As pharmaceutical companies look to develop single enantiomers as
drug candidates, chemists are increasingly faced with the problems
associated with this subclass of organic synthesis. The Handbook of
Chiral Chemicals, Second Edition highlights the problems associated
with the production of chiral compounds on a commercial scale.
The handbook first elaborates upon starting materials obtained
from a "chiral pool," which can be derived from natural products.
Then it explains methods and reactions that can introduce or
influence stereogenic centers, particularly asymmetric
hydrogenations, oxidations, pericyclic reactions, and enzymatic
methods. While hydrogenations have been the most widely employed
approach for the large-scale synthesis of several commercial
compounds, the search for the ideal catalyst has consistently led
researchers to enzymes present in biological systems. Several
chapters concentrate on understanding how to manipulate enzymes for
catalyzing new reactions for taking new substrates. Other
significant topics include chiral auxiliaries, chromatographic
techniques, enantiomers-specific reactions, and resolution.
This second edition updates all its chapters, illustrating the
speed of development in this field, and features new chapters that
highlight successful approaches in an industrial setting. The
Handbook of Chiral Chemicals, Second Edition is a guide to advances
in the field that result in more efficient and cost-effective
synthesis of chiral chemicals.
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