This book addresses the issues relating to a wide variety of ocular diseases from which millions of people suffer. Long-term challenges include visual impairment and ocular blindness. Certain ocular diseases are quite rare, whereas others, such as cataracts, age-related macular degeneration (AMD), and glaucoma, are very common, especially in the aging population. A rapid expansion of new technologies in ocular drug delivery and new drug candidates, including biologics, to treat these challenging diseases in the retina and posterior segments of the eye have recently emerged. These approaches are necessary because the eye has many unique barriers to drug delivery. Thus, this timely reference Drug Delivery for the Retina and Posterior Segment Disease compiles and analyzes recent advances in the research and development of drug delivery systems for retina and posterior segment diseases of the eye, with an emphasis on the use of implantable devices, iontophoresis as well as micro- and nanoparticles.

The concept of visual search embraces a wide range of processing activities, from human cognitive phenomana to applied problems for both human and machine vision in industrial, medical and military environments. This book, the second to be derived from the series of internationl conferences on visual search organized under the auspices of the Applied Vision Association, brings together research from a variety of disciplines, enabling the reader to share experiences at the cutting edge, accessing knowledge which might otherwise be locked away in specialist journals or grey literature.

Ophthalmic Imaging serves as a reference for the practicing ophthalmic imager. Ophthalmic imaging combines photography and diagnostic imaging to provide insight into not only the health of the eye, but also the health of the human body as a whole. Ophthalmic photographers are specialists in imaging through and in the human eye, one of the only parts of the body where the circulation and nervous system is visible non-invasively. With technical perspective as context, this book will provide instructional techniques as well as the background needed for problem solving in this exciting field. The book covers all aspects of contemporary ophthalmic imaging and provides image support to ophthalmologists and sub-specialties including retinal specialists, corneal specialists, neuro-ophthalmologists, and ocular oncologists. This text serves as a reference for the practicing ophthalmic imager, or to imagers just getting started in the field.

Dermal and Ocular Toxicology: Fundamentals and Methods is a procedurally-oriented volume of detailed methods and practical examples discussing the dermal and ocular aspects of toxicology. The book is divided into a dermal section and an ocular section. Each section begins with a chapter on the anatomy and physiology of each organ system and then progresses to more specialized chapters discussing such topics as the toxicological pathology of each system, state-of-the-art in vitro and in vivo evaluatory procedures, statistical considerations for test design and data interpretation, and the utilization of test findings. Test methods are provided for acute dermal exposure effects, dermal hypersensitivity and photoallergy assessment, dermal and ocular 0.pharmacokinetics, skin flap and skin grafting techniques, and in vitro alternative methods. This book can be used as an instructional text or as a sourcebook for practicing toxicologists, pharmacologists, industrial hygienists, occupational health professionals, and graduate students.

This book provides an overview of clinical ophthalmology using the logical, stepwise format of mind maps. It is an excellent rapid-revision tool, suitable for medical students, ophthalmology trainees, orthoptists, optometrists, general practitioners and other health professionals.

Optical coherence tomography has become a part of clinical routine in everyday eye practice, allowing objective, quantitative structural assessment and driving clinical decision making in retinal diseases, glaucoma and cataract surgery. To guide the eyecare professionals who rely on this technology, Everyday OCT: A Handbook for Clinicians and Technicians, Second Edition is a user-friendly, practical reference that provides all of the information they need to know about current OCT technologies and their clinical utilities. Drs. Joel S. Schuman, Carmen A. Puliafito, James G. Fujimoto, and Jay S. Duker represent the cutting edge of OCT applications and, together with their expert contributing authors, they have created a clear and concise guide designed to provide clinicians and technicians with the knowledge and tips to best utilize OCT technology. This Second Edition is split into three parts: an operational guide with in-depth guidance and tips on the six major OCT devices from six different manufacturers, an interpretation guide featuring all the major pathologies OCT can visualize, and a technical guide containing detailed technical aspects of the SD-OCT and the future of OCT technologies. Everyday OCT, Second Edition explains how to: Set up and employ OCT technology Select and facilitate scans Ensure and assess the quality of scans Accurately interpret OCT images Everyday OCT: A Handbook for Clinicians and Technicians, Second Edition covers the diversity of new devices and applications in the field of OCT in a succinct and easy-to-read format, making it the ideal resource for clinicians and technicians to have by their side when performing or interpreting OCTs.

This book represents a brilliant primer and the tools and skills it equips the clinician with are designed to help them navigate the uncertainties of medical practice today. It is essential for those who wish to practice medicine in the best possible way for their patients.

This book contains all oral presentations, posters, and workshop transactions of the 28th Meeting of the European Strabismological Association that took place in Bergen, Norway. The highlight of the meeting is the ESA-lecture what can eye muscle studies tell us about strabismus by Prof. Gunnar Lennerstrand from Stockholm. All 60 oral presentations of the following sessions are described: screening, amblyopia, eye movements, vision, refraction, nystagmus, stereopsis, exotropia, vergence problems, refractive surgery, cataract and strabismus, strabismus surgery, botulinum toxin, EMG, oblique muscles, paralytic strabismus, thyroid, duane syndrome and varia.

Different animals have different visual systems and so presumably have different ways of seeing. How does the way in which we see depend on the optical, neural and motor components of our visual systems? Originally published in 1993, the mathematical tools needed to answer this question are introduced in this book. Elementary linear algebra is used to describe the transformations of the stimulus that occur in the formation of the optical, neural and motor images in the human visual system. The distinctive feature of the approach is that transformations are specified with enough rigour for readers to be able to set up their own models and generate predictions from them. Underlying the approach of this book is the goal of providing a self-contained source for the derivation of the basic equations of vision science. An introductory section on vector and matrix algebra covers the mathematical techniques which are applied to both sensory and motor aspects of the visual system, and the intervening steps in the mathematical arguments are given in full, in order to make the derivation of the equations easier to follow. A subsidiary goal of this book is to demonstrate the utility of current desktop computer packages which make the application of mathematics very easy. All the numerical results were produced using only a spreadsheet or mathematics package, and example calculations are included in the text.

Gonioscopy is a very important differential diagnostic tool that permits assessment of the anterior chamber angle and correct classification of glaucoma as a basis for specific treatment. This book clearly explains how to perform gonioscopy to best effect. The anatomy of the chamber angle is systematically described, and the impact of age, developmental disorders, and other pathologies on the chamber angle is explained. Particular attention is focused on primary and secondary open-angle and angle-closure glaucomas. In each case, the role of gonioscopy in evaluating the chamber angle is described with the help of many photographs and illustrations. The importance of knowledge of the chamber angle for laser treatment and surgery is fully explained, and the impact of medications is discussed. The practitioner will find in "Gonioscopy" all the information required to use the technique effectively in diagnosis and treatment.

"Textbook of Laser Refractive Cataract Surgery "is a comprehensive reference for the general ophthalmologist and cataract surgeon regarding the explosive new technology in femtosecond laser cataract surgery. Femtosecond laser allows extreme precision in surgery, and is used in refractive surgery and for cuts in the cornea, leading to a more uniform treatment for the patient. "Textbook of Laser Refractive Cataract Surgery "is for cataract surgeons and all eye care providers managing or diagnosing cataracts who wish to be informed about this technology and its applications.

Edited and written by recognized leaders in the field, this book covers background, technical, clinical, and commercial aspects of this exciting technology. Some of the topics covered include the evolution of cataract surgery, femtosecond laser fundamentals, challenges of femtosecond laser technology for cataract surgery, and the economics of laser cataract surgery.

Edited and written by recognized leaders in the field, this book covers background, technical, clinical, and commercial aspects of this exciting technology. Some of the topics covered include the evolution of cataract surgery, femtosecond laser fundamentals, challenges of femtosecond laser technology for cataract surgery, and the economics of laser cataract surgery.

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Leading academic and pharmaceutical researchers and clinicians from many disciplines synthesize and summarize current clinical and basic knowledge concerning abnormal growth of blood vessels in the eye, the cause of major neovascular eye diseases. The authors also identify and assess the most promising approaches with potential for commercial exploitation and discuss the challenges encountered in developing therapeutics for ocular neovascular diseases. Highlights include illuminating chapters on gene therapy and novel drug delivery systems and excellent summaries of the newest therapeutic approaches. A companion CD contains color versions of important figures used in the book.

The text's distinguished authors have perfected the most frequently performed oculoplastic surgical techniques. Starting with eyelid repair, their atlas is designed to instruct all ophthalmologists who wish to learn these techniques and thus enhance their income. Mastery of these procedures is made easier by following the step-by-step illustrations that are complemented by 22 video clips on 2 CD-ROMs. The study of the supporting anatomy, followed by clear-cut guidelines with heavily-illustrated techniques, offers a format which will allow the learner to gain the necessary understanding for achieving a more favorable result.

This book is an essential revision aid for those revising for the short answer paper of the Part 1 MRCOphth examination in the United Kingdom and similar examinations elsewhere. It covers many of the frequently asked questions and presents answers in a format that can be reproduced under examination conditions. It covers the basic sciences, and is also a useful reference to refresh the knowledge of experienced ophthalmologists and allied health professionals.

Excellent microsurgery derives not from natural dexterity alone or from pure book knowledge, but from these features combined with an appreciation of the instrumentation, physical forces, and tissue reactions that create the environment of microsurgery. "Ophthalmic Microsurgery: Principles, Techniques, and Applications" conveys both the art and science of microsurgery from an ophthalmic perspective.

This unique resource begins with the principles and techniques of microsurgery, which can be applied to all types of surgeries and includes detailed laboratory exercises to teach the key concepts. The second section of "Ophthalmic Microsurgery "addresses the specific applications. While not an encyclopedia of all surgical interventions, Drs. Sumit "Sam" Garg and Roger Steinert, along with their contributors, provide an overview of key surgical competencies that are relevant to the various ophthalmic subspecialties.

"Ophthalmic Microsurgery "is set apart from other similar resources by having a comprehensive and concise focus on translating surgical principles into reality through simple and inexpensive exercises.

Grounded in practicality and requiring only basic materials, "Ophthalmic Microsurgery: Principles, Techniques, and Applications "covers the theory and basics of microsurgery needed during the ophthalmic surgical training of residents and fellows and serves as an excellent manual for the more experienced ophthalmologists looking to refine their technique in microsurgery.

Edited by and featuring contributions from world-class researchers, Ophthalmological Imaging and Applications offers a unified work of the latest human eye imaging and modeling techniques that have been proposed and applied to the diagnosis of ophthalmologic problems, including inflammation, cataracts, diabetic retinopathy, and glaucoma. With a focus on theory, basic principles, and results derived from research, the book: Explores various morphological, textural, higher-order spectral, and wavelet transformation techniques used to extract salient features from images of the human eye Examines 2D and 3D finite element and boundary element models of the human eye developed to simulate thermal steady-state conditions Addresses the difficult task of benchmarking the validity of human eye imaging techniques and computer-simulated results with experimental measurements Intended to be a companion to Image Analysis and Modeling in Ophthalmology, this volume covers several aspects of multimodal ophthalmological imaging and applications, presenting information in an accessible manner to appeal to a wide audience of students, researchers, and practitioners. Ophthalmological Imaging and Applications considers promising simulations that pave the way for new possibilities in computational methods for eye health care.

Ocular Electrophysiology: Retinal Toxicology Study Using Electrophysiological Methods in Rabbits; Y. Shirao, K. Kawasaki. Experimental Study of the Retinal Toxicity of Iron after Vitreous Hemorrhage; W.J. Nie, X.F. Zhang. Ocular Pharmacokinetics: Effects of Different Vehicles on Ocular Kinetics/Distribution; M.F. Saettone. Drug Distribution Studies in Single Lens Layers through the Application of a Sectioning Technique; M. Kojima. Lens/Cataract: Relevance of Cataract Models in Rodents as a Tool to Evidence a Co or Syncataractogenic Potential of Drugs in Preclinical Studies; A. Wegener, O. Hockwin. Investigations into the Cataractogenic Potency of a Nontricyclic Antidepressant; A. Wegener, et al. In vitro Methods:: Characterization of Sialomucins Expressed by Human Conjuctival Goblet Cells; W. Naib-Majani, et al. Regulatory Affairs: Critical Evaluation of the Evidence for an Association between Ocular Disease and Exposure to Organophosphorus Compounds; M.D. Stonard, et al. Miscellaneous: Influence of Chronic Alcoholic Intoxication on Healing of Corneal Epithelial Defects: Effectivity of Treatment by Protease Inhibitor Contrycal (Aprotinin) and Autologous Fibronectin; I.A. Makarov, et al. 34 additional articles. Index.

Written by internationally renowned experts, Clinical Ophthalmic Oncology provides practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. The book supplies all of the state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible. Using the information provided, readers will be able to provide effective patient care using the latest knowledge on all aspects of ophthalmic oncology, to verify diagnostic conclusions based on comparison with numerous full-color clinical photographs, and to locate required information quickly owing to the clinically focused and user-friendly format. This volume describes the classification, differential diagnosis, and imaging of orbital tumors and discusses the most suitable treatment options for different tumor types. "

Optic Nerve Disorders: Diagnosis and Management, Second Edition, is a thoroughly revised and updated reference, including new information on diagnostic techniques such as genetic testing for hereditary optic neuropathies, new data on toxic/drug-related optic neuropathies, and recent data from clinical trial studies. Additional novel therapies, including stem cell therapies, the use of nanotechnology, and gene therapies are featured highlights, as is spectral domain optical coherence tomography (OCT) for imaging of the optic nerve. The way in which OCT is used in differentiating optic nerve disorders from other retinal disorders, and how OCT is used in monitoring the course of the disease, is also discussed. This practical reference focuses on common optic nerve disorders. It addresses diagnosis, pathophysiology, management, and prognosis, and is written in a clear, concise style for quick, easy reference in the clinic. With additional color photographs to better illustrate the material, the second edition will prove to be the go-to reference for ophthalmologists, neurologists, and neurosurgeons working with optic nerve disorders.

Advanced image processing and mathematical modeling techniques are increasingly being used for the early diagnosis of eye diseases. A comprehensive review of the field, Human Eye Imaging and Modeling details the latest advances and analytical techniques in ocular imaging and modeling. The first part of the book looks at imaging of the fundus as well as infrared imaging. It begins by exploring developments in the analysis of fundus images, particularly for the diagnosis of diabetic retinopathy and glaucoma. It also reviews anterior segment imaging and reports on developments in ocular thermography, especially the use of thermal imaging as the basis of tear evaporimetry and dry eye diagnosis. The second part of the book delves into mathematical modeling of the human eye. Coverage includes modeling of the eye during retinal laser surgery, a framework for optical simulation, heat distribution using a 3D web-splines solution, and exposure to laser radiation. The text also examines computer simulation of the human eye based on principles of heat transfer, as well as various bioheat equations to predict interior temperatures based on the surface temperature. Featuring contributions by established experts in eye imaging, this is a valuable reference for medical personnel and researchers who want to know more about state-of-the-art computer-based imaging and detection methods. It presents novel imaging and modeling algorithms that can aid in early diagnosis, with the aim of enriching the lives of people suffering from eye abnormalities.

"Illustrative Guide to Cataract Surgery "by Editor, Dr. Amar Agarwal and Associate Editor, Soosan Jacob is a unique book that includes matching step-by-step clinical photographs, medical illustrations, and videos to explain the most common techniques and steps in cataract surgery. With more than 650 illustrations, ophthalmologists and residents will visually learn the most essential procedures in cataract surgery, step-by-step.

The content, comprised from leading ophthalmic surgeons, is structured into systematically divided sections such as phaco surgery, microincision cataract surgery, challenging cases, and complications. It allows for quick reference, without having to search through voluminous books. Each image is supplemented with concise, informative text that helps further explain the techniques.

In addition, video instruction is offered through a companion website, with each book purchase. Using the same approach as the book, the website presents videos that match each technique or step in cataract surgery.

Just a few of the procedures explained:

- Vertical chopping
- Biaxial microincisional cataract surgery
- Posterior polar cataract
- Iris hooks in small pupil phaco
- Subluxated cataracts
- Torn rhexis
- Glued IOL implantation
- Intraocular lens implantation

With a combination of matching photos and illustrations alongside brief text and companion website, "Illustrative Guide to Cataract Surgery "stands apart from traditional books.

This book presents descriptive overviews of gene editing strategies across multiple species while also offering in-depth insight on complex cases of application in the field of tissue engineering and regenerative medicine. Chapters feature contributions from leaders in stem cell therapy and biology, providing a comprehensive view of the application of gene therapy in numerous fields with an emphasis on ophthalmology, stem cells, and agriculture. The book also highlights recent major technological advances, including ZFN, TALEN, and CRISPR. Precision Medicine, CRISPR, and Genome Engineering is part of the highly successful Advances in Experimental Medicine and Biology series. It is an indispensable resource for researchers and students in genetics as well as clinicians.