In multiple sclerosis (MS), conventional magnetic resonance
imaging (cMRI) has proved to be a valuable tool to increase
diagnostic confidence and for monitoring the efficacy of
experimental treatment. However, cMRI has limited specificity and
accuracy of cMRI to the most disabling aspects of the MS pathology,
known to occur in and outside macroscopic lesions. Modern
quantitative MR techniques have the potential to overcome the
limitations of cMRI, and their application is changing dramatically
our understanding of how MS causes irreversible disability. In
detail, there is an increasing body of MR evidence that MS is not
only a white matter disease and does not only cause focal lesions,
as well as that neurodegeneration is an important aspect of the
disease (since the earliest clinical phases), which is only
partially related to inflammatory changes. There is also increasing
perception that modern MR methodologies should be more extensively
employed in clinical trials to derive innovative information.
Written by world-renowned scientists, the volume provides a
state-of-the-art on the most recent MRI techniques related to MS,
and it will bi and indispensable tool for all those working in this
field.
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