The development of the young brain after birth and the emergence of
cognitive capacities, mind, and individuality rest on the
maturation of a dense net of synaptic connections between neurons.
Memory Makes the Brain describes the dramatic, competitive
elimination of surplus synapses that occur in the young, maturing
brain - in a process called synaptic pruning that was discovered by
pediatric neurologist Peter Huttenlocher in the 1970's at the
University of Chicago. Explaining similarities between
developmental pruning and learning processes in the adult brain,
neurobiologist Christian Hansel offers a unique perspective on
brain adaptation and plasticity throughout lifetime, at times
weaving in personal accounts and memories. The cellular plasticity
machinery that enables learning is known to be affected in brain
developmental disorders such as autism. Memory Makes the Brain
explains how both maturation and adult synaptic plasticity are
deregulated in autism, and how we begin to trace back
autism-typical behavioral abnormalities to such synaptopathies.
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