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Hypertrophic Cardiomyopathy - The Therapeutic Role of Calcium Antagonists (Paperback, Softcover reprint of the original 1st ed. 1982)
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Hypertrophic Cardiomyopathy - The Therapeutic Role of Calcium Antagonists (Paperback, Softcover reprint of the original 1st ed. 1982)
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First described in 1907 by Schicke but recognized as a clinical
entity only as recently as 1958, when Teare published the
pathologic findings in patients with hypertrophic cardiomyopathy
(HeM), an explosion of knowledge about this fascinating disease has
occurred, which has caused a profound evolution of our
understanding of its broad pathophysiologic and clinical spectrum.
Progress has been particularly rapid in the past few years when
M-mode echocardiography, and more recently 2-dimen sional
echocardiography have been applied to the study ofHCM. In addition
to new insights as to what the disease is, there has been enormous
progress concerning its treatment, with the application of
beta-adrenergic blocking agents and surgical relief of left
ventricular outflow tract obstruction. Although these approaches
have led to great strides in the symptomatic control of the
disease, many patients' symptoms have remained refactory to medical
and surgical therapy. Most discouragingly, sudden death still
occurs, even in patients on large doses of beta-blocking agents and
in patients who have had surgical relief of left ventricular
outflow tract obstruction."
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