This book bridges the gap between data scientists and clinicians by introducing all relevant aspects of machine learning in an accessible way, and will certainly foster new and serendipitous applications of machine learning in the clinical neurosciences. Building from the ground up by communicating the foundational knowledge and intuitions first before progressing to more advanced and specific topics, the book is well-suited even for clinicians without prior machine learning experience. Authored by a wide array of experienced global machine learning groups, the book is aimed at clinicians who are interested in mastering the basics of machine learning and who wish to get started with their own machine learning research. The volume is structured in two major parts: The first uniquely introduces all major concepts in clinical machine learning from the ground up, and includes step-by-step instructions on how to correctly develop and validate clinical prediction models. It also includes methodological and conceptual foundations of other applications of machine learning in clinical neuroscience, such as applications of machine learning to neuroimaging, natural language processing, and time series analysis. The second part provides an overview of some state-of-the-art applications of these methodologies. The Machine Intelligence in Clinical Neuroscience (MICN) Laboratory at the Department of Neurosurgery of the University Hospital Zurich studies clinical applications of machine intelligence to improve patient care in clinical neuroscience. The group focuses on diagnostic, prognostic and predictive analytics that aid in decision-making by increasing objectivity and transparency to patients. Other major interests of our group members are in medical imaging, and intraoperative applications of machine vision.

Retinal Detachment: Principles and Practice provides a historical review of current information on the diagnosis and treatment of retinal detachment. It is intended as both an introduction for graduate students in ophthalmology and a concise review or reference for practicing ophthalmologists. The volume defines the types of retinal detachments, their classifications and causes, and covers preoperative examination, preoperative management, prophylactic procedures, surgery, complications of surgery, and results of reattachment surgery. It also includes a historical introduction, suggested readings at the end of each chapter, and the classic article 'The Technique of Binocular Indirect Ophthalmoscopy, ' by Morten L. Rosenthal.

This book provides a list of concise extemporaneous ophthalmic preparations, and standardizes the formulation of the products by suggesting specific strength, route of administration, appropriate vehicle, and method of preparation. Pharmaceutical industries have greatly expanded their share of ophthalmic drugs in recent years. However, physicians and pharmacists are frequently called to prepare sterile products intended for ophthalmic use due to lack of availability of licensed drugs in the market. This book contains the most appropriate formulation of each medication based on published and documented stability data. Extemporaneous Ophthalmic Preparations is the first book of its kind, making it a unique and valuable companion for many physicians and pharmacy practitioners who are frequently engaged in the compounding of sterile ophthalmic preparation.

Bernard Jensen, who pioneered iridology worldwide, presents a basic introduction to the science which analyzes the delicate structures of the iris to reveal and locate inflammation in the body.

This book provides a practical overview of pathology and interventions in the suprachoroidal space of the eye. Concise and well-structured chapters examine anatomy, physiology and pathophysiology, suprachoroidal haemorrhage, choroidal effusions and ocular hypotony management, imaging, suprachoroidal buckling for retinal detachment, drug delivery, suprachoroidal glaucoma devices, subretinal gene therapy and suprachoroidal retinal implant. Suprachoroidal Space Interventions meets the need for a book that improves awareness of established and novel interventions in the suprachoroidal space, particularly as it has been increasingly recognised as a potential space for glaucoma surgery, drug deliveries and retinal surgery. Ophthalmologists and scientists with an interest in glaucoma and retinal surgery will find the book to be an easy to use reference tool for a rapidly developing area of ophthalmology that can be applied in modern clinical practice.

Just as neuro-ophthalmology links ophthalmology with other medical specialties, so too the optic nerve links the eye with the central nervous system. Thus, ophthalmologists must be familiar with a wide variety of optic nerve diseases, which may occur in isolation or form part of a generalised neurologic or systemic disorder. Optic Nerve Disorders is an up-to-date guide to the relevant literature on a wide variety of clinical diseases of the optic nerve that will give the clinician a handy reference to assist in both their diagnosis and management. It provides a succinct, yet comprehensive review of optic nerve disorders commonly encountered in clinical practice, briefly reviews the anatomy and physiology of the optic nerve, and outlines those techniques of particular importance during clinical testing of optic nerve function. Chapter 1 reviews the major anatomic aspects of the optic nerve at both a macroscopic and a microscopic level, and discusses the critical role of axonal transport in optic nerve physiology. Chapter 2 takes the reader back to basics, emphasising the importance of obtaining a detailed patient history and performing a careful ophthalmologic examination. Chapters 3 through 9 cover the major clinical disorders affecting the optic nerve: papilledema, optic neuritis, ischemic optic neuropathy, compression of the anterior visual pathways, developmental and hereditary optic nerve disorders, toxic and nutritional optic neuropathy, and traumatic optic neuropathy. The last chapter, Chapter 10, summarises those optic neuropathies that cannot easily be categorised, but that frequently confront the general ophthalmologist in clinical practice.

Optical Coherence Tomography Angiography (OCTA) is a novel, non-invasive, dyeless imaging modality that has emerged as an indispensable tool in the fields of optometry and ophthalmology.  OCTA provides three-dimensional volumetric images of the retinal and choroidal vasculature by using a motion-contrast decorrelation algorithm.  This cutting-edge imaging technology has widespread clinical utility as a non-invasive alternative for visualizing microvasculature in detail, but there are no textbooks dedicated to its use and the interpretation of scans. To fill this need, Optical Coherence Tomography Angiography Atlas: A Case Study Approach, by Dr. Julie A. Rodman, is a richly illustrated, practical guide to OCTA. It provides detailed information on the fundamental principles behind the technology, as well as clinical applications critical for accurate interpretation. The first section of the book discusses the principles behind OCTA and provides an introduction into the interpretation of OCTA images, including a chapter devoted to terminology. The remainder of the book provides detailed analysis of a myriad of inner and outer retinal disorders, including diseases of the optic nerve head. Most importantly for the clinical setting, the cases are presented with numerous images and a multitude of arrows and callouts to assist in the recognition of various clinical findings. Case examples include: Vascular Occlusive Disease Pigment Epithelial Detachment Choroidal Neovascular Membrane Diabetic Retinopathy Optic Disc Edema Dr. Rodman's emphasis on the clinical use of OCTA technology and step-by-step interpretation of images makes Optical Coherence Tomography Angiography Atlas: A Case Study Approach a must-have resource for physicians, residents, students, and ophthalmic technicians looking for a simple, comprehensive guide to OCTA.

Abnormal or deficient capsular anatomy creates numerous surgical challenges and predisposes eyes to IOL complications. Literally dozens of different approaches have been devised to implant IOLs in the face of compromised capsular support. However, a comprehensive compendium of the most important surgical strategies has not existed, until now. Advanced IOL Fixation Techniques: Strategies for Compromised or Missing Capsular Support provides this much-needed resource with more than 70 different chapters that cover the wide array of surgical approaches. Among the contributors are many of the original innovators of the most important technologies and methodologies. In addition to teaching a specific surgical technique, these authors cover its history, rationale, and clinical results. Editor Dr. David F. Chang is well known and acclaimed for 2 best-selling cataract textbooks-Mastering Refractive IOLs and Phaco Chop and Advanced Phaco Techniques. Along with associate editors Drs. Bryan S. Lee and Amar Agarwal, Dr. Chang has now tackled this new major subject area-how to best fixate IOLs when capsular support is compromised or absent. Part One covers capsular fixation with either zonulopathy or following posterior capsule rupture. Topics include using conventional and modified capsular tension rings, capsular tension segments or capsular anchors, standard and reverse optic capture with anterior capsulorrhexis, sulcus fixation, posterior capsulorrhexis, and capsular membrane suture fixation. Part Two covers noncapsular fixation. Topics include anterior chamber IOLs, iris claw IOLs, iris and transscleral suture fixation of posterior chamber IOLs, and intrascleral haptic fixation using the Yamane double-needle or glued IOL methods. Part Three covers miscellaneous topics such as anterior vitrectomy, IOL power calculation for noncapsular IOLs, and sliding slip knots and suture pupilloplasty. To facilitate skills transfer, most chapters present detailed, step-by-step descriptions of the different techniques. The maneuvers are illustrated by over 1,100 diagrams and high-resolution surgical images. Finally, nearly every chapter is accompanied by narrated instructional videos. Combining over 150 videos, schematic diagrams, surgical images, and detailed written descriptions, Advanced IOL Fixation Techniques provides the most effective way to learn advanced surgical techniques. With its comprehensive and practical approach to covering the gamut of strategies and devices, Advanced IOL Fixation Techniques: Strategies for Compromised or Missing Capsular Support will be an indispensable resource for cataract surgeons at all levels of experience.

Due to its instantaneous and visible results for patients both anatomically and visually, anterior lamellar keratoplasty is a field of great interest to corneal surgeons. Newer techniques of DALK, femtosecond assisted DALK, TILK, and more have inherent advantages that make them supersede older techniques of keratoplasty by far. Mastering DALK: A Video Textbook on Deep Anterior Lamellar Keratoplasty by Dr. Soosan Jacob combines the practical explanation of written text with the dynamic demonstration of surgical videos. From pre-operative to post-operative patient management and every surgical technique in between, this unique book and its included video website is a complete education on DALK. This includes the history and basics of lamellar keratoplasty, as well as tutorials on various surgical techniques currently in use, advice for complex situations, and management of possible complications. Each chapter includes high-quality photographs and illustrations and is paired with videos on the accompanying website to demonstrate techniques and provide step-by-step instructions. The surgeries in these videos are performed and narrated by the same team of leading international experts who have also written all of the clinical tips, tricks, and pearls of wisdom throughout the book. Some videos include: Retrieving the Lost Bubble DALK Surgery with Type 1 Big Bubble Groove Peel DALK Femtosecond Laser Assisted DALK SMILE Away a Dermoid Any surgeon looking to add anterior lamellar keratoplasty to their practice will appreciate the digestible nature of Mastering DALK: A Video Textbook on Deep Anterior Lamellar Keratoplasty, which provides both the crucial detail of a book and the irreplaceable value of visual demonstration.

Pathologic Myopia is a major cause of severe vision loss worldwide. The mechanisms for vision loss include cataract, glaucoma, retinal detachment, and above all, myopic maculopathy within the posterior staphyloma. The first edition of Pathologic Myopia is one of the only current books to specifically address this disease and discusses recent developments in imaging technologies and various approaches to treatments, such as laser photocoagulation, photodynamic therapy, pharmaco-therapeutic injections in the vitreous, and surgery. This new edition is a timely update to the standard reference in the field, with new chapters on advanced refractive error correction, genetics, developing a classification system, and special surgical approaches for pathologic myopia. Complete with even more high-quality color images and informative tables, this book is written and edited by leaders in the field and is geared towards ophthalmologists, including residents and fellows in training, glaucoma and cataract specialists, and vitreoretinal macula experts.

Due to the growing population of dry eye patients, there has been much study of dry eye disease. Following the 2007 and 2017 full reports of the international Dry Eye Workshop (DEWs I and II), as well as the recent Dry Eye Assessment and Management (DREAM) trial, there is a growing body of consensus and evidence-based literature on the treatment of dry eye. Dry Eye Disease: A Practical Guide, synthesizes all these scientific sources into a comprehensive yet user-friendly clinical reference. From epidemiology and pathogenesis, to disease subgroups, diagnostics, and management, Drs. Francis S. Mah and Michelle K. Rhee with their team of over 35 renowned contributors have distilled all the latest information on dry eye disease into an easily digestible guide. Featuring diverse case scenarios pulled from clinical practice, Dry Eye Disease engages the reader and encourages critical thinking to apply current understanding of dry eye disease to the office and operating room. All aspects of this complex disease are discussed, including the relationship between dry eye and surgical outcomes and contact lens wear. Topics include: The latest biomarker diagnostics Meibomian gland dysfunction therapeutic technologies The role of integrative medicine Advances in therapeutic contact lenses Ophthalmologists and optometrists of all specialties and skill levels will find Dry Eye Disease a comprehensive yet practical clinical guide for treating the growing population of dry eye patients.

This book provides a visual overview of how to master ultrasonography and ultrasound biomicroscopy techniques. Updated ultrasonic information is included in a simple brief way, featuring didactic points, with a variety of documented scans and illustrated lines underneath for more clarification. Each pathology is accompanied with several scans of different findings to give more information of distinct detections. Ophthalmic Ultrasonography and Ultrasound Biomicroscopy: A Clinical Guide examines many clinical complexities with possible solutions when performing and interpreting ultrasound while also breaking down information for easier intake. The clinical cases are from a specialist eye hospital where many complicated cases are treated, giving a unique insight for the reader to understand treatment for a variety of cases. The book also emphasises the importance of everyday cases with further explanation whilst utilising a diversity of pictures and labels.

Strabismus is a disorder in which the eyes are misaligned. This volume is the most advanced reference for techniques in diagnosis and treatment of strabismus. Chapters cover diagnosis of, surgical and nonsurgical treatments for, and management of esotropia (eyes aligned inward) exotropia (eyes aligned outward), dissociated strabismus complex, paralytic strabismus, restrictive strabismus, and nystagmus. It also contains a chapter on reoperation strategies.

The Understanding Glaucoma chart shows the structure of the eye along with a visual depiction of the fluid pressure associated with glaucoma. The optic nerve, the Canal of Schlemm and normal and damaged retinas are shown as close-up views. Heavy gauge 3ml lamination with sealed edges and two metal eyelets for hanging makes chart highly durable. Write-on/wipe-off with dry erase marker (not included).

This book provides a practical guide to the most recent advances in the diagnostic management of corneal ectasia. Clear, concise chapters address new standardized nomograms of treatment of early progressive ectasia, new epithelium on future crosslinking with and without oxygen supplement, customized protocols, laser assisted corneal regularization protocols and the new femtolaser assisted lamellar corneal transplant. Clinicians and surgeons seeking a go-to guide on the topic of corneal ectasia will find this book to be an essential resource for the latest developments and predicted future trends in the field.

The Neuropsychology of Vision describes a range of new approaches to neuropsychological investigation and provides a broad overview of visual neuropsychology. The book starts by presenting the results from new research employing single-unit recordings, on the neuronal basis of perception demonstrating that the visual system relies strongly on feedback from higher to lower levels of information processing, and that neuronal plasticity exists in the primary sensory cortices of adults, areas previously considered to be hard-wired. The book also describes other new and adapted techniques to measure brain activity, including multi-unit sum potential recording, functional magnetic resonance imaging and employing transcranial magnetic stimulation to induce temporary, circumscribed functional lesions in the cortices of normal subjects to mimic disorders.

The coverage then moves on to review the experience of patients suffering from disturbances of visual perception. The disorders covered include agnosia, neglect, blindsight and achromatopsia. The final chapter is devoted to recovery and rehabilitation from cerebral visual disorder.

Professors Fahle and Greenlee have brought together some of the leading international specialists in the field to provide this comprehensive and up-to-date review.

This book focuses on the concept of ocular rigidity, the biomechanical properties and hydrodynamics of the human eye. The basics of anatomy and physiology are explored and the relevant data for the clinician are emphasized throughout the book. The engineering aspects as well as the clinical interpretation are presented to provide context. Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye summarises recent evidence on ocular rigidity, but also provides a complete presentation of the data so far. The authors have recently worked on ocular rigidity corneal and globe biomechanics and hydrodynamics and the new, up-to-date data on the subject are highlighted in each chapter. The aim is to provide the framework or the understanding of these parameters and to determine their relevance in health and disease. This book will be an essential read for all practicing ophthalmologists looking to gain a more in-depth understanding of this interesting area of research particularly in refractive surgery and glaucoma.

This monograph introduces rehabilitation, looks at the history of low vision rehabilitation, enhancing low vision effectively, assessing daily living needs, addressing paediatric needs, and considering psychological aspects.

Even the most experienced cataract surgeon can encounter stressful situations in the operating room. With the new edition of More Phaco Nightmares: Conquering Cataract Catastrophes, surgeons can be prepared to manage unavoidable complications with ease. Dr. Amar Agarwal, along with over 35 of today's cataract surgery leaders, explain all there is to know about phacoemulsification and bring their extensive experience with their own surgical nightmares. The book contains 5 sections that gradually escalate from the basics to nightmares, furnishing phaco surgeons with complicated scenarios and the essential guidance to assess, manage, and resolve. Featuring updated content and brand new, state-of-the-art chapters on a variety of complex situations, More Phaco Nightmares is the toolkit surgeons need to stay in control when facing unique and especially challenging intra- and postoperative complications. Sample chapters include: The Phaco Machine Air Pump, Gas-Forced Infusion, and Active Fluidics Intraoperative Floppy Iris Syndrome Single-Pass Four-Throw Pupilloplasty Management of Capsule Rupture at Cataract Surgery Malpositioned Intraocular Lens Optic Capture Glued Intraocular Lens Management and Prevention of Negative Dysphotopsia Pseudophakic Cystoid Macular Edema More than 350 illustrations and photographs supplement the text, providing visual as well as textual references for each case. Plus, an accompanying video website contains over 4 hours of new, original, high-quality video content, offering additional visual learning to demonstrate the techniques discussed. Offering cutting-edge information, More Phaco Nightmares: Conquering Cataract Catastrophes will guide surgeons on how to mitigate the common problems and unanticipated disasters that may arise for even the most experienced surgeons.

This book is a comprehensive overview of blepharitis that covers the various types of this common and challenging entity. Concise and unique, chapters are clinically focused, providing an equal emphasis on the medical as well as surgical management of this condition. The book concludes with a look at future directions in the field as they pertain to diagnosis and management. Blepharitis is an invaluable reference written specifically for comprehensive ophthalmologists, cornea and external disease specialists, residents, fellows, and optometrists.

Thorough, up to date, and unique in the field, Comprehensive Textbook of Eyelid Disorders and Diseases, by Drs. Jonathan J. Dutton, Hatem A. Tawfik, and Alan D. Proia, offers a complete up-to-date review of the most common eyelid disorders. In 147 chapters, the authors provide highly illustrated discussions of each condition, suitably detailed for ophthalmologists working in oculoplastics, neuro-ophthalmology, and pediatrics, as well as facial surgeons, dermatologists, and dermatopathologists. Offers detailed coverage on a full range of eyelid disorders, including congenital and developmental anomalies, eyelid malpositions, benign lesions, movement disorders, aging phenomena, and malignant neoplasms Presents information in an easy-to-reference, consistent format: historical background, etiology and pathogenesis, clinical presentation, differential diagnosis, histopathology, known genetic relationships, treatment options, prognosis, current research, and extensive references Includes introductory chapters on key topics such as evolution of the vertebrate eyelids, embryology, anatomy, basics of histopathology and terminology, clinical history and eyelid examination Provides superb visual guidance in more than 800 highly-quality, full-color photographs and histopathology sections Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Time is an incredibly valuable resource for ophthalmic and para-optometric personnel, whether they are still studying on their way to certification or they are already in the trenches in daily practice. To keep up, they need a single, cohesive text containing everything they need to learn. Principles and Practice in Ophthalmic Assisting: A Comprehensive Textbook meets that need, covering all subject areas in detail while also maintaining a readable, user-friendly style. Editors Janice K. Ledford and Al Lens have gathered a prestigious team of over 40 contributors, all of them ophthalmic and optometric medical personnel, who actively perform the tasks they write about. Their time-tested expertise is like having a group of specialists right by your side to show how it's done and answer questions. From A-scan to zygoma, Principles and Practice in Ophthalmic Assisting: A Comprehensive Textbook includes everything ophthalmic and para-optometric personnel need to know to effectively perform their duties, assist their patients, and advance their careers. Each chapter is written in a friendly manner and follows an established framework, making it easy to digest any new information or as a quick reference to the material needed. Chapters also include valuable "tricks of the trade" that could only come from authors with intimate knowledge of their topics. Topics covered: General ophthalmic knowledge Ophthalmic skills Optical skills Ophthalmic medical sciences Surgical services and skills Administrative skills Whether perfecting current skills, learning new ones, or studying for exams, Principles and Practice in Ophthalmic Assisting: A Comprehensive Textbook makes both a perfect learning tool for students and a complete reference tool for staff, whether they are new to the eye care industry or have years of experience.