The Guest Editors have put together an issue of clinical reviews
that provides the most current look at PBC. Authors, all experts in
their respective areas, have submitted articles in the following
areas: Changes in epidemiology of PBC; Genetic and epigenetics in
PBC; Role of bile acids and the bicarbonate umbrella in the
pathogenesis of PBC; Current treatment options in PBC; Work in
progress: Drugs in development; Natural history of PBC in the UDCA
era: Role of scoring systems; Treatment of Pruritus: Tricks of the
trade; Chronic complications of cholestasis: Work-up and
Management; Individualizing care: Management beyond medical
therapy; Role of liver biopsy: When to do, how to stage;
AMA-negative PBC: Is it really the same as AMA-positive PBC?; New
thoughts on Overlap syndrome with auto-immune hepatitis; and
Current status of liver transplantation for PBC.
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