The identification of hepatitis C virus by Michael Houghton and his
c- leagues at the Chiron Corporation nearly years ago represented a
technical tour de force of modern molecular medicine. This
breakthrough not only unearthed the causative agent of non-A non-B
hepatitis that had eluded the best of scientists for more than 20
years, but also was symbolic of another chapter in the changing
paradigm of modern science and medicine. The re- lutionary concept
of identifying a pathogen without actually visualizing or detecting
it will forever redefine the way we approach pathogenesis of d-
eases whose cause is unknown. It is benefitting that this discovery
treads on the heels of the human immunodeficiency pandemic, and
parallels the ala- ing emergence of various microbial pestilences
in the world. Despite the rapid advances in our understanding of
the virus, there is much remaining to learn about it. This book
highlights some of the important areas yet to be unraveled. As
illustrated in this book, the marriage between basic science and
clinical medicine is essential in our quest for these unknowns. The
last decade has focused on the fundamentals of the virus; the next
decade must underscore translational research, bridging clinical
medicine and basic science with re- ization of fundamental
knowledge to improve prevention, diagnosis, and tre- ment of viral
hepatitis C.
General
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