It has been over 50 years since Hans Selye formulated his concept
of stress. This came after the isolation of epinephrine and
norepinephrine and after the sympathetic system was associated with
Walter Cannon's "fight or flight" response. The intervening years
have witnessed a number of dis coveries that have furthered our
understanding of the mechanisms of the stress response. The
isolation, identification and manufacture of gluco corticoids, the
identification and synthesis of ACTH and vasopressin, and the
demonstration of hypothalamic regulation of ACTH secretion were
pivotal discoveries. The recent identification and synthesis of CRR
by Willie Vale and his colleagues gave new impetus to stress
research. Several new concepts of stress have developed as a result
of advances in bench research. These include the concept of an
integrated "stress sys tem," the realization that there are
bi-directional effects between stress and the immune system, the
suggestion that a number of common psychiatric disorders represent
dysregulation of systems responding to stress, and the
epidemiologic association of stress with the major scourges of
humanity."
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