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Epigenetic Epidemiology (Hardcover, 2012)
Loot Price: R4,576
Discovery Miles 45 760
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Epigenetic Epidemiology (Hardcover, 2012)
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Total price: R4,596
Discovery Miles: 45 960
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The exploding field of epigenetics is challenging the dogma of
traditional Mendelian inheritance. Epigenetics plays an important
role in shaping who we are and contributes to our prospects of
health and disease. While early epigenetic research focused on
plant and animal models and in vitro experiments, population-based
epidemiologic studies increasingly incorporate epigenetic
components. The relevance of epigenetic marks, such as DNA
methylation, genomic imprinting, and histone modification for
disease causation has yet to be fully explored.This book covers the
basic concepts of epigenetic epidemiology, discusses challenges in
study design, analysis, and interpretation, epigenetic laboratory
techniques, the influence of age and environmental factors on
shaping the epigenome, the role of epigenetics in the developmental
origins hypothesis, and provides the state of the art on the
epigenetic epidemiology of various health conditions including
childhood syndromes, cancer, infectious diseases, inflammation and
rheumatoid arthritis, asthma, autism and other neurodevelopmental
disorders, psychiatric disorders, diabetes, obesity and metabolic
disorders, and atherosclerosis. With contributions from: Peter
Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many
other experts in epigenetics!
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