Numerous studies have pointed to the key role of complement in the pathogenesis of retinal disease, particularly age-related macular degeneration (AMD). Reports about new gene associations and links to other physiological pathways are emerging almost on a weekly base. Several promising clinical candidates covering a wide area of potential treatment applications are in the pipelines of both industrial and academic groups. This indicates an increasing interest in complement as a therapeutic target. In view of these exciting discoveries, scientists from around the world convened at the First Aegean Conferences Conference on Inflammation and Retinal Disease: Complement Biology and Pathology (June 10-17, 2007) in Crete, Greece, to discuss recent advances in this rapidly-evolving field. This volume represents a collection of topics on the functions of complement in eye diseases, pathophysiology, protein structures, and complement therapeutics discussed during the conference. Our sincere thanks to the contributing authors for the time and effort they have devoted to writing what I consider exceptionally informative chapters in a book that will have a significant impact on the complement field. We would also like to express my thanks to Rodanthi Lambris for her assistance in collating the chapters and preparing the documents for publication and I gratefully acknowledge the generous help provided by Dimitrios Lambris in managing the organization of this meeting. Finally, I also thank Andrea Macaluso of Springer Publishers for her supervision in this book's production. John D. Lambris Anthony P.

This edited book focuses on the recent advances in our understanding of age-related macular degeneration (AMD), combining epidemiology and clinical diagnosis, with genetics and immunological aspects as well as the role of proteostasis and mitochondria before diving into new therapies including stem cell based approaches. AMD is a leading cause of largely incurable blindness worldwide and projected to double from 2.07 million to 5.44 million individuals by 2050 in the United States. Globally, 288 million individuals are projected to have AMD by 2040. The disease has enormous socioeconomic impact on the affected individuals, their families and the society. This book will bring together the state of the art basic science knowledge with clinically relevant findings and address the challenges for future research in AMD. The intersection of different disciplines will provide potential areas for further investigations to reduce the burden of blindness from AMD. This book offers an appealing and insightful resource for clinicians, scientists, students and fellows.

A compilation of selected papers, posters and lectures presented at the 29th meeting of the European Strabismological Association in Izmir, Turkey, June 2004, outlining the latest developments in the fields of eye surgery, vision screening, ophthalmology and related disciplines. The highlight of this meeting was the special lecture given by Gunter von Noorden, "History of Strabismology," included here in full.

The meeting also covered a number of important problems associated with strabismology, including ambyopia, botulinum toxin, Browna (TM)s syndrome and congenital fibrosis syndrome. In addition, new methods and techniques are outlined, giving a complete overview of the hot topics in strabismology for strabismologists, pediatric opthalmologists and orthoptists.

The Essentials in Ophthalmology series represents readership acceptance of the first two series, each of an unique updating publication on the progress in all eight volumes. This is a success that was made p- subspecialties of ophthalmology. sible predominantly by the numerous opinion-leading In a quarterly rhythm, eight issues are published authors and the outstanding section editors, as well as covering clinically relevant achievements in the whole with the constructive support of the publisher. There field of ophthalmology. This timely transfer of advance- are many good reasons to continue and still improve ments for the best possible care of our eye patients has the dissemination of this didactic and clinically r- proven to be effective. The initial working hypothesis of evant information. providing new knowledge immediately following p- lication in the peer-reviewed journal and not waiting G.K. Krieglstein for the textbook appears to be highly workable. R.N. Weinreb We are now entering the third cycle of the Essentials Series Editors in Ophthalmology series, having been encouraged by September 2008 Preface We are pleased to share with our readers this Third uncorrected and, in one instance, corrected vision. Edition of Cataract and Refractive Surgery, less than Topics in corneal refractive surgery include disc- three years from publication of the Second Edition. sion of the management of higher order aberrations The dramatic pace of change in cataract and refractive and corneal procedures for treating presbyopia.

Endophthalmitis: Diagnosis and Treatment covers every aspect of this serious disease, beginning with inflammation and immunology. The causes of postoperative, post-traumatic and endogenous endophthalmitis are discussed in detail and therapeutic options for the various types of the condition are suggested. Particular emphasis is given to the prevention, accurate diagnosis and management of endophthalmitis as these are vital to the preservation of vision. A comprehensive resource for the ophthalmologist.

Glaucoma is one of the leading causes of blindness worldwide. Robust screening alongside early diagnosis and prompt management is essential for preserving vision. Advanced ophthalmic nurse practitioners, optometrists and orthoptists are increasingly becoming part of a multi-disciplinary team approach that is designed to provide the best outcomes for our patients.This full-colour book has been written by experienced ophthalmologists and optometrists, and details all that a practitioner needs to know about the condition. It will also serve as a useful reference for junior ophthalmic trainees and medical students.

Hyperopia and Presbyopia offers at-hand guidance on recent technologies such as thermal or conductive keratoplasty, corneal implants, laser scleral relaxation, scleral expansion rings, intraocular lenses, and LASIK modifications. Features developmental trials, clinical results, and troubleshooting strategies. Delving into current, established, and emerging treatments for the correction of hyperopia and presbyopia, this reference offers at-hand guidance on recent technologies such as thermal or conductive keratoplasty, corneal implants, laser scleral relaxation, scleral expansion rings, intraocular lenses, and LASIK modifications.

Extensively revised and updated, this second edition compares conventional and innovative drug delivery systems. The book covers significant ophthalmic advances and breakthroughs in gene therapy, ocular microdialysis, vitreous drug disposition modelling, and receptor/transporter targeted drug delivery. It examines procedures in pharmacokinetic/pharmacodynamic modeling for the determination of appropriate dosing regimens, covers new developments in animal modeling, and discusses current regulations governing patenting, commercial product release, and human testing. This in-depth reference lays the groundwork for overcoming constraints on the delivery of ophthalmic drugs.

Minimize postoperative complications Emphasizes the latest tools and step-by-step procedures to increase the safety, predictability, and long-term stability of LASIK procedures LASIK discusses in-depth preoperative patient evaluation, preparation, and selection the use of computerized videokeratography and wavefront technology for appropriate preoperative assessment and postoperative evaluation surgical strategies and techniques LASIK is a timely and authoritative source for refractive, corneal, and cataract surgeons; ophthalmologists; optometrists; ophthalmic surgeons; and upper-level undergraduate, graduate, and medical students in these disciplines.

The development of ophthalmology to its present level of sophisticated practice is an extraordinary story of research, experiment, and achievement. Dates in Ophthalmology: A Chronological Record of Progress in Ophthalmology over the Last Millennium charts the progress of that achievement over the last millennium, highlighting and describing the key dates of advancement. It presents a concise listing of the chief personages, periods, publications, and events in the history of ophthalmology from ancient times to the present.

The book demonstrates how ideas, discoveries, and technologies cross borders and oceans. It illustrates the interplay of subspecialties, the changing pre-eminence of countries and cities, and the explosions of creativity and generations of dormancy in various areas. The author highlights the numerous and diverse events and people responsible for shaping this specialty.

There are many ways of looking at history: from the standpoint of the lives of major figures, of society and impact, of subspecialties, of countries, of institutions, and of books. By presenting its information chronologically, Dates in Ophthalmology explores the how these areas intersect, influence, and impact each other.

The aim of eye muscle surgery is to restore alignment of the visual axes and ocular stability. Albeit compensatory and largely empirical, this surgery can be perfected with a better understanding of the physiopathological mechanisms involved, more detailed semiological analysis, the taking into account of intraoperative data and the use of microsurgical technique. The three parts of this book allow each of these factors to be discussed at length.

Ophthalmic practices have many types of leaders, functioning at all levels of the organization.  Ophthalmic Leadership: A Practical Guide for Physicians, Administrators, and Teams, Second Edition can provide each of these leaders with the tools to be more decisive, motivating, and effective.   John B. Pinto, America’s most published author on the business of ophthalmology, has firsthand experience with the best and worst practice leadership habits from his decades of experience as an ophthalmic practice consultant. He has coached countless physician and lay leaders to the next level of their careers. Together with his team of more than 20 expert contributors, Pinto covers every aspect of leadership in ophthalmology, no matter the size of the practice or the current experience of the team. Chapters include: •    What Do You Believe in? Developing a List of Core Values for Your Practice •    Grooming and Moving Line Staff Up to Middle Management •    Contingency Planning in a Less-Certain Environment •    Leading Your Team Past the Inevitable Conflicts of Practice Life Everyone in ophthalmology can benefit from the lessons inside Ophthalmic Leadership: A Practical Guide for Physicians, Administrators, and Teams, Second Edition—from the rising ophthalmic technician or department manager, to the managing partner, and even the most seasoned practice administrator. “The book you now hold is a wonderful opportunity to rededicate yourself to your professional development as a leader and to the success of your organization.�  From the Foreword by Richard L. Lindstrom, MD

This book reviews the current state of ocular drug therapy and future therapeutic opportunities for a wide variety of conditions, including Age-related Macular Degeneration, Diabetic Retinopathy and Macular Edema, Glaucoma, and Inherited Retinal Diseases. Retinal diseases are major contributors to moderate or severe vision impairment in adults aged 50 years and older. The respective patient populations for many of these indications is expected to significantly increase as the world population continues to grow older. An improved understanding of the etiological underpinnings of ocular degenerative diseases over the past decade has significantly bolstered ophthalmic drug discovery. In this volume, contributions from leading experts explore the unique challenges faced for ocular drug discovery and delivery providing the reader with detailed information on ocular pharmacokinetics, in vitro, ex vivo and in vivo models for retinal disease pathology and emerging gene therapy treatments. The book is intended for all researchers and clinicians who wish to increase their knowledge on the latest findings in ocular drug therapy.

The first reference of its kind, "An Evidence Base for Ophthalmic Nursing Practice" alleviates the need for every ophthalmic practice area to develop diverse, often contradictory, guidelines. This book informs guidelines and protocols and provides up to date, evidence based information, covering: condition management (lice infestation, conjunctivitis, recurrent corneal erosion, removing foreign bodies, chalazion, pain management, acute glaucoma); techniques (padding, taking eye swabs, irrigation, administering eye drops, keratometry); and other topics, including papillary dilation, standards for driving, screening, topical anaesthesia and the eye, and prescribing.

This book presents new and noteworthy research into retinal diseases.

It focuses on what we currently know about the environment, genetics and mechanisms that lead to retinal degenerations, new diagnostics, and innovative therapeutic modalities to preserve vision. Written by renowned scientific investigators, this innovative collection of treatment strategies and technological discoveries allows for the realistic translation of research into practice.

"Visual Prosthetics" provides an in-depth analysis of the principles of operation, current state, anticipated developments, and functional aspects of visual prosthetics restoring sight to visually impaired individuals. This volume uniquely describes the human visual system in health and disease in a pedagogical and didactic manner, fitting to professionals and researchers with a bioengineering background. Readers will find a balanced overview of electrical, molecular chemical and synthetic chromophore stimulation, in addition to the biophysics and psychological aspects of vision restoration. Unlike competitive texts, this introduction also includes the need and methods for functional evaluation and rehabilitation.

Professionals in the field of biomedical engineering and graduate and postgraduate researchers will find "Visual Prosthetics" a valuable reference.

Filling the need for a succinct, up-to-date guide in the management of sight-threatening disorders, this source provides a clear and practical approach to the treatment and analysis of posterior segment intraocular inflammatory conditions. Practical Manual of Intraocular Inflammation includes: full coverage of diagnosis, clinical assessment, and management of symptoms descriptions of external inflammatory conditions, as well as uveitis full-color algorithms, scientific charts, schematic illustrations, and clinical photographs With over 60 color images, ophthalmologists, optometrists, and primary care physicians will find this source well-illustrated and documented, making this reference indispensable to any eye and vision practice.

Using a clinically oriented framework, this reference describes the basic aspects of eye movement control as well as clinical implications and practical use. Covers basic eye movement systems and eye movement recording systems along with listings of the various types, costs and characteristics of each. Extensive use of graphics, case studies and original eye movement recordings makes it an easy-to-use resource.

"Molecular Genetics of Inherited Eye Disorders" provides an authoritative and up-to-date account of molecular genetic advances in a wide spectrum of genetic eye disorders, and forms the second volume in the Modern Genetics book series. The field has produced some dramatic and often unexpected findings in recent years ranging from the elegant unravelling of the molecular basis of colour vision defects to the subtle complexity of the retinoblastoma gene. The role of crystallins in congenital cataract and of the rhodopsin molecule in retinitis pigmentosa are discussed, illustrating the importance of the "candidate gene" approach to genetic eye disease. "Reverse genetic" approaches to the cloning of genes responsible for aniridia and choroideremia exemplify the power of the new genetic techniques and signal the start of the next experimental phase, in which the functional characterization of identified genes begins. Sections on albinism, retinitis pigmentosa and collagen disorders deal w

The classic reference text for surgeons and managers alike that has been improving ophthalmic practices for decades, John Pinto's Little Green Book of Ophthalmology: Strategies, Tips, and Pearls to Help You Grow and Manage a Practice of Distinction, Sixth Edition, has been updated into a new edition. Author John B. Pinto, a world-renowned expert on the business of ophthalmic practice, has brought his decades of expertise to bear in this comprehensive guide to practice management. Inside, Pinto covers everything from the basics of business planning to esoteric and complex topics unique to ophthalmology. Topics include: Strategic business planning Leadership, governance, and discipline Finance, accounting, and patient accounts management Staff evaluation, training, and supervision Marketing and development Managing physicians Operations enhancement Facility design and management Improving an optical dispensary This Sixth Edition features updates and edits throughout the book as well as 9 new appendices covering the latest trends and advice in ophthalmic administration. It is also designed in a flexible format, allowing readers to read it straight through, or just hunt down advice on the focused problems facing their practice. As the business of ophthalmology continues to change, the proven guidance of John Pinto's Little Green Book of Ophthalmology, Sixth Edition, will help any practice adapt and thrive.