converts patterns of light at the input into a rich palette of representations at the output. The parallel streams of information in the optic nerve encode features like color, contrast, orientation of edges, and direction of motion. Image processing in the retina is undeniably complex, but as one of the most accessible parts of the central nervous system, the tools to study retinal circuits with unprecedented precision are up to the task. This book provides a practical guide and resource about the current state of the field of retinal computation. Editorial Reviews: "...this book is also a unique overview of our current understanding of the why and the how of retinal computation and there is something here for anyone with a grounding in vision science who recognises that there is more to what the retina does than... meets the eye." -- Prof Steven Dakin, New Zealand Optics, May 28, 2022. "I want to commend Dr. Schwartz for assembling this incredible resource and strongly recommend Retinal Computation to everyone who is a student of vision. The vast majority of modern topics in retina are covered yet in a fashion that is clear, and concise. The book covers the cellular and circuit basis of computations ranging from those covered by most textbooks, such as center-surround receptive field or direction selectivity , to those you probably do not associated with the retina such as "motion anticipation" and "threat detection". Each chapter is self-contained, meaning you can easily "pick and choose" the topics. A quick perusal of the chapter titles are almost certainly going to pique your interest. For example, you may know that the retina has single photon sensitivity but do you know "How many photons does it take to create a percept"? (Chapter 1). How does the retina encode texture (i.e. spatial fluctuations within the receptive field)? (Chapter 7). Is object motion sensitivity related to Direction selectivity? (Chapter 12). The list goes on. This book will also serve as a great resource for those teaching advanced undergraduate or graduate level vision courses for students with backgrounds in experimental or computational vision science. Each chapter contains what Dr. Schwartz's considers a "landmark paper" in the field, with a set of questions that can be used as a guide for reading these papers. And finally he includes programming exercises that can be easily implemented in Matlab to address basic concepts introduced in the chapter. The instructions are detailed so that even those new to Matlab will be able to implement these exercises these straightforward. It is this combination - textbook chapter + primary literature + quantitative exercises that will solidify these concepts. There are many vision science topics not covered in the book. For example, there is little on retinal disease or development. But these limitations are far outweighed by where the book succeeds. The vast majority of the book is written by Dr. Schwartz, giving it a uniformity that is welcome. Despite tackling quite modern questions where there is ongoing progress, Dr.Schwartz has extracted what are key findings that are likely to stand the test of time. And finally, it is really interesting! For those who think that the retina is "solved", think again. Retinal computations is a fantastic way for all circuit neuroscientist to learn how much computations can be achieved with very few synapses." -- Marla B. Feller, Ph. D., Paul Licht Distinguished Professor in Biological Sciences, Division of Neurobiology, Department of Molecular and Cell Biology & Helen Wills Neuroscience Institute University of California, Berkeley "This fantastic new textbook from a rising star in the field clearly and thoroughly updates our picture of what the retina computes. It is detailed enough for senior researchers but also pedagogical, providing a go-to reference for students. The illustrations within the text and for the chapter headings are both beautiful and informative." -- Stephanie E. Palmer, Ph.D., Associate Professor, Department of Organismal Biology and Anatomy, Department of Physics, University of Chicago "This book summarizes the impressive recent progress in understanding how visual computations are performed by retinal circuits. The book is an important resource not only for retinal experts, but more generally for anyone seeking to explain how the brain works at the level of neural circuits. Greg Schwartz and his co-authors have made a major contribution to the field." -- Sebastian Seung, Anthony B. Evnin '62 Professor, Neuroscience Institute and Computer Science Dept., Princeton University "This is a wonderful book from a true expert in the retina field. It is a fantastic resource for researchers, lecturers, and students alike. The book nicely covers the many facets of how the retina processes the visual input that enters the eye. Despite the richness in material, the presentation manages to stay accessible and always connects back to fundamental questions of visual processing. Each chapter by itself is a great entry point into a particular area of how the neural network of the retina deals with a specific set of visual challenges. I have thoroughly enjoyed this wonderful overview of retinal computation, served on a silver platter, and I will use the book both as background material for research and as a resource for teaching. I particularly like the sets of exercises that conclude each chapter." -- Dr. Tim Gollisch, Professor for Sensory Processing in the Retina, Department of Ophthalmology, University Medical Center Goettingen

Glaucoma: A Pancitopatia of the Retina and Beyond, Volume 257, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this volume include the Genetics of glaucoma, Artificial intelligence and deep learning in glaucoma detection and monitoring, The role of commensal microflora-induced T cells responses in glaucoma neurodegeneration, Retinal cell death in experimental glaucoma, Experimental and clinical evidence on the neuroprotective properties of Citicoline in glaucoma, Glaucoma neurodegeneration and myopia, Neuronal regeneration with pluripotent stem cells in glaucoma, and more.

Dry eye is one of the most common ocular diseases. With the wide use of consumer electronics, environmental pollution and aging population, it has been prevalent and has seen a rising trend globally. Symptoms of dry eye affect daily activities and quality of life. This book details and illustrates popular medical science knowledge about dry eye. The cartoonist also shares her own treatment process. Various questions and doubts raised by dry eye patients and the effective therapy and treatment are well explained. The book provides a good resource for readers to acquire in-depth knowledge on causes and hazards brought about by dry eye as well as how to prevent its occurrence.

This book is a practical, patient-centered, clinical approach to assist ophthalmologists and ophthalmology trainees in the early diagnosis and management of walk-in patients presenting with uveitis of unknown etiology. It is symptoms- and signs-oriented and illustrated with many images, such that it may be an easily used reference for deciding on diagnostic tests and treatment options. Written by leading international experts in the field, Uveitis Management serves as a practical tool for daily work in an ophthalmic clinic, helping you through the first steps of investigation, management and treatment decisions for these complex patients, highlighting pitfalls, how to avoid them, and how to manage complications as they occur.

Corneal tomography is a non-invasive medical imaging technique for mapping the surface curvature of the cornea, the outer structure of the eye. This procedure may be carried out with a Pentacam, which uses a rotating camera to create a 3D image of the anterior of the eye. This fourth edition provides the latest developments in corneal tomography using the Pentacam system. Previous edition (9789386261106) published 2018. Beginning with an introduction, the following sections cover corneal maps and profiles, corneal refraction, Wavefront analysis, systematic interpretation of corneal tomography, and corneal tomography in ectatic corneal diseases.

Immediately Sequential Bilateral Cataract Surgery (ISBCS): Global History and Methodology is a comprehensive guide for the safe and efficient performance of ISBCS. It provides an overview of the history, recommended protocols, necessary precautions, exclusion criteria, benefits and risks associated with this procedure, organizational standards, and more. Written by the most prominent ISBCS surgeons in the world, chapters recount the arguments for and against bilateral surgery that have been made throughout the ages, up to the present, and deliver achieved and proposed resolutions to all problems discussed. Topics such as ethics and medico-legal issues surrounding ISBCS are also discussed, and a chapter on the global evolution of bilateral cataract surgery provides readers with a complete overview of the development of ISBCS practices in countries from all continents.

Optical coherence tomography (OCT) is a non-invasive imaging test that uses light waves to take cross-sectional pictures of the retina, the light-sensitive tissue lining the back of the eye (eyeSmart). The technique is recognised worldwide as an essential device for diagnosis, assessment and follow up of retinal diseases and glaucoma. The third edition of this comprehensive manual has been fully revised to provide clinicians and trainees with the most recent advances in OCT imaging. New examination and diagnostic protocols are covered in depth and this edition includes a step by step guide to data interpretation. Divided into three sections, the book begins with discussion on interpretation of OCT images, including 'en face' and dyeless angiography. The second section covers lesions and diseases, and part three explains new syndromes and classifications. Highly illustrated with clinical images and tables, this practical reference has been written by renowned experts based in Italy. Key points Practical guide to recent advances in OCT imaging Fully revised, new edition covers new examination and diagnostic protocols, with step by step guide to data interpretation Internationally recognised, Italy-based author team Previous edition (9789351525318) published in 2014