Chemical genomics is an exciting new field that aims to transform
biolo- cal chemistry into a high-throughput industrialized process,
much in the same way that molecular biology has been transformed by
genomics. The inter- tion of small organic molecules with
biological systems (mostly proteins) underpins drug discovery in
the pharmaceutical and biotechnology industries, and therefore a
volume of laboratory protocols that covers the key aspects of
chemical genomics would be of use to biologists and chemists in
these orga- zations. Academic scientists have been exploring the
functions of proteins using small molecules as probes for many
years and therefore would also b- efit from sharing ideas and
laboratory procedures. Whatever the organizational backgrounds of
the scientists involved, the challenges of extracting the ma- mum
human benefit from genome sequencing projects remains considerable,
and one where it is increasingly recognized that chemical genomics
will play an important part. Chemical Genomics: Reviews and
Protocols is divided into two sections, the first being a series of
reviews to describe what chemical genomics is about and to set the
scene for the protocol chapters. The subject is introduced by Paul
Caron, who explains the various flavors of chemical genomics. This
is f- lowed by Lutz Weber and Philip Dean who cover the interaction
between organic molecules and protein targets from the different
perspectives of la- ratory experimentation and in silico design.
The protocols begin with the me- ods developed in Christopher
Lowes' laboratory (Roque et al.
General
| Imprint: |
HumanaPress
|
| Country of origin: |
United States |
| Series: |
Methods in Molecular Biology, 310 |
| Release date: |
November 2010 |
| First published: |
2005 |
| Editors: |
Edward D. Zanders
|
| Dimensions: |
229 x 152 x 15mm (L x W x T) |
| Format: |
Paperback
|
| Pages: |
280 |
| Edition: |
Softcover reprint of hardcover 1st ed. 2005 |
| ISBN-13: |
978-1-61737-541-5 |
| Categories: |
Books >
Science & Mathematics >
Biology, life sciences >
Biochemistry >
General
|
| LSN: |
1-61737-541-1 |
| Barcode: |
9781617375415 |
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