The Seventh International Visual Field Symposium organized by the Interna tional Perimetric Society was held in Amsterdam, The Netherlands, September 6-10,1986. In many respects it was an exciting and fruitful meeting. The number of participants was greater than ever. The number of papers was too great to accommodate all of them. The quality of the papers reflects the continuously rising interest in perimetry in general and in automated perimetry in particular. Last but not least the social programme was organized in the, by now, almost classical friendly, enjoyable and humouristic style of the International Perimetric Society. This created an atmosphere of openness and free exchange of informa tion whICh was clearly also felt in the scientific sessions. The scientific part was divided in seven sessions with 44 spoken papers and a separate postersession during which the 46 posters were discussed. The major themes of the meeting were 'The influence of media-disturbances on the visual field' and 'Advances in perimetry in glaucoma with special emphasis on pro gression'. The session on 'media' provided interesting information on how the visual field was effected by preretinal filters. The authors either studied the influence of lens or corneal opacities or simulated opacities by special filters placed in front of the eye. In two papers the effect of cataract was qualified by photography or stray light measurements."

The eye has fascinated scientists from the earliest days of biological in vestigation. The diversity of its parts and the precision of their interaction make it a favorite model system for a variety of developmental studies. The eye is a particularly valuable experimental system not only because its tissues provide examples of fundamental processes, but also because it is a prominent and easily accessible structure at very early embryonic ages. In order to provide an open forum for investigators working on all aspects of ocular development, a series of symposia on ocular and visual devel opment was initiated in 1973. A major objective of the symposia has been to foster communication between the basic research worker and the clinical community. It is our feeling that much can be learned on both sides from this interaction. The idea for an informal meeting allowing maximum ex change of ideas originated with Dr. Leon Candeub, who supplied the nec essary driving force that made the series a reality. Each symposium has concentrated on a different aspect of ocular development. Speakers have been selected to approach related topics from different perspectives."

This book has been written for radiologists, ophthalmologists, neurologists, neurosur geons, plastic surgeons, and others interested in the evaluation of disorders with ophthalmologic signs and symptoms. It is designed to provide recent knowledge in this area derived from ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI). In the past decade, the advent of ultrasonography, computed tomography, and more recently magnetic resonance imaging has provided diagnostic images of the eye, orbit, and brain in a fashion that had been a dream of many prior to the develop ment of these techniques. These newer modes of diagnosis have replaced some previous techniques, such as nuclear medicine imaging and, to some degree, vascular studies and orbitography. There are three sections to this book. The first section is a discussion of the imaging techniques. The second is devoted to the role of these imaging methods in the evaluation of ophthalmic disorders. The last section, dealing with radiotherapy for ophthalmologic tumors, is included because the current imaging techniques are needed for treatment planning. We wish to thank the many people who have assisted us in preparing this manuscript. Among these are many librarians, secretaries, trainees, and photographers. Weare especially indebted to artist Peter Clark for his illustrations and to Mr. Martin Leibo vici, Associate Curator of New York University Medical School and Director of Health Sciences Library of Goldwater Memorial Hospital, New York City. Also, we wish to thank our families for their help and patience."

This volume is a collection of essays which attempts to summarize the recent progress in the field of photoreceptor and retinal physiology. Reflecting the way in which research is organized, each author reports on the studies performed with the techniques with which he is most familiar: morpholo gical, chemical or physiological. The first chapters describe the structure of visual cells and the histological architecture of the retina. Next comes a summary of the laws governing photochemical reactions and a report on the biochemistry of photopigments. Four articles cover the optical properties of invertebrate eyes and the electrophysiology and the interactions of their photoreceptors. These are followed by a discussion of the properties of vertebrate eyes, including chapters on optics, on the electrical responses of rods and cones and on the functional organization of the retina. The final chapter provides an extensive review of retinal biochemistry and metabolism. Even though the experimental approach differs, all studies are directed toward the solution of two basic problems: transduction in the photoreceptors and orga nization (often called "information processing") in the retina. The central problem of photoreceptor cells is to determine how light produces a response. We know that illumination evokes electrical changes and we have recently learned a great deal about the features of these changes. The evidence indicates however that elaborate processes must be interposed between the ab sorption of photons by the pigment and the production of electric currents through the membrane. These intermediary cvents remain to be unraveled."

Colour Vision Deficiences VIII brings together information on the latest trends in the following areas of research: -Visual effects of intense lights; -Effects of intoxications on colour vision; -Ageing and vision; -Methods of examination; -Congenital defects; -Acquired defects; -Practical aspects; -Physiological bases.
This volume is a natural follow-up on Volumes VI and VII published in 1981 and 1983 respectively by Dr. W. Junk Publishers.

Evoked potentials are potentials that are derived from the peripheral or central nervous system. They are time locked with an external stimulus and can be influenced by subjective intentions. Evoked potentials have become increasingly popular for clinical diagnosis over the last few years. Evoked potentials from the visual system are used by ophthalmologists in order to localize the abnormalities in the visual pathway. The otologists are mainly involved in brainstem auditory evoked potentials, while the pediatricians, neonatologists, neurologists and clinical neurophysiologists make use of multimodal stimulation. The psychiatrists and psychologists, generally, examine the slow potentials such as P300 and CNV. Anesthesiologists use short latency somatosensory and visual evoked potentials in order to monitor the effectiveness of the anesthesia. Pharmaco evoked potentials are very promising measures for the quan tification of the effectiveness of drug action on the cerebral cortex. Urologists are more and more involved in pudendal somatosensory evoked potentials and in the intensive care unit evoked potentials are used in order to monitor the functional state of the central nervous system of the patient. This overwhelming number of examinations and exam ina tors clearly demonstrates the need for guidelines and standardization of the methods used. The evoked potential metholody is restricted by the relative poor signal to noise ratio. In many diseases this signal to noise ratio decrease rapidly during the progression of the illness. Optimal technical equipment and methodology are therefore essential."

This book has been conceived to aid eye care practitioners such as ophthalmologists and optometrists as well as other eye care or research professionals such as biologists, biochemists and medical doctors interested in the Ocular Surface. This text is divided into four main sections. The first section is dedicated towards the anatomy and physiology of the ocular surface (defining ocular surface concept, tear film structure, corneal and conjunctival anatomy, etc.). The second section covers the most common ocular surface disorders (dry eye, anterior and posterior blepharitis, keratitis, ocular allergy, cicatricial conjunctivitis, and the ocular surface alterations related with Glaucoma treatment). The third section delineates the therapeutic care of these disorders, including topical, systemic and surgical treatment options and the fourth section addresses the relationship of the ocular surface and contact lenswear (describing the indications for contact lenses wear, their complications and managing the adverse effects related with contact lens-wear).

Over the more than three decades of my life as a physician, I have been constantly amazed at how subtle and elegant nature is as a teacher. Our questions to her, though, must be clear and unambiguous. Otherwise, the answers we receive are likely to be misleading and confusing. As I have matured as a clinician, I have tried to improve my questions to increase my chances of receiving an answer. For the past decade, I have been pondering the subject of strabismus with which I have busied myself for practically two and one-half decades. I began to realize that my time, my share of wisdom, my abilities to carry out the prodigious work necessary to create a book out of nothing but thought, reading, and reflection on the work of others, as well as my own experience, were perhaps becoming limited. I do not doubt that they will become even more limited Thus I have been led to write this book. Further, I am left in greater awe of prolific writers, particu larly those who write with the precision and attention to detail necessary for a medical text. Let me warn the reader at the outset that my approach in this book is "teleologi cal. " I am well aware of the conflict between science's notion of causality as only local and instrumental as opposed to the anthropomorphic notion of purpose or design in nature implied by the choice of this teleology."

The purpose of this book is to provide an update both on the present management of proliferative vitreoretinopathy (PVR) and on clinical and experimental research being done to control this disease. The book is divided into three parts. The first part deals with the current management of PVR. The Retina Society Classification of PVR is based in part on a gradation of severity from minimal to massive; therefore, this book attempts to correlate the management of PVR with its severity. The treatment of PVR of varying degrees of severity, from mild to the most severe form, is described by those authors with extensive experience with this spectrum of cases. Much progress has been made in the management of severe PVR as a result of vitreous injections, vitrectomy, periretinal membrane surgery, and retinal surgery. Authors in this book show that in mild and moderately severe PVR excellent results can be obtained with techniques that are less invasive and possibly less likely to stimulate further abnormal cellular proliferation. The new modalities for treatment of PVR are discussed by authors having extensive experience with them. The current status of pharmacological treatment and new concepts of the pathobiology of PVR are discussed. The second part of the book deals with questions frequently encountered in the management of PVR. These questions are answered by a panel of experts including Gary W. Abrams, Steven T. Charles, William H. Havener, Robert Machemer, Charles L. Schepens, and Walter H. Stern.

Corneal Topography is designed to provide complete, practical coverage of a new field for both the general ophthalmologist and the subspecialist in the area of corneal disease. The volume explores the history of corneal topography and comprehensively demonstrates the usefulness of all forms of current instrumentation in clinical and ivestigative work striving toward improved surgical intervention in the cornea

The eye has fascinated scientists from the earliest days of biological in vestigation. The diversity of its parts and the precision of their interaction make it a favorite model system for a variety of developmental studies. The eye is a particularly valuable experimental system not only because its tissues provide examples of fundamental processes, but also because it is a prominent and easily accessible structure at very early embryonic ages. In order to provide an open forum for investigators working on all aspects of ocular development, a series of symposia on ocular and visual devel opment was initiated in 1973. A major objective of the symposia has been to foster communication between the basic research worker and the clinical It is our feeling that much can be learned on both sides from community. this interaction. The idea for an informal meeting allowing maximum ex change of ideas originated with Dr. Leon Candeub, who supplied the nec essary driving force that made the series a reality. Each symposium has on a different aspect of ocular development. Speakers have concentrated been selected to approach related topics from different perspectives."

Proceedings of the International Symposium at the Katholieke Universiteit Leuven, Belgium, May 17-19, 1984

The eye can become involved in immune-mediated diseases that affect it alone or as part of a multi-organ disease process. Much immunological attention has been focused on other organs affected by these processes and the subject of the immunology of eye diseases is a relatively new one. Many of these diseases that involve the eye are not life-threatening but can result in devastat ing loss of sight that if bilateral, will have major effects on the patient's life. Systemic immunological investigations are generally unhelpful in these patients and one of the major problems in this field has been the lack of diseased tissue available for examination to determine the pathological processes involved. Our poor understanding of basic mechanisms of disease in the eye has meant that treatment of many of these conditions is often inadequate. It has become possible to apply in the eye many ofthe techniques used to investigate the role of the immune system in other systems. Animal models of many of the disease processes have also allowed dissection of the immune response both within and outside the eye. It is my belief that a greater understanding of the mechanisms by which the structures in the eye become damaged will allow more specific and effective therapeutic strategies to be devised."

Retinopathy of Prematurity presents a review of the current knowledge of this disease, which tragically renders many premature infants blind. First, the volume covers the natural history, classification and histopathology of ROP, followed by examination techniques, recommendations for follow-up and therapy and finally a panel discussion providing answers to frequent questions and areas of legal concern.

The European Glaucoma Society was founded in the spring of 1978 at the initiative of Drs Fran ois, Leydhecker and Greve. Representatives of most European countries met in Ghent and agreed to create a society that would promote the contacts and exchange of knowledge between European glauco matologists. The European Glaucoma Society serves to stimulate glaucoma research and diffuse specific knowledge to general ophthalmologists. The European Glaucoma Society would like to cooperate closely with similar glaucoma organizations in other continents. The first symposium of the EGS was held in April 1980 in Brighton, England. No proceedings were published. The second symposium took place in May 1984 in Hyvinkiiii, Finland. A great number of participants enjoyed a well organized scientific programme of attractive quality. The local organization was in the able hands of Raitta and her colleagues, Raivio and Lehto. The scientific programme was coordinated in Amsterdam where a great amount of work was done by Stella Ompi, secretary to the general secretary. The contents of the meeting have been summarized in this book. This second symposium of the EGS, which took place in an atmosphere of great enthusiasm and friendship, has shown great promise for the future of the European glaucoma."

This report for the Belgian Ophthalmological Society concerns a number of fundus diseases, which most ophthalmologists only rarely encounter. Still it is of importance that they should be able to recognize them, not only because most of these eye diseases are treatable when they are diagnosed early enough, but also because they are sometimes associated with major visceral and neurological problems. The ophthalmologist may be the first practitioner to suspect a von Hippel-Lindau's disease or a neurofibromatosis. He should realize at that moment that his role is not only to treat the eyes but also to advise his patient, refer him to other specialists and consider the genetical implications of his diagnosis. Clinicopathologic correlations are of great importance and we felt that it was necessary to emphasize the histopathological aspect of these diseases. A report has to overview the literature on a specific topic. The literature on vascular tumors of the fundus is extremely vast and even if we tried to be as complete as possible, we must confess that we did not cite every author who published on such cases. A third aspect, which was considered as important, was to provide sufficient clinical and histopathologic examples of the various disease, which are reviewed. We are indebted to a large number of friends who kindly authorized the publication of their material. In particular we wish thank Prof. A. Brini (Strasbourg), Dr. D. de Wolff-Rouendaal (Leiden), Prof. P.

Researchers in recent decades have elucidated signal transduction in the retina and the function of the visual cortex. The highly flexible nature of neural circuits in the visual cortex especially during the critical period has been an interesting subject for studying neural plasticity and development. Recent advances in the visual neurosciences of the vertebrate retina and the visual cortex were discussed during the 12th Keio International Symposium for Life Science and Medicine, meeting jointly with Vision Forum 2002. Contributions to the symposium collected in this volume reflect the convergence of physiological, cell biological, molecular, mathematical, and clinical approaches. The book covers topics ranging from phototransduction to visual information processing in the primary visual cortex, and includes clinical studies on hereditary night blindness, creating a valuable source of information for researchers and clinicians in the visual neurosciences.

Amaurosis fugax, or "fleeting blindness," has been known as a clinical entity for hundreds of years (1). Since 1859, we also have understood that the phenomenon frequently is related to atheroembolic disease and that it is considered a classic manifestation of ocular transient ischemic attacks and a potential precursor to stroke. However, many questions about this syndrome have remained unanswered until quite recently, when a great deal of new information and thought has been directed to the subject. Transient monocular blindness (TMB) is only one manifestation of a complicated syndrome of ocular, systemic, and cerebral diseases that may include some degree of monocular blindness. The duration of blindness varies from very brief (seconds) to complete and permanent. The per manent type is referred to as ocular infarction or ocular stroke. Retinal infarction is the most severe degree of monocular blindness and usually is due to embolic occlusion of the central retinal artery or one of its branches. Varying types of arterial emboli have been described, including thrombus, cholesterol, platelets, and fibrin.

Nitric oxide (NO) is a simple gas with free radical properties. No one would have imagined a role for such a simple substance in the human body. In 1998, R. E Furchgott, E Murad, and L. J. Ignarro received the Nobel prize for their work on NO. Interestingly, Alfred B. Nobel, who invented dynamite by combining nitro glycerin with other substances, took nitroglycerin for his chest pain without realizing that NO mediates its action. Now, in addition to its vasodilating action, NO is known to possess many fundamental functions that include neurotrans mission, blood pressure control, blood clotting, and immune responses. These diverse functions, conversely, imply that the simple NO molecule may unite neuroscience, physiology, and immunology and may change our understanding of how cells communicate and defend themselves. In this context, the Inter national Symposium, Nitric Oxide and Free Radicals, was organized to address current thinking about the widespread distribution and variety of functions of NO in the eye. The symposium was held in Kyoto, Japan, September 28-29 as a Satellite Symposium of the XII International Congress of Eye Research, 1996. The Symposium was the first international gathering of leading scientists and ophthalmologists meeting to present and discuss their most recent results in a specialized area of research, specifically concerning the eye.

ince 1985, it has been my privilege to be the Director of The - ciety of Byron Smith Fellows. During the years in which Byron SSmith was with us, his former fellows would meet at the Ame- can Academy of Ophthalmology's annual meeting. They would present to him, and to one another, interesting cases of their own compli- tions that had occurred or cases that had been sent to them that were complications to be repaired. This forum provided the fellows with an excellent format for evaluating their own problems and also for d- cussing how to treat extremely difficult cases. Shortly after Dr. Brian Brazzo completed his fellowship with me in 1998, he asked if I thought it would be appropriate for him to edit a new book on complications of ophthalmic plastic surgery. Certainly, during his fellowship, it became apparent that Dr. Brazzo was pr- ably the most gifted academician and writer that I had ever had the pleasure of training and meeting. I could think of no one more - propriate to continue the work initiated by Dr. Byron Smith and c- ried on by his students.

The best-selling exam preparation manual for more than 15 years has been extensively updated into a Third Edition. With revisions and additional material that match the new JCAHPOr criteria for Certified Ophthalmic Assistants (COAr), this study resource will remain the top choice for those studying for certification. With nearly 1,400 questions, the Certified Ophthalmic Assistant Exam Review Manual, Third Edition contains more questions with explanatory answers than any other study aid. Additionally, all 19 exam criteria headings are covered inside, including history taking, visual assessment, medical ethics, pharmacology, ophthalmic imaging, surgery, and more. Features: * Study tips, hints, and test-taking strategies * Explanatory answers for every question * Updated to reflect new JCAHPO COA exam criteria Certified Ophthalmic Assistant Exam Review Manual, Third Edition by Janice K. Ledford will be the most talked-about resource for those studying for the COAr exam, students in ophthalmic and optometric assisting programs, and those who wish to review before taking the COTr exam.

The surgical correction of refractive vision errors has dramatically and continually changed over time. The evolution of laser vision correction has been aided by advancements in the technology, growing experience, and improved understanding of the eye and its response to surgery. However, not all refractive errors can be treated with the laser. Phakic IOLs: State of the Art is designed to provide the advances in phakic IOL technology and techniques, ideal for physicians who treat many of the patients who are not candidates for laser vision correction. The collaboration of Dr. Lucio Buratto, Dr. Stephen G. Slade, and Dr. Nicola D. Hauranieh, along with a team of international surgeons, has produced a complete book specifically aimed to improve the treatment and therefore the quality of vision of patients. Phakic IOLs: State of the Art is designed for ophthalmologists interested in learning the concepts, developing the skills, and preparing for phakic IOL procedures. This book contains a detailed description of the basic technique of the operations, as well as the special techniques devised by the international contributors. Richly illustrated with over 200 images that demonstrate the various concepts, readers are able to develop a more thorough understanding of phakic IOL implantation. This definitive resource couples both the authors’ and contributors’ diverse experience and knowledge to produce a complete resource of vision correction with phakic IOLs. Expert ophthalmologists interested in being on the cutting edge and enhancing their surgical skills, as well as new physicians, will benefit from adding Phakic IOLs: State of the Art to their personal library.

There have been greater advances in our knowledge of the visual function and its disabilities in the past 50 years than had accumulated in all of the previous years. This applies not only to the basic science of biochemistry, physiology, physiopathology, and cytopathology but also to the diagnosis and treatment of visual dysfunction and ocular disease. These advances have been aided by a proliferation of ingenious instruments. When I began my residency in ophthalmology at The Wilmer Institute in 1938, one was supposed to learn not only the physiology of vision but also how to diagnose and treat all phases of ophthalmology including disabilities of the orbit, sclera, retina, lens, and cornea. In addition he or she was supposed to understand neuro-ophthalmology, ophthalmic genetics, and so-called uveitis. It soon became evident that no one could adequately comprehend all of these areas and, therefore, most young trainees today take a year or two of fel lowship in a specialized area following their three-to five-year residency train ing. Following this they join a group of other ophthalmologists and specialize. Thus, they become more expert in the diagnosis and treatment in a limited area in ophthalmology. When I returned to The Wilmer Institute in 1955 as Head of the Department I was the only full-time member of the staff. To date we have some 28 full-time ophthalmologists working in highly specialized areas of our institution.