The Theory of Binocular Vision is a book about neurological control theory. In this sense it was far ahead of its time, for the formal development of control theory was many decades in the future when this book appeared in 1868. Hering's principal concept is that the control of eye movements is greatly simplified if there is only one neurological control system commanding the 'double-eye' as a single organ. This idea leads directly to the first thorough exposition of what is now known as Hering's law, that the corresponding muscles of the two eyes are always equally innervated. As Hering eloquently states it, "one and the same impulse of will directs both eyes simultaneously as one can direct a pair of horses with single reins" (Ch. 2). The 19th Century The book was written during an exciting era for physiological research. Before the mid-19th century the study of physiology had been limited to isolated efforts by great men who worked largely without colleagues or organized laboratories. Now for the first time of inquiry, with many sensory physiology was becoming a living field groups working simultaneously on fundamental problems. Like the classical Greeks before them in philosophy, the physiologists of the 19th century were defining in a burst of creative energy the problems 1 2 Introduction which would shape subsequent inquiry; and like the Greeks, they produced a splendid period of science.

The proceedings of this symposium on Medical Therapy in Glaucoma are divided in four major parts. The pharmacological introduction gives the reader a short description of factors that are involved between administration of the drug and its action at the desired position in the eye. The new and exciting field of drug delivery systems will be dealt with in this part and part II. Originally we had asked Ken Richardson to give part of the lectures on Membrane technology and basic aspects of cholinergic action. Unfortu nately at the last moment he could not come. Our thanks go to Gavin Paterson and Klaus Heilmann who were willing to take over a part of his job. Part II on cholinergic action offers next to the well-known drugs infor mation about Ocusert. Part III covers the new developments in the adrenergic field, including guanethidine and atenolol. The clinical aspects of medical therapy in glaucoma are covered by Part IV. Many subjects could not be handled. We left out the systemic treatment of glaucoma (diamox, mannitol etc.). We left out all special cases and prob lem cases. Some questions could be answered during the round table discus sion, most remained unanswered. It is clear that there is enough subject-mat ter and interest for another symposium on therapy of glaucoma."

Dominant exudative vitreoretinopathy (DEVR) is an eye disease which has only recently received wider attention. In 1969 Criswick and Schepens used the designation "familial exudative vitreoretinopathy" to describe a syndrome they observed in six patients belonging to two families. The condition was characterized by several symptoms involving the vitreous and retina, e. g. "posterior vitreous detachment, organized vitreous membranes, heterotopia of the macula, retinal neovascularizations, subretinal and intraretinal exudates, and localized retinal detachment". The clinical features impressed the authors as strongly reminiscent of retrolental fibroplasia, but none of the patients had a record of premature birth or postnatal oxygen administration. In 1971 Cow and Oliver described the same syndrome in several members of one family. They considered their findings to be compatible with auto- somal dominant transmission. Canny and Oliver (I976) were the first to de- monstrate the fluorescein-angiographic changes of DEVR in four members of the abovementioned family. The most striking finding was "abrupt cessation of the capillary network in a scaloped edge near the equator". Fluorescein was seen to leak from the retinal vessels localized in this marginal zone, and in some eyes from massive fibrovascular lesions as well. Similar fluorescein- angiographic changes have been described in recent years in other reports on families with DEVR (Nijhuis et aI. , 1979; Slusher and Hutton, 1979; Dudgeon, 1979; Ober et a1. , 1980; Laqua, 1980). In 1979 I commenced a clinical study of this still little-known condition at the Nijmegen University Institute of Ophthalmology (The Netherlands).

This text was designed for the physicians, nurses, technical personnel, and staff members of medical facilities using lasers for surgical, therapeutic, and diagnostic purposes. The objective is to provide an understanding of the potential health and safety hazards associated with the use of medical laser systems and the precautions needed to use them safely. To do this, it is necessary to have an awareness of applicable standargs and regula tions that apply to laser use. This book is not intended as a substitute for the American National Standards Institute (ANSI) Z-136. 3, "Safe Use of Lasers in Health Care Facilities," but to facilitate its implementation as well as the implementation of the many other related regulations and guidelines that are pertinent. These other regulations include the Medical Device Amendments to the Food and Drug Act, the Federal Laser Product Performance Standards issued under the Radiation Control for Health and Safety Act, and applicable regulations of the Occupational Safety and Health Administration (OSHA). The text is organized to provide first an overview of laser hazards, laser surgical applications, and laser biological effects. General safety control measures and safety standards are then presented. Because laser tech nology is rapidly evolving, these general guidelines will allow safe use of new laser systems as they become available. Finally, specific safety guide lines and precautions are provided for specialized laser applications in the different health care specialties."

The need to study the corneal complications of measles was not very obvious. Everyone knew of the (kerato) conjunctivitis of measles and considered it to be an innocuous feature of the disease. Every medical worker in developing countries knew that measles in under- or malnourished children runs a very serious course leading to, e. g., corneal The latter are seen frequently that medical workers in complications. developing countries are in the habit of speaking of post-measles blind ness. The aspect of the cornea in post-measles blindness is reminiscent of the keratomalacia in vitamine A deficiency and kwashiorkor. It was suggested that in measles the last reserves of vitamine A are exhausted, thereby precipitating the keratomalacia. The virological origin of measles keratitis has been more or less neglected in literature up till now. This study provides clinical and laboratory data concerning the kerato conjunctivitis of measles, gathered from a number of hospitalized children in a rural area of Kenya. The merits of this monograph is that it gives a careful description of the clinical course of measles keratoconjunctivitis and that it emphasizes the role of the virus-infection in addition to protein deficiency and vitamine A-deficiency in the etiology of post-measles blind ness. The possible roles of exposure in semi-comatose patients and of the application of traditional autochthone medicine are mentioned. Measles is no longer seen in developed countries but will still be encountered in the developing countries."

This volume contains chapters derived from a N. A. T. O. Advanced Study Institute held in June 1983. As the director of this A. S. I. it was my hope that some of the e1ectrophysiologists could express the potentialities of their work for perceptual theory, and that some perceptionists could speculate on the underlying "units" of perception in a way that would engage the imagination of physio logists. The reader will have to be the judge of whether this was achieved, or whether such a psychophysiological inter1ingua is still overly idealistic. It is clear that after the revolution prec pitated by Hube1 and Weisel in understanding of visual cortical neurons we still have only a foggy idea of the behavioral output of any particular species of cortical detector. It was therefore particularly unfortunate that two persons who have made great strides in correlating interesting facets of cat cortical physio logy with human psychophysics (Max Cynader and Martin Regan of Dalhousie University) were unable to attend this meeting. Never theless, a number of new and challenging ideas regarding both spatial perception and cortical mechanisms are represented in this volume, and it is hoped that the reader will remember not only the individual demonstrations but the critical questions posed by the apposition of the two different collections of experimental facts. David Ingle April 1984 VII TABLE OF CONTENTS PREFACE V D. N. Lee and D. S. Young Visual Timing of Interceptive Action 1 J. J."

Colour Vision Deficiences VIII brings together information on the latest trends in the following areas of research: -Visual effects of intense lights; -Effects of intoxications on colour vision; -Ageing and vision; -Methods of examination; -Congenital defects; -Acquired defects; -Practical aspects; -Physiological bases.
This volume is a natural follow-up on Volumes VI and VII published in 1981 and 1983 respectively by Dr. W. Junk Publishers.

Over the more than three decades of my life as a physician, I have been constantly amazed at how subtle and elegant nature is as a teacher. Our questions to her, though, must be clear and unambiguous. Otherwise, the answers we receive are likely to be misleading and confusing. As I have matured as a clinician, I have tried to improve my questions to increase my chances of receiving an answer. For the past decade, I have been pondering the subject of strabismus with which I have busied myself for practically two and one-half decades. I began to realize that my time, my share of wisdom, my abilities to carry out the prodigious work necessary to create a book out of nothing but thought, reading, and reflection on the work of others, as well as my own experience, were perhaps becoming limited. I do not doubt that they will become even more limited Thus I have been led to write this book. Further, I am left in greater awe of prolific writers, particu larly those who write with the precision and attention to detail necessary for a medical text. Let me warn the reader at the outset that my approach in this book is "teleologi cal. " I am well aware of the conflict between science's notion of causality as only local and instrumental as opposed to the anthropomorphic notion of purpose or design in nature implied by the choice of this teleology."

Corneal Topography is designed to provide complete, practical coverage of a new field for both the general ophthalmologist and the subspecialist in the area of corneal disease. The volume explores the history of corneal topography and comprehensively demonstrates the usefulness of all forms of current instrumentation in clinical and ivestigative work striving toward improved surgical intervention in the cornea

Part of the Oxford American Ophthamology Library, this book provides clear and detailed guidelines on the diagnosis and treatment of glaucoma. Coverage spans the entire spectrum of glaucoma, including descriptions of traditional and newly emerging modalities available for glaucoma diagnosis and management. Chapters discuss current imaging technology for glaucoma diagnosis and monitoring, providing practical tips using case examples. Management is also thoroughly addressed, from the treatment of primary open angle glaucoma to management of complex secondary glaucoma. Evidence-based management of glaucoma in different stages of the disease is also discussed with highlights of the multicenter glaucoma clinical trials.

The eye has fascinated scientists from the earliest days of biological in vestigation. The diversity of its parts and the precision of their interaction make it a favorite model system for a variety of developmental studies. The eye is a particularly valuable experimental system not only because its tissues provide examples of fundamental processes, but also because it is a prominent and easily accessible structure at very early embryonic ages. In order to provide an open forum for investigators working on all aspects of ocular development, a series of symposia on ocular and visual devel opment was initiated in 1973. A major objective of the symposia has been to foster communication between the basic research worker and the clinical It is our feeling that much can be learned on both sides from community. this interaction. The idea for an informal meeting allowing maximum ex change of ideas originated with Dr. Leon Candeub, who supplied the nec essary driving force that made the series a reality. Each symposium has on a different aspect of ocular development. Speakers have concentrated been selected to approach related topics from different perspectives."

The eye can become involved in immune-mediated diseases that affect it alone or as part of a multi-organ disease process. Much immunological attention has been focused on other organs affected by these processes and the subject of the immunology of eye diseases is a relatively new one. Many of these diseases that involve the eye are not life-threatening but can result in devastat ing loss of sight that if bilateral, will have major effects on the patient's life. Systemic immunological investigations are generally unhelpful in these patients and one of the major problems in this field has been the lack of diseased tissue available for examination to determine the pathological processes involved. Our poor understanding of basic mechanisms of disease in the eye has meant that treatment of many of these conditions is often inadequate. It has become possible to apply in the eye many ofthe techniques used to investigate the role of the immune system in other systems. Animal models of many of the disease processes have also allowed dissection of the immune response both within and outside the eye. It is my belief that a greater understanding of the mechanisms by which the structures in the eye become damaged will allow more specific and effective therapeutic strategies to be devised."

This report for the Belgian Ophthalmological Society concerns a number of fundus diseases, which most ophthalmologists only rarely encounter. Still it is of importance that they should be able to recognize them, not only because most of these eye diseases are treatable when they are diagnosed early enough, but also because they are sometimes associated with major visceral and neurological problems. The ophthalmologist may be the first practitioner to suspect a von Hippel-Lindau's disease or a neurofibromatosis. He should realize at that moment that his role is not only to treat the eyes but also to advise his patient, refer him to other specialists and consider the genetical implications of his diagnosis. Clinicopathologic correlations are of great importance and we felt that it was necessary to emphasize the histopathological aspect of these diseases. A report has to overview the literature on a specific topic. The literature on vascular tumors of the fundus is extremely vast and even if we tried to be as complete as possible, we must confess that we did not cite every author who published on such cases. A third aspect, which was considered as important, was to provide sufficient clinical and histopathologic examples of the various disease, which are reviewed. We are indebted to a large number of friends who kindly authorized the publication of their material. In particular we wish thank Prof. A. Brini (Strasbourg), Dr. D. de Wolff-Rouendaal (Leiden), Prof. P.

Amaurosis fugax, or "fleeting blindness," has been known as a clinical entity for hundreds of years (1). Since 1859, we also have understood that the phenomenon frequently is related to atheroembolic disease and that it is considered a classic manifestation of ocular transient ischemic attacks and a potential precursor to stroke. However, many questions about this syndrome have remained unanswered until quite recently, when a great deal of new information and thought has been directed to the subject. Transient monocular blindness (TMB) is only one manifestation of a complicated syndrome of ocular, systemic, and cerebral diseases that may include some degree of monocular blindness. The duration of blindness varies from very brief (seconds) to complete and permanent. The per manent type is referred to as ocular infarction or ocular stroke. Retinal infarction is the most severe degree of monocular blindness and usually is due to embolic occlusion of the central retinal artery or one of its branches. Varying types of arterial emboli have been described, including thrombus, cholesterol, platelets, and fibrin.

Curbside Consultation in Cataract Surgery: 49 Clinical Questions has been updated into a Second Edition! The Second Edition contains new questions and is completely updated! Curbside Consultation in Cataract Surgery, Second Edition contains new questions and brief, practical, and evidence-based answers to the most frequently asked questions that are posed during a "curbside consultation" between surgical colleagues. Dr. Terry Kim and associate editors Drs. Derek Delmonte and Preeya Gupta have assembled 49 of the top cataract consultants from the U.S. and abroad to offer expert advice, preferences, and opinions on tough clinical questions commonly associated with cataract surgery in this updated reference. The unique Q&A format provides quick access to current information related to cataract surgery in the simplicity of a conversation between two colleagues. Numerous images, diagrams, and references are included to enhance the text and to illustrate surgical pearls. Some of the questions that are answered inside the Second Edition include: My patient has unreliable topography due to ocular surface pathology. What are my options for treatment and IOL selection? How do I pick the right IOL formula for my patient with a longer/shorter than average eye? My capsulorhexis is heading out peripherally. How should I proceed and what should I do if it tears radially? How/when should I change my phaco/fluidics settings in the following situations: IFIS, shallow chamber, high axial length, post vitrectomy? I have a radial tear in the anterior capsule. How do I proceed with phaco and IOL implantation? When should I use a toric intraocular lens versus astigmatic keratotomy/LRI? How do I incorporate femtosecond (FS) laser into my current cataract surgery techniques? Curbside Consultation in Cataract Surgery: 49 Clinical Questions, Second Edition provides information basic enough for residents while also incorporating expert pearls that even experienced cataract surgeons will appreciate. General ophthalmologists, residents, and cataract specialists alike will benefit from the user-friendly and casual format as well as the expert advice contained within.

Nitric oxide (NO) is a simple gas with free radical properties. No one would have imagined a role for such a simple substance in the human body. In 1998, R. E Furchgott, E Murad, and L. J. Ignarro received the Nobel prize for their work on NO. Interestingly, Alfred B. Nobel, who invented dynamite by combining nitro glycerin with other substances, took nitroglycerin for his chest pain without realizing that NO mediates its action. Now, in addition to its vasodilating action, NO is known to possess many fundamental functions that include neurotrans mission, blood pressure control, blood clotting, and immune responses. These diverse functions, conversely, imply that the simple NO molecule may unite neuroscience, physiology, and immunology and may change our understanding of how cells communicate and defend themselves. In this context, the Inter national Symposium, Nitric Oxide and Free Radicals, was organized to address current thinking about the widespread distribution and variety of functions of NO in the eye. The symposium was held in Kyoto, Japan, September 28-29 as a Satellite Symposium of the XII International Congress of Eye Research, 1996. The Symposium was the first international gathering of leading scientists and ophthalmologists meeting to present and discuss their most recent results in a specialized area of research, specifically concerning the eye.

Researchers in recent decades have elucidated signal transduction in the retina and the function of the visual cortex. The highly flexible nature of neural circuits in the visual cortex especially during the critical period has been an interesting subject for studying neural plasticity and development. Recent advances in the visual neurosciences of the vertebrate retina and the visual cortex were discussed during the 12th Keio International Symposium for Life Science and Medicine, meeting jointly with Vision Forum 2002. Contributions to the symposium collected in this volume reflect the convergence of physiological, cell biological, molecular, mathematical, and clinical approaches. The book covers topics ranging from phototransduction to visual information processing in the primary visual cortex, and includes clinical studies on hereditary night blindness, creating a valuable source of information for researchers and clinicians in the visual neurosciences.

During the past decade a significant international research effort has been directed towards understanding the composition and regulation of the preocular tear film. This effort has been motivated by the recognition that the tear film plays an essential role in maintaining corneal and conjunctival integrity, protecting against microbial challenge and preserving visual acuity. In addition, research has been stimulated by the knowledge that alteration or deficiency of the tear film, which occurs in countless individuals throughout the world, may lead to desiccation of the ocular surface, ulceration and perforation of the cornea, an increased incidence of infectious disease, and potentially, pronounced visual disability and blindness. 7 To promote further progress in this field of vision research, the International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance was held in the Southampton Princess Resort in Bermuda from November 14 to 17, 1992. This meeting was designed to assess critically the current knowledge and 'state of the art' research on the structure and function of lacrimal tissue and tears in both health and disease. The goal of this conference was to provide an international exchange of information that would be of value to basic scientists involved in eye research, to physicians in the ophthalmological community, and to pharmaceutical companies with an interest in the treatment of lacrimal gland, tear film or ocular surface disorders (e. g. Sjogren's syndrome).

The macular carotenoids play key roles in eye health and retinal disease. Age-related macular degeneration (AMD), the most common cause of acquired blindness in much of the world, is associated with low levels of macular pigment. Macular pigment is also essential for enhancing visual performance by reducing glare disability and improving photostress recovery. Carotenoids and Retinal Disease presents an up-to-date, thorough volume devoted to the chemistry, pathobiology, visual science, and medical and public health significance of the macular carotenoids. With contributions from an international group of leading experts, this book covers a range of topics, from macular anatomy to clinical trials. It begins with a chapter tracing the discovery of macular pigment through the more recent functional recognition of carotenoids. The text covers AMD risk factors, epidemiology, pathogenesis, and classifications. It reviews evidence from epidemiological studies of relationships between AMD and the carotenoids lutein, zeaxanthin, and meso-zeaxanthin, as well as evidence from clinical trials on the effects of macular carotenoid supplementation in subjects with AMD and normal subjects. The book explores the use of molecular genetics in studying macular pigment and AMD pathogenesis; bioavailability of macular pigment; functions of lutein, zeaxanthin, and meso-zeaxanthin; and the identification of macular carotenoid binding proteins involved in pigment uptake and transport. It also covers xanthophyll-membrane interactions, and the macular carotenoids in human serum and their capacity to protect against AMD. Further, the implications of light distribution on the retina for AMD are discussed. Advancing our understanding of how the macular carotenoids enhance vision and prevent vision loss, this book provides a valuable reference for researchers and clinicians involved in the treatment and prevention of retinal disease.

Since its inception, the International Research Group on Colour Vision Deficiencies (IRGCVD) has followed the policy that the Symposium Pro ceedings should be as close as possible to a complete record of the scientific content of the meeting. This policy has the advantage of providing an accurate picture of the current state of the art in research on color vision deficiencies, but it also has the disadvantage that papers typically span a wide range of quality. In this volume, however, we have instituted a system of peer review in an effort to enhance scientific quality as much as possible while continuing our past policy of publishing all submitted manuscripts. In addition to being edited for English composition and grammar, each of the papers included here has been carefully reviewed by an IRGCVD member selected for his or her expertise in the specific topic of the paper. Reviewers were instructed to include in their comments suggestions for improvement rather than recom or rejection. In our opinion, this review process mendations for publication has resulted in substantial improvement of many of the articles and has enhanced the value of the publication. We are pleased to acknowledge the efforts of our reviewers and offer them our sincere thanks for their important contributions to Colour Vision Deficiencies X. The Editors B. Drum, J. D. Moreland & A. Serra (eds. ), Colour Vision Deficiencies X, p. xiii."

Enormous developments have been made in ophthalmology during the last century. Higher precision and newer instrumentation in surgery as well as better examination methods and progress in microbiology have given us access to much more information about the pathological physiology and anatomy that we are confronted with in our various fields of expertise. As we have approached a new millennium we decided to capture some of these new ideas and incorporate them into a conference where we could share our work and benefit from each others' experiences. This book is based on contributions nd presented at the "2 International Conference on Vitreoretinal Diseases" which was held in September 2002 in Vienna, Austria which focused on the retinal macula. The meeting was very fortunate to have the world's most renowned leaders in macular research attend and share their vast experience and expertise as well as their latest research and results. This meeting followed the "First International Conference on Vitreoretinal Diseases" which was held in Vienna, Austria in 1998, and focused on retinal transplantation and retinal microsurgery. nd After the great success of the "2 International Conference on Vitreoretinal Diseases" an overwhelming interest was expressed to gather all these new and innovative ideas that had been developed in a book in order to give colleagues and students access to a valu able collection of the information presented at the meeting. This international meeting was administrated by, Mrs. Tilly and Mr.

Posterior Capsular Rupture: A Practical Guide to Prevention and Management addresses a nightmare of every cataract surgeon: a posterior capsular rupture. The book details each aspect of the process, from prevention of a posterior capsular rupture to management and IOL placement. Dr. Amar Agarwal and his contributors, leading international ophthalmic surgeons, discuss the latest techniques in easy-to-understand text and format and include more than 250 high-quality photographs that enhance reader comprehension. Posterior Capsular Rupture: A Practical Guide to Prevention and Management presents a variety of complicated cases and complications such as posterior polar cataracts, IOL scaffold & glued IOL, sutured IOLs, management of dislocated IOLs, and corneal damage & posterior capsule rupture, to name a few. & Additionally, a video website accompanies Posterior Capsular Rupture: A Practical Guide to Prevention and Management and allows readers to gain a better understanding of the subject. As a bonus, readers will be able to submit questions and receive clinical answers from Dr. Agarwal through the video website. Practising ophthalmologists, residents, and post-graduate students alike will benefit from this book's clear portrayal of this difficult medical issue.

With a revolution in the surgical management of mild to moderate glaucoma, new procedures allow for the use of microinvasive techniques that avoid disruption of the conjunctiva and formation of a bleb. These approaches range from laser therapies targeting the outflow system of the eye to the implantation of miniature devices in Schlemm's canal or the suprachoroidal space. The emergence of this new branch of glaucoma surgery, often coupled with micro-incisional cataract surgery, requires the practicing surgeon to learn about anatomical nuances to ensure success. MIGS: Advances in Glaucoma Surgery will aid the novice resident as well as the seasoned ophthalmic surgeon facing these new issues in glaucoma treatment. The book addresses preoperative patient selection advice, intraoperative pearls for success, and post operative management skills, which are some of the important aspects of the process towards the adoption of MIGS. Why you will want to read MIGS: Advances in Glaucoma Surgery: * Forward thinking contributions from seasoned MIGS experts who have intimate knowledge of the devices benefits and potential pitfalls in their use * Basic knowledge is provided that will allow each surgeon to tailor their treatment plan while leveling the learning curve * Assists in indentifying patients with a milder form of the disease and higher target pressures who may benefit from the MIGS devices MIGS: Advances in Glaucoma Surgery is the first book of its kind to cover the range of devices in this arena using expert contributors and offering real world pearls for practice that can be used in the operating room. Practicing cataract and glaucoma physicians, residents, and fellows will benefit from this timely resource as the thought process for how to treat glaucoma has advanced.

Fresh insights into the pathogenic mechanisms by which hyperglycemia induces tissue and organ injurt are the basis for rapidly evolving promising therapies in diabetes. Especially promising as targets for intervention are products of oxidative stress, including kinins and growth factors. Improving results of renal replacement regimes now incorporating pancreatic islet transplants are able to delay and prevent end-organ damage in diabetic individuals. The evolving story of the taming of diabetes is of direct concern to nephrologists, endocrinologists, ophthalmologists, primary care physicians and medical students.