Bone Drugs in Pediatrics brings together in one place the evidence
for the use of certain drugs in the treatment and prevention of
bone loss in children, as well as the reservations still present in
the pediatric community regarding their use. Beginning with a
discussion of developmental pharmacokinetics and drug development
for pediatric diseases where bone loss occurs, such as osteogenesis
imperfecta, the physiology of pediatric bone and how best to
monitor the safety and efficacy of these drugs is presented. The
pros and cons of utilizing the drugs themselves - such as
bisphosphonates, antiresorptives and anabolic agents - within the
pediatric population are carefully considered, with an eye toward
safe and effective integration. The potential use of drugs in
future treatment is also highlighted. On the whole, Bone Drugs in
Pediatrics is a cogent presentation of the ongoing debate
surrounding the potential for pharmacological interventions in
pediatric bone loss.
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