Elastic Filaments of the Cell (Paperback, Softcover reprint of the original 1st ed. 2000)

Elastic filaments refer mainly to titin, the largest of all known proteins. Titin was discovered initially in muscle cells, where it interconnects the thick filament with the Z-line. Titin forms a molecular spring that is responsible for maintaining the structural integrity of contracting muscle, ensuring efficient muscle contraction. More recently, it has become clear that titin is not restricted to muscle cells alone. For example, titin is found in chromosomes of neurons and also in blood platelets. This topic is fast becoming a focal point for research in understanding viscoelastic properties at the molecular, cellular, and tissue levels. In titin may lie a generic basis for biological viscoelasticity. It has become clear that titin may hold the key to certain clinical anomalies. For example, it is clear that titin-based ventricular stiffness is modulated by calcium and that titin is responsible for the altered stiffness in cardiomyopathies. It is also clear from evidence from a group of Finnish families that titin mutations may underlie some muscular dystrophies and that with other mutations chromatids fail to separate during mitosis. Thus, it is clear that this protein will have important clinical implications stemming from its biomechanical role. One aspect of this field is the bringing together of bioengineers with clinical researchers and biologists. Genetic and biochemical aspects of titin-related proteins are being studied together with front-line engineering approaches designed to measure the mechanics of titin either in small aggregates or in single molecules.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	Advances in Experimental Medicine and Biology, 481
Release date:	November 2012
First published:	2000
Editors:	H. L. Granzier • Gerald H. Pollack
Dimensions:	254 x 178 x 23mm (L x W x T)
Format:	Paperback
Pages:	425
Edition:	Softcover reprint of the original 1st ed. 2000
ISBN-13:	978-1-4613-6916-5
Categories:	Books > Professional & Technical > Veterinary science > General Books > Science & Mathematics > Biology, life sciences > Biochemistry > General Promotions
LSN:	1-4613-6916-9
Barcode:	9781461369165

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