Targeting of Drugs (Paperback, Softcover reprint of the original 1st ed. 1982)

Successful drug use in biology and medicine is often prejudiced by the failure of drugs that are otherwise active in vitro to act as efficiently in vivo. This is because in the living animal drugs must, as a rule, bypass or traverse organs, membranes, cells and molecules that stand between the site of administration and the site of action. In practice, however, drugs can be toxic to normal tissues, have limited or no access to the target and be prematurely excreted or inactivated. There is now growing optimism that such problems may be resolved by the use of carrier systems that will not only protect the non-target environment from the drugs they carry but also deliver them to where they are needed or facilitate their release there. Carrier systems presently under investigation include antibodies, glycoproteins, cells, reconstituted viruses and liposomes. Recent advances in the chemistry of cell receptor and receptor-recognising molecules, llnmunology, and natural and artificial membranes have revealed a multitude of ways in which such carrier systems can be modified or improved upon.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	NATO Science Series A:, 47
Release date:	December 2012
First published:	1982
Editors:	Gregory Gregoriadis
Dimensions:	244 x 170 x 22mm (L x W x T)
Format:	Paperback
Pages:	430
Edition:	Softcover reprint of the original 1st ed. 1982
ISBN-13:	978-1-4684-4243-4
Categories:	Books > Medicine > Other branches of medicine > Pharmacology > General
LSN:	1-4684-4243-0
Barcode:	9781468442434

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