GABA (gamma-aminobutyric acid) is the main neurotransmitter
regulating sleep. The majority of drugs presently in use for the
treatment of sleep disorders act by enhancing GABAergic neuronal
inhibition. The GABA system is, therefore, of prime clinical
relevance for the therapy of insomnia.
The focus of this volume is on the neuropsychopharmacology and
the clinical impact of the GABA system in regulating sleep and
wakefulness. It presents molecular, neuropharmacological,
systems-biological and clinical approaches to the understanding of
the mechanism of action of GABA and GABAergic drugs. It also
explores the role of GABA in the basic drives that affect sleep,
and the influences that adapt sleep and wakefulness to external
events.
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