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Adverse Events and Oncotargeted Kinase Inhibitors (Hardcover)
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Adverse Events and Oncotargeted Kinase Inhibitors (Hardcover)
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Adverse Events and Oncotargeted Kinase Inhibitors gathers and
evaluates data on adverse events associated with tyrosine kinase
inhibitors (TKIs), a powerful anti-tumor drug class that has
recently been introduced for human therapy. This book compiles a
comprehensive safety profile of each TKI from experiences in
official therapeutic indications, also exploring off-label
exploratory investigations and postmarketing pharmaceutical
surveillance databases. A brief history of each drug's development
and submission is provided, along with a more detailed analysis of
the mechanism(s) of action involved in therapeutic activity or
related to the insurgence of specific adverse events. Early
chapters focus on general characteristics of TKIs, typology, and
classification of adverse events, while the final chapters analyze
TKIs as AE inducers and classes of AEs by system or organ
involvement. This comprehensive resource compiles and critically
reviews all of the relevant safety data for this class of drugs,
with the goal of improving the understanding of pathogenesis and
facilitating the prevention, monitoring, and management of these
adverse events.
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