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The alpha-1 Adrenergic Receptors (Hardcover, 1987 ed.)
Loot Price: R5,806
Discovery Miles 58 060
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The alpha-1 Adrenergic Receptors (Hardcover, 1987 ed.)
Series: The Receptors
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During the past decade, great strides have been made in our un
derstanding of the biochemistry and pharmacology of the alpha-l
adrenergic receptor. The alpha-l adrenergic receptor plays a key
role in biological function. This is evidenced by the fact that the
alpha-l adrenergic receptor plays a prominent functional role in
most organs of the body and in the key systems responsible for
survival of the organism and maintenance of optimum biological
activity. This is most apparent in the cardiovascular system, in
which alpha-l adrenergic receptors are the single most important
receptor involved in the maintenance of blood pressure and circu
latory function. It is appropriate, therefore, that recent findings
related to the pharmacology and biochemistry of the alpha-l
adrenergic receptor be compiled, since this subject has not been
reviewed in detail in recent years. It is the purpose of this book
to present a series of reviews of key experimental findings that
shed new light on the alpha-l adrenergic receptor and the manner in
which it functions. Classically, most receptors have been
characterized based on structure-activity relationships obtained
for selective agonists and antagonists interacting with the
receptor. Although there are many newer and more sophisticated
approaches to receptor char acterization, structure-activity
relationships still provide impor tant information regarding the
chemical requirements made by the receptor for its occupation by
ligands and its subsequent acti vation by those ligands possessing
intrinsic efficacy and, there fore, agonist activity."
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