The multiple actions of estrogens on different cell types have
not only intrigued endocrinology researchers but also inspired the
development of selective estrogen receptor modulators, or SERMs,
that modulate estrogen signaling in a cell type-specific manner.
Current molecular understanding of estrogen action has greatly
profited from advances in molecular cell biology to dissect the
mechanisms of estrogen-regulated gene expression in target cells,
from in vivo analyses using genetic models deficient in estrogen
signaling and from synthetic estrogen receptor ligands with
isoform- or pathway-selective activity. These advances, and their
implications for clinical use, were discussed by leading
researchers from industry and academia during an international
symposium held in Berlin, 1-3 March 2006.
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