Nitric oxide (NO) is a tiny molecule with tremendous impact in
biology, biochemistry, physiology, biomedicine and clinical
practice. Nitric oxide, as a signaling molecule, significantly
contributes in the regulation of transcriptional, translational and
post-translational processes, aging, inflammation, and major human
pathologies. This book represents a view on the area from physical
chemists with long and broad expertise in chemical biophysics,
mechanisms of enzyme catalysis and physical methods for application
in biology, in particular. This book forms the physicochemical
basis for a deep understanding of the biochemical and physiological
impact of nitric oxide. With numerous references to essential
literature, this volume provides a tool to fundamental knowledge in
all important aspects of the vast area. The book chapters are
dedicated to basic physical and chemical properties of nitric
oxide, NO donors, NO metallocomplexes, and methods of NO analysis.
A general survey is made of data on nitric oxide synthase and
soluble guanylate cyclase, an NO receptor, and reactive nitrogen
species. Brief reviews of the nitric oxide involving genetics and
aging, occurrence of pathology and treatment of cancer, arterial
and bone diseases, central nervous systems and neurodegenerative
diseases, and other miscellaneous diseases are all presented. This
book is intended for scientists working in areas related to the
impact of nitric oxide in biochemistry, molecular biology and
biophysics, physiology and biomedicine. The book will also be
useful for doctors and pharmacologists involved in the clinical
practice. This text, as a whole or as separate chapters, can also
be employed as subsidiary manuals for instructors, graduate and
undergraduate students of university physics, bio-physics,
chemistry, biochemistry, and biomedicine departments, and
researchers of laboratories for pharmacological companies.
General
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