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Progress in DNA Methylation Research (Hardcover, Illustrated Ed)
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Progress in DNA Methylation Research (Hardcover, Illustrated Ed)
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DNA methylation is a type of chemical modification of DNA that can
be inherited without changing the DNA sequence. As such, it is part
of the epigenetic code and is the most characterised epigenetic
mechanism. DNA methylation involves the addition of a methyl group
to DNA -- for example, to the number 5 carbon of the cytosine
pyrimidine ring. DNA methylation is probably universal in
eukaryotes. In humans, approximately 1% of DNA bases undergo DNA
methylation. In adult somatic tissues, DNA methylation typically
occurs in a CpG dinucleotide context; non-CpG methylation is
prevalent in embryonic stem cells.In plants, cytosines are
methylated both symmetrically (CpG or CpNpG) and asymmetrically
(CpNpNp), where N can be any nucleotide. The methylation status of
specific cytosines can be determined using methods based on
bisulfite sequencing. This book presents leading-edge research
advances in the field.
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