Phillips and Ruth Thygeson were pioneers in medical research on external diseases of the human eye. Together, this husband-and-wife team shared a mutual story of extraordinary accomplishment including, among other things, the discovery of the cause and the cure of trachoma, a potentially blinding disease that affects millions of people worldwide.This comprehensive biography tells the complete story of their personal lives and careers. Beginning with each of their childhoods, the story continues through their meeting on the campus of Stanford University, their years of practicing ""frontier medicine"" in rural Colorado (where they built a log cabin with their own hands), their world travels in search of a cure for trachoma, and their considerable roles in establishing the Francis I. Proctor Foundation for Research in Ophthalmology. The story of this couple is one of a lifelong collaboration in medicine, a 70-year love affair, and an unending quest to conquer preventable blindness around the world.

Digital fundus images can effectively diagnose glaucoma and diabetes retinopathy, while infrared imaging can show changes in the vascular tissues. Likening the eye to the conventional camera, Image Analysis and Modeling in Ophthalmology explores the application of advanced image processing in ocular imaging. This book considers how images can be used to effectively diagnose ophthalmologic problems. It introduces multi-modality image processing algorithms as a means for analyzing subtle changes in the eye. It details eye imaging, textural imaging, and modeling, and highlights specific imaging and modeling techniques. The book covers the detection of diabetes retinopathy, glaucoma, anterior segment eye abnormalities, instruments on detection of glaucoma, and development of human eye models using computational fluid dynamics and heat transfer principles to predict inner temperatures of the eye from its surface temperature. It presents an ultrasound biomicroscopy (UBM) system for anterior chamber angle imaging and proposes an automated anterior segment eye disease classification system that can be used for early disease diagnosis and treatment management. It focuses on the segmentation of the blood vessels in high-resolution retinal images and describes the integration of the image processing methodologies in a web-based framework aimed at retinal analysis. The authors introduce the A-Levelset algorithm, explore the ARGALI system to calculate the cup-to-disc ratio (CDR), and describe the Singapore Eye Vessel Assessment (SIVA) system, a holistic tool which brings together various technologies from image processing and artificial intelligence to construct vascular models from retinal images. The text furnishes the working principles of mechanical and optical instruments for the diagnosis and healthcare administration of glaucoma, reviews state-of-the-art CDR calculation detail, and discusses the existing methods and databases. Image Analysis and Modeling in Ophthalmology includes the latest research development in the field of eye modeling and the multi-modality image processing techniques in ocular imaging. It addresses the differences, performance measures, advantages and disadvantages of various approaches, and provides extensive reviews on related fields.

This book discusses why specific diseases are being targeted for cell-based retinal therapy, what evidence exists that justifies optimism for this approach, and what challenges must be managed in order to bring this technology from the laboratory into routine clinical practice. There are a number of unanswered questions (e.g., surgical approach to cell delivery, management of immune response, optimum cell type to transplant) that very likely are not going to be answered until human trials are undertaken, but there is a certain amount of "de-risking" that can be done with preclinical experimentation. This book is essential reading for scientists, clinicians, and advanced students in stem cell research, cell biology, and ophthalmology.

If you are considering a career in ophthalmology, this book is for you. Ophthalmology is among the most popular and rewarding specialties in medicine. This book is packed full of useful strategies to maximise your chances of securing an ophthalmic specialist training (OST) post in the United Kingdom. Each step of the application process is covered, based on official guidance and the author's first-hand experience. An overview of the OST Person Specification and Multi-Specialty Recruitment Assessment (MSRA) is provided. The Evidence Folder (portfolio) is covered in detail, with targeted strategies for boosting scores across all sections. Interview preparation material is provided for the in-person interview format, including critical appraisal, improving patient care (audit and quality improvement), communication skills and clinical knowledge. Interview preparation material is also provided for the 2021 online interview (patient consultation). Three mock interviews with solutions/guidance are provided for both the in-person and online interview formats. The author also gives a candid account of his own journey in ophthalmic specialist training, plus "a week in the life of an ophthalmology trainee". This book is unique in its broad, easy-to-access approach to preparation strategies, theory and practice for aspiring ophthalmologists applying for OST posts in the UK.

After diabetic retinopathy, the varieties of retinal vein occlusion constitute the most prevalent category of retinal vascular disease. For macular edema associated with central retinal vein occlusion (CRVO), no effective therapy existed until 2009, despite decades of research and failed pilot therapies. This comprehensive, illustrated text integrates recent advances in treatments with the parallel progress in understanding of disease mechanisms. Complete with case studies, this text is perfect for retina specialists, ophthalmologists, optometrists, and residents and fellows in these fields.

Glaucoma Update VI comprises the latest progress in scientific glaucomatology. Forty-one articles of highly reputed experts in the field cover the genetics and other risk factors of the disease and provide new insights into the pathophysiology of blood flow, visual function and optic neuropathy in glaucoma. Special emphasis is placed on innovative treatment options, both medical and surgical.

First published in 1998. Routledge is an imprint of Taylor & Francis, an informa company.

Colour Vision Deficiences VIII brings together information on the latest trends in the following areas of research: -Visual effects of intense lights; -Effects of intoxications on colour vision; -Ageing and vision; -Methods of examination; -Congenital defects; -Acquired defects; -Practical aspects; -Physiological bases.
This volume is a natural follow-up on Volumes VI and VII published in 1981 and 1983 respectively by Dr. W. Junk Publishers.

This is a practical guide to using lasers in the Eye clinic and includes all commonly performed Lasers for a range of ocular conditions. It uses multiple illustrations of real-life fundus photographs, FFA images, OCT images and digitally modified retinal images to simplify learning the fundamentals of laser physics and physiology, laser safety and an overview of the variety of ophthalmic lasers in current use. It standardizes Laser procedures and serves as a reference guide for Ophthalmic trainees learning the technique that can be transferred to their clinical practice. The book simplifies understanding of Ophthalmic Lasers and answers common questions of how and why things are done. Key Features * Emphasizes on Nd-YAG Laser, Lasers in Glaucoma and Photothermal Lasers for Retinal Pathology, with clarity on techniques and pearls on dealing with common laser related issues that come with experience. * Provides content in a Q&A format which is ideal as a lesson from trainer to trainee and answers all the doubts and laser related questions a trainee may have and aids their learning and progression to performing Lasers safely and independently. * Uses digitally modified images with bullet points and reference text boxes, making the content user friendly and easy to understand.

1. Features recent developments like 3-D surgery, telescopic IOL, bionic implants and robotic surgery. 2. Highlights case selection and important precautions to be taken by vitreoretinal surgeons and senior residents. 3. Covers the controversies surrounding primary VR versus RD surgery in Phakic, fresh retinal detachments; Positioning after macular hole/ VR surgery; and to peel or not peel ILM in non-macular hole retinal surgery.

Originally published in 1925, this book embodies the results of research on red-green colour-blind subjects, supplemented by brief accounts of blue-yellow, total, and acquired colour-blindness to complete the description of the different forms of the defect. After a historical survey of previous work by such men as Dalton, Helmholtz, Rayleigh, Edridge-Green and others, the author deals with the most important theories of colour-blindness, and with a description of the tests and a discussion of their results.

Are you looking for concise, practical answers to those questions that are often left unanswered by traditional texts and references in oculoplastics? Are you seeking brief, evidence-based advice for common clinical dilemmas or complications? Curbside Consultation in Oculoplastics: 49 Clinical Questions provides quick and direct answers to the thorny questions most commonly posed during a "curbside consultation" between experienced clinicians. Dr. Robert C. Kersten and Dr. Timothy J. McCulley, have designed this unique reference in which oculoplastic specialists offer expert advice, preferences, and opinions on tough clinical questions commonly associated with oculoplastics. The unique Q&A format provides quick access to current information related to oculoplastics with the simplicity of a conversation between two colleagues. Images, diagrams, and references are included to enhance the text and to illustrate common clinical dilemmas. Curbside Consultation in Oculoplastics: 49 Clinical Questions provides information basic enough for residents while also incorporating expert pearls that even high-volume ophthalmologists will appreciate. Residents, fellows, and practicing physicians alike will benefit from the user-friendly and casual format and the expert advice contained within. Some of the questions that are answered:What do I do when a patient on anti-coagulants needs surgery? When does an eyelid lesion need to be biopsied? What are the general treatment guidelines for Graves' ophthalmopathy? How should I treat bacterial orbital cellulitis? How do you distinguish an orbital infection from sterile inflammation? When should I be concerned about systemic disease in a patient with blepharoptosis? What are the oculoplastic uses of botulinum toxin? How do I know when to order an MRI or a CT?

Get the foundational knowledge you need in the area of visual optics with the text that is easy to comprehend, visually appealing, and engaging from cover to cover. Introduction to Visual Optics: A Light Approach covers the basic information you need in this complex area in a significantly more approachable manner than other resources on the market. You'll find clear, easy-to-read explanations that work hand-in-hand with colourful charts, graphs, illustrations, and diagrams created by the author, Dr. Samantha Strong. This unique text is perfect for optometry students, optometrists, ophthalmology residents, student dispensing opticians, and others in the eye care field. Covers foundational visual optics knowledge, from refraction to reflection, vergence, and more in a fun, easy-to-read format. Features a highly visual format, with full-colour illustrations, tables, and boxes throughout to aid in understanding and memory recall. Discusses underlying principles of several key ophthalmic imaging techniques. Includes experiments you can try at home (create your own cornea, build a camera obscura, create a blue sky in your kitchen, create an interference film, create a prism) with companion demonstration videos to facilitate and apply key learning objectives. Contains approximately 200 practice questions and equations throughout that test your knowledge of core concepts. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

The eleventh Symposium of the International Research Group on Colour Vision Deficiencies (IRGCVD) was held 20-23 June 1991 in Sydney, Aus tralia, ably hosted by local organizer Stephen Dain. A total of 35 talks and 10 posters were presented. Papers based on 37 of these presentations are included here, in Colour Vision Deficiencies XI. The scientific program featured sessions on three special topics, with each topic highlighted by an invited speaker. The opening session on the Genetics of congenital colour vision deficiencies began with a superb invited lecture by Charles Weitz about his pioneering work on the molecular genetics of tritanopia. The session on the second special topic, Spatial aspects of colour vision, began with the launching of a new IRGCVD tradition, as 1991 Verriest Memorial Award recipient Harry Sperling presented the first Ver riest Memorial Lecture on his recent studies of spatial discrimination of heterochromatic stimuli. Dr. Sperling reported new evidence that certain asymmetries in red-green opponent colour vision can be explained by the spatial organization of colour-opponent retinal neurons. In the third special session, on Occupational aspects of colour vision, Barry Cole took the audi ence on a fascinating tour of the historical development of colour vision standards in his invited lecture entitled 'Does defective colour vision really matter?'. In addition to the three special topics, many interesting presentations were given in topical sessions on Variations in normal colour vision, Acquired colour vision deficiencies and Colour vision tests and testing methods."

Cytopathologic, Physiologic, Diagnostic and Clinical Aspects of Retinal Degeneration: Histochemical Comparison of Ocular Drusen in Bruch's Membrane and Drusen in Eyes from Normal and Age-Related Macular Degeneration Donors; M. Kamei, et al. Animal Models of Retinal Degeneration: Development of a Model for Macular Degeneration; P.E. Rakoczy, et al. Subretinal Iodoacetate: A Model of Retinal Degeneration in Cats; J.C. Huang, et al. Mechanisms of Retinal Degeneration and Cell Death: Nitric Oxide-Induced Increases in Retinal cGMP: A Role in Photoreceptor Degenerations; I. Morgan, J.W. Wellard. Candidate Genes, Cloning Mapping and Other Molecular Genetics of Retinal Degeneration: Isolation of Candidate Genes for Retinal Degenerations; G. Inana, et al. Transplantation, Gene Therapy and Cell Rescue: bFGF Transfected Iris Pigment Epithelial Cells Rescue Photoreceptor Cell Degeneration in RCS Rats; M. Tamai, et al. Structural, Physiologic and Ageing Correlates of Retinal Degeneration. Further Studies on the Phagocytosis of Photoreceptor Outer Segments by Rat Retinal Pigment Epithelial Cells; M.O. Hall. 36 Additional Articles. Index.

Intravitreal injections (injections into the eye) are a new form of treatment for various conditions such as age-related macular degeneration, diabetic eye disease and vascular eye problems. The use of these injections has become so widespread that most departments around the world (and particularly in the U.K) do not have enough doctors to meet the service provision demands of an ever increasing number of patients. Many departments have trialed training ophthalmic nurse practitioners as a solution and the number of such specifically trained nurses is set to rise exponentially in the future. This book is meant to be an easy to carry A5 handbook detailing all that an ophthalmic nurse practitioner needs to know about performing the procedure. It is hoped that the book will also be of benefit to trainee ophthalmologists learning the procedure.As this is an emerging area of expertise in ophthalmology, currently there exists no other books on the topic. The readers will benefit from having a single resource detailing all that they need to know about the procedure. This means that nurses will not have to cross reference multiple complicated ophthalmic textbooks. As an A5 handbook, it will be easy to carry and reference in clinics. It is deliberately meant to be concise (around 100 pages), thus concentrating only on the core knowledge required.

Digital fundus images can effectively diagnose glaucoma and diabetes retinopathy, while infrared imaging can show changes in the vascular tissues. Likening the eye to the conventional camera, Image Analysis and Modeling in Ophthalmology explores the application of advanced image processing in ocular imaging. This book considers how images can be used to effectively diagnose ophthalmologic problems. It introduces multi-modality image processing algorithms as a means for analyzing subtle changes in the eye. It details eye imaging, textural imaging, and modeling, and highlights specific imaging and modeling techniques. The book covers the detection of diabetes retinopathy, glaucoma, anterior segment eye abnormalities, instruments on detection of glaucoma, and development of human eye models using computational fluid dynamics and heat transfer principles to predict inner temperatures of the eye from its surface temperature. It presents an ultrasound biomicroscopy (UBM) system for anterior chamber angle imaging and proposes an automated anterior segment eye disease classification system that can be used for early disease diagnosis and treatment management. It focuses on the segmentation of the blood vessels in high-resolution retinal images and describes the integration of the image processing methodologies in a web-based framework aimed at retinal analysis. The authors introduce the A-Levelset algorithm, explore the ARGALI system to calculate the cup-to-disc ratio (CDR), and describe the Singapore Eye Vessel Assessment (SIVA) system, a holistic tool which brings together various technologies from image processing and artificial intelligence to construct vascular models from retinal images. The text furnishes the working principles of mechanical and optical instruments for the diagnosis and healthcare administration of glaucoma, reviews state-of-the-art CDR calculation detail, and discusses the existing methods and databases. Image Analysis and Modeling in Ophthalmology includes the latest research development in the field of eye modeling and the multi-modality image processing techniques in ocular imaging. It addresses the differences, performance measures, advantages and disadvantages of various approaches, and provides extensive reviews on related fields.

Many of the studies discussed in this book were addition to discussions of a variety of hormonal, presented at the First Pan American Congress of biochemical, immunological, physical, and me Andrology, which was held in Caracas, Venezuela, chanical approaches. It is our hope that the efforts in March 1979. An international group of in of the contributors will help to intensify research vestigators have contributed reviews designed to and development of improved methods for safely be informative to medical, graduate, and post regulating male fertility. graduate students, as well as clinicians and in vestigators working in the area of male reproduc G. R. CUNNINGHAM tion. Current physiological concepts that may W. B. SCHILL provide insight for new initiatives are examined in E. S. E. HAFEZ TABLE OF CONTENTS Preface v Contributors IX Foreword by C. SCHIRREN XI 1. PHYSIOLOGY OF MALE REPRODUCTION 1. Hormonal regulation of testicular function 5 P. FRANCHIMONT 2. Inhibin: new gonadal hormone 15 P. FRANCHIMONT, A. DEMOULIN, J. VERSTRAELEN-PROYARD, M. T. HAZEE-HAGELSTEIN, and J. P. BOURGUIGNON 3. Morphological features of the epididymis: possible significance in male contraception 25 T. D. GLOVER 4. Regulatory physiology of male accessory organs 35 E. S. E. HAFEZ and G. R. CUNNINGHAM 5. Methods for evaluating contraceptive techniques 41 T. Z. HOMONNAI and F. G. PAZ II. HORMONAL CONTRACEPTION 6. Inhibition of male reproductive processes with an LH-RH agonist 55 A. CORBIN and F. J. BEX 7."

Originally published in 1989, much was known about blindness, but the field was divided into specialties. Experts in the different areas were widely dispersed among university departments, rehabilitation agencies, and school systems, with the result that people in one specialty area often knew little about developments in other areas. It was hoped that this work would be useful in reducing that isolation, by presenting, within a single volume, basic information derived from different approaches to the subject of blindness. Individuals already familiar with material in some of the chapters could gain added perspective on the field as a whole by reading about other aspects of blindness outside their specialty area.

Contains the proceedings of the XVI International Symposium on Retinal Degeneration (RD2014), to be held July 13-18, 2014 at the Asilomar Conference Center in Pacific Grove, California. A majority of those who will speak and present posters at the meeting will contribute to this volume. The Symposium addresses the blinding diseases of inherited retinal degenerations, which have no effective treatments and age-related macular degeneration, which has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 75. The RD2014 Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy; and several sight restoration approaches, including optogenetics. While advances in these areas of retinal degenerations will be included, several new topics either were in their infancy or did not exist at the time of the last RD Symposium, RD2012. These include many new developments in sight restoration using optogenetics, retinal or RPE cell transplantation, stem cell approaches and visual prosthetic devices. In addition, major advances will be presented in other basic mechanisms in age-related macular degeneration, several new aspects of gene and antioxidant therapy and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those will be reported at the RD2014 meeting and included.

This book provides the first general and unified theory of visual discomfort. Based on the author's observation that people find certain visual stimuli uncomfortable--and that these same stimuli induce seizures in patients with photosensitive epilepsy--the book offers fascinating insights into a variety of visual stresses that arise from design, reading, lighting, television, and VDU terminals. A range of techniques for preventing and treating visual discomfort--from color therapy to precision tinting of spectacle lenses--are described in detail. Students and researchers in perceptual psychology, visual science, neurology, and optometry will want to read this pioneering new work.

In the 6th edition of this Colour Atlas of Ophthalmology, all the chapters have been comprehensively updated to incorporate the latest advances in the understanding, diagnosis, investigations and treatment of ocular diseases. This edition has new chapters on glaucoma, trauma, global blindness with major revisions of chapters particularly cornea, cataract and retina. Photographs and images have been updated to reflect the progress in imaging systems and new diagnostic modalities. The electronic version of this book also includes short videos of common surgeries in ophthalmology. With more than 300 high quality pictures and concise text, this book will be an excellent reference for medical students, general practitioners, optometrists, paramedical personnel and community ophthalmic assistants to help understand and treat common eye diseases.

In this 5th edition of the concise and clearly written best selling title, all the chapters have been thoroughly updated and expanded, particularly the sections on the retinal, macular, phacoemulsification, lasik, new equipment and ophthalmic drugs.The book is generously illustrated with more than 200 colour pictures and is an excellent volume for medical students, general practitioners, ophthalmic students and all paramedical personnel who have to deal with common eye diseases.

Basic and Clinical Applications of Vision Sciences contains the edited papers presented at the Enoch Vision Science Symposium, April 27-30 1996, which was organized in honor of the pioneer in vision science, Dr Jay M Enoch. Dr Enoch served for twelve years as Dean, School of Optometry, University of California, Berkeley. The book is organized along the lines of Dr. Enoch's contributions to vision science, but is not limited to these topics. Of special note, the reader will find papers on important new developments in photoreceptor, ophthalmic and visual optics, retinal imaging, ophthalmic physiology and pathophysiology, visual psychophysics and visual techniques. The papers are grouped into the following sections: photoreceptor optics; ophthalmic and visual optics; binocular vision, developmental vision, eye movements and physiology; ophthalmic dysfunction; visual psychophysics and clinical applications; history of vision science. GBP/LISTGBP

This book is a comprehensive treatise on infective and inflammatory pathologies of the cornea with corresponding clinical images and diagrammatic illustrations. Corneal infections and inflammations are a major cause of ocular morbidity and visual impairment. Early diagnosis and treatment can lead to improved visual outcome and quality of life. Both infectious (bacterial, fungal, viral and protozoan) and non-infectious keratitis that cause corneal vascularisation, scarring and vision loss are covered extensively. The illustrated clinical findings presented in the form of diagrams, photographs, cases and videos aim to serve as a practical teaching tool for fellows, trainees and practising ophthalmologists. KEY FEATURES Focuses on clinically relevant parts of corneal diseases, using illustrations with arrows indicating different pathologies and signs Serves as a ready clinical compendium for trainees, fellows and ophthalmologists Explores various corneal pathologies through a wealth of accompanying illustrations and teaching videos