Understanding the phenomenon of long-lasting vulnerability to
addiction is essential to developing successful treatments. Written
by an international team of authorities in their respective fields,
Advances in the Neuroscience of Addiction provides an excellent
overview of the available and emerging approaches used to
investigate the biologic mechanisms of drug addiction. It also
delineates the promising research discoveries being made in relapse
prevention. The book begins with current animal models of
addiction, which mimic the state of humans entering treatment:
recently-abstinent animals that receive common triggers for relapse
(classical conditioning, stress, and neuroadaptive dysregulation).
Coverage then shifts to the use of electrophysiologic approaches,
which enable researchers to characterize the discharge patterns of
single neurons during drug self-administration. After exploring
advances in voltammetry and enzyme-linked biosensors for measuring
glutamate, the book discusses the theoretical background and
results of neuroimaging studies related to neuronal networks that
are activated by drug-specific cues. It then describes modern
genetic approaches to manipulate target proteins that influence
addictive behavior. The book rounds out its coverage by
illustrating how a neuroeconomic approach can inform studies of
reward processing in general and addiction in particular. It is a
comprehensive introduction to the methodologies of the field for
students and beginning researchers and an essential reference
source for established investigators.
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