One of the currently most expanding and exciting areas in
cardiovascular research is the study of receipt and dispatch of
chemical signals by different cell types. Major progress has been
made during the last years and a number of intercellular mediators
have been structurally identified and their regulation studied. The
impressive developments in molecular biology have provided most
effective tools, enabling us to understand message generation in
much more detail than anyone would have appreciated a couple of
years ago. These developments also have a major impact on
cardiovascular pharmacology. This involves both the molecular
design of new drugs as well as an improved understanding of how
established drugs act. Clearly, changes in one mediator system will
also affect others and it might be difficult to take out just one
factor and to ignore others. This is definitely true for myocardial
ischemia where many different mediators are synthesized and
released at about the same time, resulting in a complex picture of
events and an even more difficult selection of the most appropriate
drug therapy.
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