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Epstein-Barr Virus (Hardcover, illustrated edition)
Loot Price: R5,721
Discovery Miles 57 210
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Epstein-Barr Virus (Hardcover, illustrated edition)
Expected to ship within 10 - 15 working days
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Total price: R5,741
Discovery Miles: 57 410
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Epstein-Barr virus (EBV) is a human gamma herpes virus that remains
one of the most successful viral parasites known to man. It is the
etiological agent of infectious mononucleosis and is the major
biological cofactor contributing to a number of human cancers
including B-cell neoplasms (e.g. Burkitt's lymphoma, Hodgkin's
disease and immunoblastic lymphomas), certain forms of T-cell
lymphoma, and some epithelial tumors (e.g. nasopharyngeal
carcinomas and gastric carcinomas). The virus has the unique
ability to persist in the infected, apparently healthy host for
life. Understanding the molecular interaction between EBV and its
human host, the ability of the virus to modulate the host immune
system, its ability to hide in B-memory cells and factors that
trigger viral reactivation are fundamental to understanding the
cellular and molecular pathogenesis of the virus. This is critical
for the development of strategies for the prevention and control of
infection and disease. In this book, world renowned EBV experts
provide a critical and comprehensive review of every aspect of this
important virus. By integrating genetic, immunologic, and cell
biologic approaches to elucidate pathogenesis, penetrating new
insights into the molecular and cellular interaction between EBV
and its human host have emerged. Topics covered include: discovery,
history and seroepidemiology, EBV and the immune response, EBV
genetics, EBV infection and persistence, latency, lytic proteins
and reactivation control, vaccine approaches, animal models, and
the future of EBV studies. This is essential reading for all EBV
virologists as well as clinical and research scientists working on
oncogenic viruses.
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