This book describes the latest developments in technologies that
can be used to obtain the 3-D structures including the high profile
structural genomics approaches being utilised worldwide. The use of
3-D protein structures in new, Fragment-based, approaches to drug
discovery are described in some detail. This book includes
experimental approaches using X-ray crystallography and NMR for
Fragment-based screening as well as other biophysical methods for
studying protein/ligand interactions. In addition, developments in
computational chemistry methodology are covered together with an
assessment of practical applications.
General
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