The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the "best" and "most important" meetings in the field. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy. While advances in these areas of retinal degenerations will be described, there will be many new topics that either were in their infancy or did not exist at the time of the last RD Symposium, RD2014. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those will be reported at the RD2018 meeting and included in the proposed volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations will be reflected in the volume.

This first volume of the series Essentials in Ophthalmology aims to give a picture of recent progress in the field of glaucoma, in both basic clinical research and applied clinical science. Its intention is not to replace textbooks on glaucoma, but to serve as a conceptual bridge between original research and textbook presentation. The volume encompasses (a) genetic aspects of different forms of glaucoma, such as normal tension glaucoma, pseudoexfoliative glaucoma, childhood glaucoma, and angle closure glaucoma, (b) methods of diagnosis, such as imaging techniques, visual fields, electrophysiology, and ultrasound biomicroscopy, and (c) aspects of therapy, such as the target pressure concept, wound modulation in glaucoma surgery, neuroprotection, treatment of normal tension glaucoma, and the evaluation of nonpenetrating surgery. The editors have set out to provide the reader with a diversity of interesting topics reflective of the evidence-based, modern approach to the field of glaucoma. Written for: Ophthalmologists in clinical and private practice, residents, ophthalmologists-in-training as well as optometrists and ophthalmic nurses

The development of ophthalmology to its present level of sophisticated practice is an extraordinary story of research, experiment, and achievement. Dates in Ophthalmology: A Chronological Record of Progress in Ophthalmology over the Last Millennium charts the progress of that achievement over the last millennium, highlighting and describing the key dates of advancement. It presents a concise listing of the chief personages, periods, publications, and events in the history of ophthalmology from ancient times to the present. The book demonstrates how ideas, discoveries, and technologies cross borders and oceans. It illustrates the interplay of subspecialties, the changing pre-eminence of countries and cities, and the explosions of creativity and generations of dormancy in various areas. The author highlights the numerous and diverse events and people responsible for shaping this specialty. There are many ways of looking at history: from the standpoint of the lives of major figures, of society and impact, of subspecialties, of countries, of institutions, and of books. By presenting its information chronologically, Dates in Ophthalmology explores the how these areas intersect, influence, and impact each other.

Studies on Retinal and Choroidal Disorders examines the role that oxidative and nitrosative stress plays in the complex physiology and pathophysiology of the retina and choroid. Both the basic science researcher and the clinical practitioner can use this book as a guide to the current understanding of retinal and choroidal cellular mechanisms involved in aging and disease. Beginning with a review of oxidative stress and inflammation in the pathoetiology of AMD and a review of the complement system in the retina, the book then takes a detailed look at oxidative stress in lipid metabolism and oxidized lipoproteins in the retina. It examines the anti-apoptotic activity of -crystallins in the presence of glutathione, oxidative stress in the mitochondria and endoplasmic reticulum, the role of iron in retinal disease, the mechanisms of pathological VEGF expression, NAPDH oxidase mechanisms, and Hepatocyte Growth Factor in oxidative stress in the retina. A detailed look at the Ccl2-/-/Cx3cr1-/- mouse model of AMD follows. Then a detailed examination of the systemic changes in AMD is followed by a discussion of cerium oxide nanoparticle reduction of oxidative stress. Two chapters discuss progenitor cells in the cause and treatment of retinal diseases including AMD and diabetic retinopathy. Natural compounds in the prevention and treatment of retinal diseases are exhaustively presented, followed by a chapter on serotonin 5-HT1A receptor agonists in oxidative stress of the retina. The current anti-VEGF treatment strategies of neovascular AMD are then given. The volume continues with a detailed look at nitric oxide and inducible nitric oxide synthase in retinal vascular disease, an explanation of an in vivo technique of studying the effect of lipid hydroperoxides on circulating leucocytes in the retina, an excellent review of oxidative stress in retinopathy of prematurity, and a look at VEGF induced oxidative stress in the retinal ganglion cell. The book ends with a detail examination of the role of carotenoids in retinal health and disease. These 31 chapters summarize what is known about oxidative stress in retinal and choroidal disorders. All those involved with degenerative diseases of the eye will find Studies on Retinal and Choroidal Disorders to be illuminating and comprehensive.

This book covers a wide range of topics concerning human tear based science, starting from basics such as the normal composition of tears and moving up to novel disease detection platforms. The entire approach is pioneering, as tears are beginning to be recognized as the most invaluable non-invasive tool in diagnostics. Interestingly, the concept is not restricted to ocular diseases: In recent years, tear diagnostics is increasingly being tapped even for cancer detection. Hopefully, non-invasive tear diagnostics will eventually replace today's invasive disease detection and monitoring techniques. Previous literature on tear diagnostics has been restricted to scientific journal articles, most of which dealt with a single tear constituent, such as a protein. This book offers a far more comprehensive and handy 'reference guide,' presenting both basic and advanced information and data. Accordingly, it will be useful for researchers in academia and the pharmaceutical industry, as well as healthcare professionals and diagnostic kit developers.

This book provides a concise yet comprehensive source of information on the classification, evaluation, diagnosis, and management of vascular lesions of the orbit and face. It highlights recent technological innovations and new treatments that have significantly improved the ability to accurately evaluate and successfully treat these lesions with reduced complications. Some of these advances include new imaging modalities, intravascular and intralesional treatment approaches, photodynamic therapy, and additional medical therapies. Many of these advances have led to paradigm shifts in the understanding and management of vascular lesions of the orbit and face. This book, written by experts in the fields of ophthalmology, dermatology, diagnostic and interventional radiology, and oculoplastic surgery, features structured, in-depth chapters that can also be quickly consulted as a reference guide. It is an excellent resource for those in training as well as seasoned practitioners wishing to acquaint themselves with the newest diagnostic and treatment techniques for orbital vascular lesions.

Extensively revised, this state-of-the-art 3rd edition of Cataract Surgery offers new perspectives and cutting-edge coverage of the rapidly evolving field of cataract surgery. Roger F. Steinert, MD, along with a who's who of top international experts, delivers comprehensive clinical coverage of the latest surgical techniques, principles, and pearls, as well as expert advice on preoperative assessment and how to avoid and manage complications. Detailed discussions on today's hot topics such as aspheric and presbyopia IOL, phacoemulsification, and more, keep you at the forefront of this burgeoning field. And, more than 1050 illustrations and a DVD containing videos of cataract procedures give you step-by-step visual guidance. Plus, with Expert Consult functionality, you'll have easy access to the full text online at www.expertconsult.com. Features expert tips on common pitfalls in cataract surgery, including advanced surgical pearls to maximize patient outcomes. Contains 10 new chapters covering Modular Intraocular Lenses (IOLs), Femtosecond-Laser-Assisted Cataract Surgery, Preoperative Evaluation and Considerations of Astigmatism, Toric Intraocular Lenses (IOLs), Managing Residual Postoperative Astigmatism, Retinal Considerations in Cataract Surgery, Management of Dysphotopsia, Refractive Enhancements after Cataract Surgery, and more. Provides rich visual guidance with more than 1,200 diagnostic, clinical, and surgical photos and illustrations with clear explanations. Includes more than 50 videos of narrated surgical footage performed by the authors, offering real-time guidance on the full range of the latest cataract surgery techniques. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. Provides access to the full-text online at www.expertconsult.com for convenient referencing. Includes a DVD of surgical videos performed by the authors, offering you real-time guidance on the full range of the latest cataract surgery techniques, including phacoemulsification in the presence of a small pupil, toric IOL implantation, biaxial microincision cataract surgery, and many others. Features expert hints and tips on the common pitfalls in cataract surgery, including advanced surgical pearls to save you valuable time and help you avoid costly errors. Offers expanded coverage on how to manage complications, to prepare you for the challenges you face. Provides the latest information on phacoemulsification techniques, keeping you on the cusp of these popular procedures. Presents new chapters on Aspheric Multifocal, Accommodating IOLs, Color-filtering IOL, IOL design, and Capsular opacification offering you the latest information in this rapidly advancing area.

Basic Principles of Ophthalmic Surgery is an essential textbook for any ophthalmology resident or trainee and will help them build a solid foundation of ophthalmic surgical knowledge. It lays the groundwork for the 80 surgical procedures covered in the companion volume, Basic Techniques of Ophthalmic Surgery, Third Edition. In this new edition, chapters have been reviewed and revised with important updates in the areas of ergonomics, intraocular fluids, patient safety issues and postoperative management. Each chapter includes key points, suggested reading and self-assessment questions. In addition, the book contains more than 200 photographs and illustrations and four videos.

As a degenerative disorder of the eye, keratoconus can cause substantial distortion of vision, with multiple images, streaking, and sensitivity to light all reported by patients. Keratoconus: Recent Advances in Diagnosis and Treatment updates ophthalmologists about the innovations that have occurred within the last decade, discussing the diagnostic imaging techniques that have been developed for keratoconus diagnosis, understanding of how examination techniques are related to the evolution of keratoconus, and how to indicate the different therapeutic tools that have been created for keratoconus over the last several years. Additionally, fundamentals for new diagnostic elements, based on the mathematical, physical and biomechanical data are analyzed in depth for a better understanding of the essential diagnostic steps for the clinician to guide patients towards the most adequate therapeutic tool in the case. Modern keratoplasty techniques, assisted by femtosecond lasers or other devices, are also covered and these techniques, along with the emerging conservative treatments, have added to more precise control of the evolution of the disease.

Confocal microscopy with laser scanning technology yields in-vivo images of ocular and ocular adnexal surfaces that are so brilliant that they rival histology in terms of quality.This unique atlas and textbook demonstrates normal in-vivo anatomy of the cornea, limbus and conjunctiva, quantifies various cellular structures using cell-density calculations and establishes correlations between novel optical sections of various diseases of the ocular surface and clinical findings. Furthermore, it supports the interpretation of novel high-magnification optical sections by comparing corneal and conjunctival imprint cytology with in-vivo images and describes early inflammatory changes in corneal grafts, as well as corneal conjunctivalisation in limbal stem cell deficiency, corneal dystrophies or infections, flap interface and margin characteristics after laser in-situ keratomileusis (LASIK). In addition, it instructs the reader about diagnostic and therapeutic follow-up strategies and provides a brief introduction to applications in other fields such as dentistry and ear, nose and throat surgery.

This issue of Neurologic Clinics, edited by Dr. Andrew Lee, will focus on Neuro-Ophthalmology. The topics covered in the issue include, but are not limited to new treatments for nonarteritic anterior ischemic optic neuropathy; idiopathic intracranial hypertension; neuroimaging for the Horner Syndrome; OCT; erectile dysfunction agents and NAION; NMO; ocular myasthenia gravis; imaging for third nerve palsy; treatment of central retinal artery occlusion; and orbital disease, among others.

This volume is devoted to the recent advances in diagnostic ultrasound in ophthalmology. It provides an overview of the progress in clinical applications of the technique. There are chapters that focus on the optic nerve and extraocular muscles, orbital and periorbital lesions, intraocular tumors and intraocular disorders. In addition there are chapters that deal with the anterior segment, instrumentation, biometry and Doppler methods. The contributions prepared by a group of international experts in the field should be of interest to all those involved in ophthalmic echography.

Prolonged microgravity exposure during long-duration spaceflight (LDSF) produces unusual physiologic and pathologic neuro-ophthalmic findings in astronauts. These microgravity-associated findings collectively define the Spaceflight Associated Neuro-ocular Syndrome (SANS). In this book, the editors compare and contrast prior published work on SANS by the National Aeronautics and Space Administration's (NASA) Space Medicine Operations Division with retrospective and prospective studies from other research groups. The book describes the possible mechanisms and potential etiologies for SANS, and provides an update and review on the clinical manifestations of SANS including: unilateral and bilateral optic disc edema, globe flattening, choroidal and retinal folds, hyperopic refractive error shifts, and focal areas of ischemic retina (i.e., cotton wool spots). The ocular imaging findings (e.g., retinal nerve fiber layer, optic disc, and choroidal changes on optical coherence tomography) of SANS is also described, including the intraorbital and intracranial findings on orbital ultrasound and magnetic resonance imaging. The knowledge gaps for in-flight and terrestrial human research including potential countermeasures for future stud is also explored, including reports on the in-flight and terrestrial human and animal research being investigated by NASA and its partners to study SANS both prospectively and longitudinally and in preparation for future long duration manned missions to space including the moon, the asteroid belt, or Mars. We think this is a unique topic and hope that NASA and its research partners continue to study SANS in preparation for future longer duration manned space missions.

Ophthalmic Epidemiology: Current Concepts to Digital Strategies provides a comprehensive guide to graduate students, ophthalmologists, and researchers in ophthalmic epidemiology. It covers recently developed new methodologies, technologies and resources in ocular epidemiological research, such as telemedicine, disease registries, EMR, bio-banks and omics. This book also summarizes recent epidemiological findings and provides up-to-date data on ocular diseases. Furthermore, it introduces and discusses the uses of epidemiology in the evaluation of health services and population screening programs and reviews the application of epidemiology in intervention trials in the communities. Key Features Comprehensive guide to the epidemiology of common eye diseases. Provides updates on the prevalence and risk factors of eye diseases. Outlines how epidemiological techniques can be utilized to evaluate ophthalmic health services and programs.

This book is written for retinal specialists and clinicians with a special interest in retinal diseases. It presents a collection of images and brief annotations of the microstructures of both the normal and diseased eye captured on swept source optical coherence tomography. The swept-source OCT is a relatively new form of imaging and is able to capture structures and details which previous generations of OCT machines cannot. This type of imaging represents the forefront in ocular imaging. This second edition includes a new chapter on optic nerve conditions and more cases on eye conditions that were imaged with the SS-OCT. It also showcases the use of swept-source OCT for OCT angiography.

Using a highly effective case study format, Case Reviews in Ophthalmology, 3rd Edition, incorporates both medical knowledge and clinical judgement to help you achieve the best possible results on practical exams. This carefully compiled study resource provides more than 165 relevant cases covering every aspect of the field: optics/refraction, neuro-ophthalmology/orbit, pediatrics/strabismus, external disease/adnexa, anterior segment, and posterior segment. Large photos highlight each case, enhancing your knowledge and reinforcing key aspects of diagnosis. Helps you prepare for examinations and clinical practice with real-world patient scenarios (19 new to this edition) with accompanying images, questions, and answers. Covers the most important and relevant aspects of each topic in a concise, bulleted format for easy recall and effective exam preparation. Contains hundreds of clinical and histological images, OCT and other current imaging methods, anatomic details, common ophthalmic test findings, and more. Presents the findings of key clinical studies with which you are expected to be familiar. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Over the weekend of 21-23 February 1997, a small group gathered in Tallahassee, Florida, at the invitation of Ted Williams, to discuss "photo stasis and related topics." The majority of participants were former students and colleagues of Ted's, but an occasional outsider such as myself was generously included. The papers presented there are collected in this volume. The theory of photo stasis was first outlined in a landmark paper by John Penn and Ted, published in 1986 in Experimental Eye Research. They provided compelling data showing that, in the albino rat eye, levels of rhodopsin, outer-segment length, rhodopsin regeneration rate, and even, perhaps, rhodopsin packing density all depend on the levels of cyclic illumination (12 hours light, 12 hours dark) in which the animal was reared. So, for example, there is fourfold less rhodopsin in a retinal extract derived from an animal reared at 400 lux than in an extract from the retina of an animal reared at 3 lux. Animals reared at intermediate levels of light show intermediate amounts of rhodopsin that are correlated with illumination level. What these data immediately suggested is that the photoreceptor cell can adjust its photon-catching ability in response to the levels of light in which an animal is reared, and they also provided a compelling rationale for outer-segment turnover, a phenomenon discovered 20 years earlier by Richard Young but whose function has remained obscure.

Key Clinical Topics in Ophthalmology presents a brand new addition to the Key Clinical Topics series. The book provides a comprehensive overview of the subject, comprising 93 carefully selected topics in alpha order that together provide an extensive understanding of the management of ophthalmic disorders. This collection of highly practical guides systematically addresses management techniques for a large number of clinical settings. Edited by experienced specialists, with contributions from consultants who have recognised expertise in their field, this book provides an authoritative and up-to-date guide on ophthalmic medicine. Designed to enable rapid access to core information, KCT in Ophthalmology offers effective exam revision and the ideal quick reference for day-to-day practice. Key point 93 topics presented in alpha order, from age-related macular degeneration to white dot syndromes Effective exam revision for postgraduate trainees in ophthalmology preparing for certification Succinct coverage of ophthalmic treatment modalities and complications Includes clinical photos and diagrams to improve understanding of concepts Contributions from experienced specialists to ensure authoritative, accurate content

New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System is the latest volume from Progress in Brain Research focusing on new trends in basic and clinical research of glaucoma. This established international series examines major areas of basic and clinical research within neuroscience, as well as emerging subfields.

Glaucoma is the second leading cause of blindness globally. Early detection and treatment can prevent its progression to avoid total blindness. This book discusses and reviews current approaches for detection and examines new approaches for diagnosing glaucoma using CAD system. Computer-Aided Glaucoma Diagnosis System, Chapter 1 provides a brief introduction of the disease and current methodology used to diagnose it today. Chapter 2 presents a review of the medical background of the disease, followed by a theoretical and mathematical background used in fundus image processing. Chapter 3 is a literature review about segmentation and feature extraction. Chapter 4 describes the formulation of the proposed methodology. In Chapter 5, the results of optic disc and optic cup segmentation algorithm are presented, the feature extraction and selection method, experimental results and performance evaluations of the classifier are given. Chapter 6 presents the conclusions and discussion of the future potential for the diagnostic system. This book is intended for biomedical engineers, computer science students, ophthalmologists and radiologists looking to develop a reliable automated computer-aided diagnosis system (CAD) for detecting glaucoma and improve diagnosis of the disease. Key Features Discusses a reliable automated computer-aided diagnosis system (CAD) for detecting glaucoma and presents an algorithm that detects optic disc and optic cup Assists ophthalmologists and researchers to test a new diagnostic method that reduces the effort and time of the doctors and cost to the patients Discusses techniques to reduce human error and minimize the miss detection rate and facilitate early diagnosis and treatment Presents algorithms to detect cup and disc color, shape features and RNFL texture features Dr. Arwa Ahmed Gasm Elseid is an assistant professor, Department of Biomedical Engineering, Sudan University of Science and Technology, Khartoum, Sudan. Dr. Alnazier Osman Mohammed Hamza is professor of Medical Imaging, College of Engineering, Sudan University of Sciences and Technology, Khartoum, Sudan.

Development of Vision and the Pre-Visual System; S.S. Easter, Jr., et al. Cellular and Molecular Aspects of Photoreceptor Differentiation; R. Adler. Embryonic Patterning of Cone Subtypes in the Mammalian Retina; K.C. Wikler, D.L. Stull. Development of Cone Distribution Patterns in Mammals; A. Szel, et al. Genesis of Topographic and Cellular Diversity in the Primate Retina; P. Rakic. Development of ON and OFF Retinal Ganglion Cell Mosaics; L.M. Chalupa, et al. Getting to Grips with Neuronal Diversity: What is a Neuronal Type? J.E. Cook. Glio-Neuronal Interactions in Retinal Development; A. Reichenbach. Comparative Anatomy and Function of Mammalian Horizontal Cells; L. Peichl, et al. Parallel Pathways of Primate Vision: Sampling of Information in the Fourier Space by M and P Cells; L. Peichl, et al. Parallel Pathways of Primate Vision: Sampling of Information in the Fourier Space by M and P Cells; L.C.L. Silveira, H.D. De Mello, Jr. Transient and Persistent Na+, Ca2+, and Mixed-Cation Currents in Retinal Ganglion Cells; A.T. Ishida. Synaptic Transmission Between Retinal Neurons; M. Wilson. Scaling the Retina, Micro and Macro; B.L. Finlay, R.L. Snow. Retinal Ganglion Cell Axonal Transport: Moving Down the Road to Functional Connections; K.L. Moya. 5 Additional Articles. Index.