The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the "best" and "most important" meetings in the field. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy. While advances in these areas of retinal degenerations will be described, there will be many new topics that either were in their infancy or did not exist at the time of the last RD Symposium, RD2014. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those will be reported at the RD2018 meeting and included in the proposed volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations will be reflected in the volume.

This book is an international effort to standardize the language, terms, and methods used in ocular toxicology.With over 300 color illustrations this consensus volume provides standards and harmonization for procedures, terminology, and scoring schemes for ocular toxicology. it is essential for industry, pharmaceutical companies, and governmental agencies to help improve the drug development process and to reduce and refine the use of animals in research. Standards for Ocular Toxicology and Inflammation is endorsed by the American College of Veterinary Ophthalmologists.

For over 25 years, The Retinoscopy Book: An Introductory Manual for Eye Care Professionals has been the only basic instruction manual designed specifically to teach the art of clinical retinoscopy. This best-selling classic has been updated and revised to include the latest changes involving the retinoscope, and to meet the developing needs of students in ophthalmology and optometry. Sections on minus cylinders, concave mirror retinoscopy for high refractive errors, and a catalog of instruments have been expanded to reflect the most recent innovations. New sections on retinoscopy after refractive surgery and instrument maintenance are unique to this fifth edition. This text is designed to supplement the Joint Commission on Allied Health Personnel in Ophthalmology (JCAHPO) instruction courses for technicians or to facilitate a do-it-yourself training program for ophthalmology residents, ophthalmic technicians, optometry students, and other eye care professionals in training. Figures and illustrations supplement time-tested exercises to facilitate learning. The user-friendly format prevalent throughout the text enables students to develop a complete understanding of the retinoscope and its many uses.

This book addresses the issues relating to a wide variety of ocular diseases from which millions of people suffer. Long-term challenges include visual impairment and ocular blindness. Certain ocular diseases are quite rare, whereas others, such as cataracts, age-related macular degeneration (AMD), and glaucoma, are very common, especially in the aging population. A rapid expansion of new technologies in ocular drug delivery and new drug candidates, including biologics, to treat these challenging diseases in the retina and posterior segments of the eye have recently emerged. These approaches are necessary because the eye has many unique barriers to drug delivery. Thus, this timely reference Drug Delivery for the Retina and Posterior Segment Disease compiles and analyzes recent advances in the research and development of drug delivery systems for retina and posterior segment diseases of the eye, with an emphasis on the use of implantable devices, iontophoresis as well as micro- and nanoparticles.

Optical coherence tomography (OCT) is a non-invasive imaging test that uses light waves to take cross-sectional pictures of the retina, the light-sensitive tissue lining the back of the eye (eyeSmart). The technique is recognised worldwide as an essential device for diagnosis, assessment and follow up of retinal diseases and glaucoma. This atlas provides ophthalmologists and trainees with a collection of OCT images to help with the identification, diagnosis and subsequent treatment of common retinal and anterior segment disorders. The images are compiled from the authors' own collections using Plex Elite and Cirrus 6000 technology. Fundus angiography images assist with the understanding of related pathologies. Divided into two sections, the book begins with images illustrating the normal fundus, then numerous different retinal disorders including diabetic retinopathy, macular disorders, retinal detachment, uveitis and toxicities. Section two covers anterior segment disorders, beginning with images of the normal cornea, then illustrating a range of disorders including corneal dystrophies, ocular surface disorders, keratoconus, glaucoma, and trauma. Each section features a multitude of images, each with brief descriptive text.

This book presents descriptive overviews of gene editing strategies across multiple species while also offering in-depth insight on complex cases of application in the field of tissue engineering and regenerative medicine. Chapters feature contributions from leaders in stem cell therapy and biology, providing a comprehensive view of the application of gene therapy in numerous fields with an emphasis on ophthalmology, stem cells, and agriculture. The book also highlights recent major technological advances, including ZFN, TALEN, and CRISPR. Precision Medicine, CRISPR, and Genome Engineering is part of the highly successful Advances in Experimental Medicine and Biology series. It is an indispensable resource for researchers and students in genetics as well as clinicians.

Selected as a Doody's Core Title for 2022! Concise, authoritative, and easy to navigate, The Duke Manual of Pediatric Ophthalmology and Strabismus Surgery offers a step-by-step, highly illustrated approach to the most commonly performed pediatric and strabismus operating room procedures. Ideal for pediatric and strabismus specialists, ophthalmic surgeons, trainees, and researchers, it contains practical guidance from experts at Duke University, making it an unparalleled "how-to" manual for the wide variety of cases and operative scenarios you may encounter. Offers a step-by-step outline for each surgical procedure, from preoperative considerations through postoperative care, including numerous surgical pearls. Contains more than 300 full-color photographs and illustrations that clearly depict techniques and other essential aspects of pediatric and strabismus surgery. Covers surgery basics, including pre-operative and post-operative considerations, as well as management of challenging surgical scenarios. Provides access, via the eBook, to approximately 15 surgical videos from the Duke archive. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

A handy manual for cornea specialists, this book provides detailed practical information about a complex, sight-threatening disease that can be challenging to diagnose and manage. This text features chapters dedicated to outlining all facets of diagnosis and management while covering both medical and surgical treatment options. Peripheral Ulcerative Keratitis, supplemented with useful references and appendices to provide simple step by step algorithms, is written by internationally renowned authors who are experts in the field.Including practical tips and guidelines for diagnosis and therapy of these disorders, Peripheral Ulcerative Keratitis is designed to serve as a guide for comprehensive ophthalmologists and should find itself on the bookshelves of ophthalmology clinics, corneal practices and training programs across the country.

This book presents a technology to help speech-, hearing- and sight-impaired people. It explains how they will benefit from an enhancement in their ability to recognize and produce speech or to detect sounds in their surroundings. Additionally, it is considered how sound-based assistive technology might be applied to the areas of speech recognition, speech synthesis, environmental recognition, virtual reality and robots. The primary focus of this book is to provide an understanding of both the methodology and basic concepts of assistive technology rather than listing the variety of assistive devices developed. This book presents a number of different topics which are sufficiently independent from one another that the reader may begin at any chapter without lacking background information. Much of the research quoted in this book was conducted in the author's laboratories at Hokkaido University and University of Tokyo. This book offers the reader a better understanding of a number of unsolved problems that still persist in the field of sound-based assistive technology.

Our understanding of human color vision has advanced tremendously in recent years, helped along by many new discoveries, ideas, and achievements. It is therefore timely that these new developments are brought together in a book, assembled specifically to include new research and insight from the leaders in the field. Although intentionally not exhaustive, many aspects of color vision are discussed in this Springer Series in Vision Research book including: the genetics of the photopigments; the anatomy and physiology of photoreceptors, retinal and cortical pathways; color perception; the effects of disorders; theories on neuronal processes and the evolution of human color vision. Several of the chapters describe new, state-of-the-art methods within genetics, morphology, imaging techniques, electrophysiology, psychophysics, and computational neuroscience. The book gives a comprehensive overview of the different disciplines in human color vision in a way that makes it accessible to specialists and non-specialist scientists alike. About the Series: The Springer Series in Vision Research is a comprehensive update and overview of cutting edge vision research, exploring, in depth, current breakthroughs at a conceptual level. It details the whole visual system, from molecular processes to anatomy, physiology and behavior and covers both invertebrate and vertebrate organisms from terrestrial and aquatic habitats. Each book in the Series is aimed at all individuals with interests in vision including advanced graduate students, post-doctoral researchers, established vision scientists and clinical investigators. The series editors are N. Justin Marshall, Queensland Brain Institute, The University of Queensland, Australia and Shaun P. Collin, Neuroecology Group within the School of Animal Biology and the Oceans Institute at the University of Western Australia.

As a degenerative disorder of the eye, keratoconus can cause substantial distortion of vision, with multiple images, streaking, and sensitivity to light all reported by patients. Keratoconus: Recent Advances in Diagnosis and Treatment updates ophthalmologists about the innovations that have occurred within the last decade, discussing the diagnostic imaging techniques that have been developed for keratoconus diagnosis, understanding of how examination techniques are related to the evolution of keratoconus, and how to indicate the different therapeutic tools that have been created for keratoconus over the last several years. Additionally, fundamentals for new diagnostic elements, based on the mathematical, physical and biomechanical data are analyzed in depth for a better understanding of the essential diagnostic steps for the clinician to guide patients towards the most adequate therapeutic tool in the case. Modern keratoplasty techniques, assisted by femtosecond lasers or other devices, are also covered and these techniques, along with the emerging conservative treatments, have added to more precise control of the evolution of the disease.

This book provides a concise yet comprehensive source of information on the classification, evaluation, diagnosis, and management of vascular lesions of the orbit and face. It highlights recent technological innovations and new treatments that have significantly improved the ability to accurately evaluate and successfully treat these lesions with reduced complications. Some of these advances include new imaging modalities, intravascular and intralesional treatment approaches, photodynamic therapy, and additional medical therapies. Many of these advances have led to paradigm shifts in the understanding and management of vascular lesions of the orbit and face. This book, written by experts in the fields of ophthalmology, dermatology, diagnostic and interventional radiology, and oculoplastic surgery, features structured, in-depth chapters that can also be quickly consulted as a reference guide. It is an excellent resource for those in training as well as seasoned practitioners wishing to acquaint themselves with the newest diagnostic and treatment techniques for orbital vascular lesions.

This book is a practical and concise atlas on ocular anatomy, with an emphasis on applied aspects and hints for easy retention strategies. The vast color illustrations and photographs consist of self-explanatory, precise, and meaningful representations of the points covered in the text. Covering chapters such as bony socket of the eye, extraocular muscles, eyelids, cornea and lens, and neurology of the eye, Atlas of Ocular Anatomy gives a summary of the important and relevant points for each topic, separating out the essential from the nonessential elements. Complete with representative schematic line diagrams and full color photographs, this atlas features the correlation between anatomic facts with their probable clinical presentations in disease.

This series of books is designed to help general practitioners. So are other books. What is unusual in this instance is their collec tive authorship; they are written by specialists working at district general hospitals. The writers derive their own experi ence from a range of cases less highly selected than those on which textbooks are traditionally based. They are also in a good position to pick out topics which they see creating difficulties for the practitioners of their district, whose personal capacities are familiar to them; and to concentrate on contexts where mistakes are most likely to occur. They are all well-accustomed to working in consultation. All the authors write from hospital experience and from the viewpoint of their specialty. There are, therefore, matters important to family practice which should be sought not within this series, but elsewhere. Within the series much practical and useful advice is to be found with which the general practitioner can compare his existing performance and build in new ideas and improved techniques. These books are attractively produced and I recommend them."

This book is designed to be a pictorial guide to ophthalmology and not a comprehensive textbook. It includes chapters on anatomy, physiology and optics to explain the simple elements of the basic sciences that are needed to understand ophthalmology. The section on examination describes the common investigations in an eye department in the hope that reports from ophthalmologists may become more easily understood. The clinical chapters represent 5 years of ophthalmic referrals by local family doctors in a part rural and part suburban area. This selection of eye disease therefore excludes some of the rare conditions, but includes those common problems that can worry not only the busy family doctor, but also the hard pressed medical student. 7 Anatomy and Physiology The sense of vision depends on the integrity of a set of Internal Eye anatomical and physiological factors, a study of which The eye consists of three concentric layers. The outer will simplify the understanding of ocular disease. most fibrous sclera is opaque and accounts for five sixths of the globe. It is continued anteriorly into the External Eye transparent cornea. The middle vascular coat or uveal The eyeball lies in the anterior part of the orbit, which tract is made up of the choroid, ciliary body and iris. is approximately pyramidal in shape. The bony orbital The innermost layer is the light sensitive retina formed margin, which outlines the base of the pyramid, affords embryologically from the forebrain vesicle (Figure 3)."

This monograph focuses on the use of analysis and processing methods for images from the Corvis (R) ST tonometer. The presented analysis is associated with the quantitative, repeatable and fully automatic evaluation of the response of the eye, eyeball and cornea to an air-puff. All the described algorithms were practically implemented in MATLAB (R). The monograph also describes and provides the full source code designed to perform the discussed calculations. As a result, this monograph is intended for scientists, graduate students and students of computer science and bioengineering as well as doctors wishing to expand their knowledge of modern diagnostic methods assisted by various image analysis and processing methods.

With this book, Dr. Zivojnovic presents to the ophthalmic community the long awaited detailed report of his surgical concepts and operative techniques in the field of vitreoretinal surgery. It is fascinating to read how his concepts for the treatment of complicated retinal detachments evolved from the intra ocular use of silicone oil to a combination of vitreous surgery with silicone oil tamponade. The next step was surgical treatment of the retina itself. It takes an unconventional mind to break major taboos and to state the retinotomies and retinectomies are necessary if scar tissue cannot be surgically removed and that buckling procedures are no longer necessary to treat retinal breaks. This book discusses the use of silicone oil in vitreoretinal surgery. Silicone oil tamponade has been proven to be a major step forward in vitreoretinal surgery and the reported results speak for themselves. The reader may have the impression that silicone is thought to be indispensible for almost all cases undergoing this type of surgery but this modality is used to treat severe cases where the chances of success are greatly enhanced by using silicone oil. Dr. Zivojnovic remains the forerunner and great surgeon who readily admits the limitations of his techniques: 'The surgical operative treatment is only partly adequate and, unfortunately, despite the correctly performed operation, often does not lead to the desired result'."

Neovascularization isanormalphaseoftissue repair mechanlsm. In theeye, however, sproutingofnewvessels withinavasculartissuesandtheirgreatertendencytobleed havedetrimentaleffectsonvision. Diabeticretinopathy, corneal neovascularization, age-related macular degeneration, retinal veinocclusion, andretinopathy of prematurity are major causes of blindness. In all, uncontrolled proliferationofnewvesselsistheunderlying pathologicalcauseleadingtotheinexorablelossofvision. Development of lasertechnologiesandtheir wide use in ophthalmology have broughtsomehopeforthetreqtment of these diseases. However, itbecameevident that direct closureofthenewvesselsand/orablationoflargepartsof thetissuearenotidealsolutionstotheproblem. Recent advances in molecular biology and genetic engineering have fosteredbasic knowledge regarding the growth factors and intercellular messengers and their association with theproliferationofnew blood vessels. These latter findings sparked a renewed interest in Michaelson's "X-factor" ofocular neovascularization and opened avenues for possible innovative therapeutic approaches. Therefore, the suggestion to organize an international gathering of clinicians and scientists interested in problems of ocular circulation and neovascularization was received with great enthusiasm. Unanimously, it wasdecidedtodedicatethe symposium to Professor I.C. Michaelson, theinnovativescientist, the greatclinician, theindefatigableteacher, andaboveall, thewonderfulhumanbeing. The meeting was highlighted by the outstanding atmosphere of friendshipandscientif.ic exchanges. This book mirrors the information delivered and includes a selectionofpapersfromthescientificprogram. Theorganizationofthismeetingandthepublicationof thebookwouldnothavebeenpossiblewithouttheharmonious teameffortsmadebytheInternational, ScientificandLocal Committees. I am thankful tothe chairpersons of the varioussessionsfortheirtime, keeninterestandendeavor for the realizationofahighscientific level. I also deeplyacknowledgethehelpand&upportofArnallPatz, Bob Murphy, BertGlaser, RobertFrank, LarryHjelmeland, Gordon Klintworth, Neville Welsh, Charles Riva, Alec Garner, DesmondArcher, EphraimFriedman, MyronYanoff, MosheLahav, Willem Manschot, Hans-WaltherLarsenand Masanobu Uyama. The powerful stimulus of Hanan Zauberman, Steve Ryan, GabrielCoscas, GiselleSoubrane, MosheIvry, YuvalYassur and Sue and Peter Ballenwasmost instrumental in the realizationofthese"dreams." Asalways, Iwasfortunate tohavetheinvaluablecollaborationofmyloyalassistants: Evelyne Cohen, Genia Maftzir, Israel Barzel, Arieh Zelikovitch, andJudithBenEzra. Thesmoothrunningofthe meeting andtimelyeditingofthebookcouldnothave been possible without theincalculablehelp and indefatigable typing and councilofJudithFisher, whoseconded me in selectingthepapersandeditingthebook."

At last, a complete reference detailing one of the most commonly performed cosmetic facial procedures - aesthetic blepharoplasty. In Aesthetic Surgery of the Eyelids, Dr. Loeb shares his 30 years of experience in the field. This unique volume distills the proven techniques of an internationally respected plastic surgeon. The "Scleral Show" chapter is the most complete treatment on this topic and the section on surgical correction of depression deformities masterfully demonstrates the author's original techniques. Aesthetic Surgery of the Eyelids is an indispensable tool for all cosmetic and reconstructive plastic surgeons.

Over the past few years there have been considerable advances in our understanding of the normal development of vision and in our ability to detect and meaSl1re visual impairment in early childhood. It was appropriate, therefore, that a workshop, sponsored by the European Communities, should be held on the 'Detection and Measurement of Visual Impairment in Pre-verbal Children.' This workshop, which was held at the Institute of Ophthalmology, London, between 1 and 3 April 1985, brought together visual physiologists and ophthalmologists who exchanged and discussed ideas of mutual interest. After an introductory session when the normal development of vision and the causes of visual impairment were reviewed, there were sessions devoted to the theoretical aspects of electrophysiological and psychophysical tests, the measurement of visual acuity in pre-verbal children, the measurement of other visual functions, and visual screening of pre-verbal children. This volume contains the papers presented at the workshop, and transcripts of the various discl1ssions that took place. It was a measure of the success of the workshop that participants from several different disciplines were able to have fruitful discussions and to suggest areas of common interest where collaborative ventures could usefully be pursued. It is hoped that this venture will be followed by others where a mul ti disciplinary approach will improve both our knowledge of visual handicap in childhood and our management of this important group of sensorily impaired children."

The 11 th Congress of SIDUO took place in the beautiful setting of Capri in springtime and was held in the impressive and stimulating atmosphere of the 'Certosa di S. Giacomo'. The organisation was sponsored by the SIEO, the 'Societa Italiana di Eco- Oftalmologia'. The Honorary President was Professor Antonio Rossi, Head of the University Department of Ophthalmology in Ferrara and one of the pioneers of Italy in this field. The organizing committee further consisted of: President: Prof. P. E. Gallenga, University Department of Ophthalmology, Chieti Vice President: Dr. G. Cennamo, University Department of Ophthalmology, Napels Scientific Secretary: Dr. J. M. Thijssen, University Department of Ophthal- mology, Nijmegen Treasurer: Dr. A. Reibaldi, University Department of Ophthalmology, Bari The organizing Committee was supported by an International Scientific Pro- gramme Committee: Regional Representatives: SIDUO Officers: G. Bellone (Torino) P. E. Gallenga (President) A. Bertenyi (Budapest) J. S. Hillman (Treasurer) D. J. Coleman (New York) B. L. Hodes (Vice-President) K. C. Ossoinig (Iowa City) J. M. Thijssen (Secretary) R. Sampaolesi (Buenos Aires) H. G. Trier (Past-President) A. W. Sawada (Miyazaki) P. Till (Wien) As A Regional Advisory Committee served: Honorary Chairmen: A. Oksala (Turka), A. Alajmo (Venezia), A. Bonovolonta (Napoli) ix Chairmen: H. G. Trier (Bonn) M. Zingiran (Genova) Members: F. Bigar (Zurich) V. Mazzao (Ferrara) w. Buschmann (Wurzburg) 1. Poujol (paris) Z. Filipezynski (Warszawa) K. Psilas (Joannina) H. C. Fledelius (Rungsted Kyst) J. Preis ova (Brno) F. F. Fridman (Moscow) A. Rivara (Genova) H. Gernet (Munster) 1.

Pathologic myopia that is due to axial elongation causes thinning of the retina and choroid, especially in cases of posterior staphyloma. The result of this myopia is the development of various kinds of chorioretinal atrophy in the posterior pole, with a gradual progression of the atrophic changes extending over several decades. Until now, studies of atrophic lesions and their clinical course have been incomplete, and diagnostic standards and classification of chorioretinopathy have been unclear. The Atlas of Posterior Fundus Changes in Pathologic Myopia discusses these and other important questions on the basis of long-term observation and research. A major feature of the book is the presentation of many case studies, with generous use of full-color photographs to show in detail the course of fundus changes. The atlas is valuable resource not only for ophthalmologists interested in myopia but for optometrists, opticians, and medical students.