Necrotic Cell Death (Hardcover, 2014 ed.)

Starting with discussion of basic concepts and the molecular mechanisms of necrosis, this book looks first at several forms of necrotic cell death that have been identified, including necroptosis, autophagic cell death, and PARP-mediated cell death. As necrotic cell death is increasingly known to play a critical role in many physiological processes, the next chapters discuss its effect on metabolism, inflammation, immunity, and development. Necrotic cell death is closely implicated in human diseases like cancer, so the next chapters examine its relevance to human diseases, and final chapters cover methodologies for measuring necrosis. This book presents comprehensive coverage of necrosis from recognized experts from leading academic and medical institutions around the world. In contrast to apoptosis, well-defined as a form of programmed cell death, necrosis used to be considered as accidental (i.e., non-programmed) cell death, usually in response to a severe injury. Accumulating evidence now suggests, however, that necrosis is also programmed and controlled by distinctive "death machinery" in response to various stimuli like oxidative stress or DNA damage.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	Cell Death in Biology and Diseases
Release date:	March 2014
First published:	2014
Editors:	Han-Ming Shen • Peter Vandenabeele
Dimensions:	235 x 155 x 21mm (L x W x T)
Format:	Hardcover
Pages:	397
Edition:	2014 ed.
ISBN-13:	978-1-4614-8219-2
Categories:	Books > Science & Mathematics > Biology, life sciences > Cellular biology > General
LSN:	1-4614-8219-4
Barcode:	9781461482192

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