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Books > Medicine > Other branches of medicine > Pharmacology
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Toxicity Assessment Alternatives - Methods, Issues, Opportunities (Paperback, Softcover reprint of the original 1st ed. 1999)
Loot Price: R4,220
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Toxicity Assessment Alternatives - Methods, Issues, Opportunities (Paperback, Softcover reprint of the original 1st ed. 1999)
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Toxicity Assessment Alternatives: Methods, Issues, Opportunities
contains a broad array of critical surveys, contributed by active
and respected investigators, describing their research and offering
updates on toxicity assessment alternatives, directions determined
by current and future grant programs, opportunities for
mechanistically based test methods to detect endocrine disruptor
activity, the use of alternatives in the Department of Defense
hazard assessment initiatives, and the issues and opportunities for
validation and regulatory acceptance. Several of these advances
make use oftransgenic models that reduce the time and cost of
carcinogenicity testing. Others use tissue cultures for the
assessment of endocrine disrupting chemicals. Cultures of human
epidermal keratinocytes are applicable as models for sulfur mustard
lesions, and in vitro protein denaturation is used as a chemical
test for assessing the ocular and dermal irritation potential of
cosmetic prod ucts. Molecular modeling is applied to explaining
chemical toxicity. Commercially developed assay systems have
undergone extensive evaluation by their manufacturers. Some of
these await external valida tion, and others await acceptance by
North American and European regulatory agencies. Toxicity
Assessment Alternatives: Methods, Issues, Opportunities provides
information from members of the scientific and regulatory
communities on what has been achieved and what has been accepted in
alternatives to animal testing.
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