This edited book focuses on the recent advances in our understanding of age-related macular degeneration (AMD), combining epidemiology and clinical diagnosis, with genetics and immunological aspects as well as the role of proteostasis and mitochondria before diving into new therapies including stem cell based approaches. AMD is a leading cause of largely incurable blindness worldwide and projected to double from 2.07 million to 5.44 million individuals by 2050 in the United States. Globally, 288 million individuals are projected to have AMD by 2040. The disease has enormous socioeconomic impact on the affected individuals, their families and the society. This book will bring together the state of the art basic science knowledge with clinically relevant findings and address the challenges for future research in AMD. The intersection of different disciplines will provide potential areas for further investigations to reduce the burden of blindness from AMD. This book offers an appealing and insightful resource for clinicians, scientists, students and fellows.

Ophthalmic Nursing provides an overview for those just setting out in a role within ophthalmic nursing. It includes basic and comprehensible anatomy and physiology - the foundations for understanding how the eye functions and why and how problems occur - and relates them to the care and needs of the patient. This accessible text includes evidence-based procedure guidelines and the inclusion of reflective activities in most chapters allows readers to apply their knowledge to the realities of the care setting. Also covered are the most recent National Institute for Health and Care Excellence (NICE) guidelines for glaucoma and age-related macular degeneration. Since the publication of the fourth edition, there have been many advances in the care and management of the ophthalmic patient. The authors have updated the chapters accordingly and included new colour images and diagrams. References, further reading and websites have also been updated to reflect current trends. A valuable resource for nurses in practice and training, this book continues to be the 'go-to' source for those caring for the ophthalmic patient.

Numerous studies have pointed to the key role of complement in the pathogenesis of retinal disease, particularly age-related macular degeneration (AMD). Reports about new gene associations and links to other physiological pathways are emerging almost on a weekly base. Several promising clinical candidates covering a wide area of potential treatment applications are in the pipelines of both industrial and academic groups. This indicates an increasing interest in complement as a therapeutic target. In view of these exciting discoveries, scientists from around the world convened at the First Aegean Conferences Conference on Inflammation and Retinal Disease: Complement Biology and Pathology (June 10-17, 2007) in Crete, Greece, to discuss recent advances in this rapidly-evolving field. This volume represents a collection of topics on the functions of complement in eye diseases, pathophysiology, protein structures, and complement therapeutics discussed during the conference. Our sincere thanks to the contributing authors for the time and effort they have devoted to writing what I consider exceptionally informative chapters in a book that will have a significant impact on the complement field. We would also like to express my thanks to Rodanthi Lambris for her assistance in collating the chapters and preparing the documents for publication and I gratefully acknowledge the generous help provided by Dimitrios Lambris in managing the organization of this meeting. Finally, I also thank Andrea Macaluso of Springer Publishers for her supervision in this book's production. John D. Lambris Anthony P.

Endophthalmitis: Diagnosis and Treatment covers every aspect of this serious disease, beginning with inflammation and immunology. The causes of postoperative, post-traumatic and endogenous endophthalmitis are discussed in detail and therapeutic options for the various types of the condition are suggested. Particular emphasis is given to the prevention, accurate diagnosis and management of endophthalmitis as these are vital to the preservation of vision. A comprehensive resource for the ophthalmologist.

The Essentials in Ophthalmology series represents readership acceptance of the first two series, each of an unique updating publication on the progress in all eight volumes. This is a success that was made p- subspecialties of ophthalmology. sible predominantly by the numerous opinion-leading In a quarterly rhythm, eight issues are published authors and the outstanding section editors, as well as covering clinically relevant achievements in the whole with the constructive support of the publisher. There field of ophthalmology. This timely transfer of advance- are many good reasons to continue and still improve ments for the best possible care of our eye patients has the dissemination of this didactic and clinically r- proven to be effective. The initial working hypothesis of evant information. providing new knowledge immediately following p- lication in the peer-reviewed journal and not waiting G.K. Krieglstein for the textbook appears to be highly workable. R.N. Weinreb We are now entering the third cycle of the Essentials Series Editors in Ophthalmology series, having been encouraged by September 2008 Preface We are pleased to share with our readers this Third uncorrected and, in one instance, corrected vision. Edition of Cataract and Refractive Surgery, less than Topics in corneal refractive surgery include disc- three years from publication of the Second Edition. sion of the management of higher order aberrations The dramatic pace of change in cataract and refractive and corneal procedures for treating presbyopia.

The best-selling exam preparation manual for more than 15 years has been extensively updated into a Third Edition. With revisions and additional material that match the new JCAHPOr criteria for Certified Ophthalmic Assistants (COAr), this study resource will remain the top choice for those studying for certification. With nearly 1,400 questions, the Certified Ophthalmic Assistant Exam Review Manual, Third Edition contains more questions with explanatory answers than any other study aid. Additionally, all 19 exam criteria headings are covered inside, including history taking, visual assessment, medical ethics, pharmacology, ophthalmic imaging, surgery, and more. Features: * Study tips, hints, and test-taking strategies * Explanatory answers for every question * Updated to reflect new JCAHPO COA exam criteria Certified Ophthalmic Assistant Exam Review Manual, Third Edition by Janice K. Ledford will be the most talked-about resource for those studying for the COAr exam, students in ophthalmic and optometric assisting programs, and those who wish to review before taking the COTr exam.

The last 20 years of research have been marked by exceptional progress in understanding the organization and functions of the primate visual system. This understanding has been based on the wide application of traditional and newly emerging methods for identifying the functionally significant subdivisions of the system, their interconnections, the response properties of their neurons, and the population responses to stimulus events.

While primates vary greatly in morphology and behavioral adaptations, all primates share certain features of the visual system. Although there are several books on vision in the market, until now no book has provided a comprehensive overview of the primate visual system. This book synthesizes the current knowledge on the anatomical and functional organization of the primate visual system and proposes new directions for research. Contributed by a multidisciplinary group of leading researchers, chapters consider a range of topics concerning various primates, including humans, and cover processing from the eye to neural codes for action, and from basic perception to memory.

Hyperopia and Presbyopia offers at-hand guidance on recent technologies such as thermal or conductive keratoplasty, corneal implants, laser scleral relaxation, scleral expansion rings, intraocular lenses, and LASIK modifications. Features developmental trials, clinical results, and troubleshooting strategies. Delving into current, established, and emerging treatments for the correction of hyperopia and presbyopia, this reference offers at-hand guidance on recent technologies such as thermal or conductive keratoplasty, corneal implants, laser scleral relaxation, scleral expansion rings, intraocular lenses, and LASIK modifications.

Extensively revised and updated, this second edition compares conventional and innovative drug delivery systems. The book covers significant ophthalmic advances and breakthroughs in gene therapy, ocular microdialysis, vitreous drug disposition modelling, and receptor/transporter targeted drug delivery. It examines procedures in pharmacokinetic/pharmacodynamic modeling for the determination of appropriate dosing regimens, covers new developments in animal modeling, and discusses current regulations governing patenting, commercial product release, and human testing. This in-depth reference lays the groundwork for overcoming constraints on the delivery of ophthalmic drugs.

Minimize postoperative complications Emphasizes the latest tools and step-by-step procedures to increase the safety, predictability, and long-term stability of LASIK procedures LASIK discusses in-depth preoperative patient evaluation, preparation, and selection the use of computerized videokeratography and wavefront technology for appropriate preoperative assessment and postoperative evaluation surgical strategies and techniques LASIK is a timely and authoritative source for refractive, corneal, and cataract surgeons; ophthalmologists; optometrists; ophthalmic surgeons; and upper-level undergraduate, graduate, and medical students in these disciplines.

The field of contact lenses continues to evolve at a rapid pace, with new optical designs and vision correction options continually being developed. Additionally, the rapid expansion of clinical instrumentation offers eye care practitioners a wide choice of investigative techniques for assessing in-eye contact lens performance and diagnosing adverse reactions. Now in its fourth edition, Contact Lens Practice has been thoroughly updated and revised to capture these developments and more, and translate them into an organised and easily digestible resource. Written and edited by award-winning author, researcher, and lecturer, Professor Nathan Efron, this title provides a comprehensive, evidence-based overview of the scientific foundations and clinical applications of contact lens fitting. The text has been refreshed by the inclusion of five new authors - a mixture of scientists and clinicians, all of whom are at the cutting edge of their specialty. Serves as an essential companion and guide to current thinking and practice in the content lens field, ideal for use by optometrists, ophthalmologists, orthoptists, opticians, students, and contact lens industry professionals. Presents subject matter in a clear and logical format to allow the reader to quickly identify and comprehend key information. Features highly illustrated chapters in full colour, helping the reader to visualize core concepts. Includes completely rewritten chapters, by new authors, on scleral and corneo-scleral contact lenses, high ametropia, therapeutic applications, post-surgical lens fitting, and practice management. A new chapter on Post-Surgery Management consolidates core information on post-operative management involving contact lenses. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

The development of ophthalmology to its present level of sophisticated practice is an extraordinary story of research, experiment, and achievement. Dates in Ophthalmology: A Chronological Record of Progress in Ophthalmology over the Last Millennium charts the progress of that achievement over the last millennium, highlighting and describing the key dates of advancement. It presents a concise listing of the chief personages, periods, publications, and events in the history of ophthalmology from ancient times to the present.

The book demonstrates how ideas, discoveries, and technologies cross borders and oceans. It illustrates the interplay of subspecialties, the changing pre-eminence of countries and cities, and the explosions of creativity and generations of dormancy in various areas. The author highlights the numerous and diverse events and people responsible for shaping this specialty.

There are many ways of looking at history: from the standpoint of the lives of major figures, of society and impact, of subspecialties, of countries, of institutions, and of books. By presenting its information chronologically, Dates in Ophthalmology explores the how these areas intersect, influence, and impact each other.

The aim of eye muscle surgery is to restore alignment of the visual axes and ocular stability. Albeit compensatory and largely empirical, this surgery can be perfected with a better understanding of the physiopathological mechanisms involved, more detailed semiological analysis, the taking into account of intraoperative data and the use of microsurgical technique. The three parts of this book allow each of these factors to be discussed at length.

This book reviews the current state of ocular drug therapy and future therapeutic opportunities for a wide variety of conditions, including Age-related Macular Degeneration, Diabetic Retinopathy and Macular Edema, Glaucoma, and Inherited Retinal Diseases. Retinal diseases are major contributors to moderate or severe vision impairment in adults aged 50 years and older. The respective patient populations for many of these indications is expected to significantly increase as the world population continues to grow older. An improved understanding of the etiological underpinnings of ocular degenerative diseases over the past decade has significantly bolstered ophthalmic drug discovery. In this volume, contributions from leading experts explore the unique challenges faced for ocular drug discovery and delivery providing the reader with detailed information on ocular pharmacokinetics, in vitro, ex vivo and in vivo models for retinal disease pathology and emerging gene therapy treatments. The book is intended for all researchers and clinicians who wish to increase their knowledge on the latest findings in ocular drug therapy.

This is a practical guide to using lasers in the Eye clinic and includes all commonly performed Lasers for a range of ocular conditions. It uses multiple illustrations of real-life fundus photographs, FFA images, OCT images and digitally modified retinal images to simplify learning the fundamentals of laser physics and physiology, laser safety and an overview of the variety of ophthalmic lasers in current use. It standardizes Laser procedures and serves as a reference guide for Ophthalmic trainees learning the technique that can be transferred to their clinical practice. The book simplifies understanding of Ophthalmic Lasers and answers common questions of how and why things are done. Key Features * Emphasizes on Nd-YAG Laser, Lasers in Glaucoma and Photothermal Lasers for Retinal Pathology, with clarity on techniques and pearls on dealing with common laser related issues that come with experience. * Provides content in a Q&A format which is ideal as a lesson from trainer to trainee and answers all the doubts and laser related questions a trainee may have and aids their learning and progression to performing Lasers safely and independently. * Uses digitally modified images with bullet points and reference text boxes, making the content user friendly and easy to understand.

This book presents new and noteworthy research into retinal diseases.

It focuses on what we currently know about the environment, genetics and mechanisms that lead to retinal degenerations, new diagnostics, and innovative therapeutic modalities to preserve vision. Written by renowned scientific investigators, this innovative collection of treatment strategies and technological discoveries allows for the realistic translation of research into practice.

Ophthalmic practices have many types of leaders, functioning at all levels of the organization.  Ophthalmic Leadership: A Practical Guide for Physicians, Administrators, and Teams, Second Edition can provide each of these leaders with the tools to be more decisive, motivating, and effective.   John B. Pinto, America’s most published author on the business of ophthalmology, has firsthand experience with the best and worst practice leadership habits from his decades of experience as an ophthalmic practice consultant. He has coached countless physician and lay leaders to the next level of their careers. Together with his team of more than 20 expert contributors, Pinto covers every aspect of leadership in ophthalmology, no matter the size of the practice or the current experience of the team. Chapters include: •    What Do You Believe in? Developing a List of Core Values for Your Practice •    Grooming and Moving Line Staff Up to Middle Management •    Contingency Planning in a Less-Certain Environment •    Leading Your Team Past the Inevitable Conflicts of Practice Life Everyone in ophthalmology can benefit from the lessons inside Ophthalmic Leadership: A Practical Guide for Physicians, Administrators, and Teams, Second Edition—from the rising ophthalmic technician or department manager, to the managing partner, and even the most seasoned practice administrator. “The book you now hold is a wonderful opportunity to rededicate yourself to your professional development as a leader and to the success of your organization.�  From the Foreword by Richard L. Lindstrom, MD

"Molecular Genetics of Inherited Eye Disorders" provides an authoritative and up-to-date account of molecular genetic advances in a wide spectrum of genetic eye disorders, and forms the second volume in the Modern Genetics book series. The field has produced some dramatic and often unexpected findings in recent years ranging from the elegant unravelling of the molecular basis of colour vision defects to the subtle complexity of the retinoblastoma gene. The role of crystallins in congenital cataract and of the rhodopsin molecule in retinitis pigmentosa are discussed, illustrating the importance of the "candidate gene" approach to genetic eye disease. "Reverse genetic" approaches to the cloning of genes responsible for aniridia and choroideremia exemplify the power of the new genetic techniques and signal the start of the next experimental phase, in which the functional characterization of identified genes begins. Sections on albinism, retinitis pigmentosa and collagen disorders deal w

The Duke Elder Exam of Ophthalmology - A Comprehensive Guide for Success is an indispensable resource for any student wishing to achieve the highest mark on the Duke Elder Exam and receive a prize. With expert knowledge of students and doctors that have scored high on the exam, along with the supervision of well-regarded ophthalmologists and trainees, we believe this is the only resource you will need to achieve a high score on the exam. Key Features In-depth coverage of the Duke Elder Curriculum including the basic sciences, anatomy, optics and all subspecialties of ophthalmology Full colour and easy to read with clinical photographs and diagrams to aid in the understanding of key topics 180 SBAs, which accurately reflect the format and difficulty of the exam