This leading textbook in the field examines the mechanisms
underlying toxicity, particularly the events at the molecular level
and the factors that determine and affect toxicity. The new edition
is updated to reflect the latest research into the biochemical
basis of toxicology and the growing concerns over the adverse
effects of drugs, environmental pollution, and occupational
hazards.
Principles of Biochemical Toxicology, Fourth Edition thoroughly
explains dose-response relationships, disposition and metabolism,
and toxic responses to foreign compounds, and presents detailed
examples to make the mechanisms of toxicity more accessible to
students encountering the subject for the first time. Comprehensive
in scope with a clear and concise approach, the text includes
summary sections, questions and model answers, and thoroughly
revised artwork that serves as an essential aid to learning and
teaching.
New to the Fourth Edition
- reorganized sections that cover basic principles followed by
sections on different types of toxicity
- extensive use of examples throughout and numerous explanatory
diagrams
- new material on risk assessment, export systems, oxidative
stress, Thalidomide, Tamoxifen and asbestos proliferators, domoic
acid, bone marrow (benzene), heart (adriamycin), blood
(primaquine), biomarkers, cytochrome P450 and other enzymes,
receptor mediated effects, endocrine disruption, ethanol, botox,
arsenic, and more
- questions with answers for each chapter for review and
self-checking
- expanded and updated chapter bibliographies
General
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